LOCUS       NM_009811               1475 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus caspase 6 (Casp6), mRNA.
ACCESSION   NM_009811
VERSION     NM_009811.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Kuijper,E.C., Overzier,M., Suidgeest,E., Dzyubachyk,O., Maguin,C.,
            Perot,J.B., Flament,J., Ariyurek,Y., Mei,H., Buijsen,R.A.M., van
            der Weerd,L. and van Roon-Mom,W.
  TITLE     Antisense oligonucleotide-mediated disruption of HTT caspase-6
            cleavage site ameliorates the phenotype of YAC128 Huntington
            disease mice
  JOURNAL   Neurobiol Dis 190, 106368 (2024)
   PUBMED   38040383
  REMARK    GeneRIF: Antisense oligonucleotide-mediated disruption of HTT
            caspase-6 cleavage site ameliorates the phenotype of YAC128
            Huntington disease mice.
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Lin,Y., Sheng,M., Qin,H., Zhang,P., Wang,C., Fu,W., Meng,X.,
            Wang,D. and Hou,Y.
  TITLE     Caspase 6 promotes innate immune activation by functional crosstalk
            between RIPK1-IkappaBalpha axis in liver inflammation
  JOURNAL   Cell Commun Signal 21 (1), 282 (2023)
   PUBMED   37828624
  REMARK    GeneRIF: Caspase 6 promotes innate immune activation by functional
            crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Li,L., Kovacs,S.B., Jorgensen,I., Larson,H.N., Lazear,H.M. and
            Miao,E.A.
  TITLE     Role of Caspases and Gasdermin A during HSV-1 Infection in Mice
  JOURNAL   Viruses 14 (9), 2034 (2022)
   PUBMED   36146839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Zheng,T.S. and Flavell,R.A.
  TITLE     Divinations and surprises: genetic analysis of caspase function in
            mice
  JOURNAL   Exp Cell Res 256 (1), 67-73 (2000)
   PUBMED   10739653
  REMARK    Review article
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Roth,K.A., Kuan,C., Haydar,T.F., D'Sa-Eipper,C., Shindler,K.S.,
            Zheng,T.S., Kuida,K., Flavell,R.A. and Rakic,P.
  TITLE     Epistatic and independent functions of caspase-3 and Bcl-X(L) in
            developmental programmed cell death
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 466-471 (2000)
   PUBMED   10618441
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Zheng,T.S., Hunot,S., Kuida,K. and Flavell,R.A.
  TITLE     Caspase knockouts: matters of life and death
  JOURNAL   Cell Death Differ 6 (11), 1043-1053 (1999)
   PUBMED   10578172
  REMARK    Review article
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   Exley,G.E., Tang,C., McElhinny,A.S. and Warner,C.M.
  TITLE     Expression of caspase and BCL-2 apoptotic family members in mouse
            preimplantation embryos
  JOURNAL   Biol Reprod 61 (1), 231-239 (1999)
   PUBMED   10377054
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Van de Craen,M., Vandenabeele,P., Declercq,W., Van den Brande,I.,
            Van Loo,G., Molemans,F., Schotte,P., Van Criekinge,W., Beyaert,R.
            and Fiers,W.
  TITLE     Characterization of seven murine caspase family members
  JOURNAL   FEBS Lett 403 (1), 61-69 (1997)
   PUBMED   9038361
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY265671.1, AK168842.1,
            AV048874.1 and AC118620.10.
            
            On Apr 3, 2015 this sequence version replaced NM_009811.3.
            
            Summary: This gene encodes a member of the cysteine proteases that
            plays important roles in regulating apoptosis and
            neurodegeneration. The encoded protein is involved in the
            transmission of pain and axonal degeneration. Genetic deletion of
            this gene in mice results in the delay of axon pruning and protects
            from axon degeneration. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002022.1, AK146363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY265671.1         2-44
            44-1273             AK168842.1         7-1236
            1274-1323           AV048874.1         112-161
            1324-1324           AC118620.10        159495-159495       c
            1325-1386           AV048874.1         163-224
            1387-1387           AC118620.10        159432-159432       c
            1388-1475           AV048874.1         226-313
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.5 cM"
     gene            1..1475
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /note="caspase 6"
                     /db_xref="GeneID:12368"
                     /db_xref="MGI:MGI:1312921"
     exon            1..92
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..134
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..936
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /EC_number="3.4.22.59"
                     /note="apoptotic protease Mch-2"
                     /codon_start=1
                     /product="caspase-6 precursor"
                     /protein_id="NP_033941.3"
                     /db_xref="CCDS:CCDS17838.1"
                     /db_xref="GeneID:12368"
                     /db_xref="MGI:MGI:1312921"
                     /translation="MTETDGFYKSREVFDPAEQYKMDHKRRGVALIFNHERFFWHLTL
                     PERRGTNADRDNLTRRFSDLGFEVKCFNDLRAEELLLKIHEVSTSSHIDADCFICVFL
                     SHGEGNHVYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDM
                     VDHQTDKLDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML
                     ARYGSSLEFTELLTLVNRKVSQRRVDFCKDPDAIGKKQVPCFASMLTKKLHFCPKPSK
                     "
     exon            135..284
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..361
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..537
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..694
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1475
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /note="hexamer: AATAAA"
     polyA_site      1313
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /note="major polyA site"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
                     /note="hexamer: AATAAA"
     polyA_site      1466
                     /gene="Casp6"
                     /gene_synonym="CASP-6; Mch2"
ORIGIN      
        1 ggggcggggc aggaggcggg gcggggctgg caggaaacgg gtggacgagc ggaggcctca
       61 gggctaggac accggtggga gctcgcgggc aggtgaaagt aaaacatgac agaaaccgat
      121 ggcttctaca aaagtaggga agtgttcgat ccagccgagc agtacaagat ggaccacaag
      181 aggagaggag ttgccctcat cttcaatcac gagaggttct tttggcacct gaccctccca
      241 gagaggcggg gcaccaacgc agacagagac aacctgactc gcaggttttc agatctagga
      301 tttgaagtga aatgctttaa cgacctcaga gcagaagaac tcctgctcaa aattcacgag
      361 gtgtcgactt caagccacat agatgccgat tgcttcatct gtgtcttcct gagccatggg
      421 gaaggcaacc acgtttacgc atacgacgcc aaaattgaaa ttcagacgtt gactggcttg
      481 ttcaaaggag acaagtgtca gagcctggtt ggaaaaccca agatatttat catccaggcc
      541 tgtcggggta gccagcatga cgtacccgtg gttcccctgg acatggtgga tcaccagaca
      601 gacaagctgg acaacgtgac ccaggtggat gctgcgtccg tgtacacgct gccggcaggg
      661 gcagacttcc tcatgtgcta ctctgtcgca gaagggtatt actctcaccg agaaactgtg
      721 aatggctcct ggtacattca ggatttgtgt gagatgctgg cgaggtacgg cagttccctg
      781 gagttcacgg agctgctcac gctggtgaac agaaaggtct ctcagcgccg cgtggacttc
      841 tgcaaagacc cggatgcaat cggcaagaag caggtgccct gcttcgcctc aatgctgacc
      901 aaaaagctgc atttctgtcc caaacctagc aagtagggcc atctgtcttg ctacatatat
      961 ttcacacaca tttccctttt tatacaaagg ccagctggtg gaagactttc acccatcaat
     1021 gtaaactgct tcaattttgt agatgccata gaaaagtaat gttttatatt tgttactttt
     1081 caatcatgtt ggacgtggtg gaagggctaa aaataatcct caggaaatta ctatgcatca
     1141 atgtctacta catttattac atttttagta aactgtaaga ttactctaaa taccaactac
     1201 tttgcctccc cttttgtgac actgtttata tgagtttact gtataatgtt tgtaaagact
     1261 tttgaaactc tagactgaga ttgttttcgc gtaataaaat gtctaagaac tcattgacac
     1321 tttctaattc ctatgtttat gtgatttata gtgggcctat ttgacttggt catgtattca
     1381 tttactatct tgtttacctc taatcaaggt aaactttata tgtggcttta attcccattt
     1441 tggaaacaat aaacctttca gaattatttt atggc
//
