LOCUS       NM_007609               1443 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus caspase 4, apoptosis-related cysteine peptidase
            (Casp4), transcript variant 1, mRNA.
ACCESSION   NM_007609
VERSION     NM_007609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Wright,S.S., Kumari,P., Fraile-Agreda,V., Wang,C., Shivcharan,S.,
            Kappelhoff,S., Margheritis,E.G., Matz,A., Vasudevan,S.O., Rubio,I.,
            Bauer,M., Zhou,B., Vanaja,S.K., Cosentino,K., Ruan,J. and
            Rathinam,V.A.
  TITLE     Transplantation of gasdermin pores by extracellular vesicles
            propagates pyroptosis to bystander cells
  JOURNAL   Cell 188 (2), 280-291 (2025)
   PUBMED   39742811
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Pizzuto,M., Hurtado-Navarro,L., Molina-Lopez,C., Soubhye,J.,
            Gelbcke,M., Rodriguez-Lopez,S., Ruysschaert,J.M., Schroder,K. and
            Pelegrin,P.
  TITLE     Ornithine lipid is a partial TLR4 agonist and NLRP3 activator
  JOURNAL   Cell Rep 43 (10), 114788 (2024)
   PUBMED   39340778
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Wan,Y., Li,J., Pu,J., Yang,J., Pei,C. and Qi,Y.
  TITLE     Role of caspase-11 non-canonical inflammasomes in retinal
            ischemia/reperfusion injury
  JOURNAL   Mol Med 30 (1), 159 (2024)
   PUBMED   39333859
  REMARK    GeneRIF: Role of caspase-11 non-canonical inflammasomes in retinal
            ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Bai,D., Zhou,C., Du,J., Zhao,J., Gu,C., Wang,Y., Zhang,L., Lu,N.
            and Zhao,Y.
  TITLE     TrxR1 is involved in the activation of Caspase-11 by regulating the
            oxidative-reductive status of Trx-1
  JOURNAL   Redox Biol 75, 103277 (2024)
   PUBMED   39059206
  REMARK    GeneRIF: TrxR1 is involved in the activation of Caspase-11 by
            regulating the oxidative-reductive status of Trx-1.
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Liang,N., Li,Y., Yuan,C., Zhong,X., Yang,Y., Liang,F., Zhao,K.,
            Yuan,F., Shi,J., Wang,E., Zhong,Y., Tian,G., Lu,B. and Tang,Y.
  TITLE     Caspase-11 signaling promotes damage to hippocampal CA3 to enhance
            cognitive dysfunction in infection
  JOURNAL   Mol Med 30 (1), 127 (2024)
   PUBMED   39179968
  REMARK    GeneRIF: Caspase-11 signaling promotes damage to hippocampal CA3 to
            enhance cognitive dysfunction in infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Colussi,P.A. and Kumar,S.
  TITLE     Targeted disruption of caspase genes in mice: what they tell us
            about the functions of individual caspases in apoptosis
  JOURNAL   Immunol Cell Biol 77 (1), 58-63 (1999)
   PUBMED   10101687
  REMARK    Review article
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Kumar,S. and Colussi,P.A.
  TITLE     Prodomains--adaptors--oligomerization: the pursuit of caspase
            activation in apoptosis
  JOURNAL   Trends Biochem Sci 24 (1), 1-4 (1999)
   PUBMED   10087912
  REMARK    Review article
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Wang,S., Miura,M., Jung,Y.K., Zhu,H., Li,E. and Yuan,J.
  TITLE     Murine caspase-11, an ICE-interacting protease, is essential for
            the activation of ICE
  JOURNAL   Cell 92 (4), 501-509 (1998)
   PUBMED   9491891
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Van de Craen,M., Vandenabeele,P., Declercq,W., Van den Brande,I.,
            Van Loo,G., Molemans,F., Schotte,P., Van Criekinge,W., Beyaert,R.
            and Fiers,W.
  TITLE     Characterization of seven murine caspase family members
  JOURNAL   FEBS Lett 403 (1), 61-69 (1997)
   PUBMED   9038361
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Wang,S., Miura,M., Jung,Yk., Zhu,H., Gagliardini,V., Shi,L.,
            Greenberg,A.H. and Yuan,J.
  TITLE     Identification and characterization of Ich-3, a member of the
            interleukin-1beta converting enzyme (ICE)/Ced-3 family and an
            upstream regulator of ICE
  JOURNAL   J Biol Chem 271 (34), 20580-20587 (1996)
   PUBMED   8702803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC141637.3 and AK151547.1.
            
            On Apr 3, 2015 this sequence version replaced NM_007609.2.
            
            Summary: This gene encodes a member of the cysteine proteases that
            plays important roles in apoptosis, cell migration and the
            inflammatory response. The encoded protein mediates production of
            pro-inflammatory cytokines by macrophages upon bacterial infection.
            Mice lacking the encoded protein are resistant to endotoxic shock
            induced by lipopolysaccharide. A 5-bp deletion encompassing a
            splice acceptor junction resulting in alternate splicing and a
            shorter non-functional isoform in certain mouse strains has been
            described. Although its official nomenclature is 'caspase 4,
            apoptosis-related cysteine peptidase', this gene and its encoded
            protein have historically been called caspase 11. This gene is
            present in a cluster of three caspase genes on chromosome 9.
            [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151547.1, BC061255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC141637.3         137511-137521
            12-1386             AK151547.1         2-1376
            1387-1443           AC141637.3         165397-165453
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1443
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /note="caspase 4, apoptosis-related cysteine peptidase"
                     /db_xref="GeneID:12363"
                     /db_xref="MGI:MGI:107700"
     exon            1..66
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1181
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /EC_number="3.4.22.64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caspase 4, apoptosis-related cysteine protease; caspase
                     11, apoptosis-related cysteine protease; caspase-11 short
                     form splicing; protease ICH-3; caspase 11,
                     apoptosis-related cysteine peptidase; caspase-4"
                     /codon_start=1
                     /product="caspase-4 isoform 1"
                     /protein_id="NP_031635.2"
                     /db_xref="CCDS:CCDS22799.1"
                     /db_xref="GeneID:12363"
                     /db_xref="MGI:MGI:107700"
                     /translation="MAENKHPDKPLKVLEQLGKEVLTEYLEKLVQSNVLKLKEEDKQK
                     FNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVDPGSHHGEANLEMEEPEESLNTL
                     KLCSPEEFTRLCREKTQEIYPIKEANGRTRKALIICNTEFKHLSLRYGANFDIIGMKG
                     LLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGTMHS
                     EKTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGV
                     DLPRNMEADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCH
                     LFDIFLKVQQSFEKASIHSQMPTIDRATLTRYFYLFPGN"
     exon            67..321
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..419
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            420..593
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..828
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            829..972
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1082
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1186
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1443
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /note="hexamer: AACAAA"
     polyA_site      1390
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /note="major polyA site"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
                     /note="hexamer: AATAAA"
     polyA_site      1441
                     /gene="Casp4"
                     /gene_synonym="CASP-11; CASP-4; Casp11; Caspl; ich-3"
ORIGIN      
        1 actttcattt tactctgtca agctgtcttc acggtgcgaa agaactgagg ctttttctca
       61 tggctgaaaa caaacaccct gacaaaccac ttaaggtgtt ggaacagctg ggcaaagaag
      121 tccttacgga gtacctagaa aaattagtac aaagcaatgt actgaaatta aaggaggaag
      181 ataaacaaaa atttaacaat gctgaacgca gtgacaagcg ttgggttttt gtagatgcca
      241 tgaaaaagaa acacagcaaa gtaggtgaaa tgcttctcca gacattcttc agtgtggacc
      301 caggcagcca ccatggtgaa gctaatctgg aaatggagga accagaagaa tcattgaaca
      361 ctctcaagct ttgttcccct gaagagttca caaggctttg cagagaaaag acacaagaaa
      421 tttacccaat aaaggaggcc aatggccgta cacgaaaggc tcttatcata tgcaatacag
      481 agttcaaaca tctctcactg aggtatgggg ctaactttga catcattggt atgaaaggcc
      541 ttcttgaaga cttaggctac gatgtggtgg tgaaagagga gcttacagca gagggcatgg
      601 agtcagagat gaaagacttt gctgcactct cagaacacca gacatcagac agcacattcc
      661 tggtgctaat gtctcatggc acactgcatg gcatttgtgg aacaatgcac agtgaaaaaa
      721 ctccagatgt gctacagtat gataccatct atcagatatt caacaattgc cactgtccag
      781 gtctacgaga caaacccaaa gtcatcattg tgcaggcctg cagaggtggg aactctggag
      841 aaatgtggat cagagagtct tcaaaacccc agttgtgcag aggtgtagat ctacctagga
      901 atatggaagc tgatgctgtc aagctgagcc acgtggagaa ggacttcatt gccttctact
      961 ctacaacccc acatcacttg tcctaccgag acaaaacagg aggctcttac ttcatcacta
     1021 gactcatttc ctgcttccgg aaacatgctt gctcttgtca tctctttgat atattcctga
     1081 aggtgcaaca atcatttgaa aaggcaagta ttcattccca gatgcccacc attgatcggg
     1141 caaccttgac gagatatttc tacctctttc ctggcaactg agaacaaagc aacaagcaac
     1201 tgaatctcat ttcttcagct tgaagaagtg atcttggcca aggatcacat tctattcctg
     1261 aaattccaga actagtgaaa ttaaggaaag aatacttatg aattcaagac cagcctaagc
     1321 aacacagtgg gattctgttc catagacaag caaacaagca aaaataaaac aaaaaaaaaa
     1381 tttaccaaaa gagaaatttg ttttatttat ttgtgtacat aaataaaaag aaagcaaata
     1441 att
//
