LOCUS       NM_007610               3506 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus caspase 2 (Casp2), transcript variant 1, mRNA.
ACCESSION   NM_007610
VERSION     NM_007610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Wei,S.J., Schell,J.R., Chocron,E.S., Varmazyad,M., Xu,G.,
            Chen,W.H., Martinez,G.M., Dong,F.F., Sreenivas,P., Trevino,R. Jr.,
            Jiang,H., Du,Y., Saliba,A., Qian,W., Lorenzana,B., Nazarullah,A.,
            Chang,J., Sharma,K., Munkacsy,E., Horikoshi,N. and Gius,D.
  TITLE     Ketogenic diet induces p53-dependent cellular senescence in
            multiple organs
  JOURNAL   Sci Adv 10 (20), eado1463 (2024)
   PUBMED   38758782
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3506)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 3506)
  AUTHORS   Hughes,C.H.K., Smith,O.E., Meinsohn,M.C., Brunelle,M., Gevry,N. and
            Murphy,B.D.
  TITLE     Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the
            ovarian reserve
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2220849120 (2023)
   PUBMED   37494420
REFERENCE   6  (bases 1 to 3506)
  AUTHORS   Hacker,G. and Vaux,D.L.
  TITLE     Expression of candidate cell death genes in cell lines during
            apoptosis
  JOURNAL   Biochem Cell Biol 72 (11-12), 451-454 (1994)
   PUBMED   7654317
REFERENCE   7  (bases 1 to 3506)
  AUTHORS   Wang,L., Miura,M., Bergeron,L., Zhu,H. and Yuan,J.
  TITLE     Ich-1, an Ice/ced-3-related gene, encodes both positive and
            negative regulators of programmed cell death
  JOURNAL   Cell 78 (5), 739-750 (1994)
   PUBMED   8087842
REFERENCE   8  (bases 1 to 3506)
  AUTHORS   Kumar,S., Kinoshita,M., Noda,M., Copeland,N.G. and Jenkins,N.A.
  TITLE     Induction of apoptosis by the mouse Nedd2 gene, which encodes a
            protein similar to the product of the Caenorhabditis elegans cell
            death gene ced-3 and the mammalian IL-1 beta-converting enzyme
  JOURNAL   Genes Dev 8 (14), 1613-1626 (1994)
   PUBMED   7958843
REFERENCE   9  (bases 1 to 3506)
  AUTHORS   Sazuka,T., Tomooka,Y., Ikawa,Y., Noda,M. and Kumar,S.
  TITLE     DRG: a novel developmentally regulated GTP-binding protein
  JOURNAL   Biochem Biophys Res Commun 189 (1), 363-370 (1992)
   PUBMED   1449490
REFERENCE   10 (bases 1 to 3506)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153915.5.
            
            On Jul 19, 2022 this sequence version replaced NM_007610.2.
            
            Summary: This gene encodes the evolutionarily ancient and most
            conserved member of the cysteine proteases that plays important
            role in stress-induced apoptosis, DNA repair and tumor suppression.
            Mice lacking the encoded protein develop normally but display cell
            type-specific apoptotic defects. Germ cells and oocytes from such
            mice were found to be resistant to cell death after treatment with
            chemotherapeutic drugs. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034262.1, Y13085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC153915.5         120069-120258       c
            191-341             AC153915.5         117617-117767       c
            342-509             AC153915.5         117205-117372       c
            510-591             AC153915.5         116978-117059       c
            592-686             AC153915.5         116286-116380       c
            687-863             AC153915.5         115810-115986       c
            864-992             AC153915.5         111221-111349       c
            993-1083            AC153915.5         108481-108571       c
            1084-1233           AC153915.5         105340-105489       c
            1234-1343           AC153915.5         105073-105182       c
            1344-3506           AC153915.5         102758-104920       c
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.54 cM"
     gene            1..3506
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /note="caspase 2"
                     /db_xref="GeneID:12366"
                     /db_xref="MGI:MGI:97295"
     exon            1..190
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..341
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..509
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..591
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..686
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..863
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..992
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1083
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1233
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1343
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..3506
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /note="hexamer: AATAAA"
     polyA_site      3506
                     /gene="Casp2"
                     /gene_synonym="CASP-2; ICH-1; NEDD-2; Nedd2"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgtgc gcaagcgcgg cgcggtggga ggctggggga gggatgcggg ggctggcgcg
       61 gcccagcgtt tgtttgtttt gtgggtggtg cgtgtgcagc ccgggaaaag ctggaaatgg
      121 cggcgccgag cgggaggtcg cagtcctccc tgcacaggaa ggggctgatg gcggctgaca
      181 ggaggagcag gattttggca gtgtgtggaa tgcatcctga ccaccaggaa acactgaaaa
      241 agaatcgagt ggtgctggcc aagcagctgc tgctgagcga gctgttagaa cacctcctag
      301 agaaggacat tatcactttg gaaatgaggg agctcatcca ggccaaaggg ggcagtttca
      361 gccagaatgt ggaactcctc aacctgctgc caaagagagg accccaggct tttgatgcct
      421 tctgtgaagc cctgcgggag accaggcagg gtcacttgga agacttactg ctcacaaccc
      481 tctcagatat tcagcacgta ctcccaccgt tgagctgtga ctatgacaca agtctccctt
      541 tctcggtgtg tgagtcctgc cctcctcaca agcagctccg cctatccaca gatgctacgg
      601 aacactcctt agataatggt gatggtcctc cctgtcttct ggtgaagcca tgcactcctg
      661 agttttacca ggcacactac cagctggcct ataggttgca atctcagccc cgtggcttgg
      721 cactggtgct gagcaatgtg cacttcactg gagagaaaga cctggaattc cgctctggag
      781 gggatgtgga ccacactact ctagtcaccc tcttcaagct tttgggctac aatgtccatg
      841 tgctacatga ccagaccgca caggaaatgc aagagaaact tcagaatttt gcacagttac
      901 ctgcacaccg ggtcacagac tcctgcgtag tggcactcct ctcacatggt gtggaaggtg
      961 gcatctatgg tgtagatggc aaactgcttc agctccaaga ggtttttcga ctttttgaca
     1021 atgctaactg tccaagtcta cagaacaagc caaaaatgtt cttcatccaa gcatgtcgtg
     1081 gagatgagac agatagaggt gtcgaccagc aagatggaaa gaaccacaca caatcccctg
     1141 gatgtgagga gagtgatgct ggcaaagagg agttgatgaa gatgagactg cctactcgct
     1201 cagacatgat atgtggctat gcttgcctta aaggtaatgc tgccatgcgg aacaccaaac
     1261 ggggttcctg gtacattgag gccctcactc aggtgttctc tgaaagagct tgtgacatgc
     1321 acgtggccga catgcttgtt aaggtgaatg cccttatcaa ggagcgtgaa ggctatgccc
     1381 ctggcacaga attccaccga tgcaaggaga tgtctgagta ctgtagtact ctgtgccagc
     1441 aactctacct gttcccaggc tacccaccca cgtgatgccg cctgctattc ctgctgttgg
     1501 aggccactgg accactgggg gcacaatgga gacttctctt cagaatggtt tttgttctgt
     1561 ctaccctctc agggatatga gattctccca ggcttgtttc ctgtcagcca tctctgtctt
     1621 tgggtatgaa acataaggat ggctcctccg gtgtcgtgtt ctctacctat agagccagct
     1681 ctgaatggat gtgttaccag aagcatttta gctacagcct agaaaatgac attgtgaaca
     1741 cagtattatt gtgggaagag ggcatttgga tttctcaatg tttgtgatat ttttgttccc
     1801 aaggcatctt aggagtactt ggatcatagc tttttttttt tttcctaaat cagttaagga
     1861 gtctcagaga tcatctcctt ttttttccat atctacaacc tcatttttcc cacagtggag
     1921 atttggaaga tgtcccaatt taatgtaggt gttttcatct gtcatgaagg gacagatgag
     1981 atcctactac ttgcgaagtt tctatgcata cctttaagtt caggccctag gtgaaggaca
     2041 gtccctcagc ctttccattg gttcctttgt gttcagtgca cccagccttt gaacagagcc
     2101 tagggtctgt atgccatgac actggaagtc atagaaattt ccctggtcat gctttgtttg
     2161 aactgtcact gaatgaacct tatcgggcat aactacatga aaatgcagtg acagctgagt
     2221 gtgctgtgtc tcacactatc acccgtcatc aggatgtctc tccttcctta ctgtggcttc
     2281 tgcatgcact tacactgtac ttgacggctg gcctccaggg tctctcttgc tttgtactgg
     2341 ttcccctctt taccttcacc attcgctgct tctgccaagt ctgtgaagcc gtcctttgta
     2401 ggatgtttct tgccacttac gctgtactgt agttgcttat tctttctgcc ttctgcttca
     2461 gcgtgaggct tctttggttt tctgtggcag cgtctccctt ctcattgttt ctctgtgttt
     2521 tagtggggat agtaccatat gtgatataac ctagaagcac ttgtctctgc tcttatgaaa
     2581 cttgcttatt cttgaaaacc ttctgcattt ccattttttc ctctcttcca atttattctc
     2641 catgtaacag agtagtttgg tttttaaaat atctggtgat gtcattctct tgcttagaac
     2701 actagcttcc tgttacgctt catctaaaat gcaaattctt acacccagct tacgagatct
     2761 ggctcatacc ttccctttgg atctcattaa atggtgattt ctcactatgc tccagcccct
     2821 cttaggtcct catctccgtc ttgcaggtgt tctgaactct cctttggcta gtctctgatt
     2881 tttgagtctg gcggaggcct cttgaccatg ctgcccatgc tgtctactgt gcctccttat
     2941 gagggcatca tgttggtctc tgttgtgctt actgcaggct gtaatggcac ttttgcttgt
     3001 ttcacttgtt ccctctgagg ctgaatgctc caagagagtg ggaactgtgc ttcttactta
     3061 ctgatatcca gtaactggca cttactaggt cttcatgaat gtttcctgag taaaggaagg
     3121 agaccagcag ctaaccttag ttagagccta ccttttgcag tttctaaatt gctattatag
     3181 tgtacagttc aattagtata tgggtttttt tttccaggtg ttttattttt atccactgtt
     3241 ttgttgttgt ttttttatat tttctacata tcacgtgtga gacaacttct ttcacatctc
     3301 catagtgccc agcaaatttg aggcctatgg tagttgaggt gctcaactaa tgtttgttgt
     3361 atgaaccaag tggtttgaag acttgctgcc aaattctgcc ttttgggtca gtataggatg
     3421 cataagtggt agaatcttca cacttcccac tgccaagatt ttgtattgcc atcaggtgcc
     3481 aaataaatgt tgatacttat tactga
//
