LOCUS       NM_009809               2346 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus caspase 14 (Casp14), mRNA.
ACCESSION   NM_009809
VERSION     NM_009809.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Li,L., Kovacs,S.B., Jorgensen,I., Larson,H.N., Lazear,H.M. and
            Miao,E.A.
  TITLE     Role of Caspases and Gasdermin A during HSV-1 Infection in Mice
  JOURNAL   Viruses 14 (9), 2034 (2022)
   PUBMED   36146839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Chien,A.J., Presland,R.B. and Kuechle,M.K.
  TITLE     Processing of native caspase-14 occurs at an atypical cleavage site
            in normal epidermal differentiation
  JOURNAL   Biochem Biophys Res Commun 296 (4), 911-917 (2002)
   PUBMED   12200134
  REMARK    GeneRIF: processing of caspase 14 in epidermal differentiation
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Kuechle,M.K., Predd,H.M., Fleckman,P., Dale,B.A. and Presland,R.B.
  TITLE     Caspase-14, a keratinocyte specific caspase: mRNA splice variants
            and expression pattern in embryonic and adult mouse
  JOURNAL   Cell Death Differ 8 (8), 868-870 (2001)
   PUBMED   11526440
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   Ahmad,M., Srinivasula,S.M., Hegde,R., Mukattash,R.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     Identification and characterization of murine caspase-14, a new
            member of the caspase family
  JOURNAL   Cancer Res 58 (22), 5201-5205 (1998)
   PUBMED   9823333
REFERENCE   9  (bases 1 to 2346)
  AUTHORS   Hu,S., Snipas,S.J., Vincenz,C., Salvesen,G. and Dixit,V.M.
  TITLE     Caspase-14 is a novel developmentally regulated protease
  JOURNAL   J Biol Chem 273 (45), 29648-29653 (1998)
   PUBMED   9792675
REFERENCE   10 (bases 1 to 2346)
  AUTHORS   Van de Craen,M., Van Loo,G., Pype,S., Van Criekinge,W., Van den
            brande,I., Molemans,F., Fiers,W., Declercq,W. and Vandenabeele,P.
  TITLE     Identification of a new caspase homologue: caspase-14
  JOURNAL   Cell Death Differ 5 (10), 838-846 (1998)
   PUBMED   10203698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134001.1, AK081645.1 and AJ007750.1.
            
            On Mar 27, 2010 this sequence version replaced NM_009809.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ007750.1, AK081645.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY134001.1         5-55
            52-1391             AK081645.1         5-1344
            1392-2346           AJ007750.1         1259-2213
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2346
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /note="caspase 14"
                     /db_xref="GeneID:12365"
                     /db_xref="MGI:MGI:1335092"
     exon            1..187
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            188..254
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..989
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /note="CASP-14"
                     /codon_start=1
                     /product="caspase-14"
                     /protein_id="NP_033939.1"
                     /db_xref="CCDS:CCDS23969.1"
                     /db_xref="GeneID:12365"
                     /db_xref="MGI:MGI:1335092"
                     /translation="MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALE
                     RMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGE
                     DEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELRGNEELGGDEELG
                     GDEVAVLKNNPQSIPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLTDVFIHKKGSIL
                     ELTEEITRLMANTEVMQEGKPRKVNPEVQSTLRKKLYLQ"
     exon            255..404
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            405..630
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            631..780
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            781..884
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
     exon            885..2331
                     /gene="Casp14"
                     /gene_synonym="MICE; mini-ICE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgtactgc tctagtcacg gacaggatct caggagaagc ttggggaaac ctttccgtgc
       61 ccgccccttc ttggagagca gcacgaggct ctaactcctc ttgaatgaca gcgctgttat
      121 cagcagcttg gagacagaca agccagggcc tgatcccaag gagaaggagc acctgcttct
      181 acagccgggc aaaacaaagg tgctgaaagc cagacatgga gtcagagatg agtgatcctc
      241 agccattgca ggaggaaaga tatgatatgt caggtgcccg cctggccctg acgctgtgtg
      301 tcaccaaagc ccgggagggt tccgaggtag acatggaggc cctggaacgc atgttccgtt
      361 acctgaaatt tgaaagcacc atgaagaggg atcccaccgc ccagcaattt ctggaagagt
      421 tggatgaatt tcagcagacc atagataatt gggaagagcc tgtcagctgt gcctttgtgg
      481 tactcatggc acatggtgag gaaggcctcc tcaagggaga agatgagaag atggtcagac
      541 tagaagacct ttttgaagtc ttgaacaaca agaactgcaa ggccctgaga ggcaagccaa
      601 aggtgtacat catccaggct tgtagaggag agcacagaga ccccggtgag gaactacgtg
      661 gaaatgagga actaggtgga gatgaggaac taggtggaga tgaggttgct gtgctcaaga
      721 acaaccccca aagtatccca acctatacgg ataccctcca catctactcc acggtagagg
      781 ggtacctctc ctatagacat gacgagaaag gctctggctt catccagacc ctgacggatg
      841 tgttcattca taaaaaagga tccatcttag aactgacaga agagatcacc cgacttatgg
      901 caaacacgga ggtgatgcag gaaggaaaac caaggaaagt gaaccctgaa gtccaaagca
      961 ccctccggaa gaagctctat ttgcaataaa agagagggca gggatggcct tcctgcaggt
     1021 gctttctctg ttgacaccag tcttcaaaga tggttactgg attcttcgtt catcacagcc
     1081 ctttgtccgt gtcagtttca gggcaagcca gccagctaga gcacattaac accaccttcc
     1141 tttcgctgga caccctaact ctgttaatgc agccttacat tgtcttccta tagctaactg
     1201 tttgctcttt tgcctcacca cgccttactc tccctcctat gactcaaccg aaaatagtca
     1261 tttctaattc agaggtagta gctttctgaa ccatttctag aaacttccaa taacctccag
     1321 ctaagatcgc cactgtgggg tttttttcat ccttggctta caattcgtca ttgtgaagaa
     1381 gtcaaggcag gaagtacaac catgagtgac atcacagaat aaatattctt cttcaaaatc
     1441 aaagaactgg agcatgaaac agtcacacca aaaaacccaa aggacttgag cagcccttcc
     1501 cctccagcta ctagccttat cccaaagggt gcgtcccaag gaagaagatg ccatgcctcc
     1561 agctactagc cttatcccaa agggcatgtc ccaaggaaga agacgccatg ttagtggtcc
     1621 tgacatctct ggtgatctca gcagcatctt cagaccaagc atgaccaaca cacacgcact
     1681 cttagtcgaa atatctatgt atacttttaa ttgtccctga tagactcttt attcctctcc
     1741 aaaaccccat gagctaggcc tcaactacca caaaacagcc tatgagctct gtttccagga
     1801 ttcaataact ttttcagccc actatactca aagcttttga attcccctca caaaaacatg
     1861 tccaaatcat aaaagtcaca tggccaaatc tatcacagca gtgaccccac ttccttggta
     1921 tccatttcta tgaaagaggt atctctggaa acctagagga gacacaaaga gcactattat
     1981 ttaaagacca aaggtaaacc ctacatctgt gtttttcata ttggtatgac tccatccaat
     2041 cagccctcag ataaattcat ctccttttct gtgaattcat tctcccagaa atgttagcat
     2101 cctctcccca tgcctctgtg cccttgccca attgaccagt tctctaagct taggtgtccc
     2161 acatggctgc ccccttctct ctcttccctt tttccactgc ctccccctca cccctgactc
     2221 cactcctaat attctttttt gcttgtgcgg ctgcctcttg cacaatgaaa tgctataatt
     2281 actttcgatt ggtgtaatga gaattcagta aacatctgtc aaactttgca aaaaaaaaaa
     2341 aaaaaa
//
