LOCUS       NM_009808               2605 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus caspase 12 (Casp12), mRNA.
ACCESSION   NM_009808
VERSION     NM_009808.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   Toltin,A.C., Belkadi,A., Gamba,L.M. and Hossain,M.M.
  TITLE     The Preventive Effects of Salubrinal against Pyrethroid-Induced
            Disruption of Adult Hippocampal Neurogenesis in Mice
  JOURNAL   Int J Mol Sci 24 (21), 15614 (2023)
   PUBMED   37958604
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Zhang,X., Xu,J., Marshall,B., Dong,Z., Smith,S.B. and Zhang,M.
  TITLE     The Role of Caspase-12 in Retinal Bystander Cell Death and Innate
            Immune Responses against MCMV Retinitis
  JOURNAL   Int J Mol Sci 22 (15), 8135 (2021)
   PUBMED   34360899
  REMARK    GeneRIF: The Role of Caspase-12 in Retinal Bystander Cell Death and
            Innate Immune Responses against MCMV Retinitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2605)
  AUTHORS   Vesela,B., Kratochvilova,A., Svandova,E., Benes,P., Rihova,K.,
            Poliard,A. and Matalova,E.
  TITLE     Caspase-12 Is Present During Craniofacial Development and
            Participates in Regulation of Osteogenic Markers
  JOURNAL   Front Cell Dev Biol 8, 589136 (2020)
   PUBMED   33178702
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2605)
  AUTHORS   Liu,L., Chen,M., Lin,K., Xiang,X., Zheng,Y. and Zhu,S.
  TITLE     Inhibiting Caspase-12 Mediated Inflammasome Activation protects
            against Oxygen-Glucose Deprivation Injury in Primary Astrocytes
  JOURNAL   Int J Med Sci 17 (13), 1936-1945 (2020)
   PUBMED   32788872
  REMARK    GeneRIF: Inhibiting Caspase-12 Mediated Inflammasome Activation
            protects against Oxygen-Glucose Deprivation Injury in Primary
            Astrocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2605)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2605)
  AUTHORS   Nakagawa,T., Zhu,H., Morishima,N., Li,E., Xu,J., Yankner,B.A. and
            Yuan,J.
  TITLE     Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and
            cytotoxicity by amyloid-beta
  JOURNAL   Nature 403 (6765), 98-103 (2000)
   PUBMED   10638761
REFERENCE   7  (bases 1 to 2605)
  AUTHORS   Roth,K.A., Kuan,C., Haydar,T.F., D'Sa-Eipper,C., Shindler,K.S.,
            Zheng,T.S., Kuida,K., Flavell,R.A. and Rakic,P.
  TITLE     Epistatic and independent functions of caspase-3 and Bcl-X(L) in
            developmental programmed cell death
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 466-471 (2000)
   PUBMED   10618441
REFERENCE   8  (bases 1 to 2605)
  AUTHORS   Exley,G.E., Tang,C., McElhinny,A.S. and Warner,C.M.
  TITLE     Expression of caspase and BCL-2 apoptotic family members in mouse
            preimplantation embryos
  JOURNAL   Biol Reprod 61 (1), 231-239 (1999)
   PUBMED   10377054
REFERENCE   9  (bases 1 to 2605)
  AUTHORS   Kumar,S. and Colussi,P.A.
  TITLE     Prodomains--adaptors--oligomerization: the pursuit of caspase
            activation in apoptosis
  JOURNAL   Trends Biochem Sci 24 (1), 1-4 (1999)
   PUBMED   10087912
  REMARK    Review article
REFERENCE   10 (bases 1 to 2605)
  AUTHORS   Van de Craen,M., Vandenabeele,P., Declercq,W., Van den Brande,I.,
            Van Loo,G., Molemans,F., Schotte,P., Van Criekinge,W., Beyaert,R.
            and Fiers,W.
  TITLE     Characterization of seven murine caspase family members
  JOURNAL   FEBS Lett 403 (1), 61-69 (1997)
   PUBMED   9038361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077256.1 and AC104914.9.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_009808.5.
            
            On Oct 6, 2007 this sequence version replaced NM_009808.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030309.1, BC028979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1659              AK077256.1         3-1661
            1660-2605           AC104914.9         74091-75036
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2605
                     /gene="Casp12"
                     /note="caspase 12"
                     /db_xref="GeneID:12364"
                     /db_xref="MGI:MGI:1312922"
     exon            1..50
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1303
                     /gene="Casp12"
                     /note="CASP-12"
                     /codon_start=1
                     /product="caspase-12"
                     /protein_id="NP_033938.3"
                     /db_xref="CCDS:CCDS22800.1"
                     /db_xref="GeneID:12364"
                     /db_xref="MGI:MGI:1312922"
                     /translation="MAARRTHERDPIYKIKGLAKDMLDGVFDDLVEKNVLNGDELLKI
                     GESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQEQLSLQFSNDEDDGPQKICTP
                     SSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFCKIKTE
                     RAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKEN
                     LTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFK
                     IFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSIT
                     KAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSF
                     EVPGELTQMPTIERVSMTRYFYLFPGN"
     exon            51..302
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            303..362
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            363..440
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            536..709
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            710..944
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1094
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1204
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1323
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..2605
                     /gene="Casp12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp12"
                     /note="putative"
     polyA_site      1659
                     /gene="Casp12"
                     /note="putative"
ORIGIN      
        1 tttcggtttt gatgcttttt atgtccagga gtcctgcaca gccatggcgg ccaggaggac
       61 acatgaaaga gatccaatct acaagatcaa aggtttggcc aaggacatgc tggatggggt
      121 ttttgatgac ctggtggaga agaatgtttt aaatggagat gagttactca aaatagggga
      181 aagtgcgagt ttcatcctga acaaggctga gaatctggtt gagaacttct tagagaaaac
      241 agacatggca ggaaaaatat ttgctggcca cattgccaat tcccaggaac agctgagttt
      301 acaattttct aatgatgagg atgatggacc tcagaagata tgtacacctt cttctccatc
      361 agaatccaag agaaaagtag aggatgatga aatggaggta aatgctggat tggcccatga
      421 atcacatcta atgctgacag ctcctcatgg actccagagc tcagaagtcc aagatacact
      481 gaagctttgt ccacgtgatc agttttgtaa gataaagaca gaaagggcaa aagagatata
      541 tccagtgatg gagaaggagg gacgaacacg tctggctctc atcatctgca acaaaaagtt
      601 tgactacctt tttgatagag ataatgctga tactgacatt ttgaacatgc aagaactact
      661 tgaaaatctt ggatactctg tggtgttaaa ggaaaacctt acagctcagg aaatggagac
      721 agagttaatg cagtttgctg gccgtccaga gcaccagtcc tcagacagca cattcctggt
      781 gtttatgtcc catggcatcc tggaaggaat ctgtggggtg aagcaccgaa acaaaaagcc
      841 agatgttctt catgatgaca ctatcttcaa aattttcaac aactctaact gtcggagtct
      901 gagaaacaaa cccaagattc tcatcatgca ggcctgcaga ggcagatata atggaactat
      961 ttgggtatcc acaaacaaag ggatagccac tgctgataca gatgaggaac gtgtgttgag
     1021 ctgtaaatgg aataatagta taacaaaggc ccatgtggag acagatttca ttgctttcaa
     1081 atcttctacc ccacataata tttcttggaa ggtaggcaag actggttccc tcttcatttc
     1141 caaactcatt gactgcttca aaaagtactg ttggtgttat catttggagg aaatttttcg
     1201 aaaggttcaa cactcatttg aggtcccagg tgaactgacc cagatgccca ctattgagag
     1261 agtatccatg acacgctatt tctacctttt tcccgggaat tagcacaggc aactctcatg
     1321 cagttcccag tcaagtattg ctgtagctga gaagaaaaga aaattccaag atcccaggat
     1381 ttttaaatgt gtaaaacttt tcagttagat attttataca atatcataag gctagataat
     1441 ttccataggt tatttttagg ggaaacctga tacgtaaaat tttgcatgaa aagtatagat
     1501 tcgttccttc cttccaaatc tgctcatctt ttactttatt ttattaaatt tatatttgca
     1561 catttttgta aaatgaataa aggaaaaaga cactaaagaa catgtctgaa catatcctgg
     1621 aacttcttct ttgtaaaatg aataaaggaa aaagacacta aagaacaaag atgatacacc
     1681 ttttgatgaa ccactttcac ctataaatta gtagtaagaa tttactcaca aggaagatct
     1741 tatctacaat gtagctgaga aatgaaactg ttgcatatgt aggtaaaact aatcatcttt
     1801 taggaataag ataaagaggt ttatgtccac tgtttgtctc tggcatacat ggttttcatg
     1861 cctagtggct acctaccatt cctttcaatc aatttcttag gatataattg acaaatttat
     1921 gctatgttta taatttttct cttaaatgct tttgtaataa gatatactca cacatacaca
     1981 tttaagattc tgtctattag tgttattgaa ataaatccta gaaacaaaaa ttaaaagttt
     2041 aaagcattaa agacaatttt gagacaaaat attctatgaa attctatgca aaattgaatt
     2101 cttctacaag tatgtgatga agcccaccta ccactatttt tgtcatcttg aggatgttat
     2161 atcattattt ttacttaact gagctcaaat taaaatcttt gtttattctt tgttctataa
     2221 aatgtttcag aatctttctt tactgcatag taagtgttag ctcatttttc ctggggttac
     2281 aagttctgta caagcatgcc ttgaaattgt gagagccacc ccttctgagt gttcttcctt
     2341 aactcatacc agatctatga tctctttctg aaagtgtcca ttaacagttc atttctaccc
     2401 tttctctctg gtcctactat cttttcagtc tatgttaaat atgtacctat ccaaaaaaaa
     2461 atctcatgag cacttttaaa ttaaggtctg gtggttcccc acatccttgc ttctttgcat
     2521 ttgtcctgat ggacttaaac atagcttgtt tttgccattt atatgtccat acctcctcac
     2581 aagaataaaa gccccacgag ggatc
//
