LOCUS       NM_009807               1533 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus caspase 1 (Casp1), mRNA.
ACCESSION   NM_009807
VERSION     NM_009807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1533)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 1533)
  AUTHORS   Wang,Y., Zhang,Y., Kim,K., Han,J., Okin,D., Jiang,Z., Yang,L.,
            Subramaniam,A., Means,T.K., Nestle,F.O., Fitzgerald,K.A.,
            Randolph,G.J., Lesser,C.F., Kagan,J.C., Mathis,D. and Benoist,C.
  TITLE     A pan-family screen of nuclear receptors in immunocytes reveals
            ligand-dependent inflammasome control
  JOURNAL   Immunity 57 (12), 2737-2754 (2024)
   PUBMED   39571575
REFERENCE   3  (bases 1 to 1533)
  AUTHORS   Weiss,F.D., Alvarez,Y., Shakeri,F., Sahu,A., Leka,P., Dernst,A.,
            Rollheiser,J., Vasconcelos,M., Geraci,A., Duthie,F., Stahl,R.,
            Lee,H.E., Gellner,A.K., Buness,A., Latz,E. and Meissner,F.
  TITLE     Retention of ES cell-derived 129S genome drives NLRP1
            hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv
            mice
  JOURNAL   Cell Death Differ 31 (12), 1717-1729 (2024)
   PUBMED   39289506
REFERENCE   4  (bases 1 to 1533)
  AUTHORS   Pizzuto,M., Hurtado-Navarro,L., Molina-Lopez,C., Soubhye,J.,
            Gelbcke,M., Rodriguez-Lopez,S., Ruysschaert,J.M., Schroder,K. and
            Pelegrin,P.
  TITLE     Ornithine lipid is a partial TLR4 agonist and NLRP3 activator
  JOURNAL   Cell Rep 43 (10), 114788 (2024)
   PUBMED   39340778
REFERENCE   5  (bases 1 to 1533)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   6  (bases 1 to 1533)
  AUTHORS   Kumar,S. and Harvey,N.L.
  TITLE     Role of multiple cellular proteases in the execution of programmed
            cell death
  JOURNAL   FEBS Lett 375 (3), 169-173 (1995)
   PUBMED   7498492
  REMARK    Review article
REFERENCE   7  (bases 1 to 1533)
  AUTHORS   Kuida,K., Lippke,J.A., Ku,G., Harding,M.W., Livingston,D.J.,
            Su,M.S. and Flavell,R.A.
  TITLE     Altered cytokine export and apoptosis in mice deficient in
            interleukin-1 beta converting enzyme
  JOURNAL   Science 267 (5206), 2000-2003 (1995)
   PUBMED   7535475
REFERENCE   8  (bases 1 to 1533)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   9  (bases 1 to 1533)
  AUTHORS   Eisenberg,S.P., Brewer,M.T., Verderber,E., Heimdal,P.,
            Brandhuber,B.J. and Thompson,R.C.
  TITLE     Interleukin 1 receptor antagonist is a member of the interleukin 1
            gene family: evolution of a cytokine control mechanism
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5232-5236 (1991)
   PUBMED   1828896
REFERENCE   10 (bases 1 to 1533)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008152.1.
            
            On Jan 31, 2006 this sequence version replaced NM_009807.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008152.1, L28095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1533
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /note="caspase 1"
                     /db_xref="GeneID:12362"
                     /db_xref="MGI:MGI:96544"
     exon            1..207
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1409
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /EC_number="3.4.22.36"
                     /note="p45; CASP-1; IL-1BC; IL-1 beta-converting enzyme;
                     interleukin-1 beta convertase; interleukin-1
                     beta-converting enzyme; IL-1B converting enzyme"
                     /codon_start=1
                     /product="caspase-1"
                     /protein_id="NP_033937.2"
                     /db_xref="CCDS:CCDS22798.1"
                     /db_xref="GeneID:12362"
                     /db_xref="MGI:MGI:96544"
                     /translation="MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIK
                     LANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATE
                     DSKGGHPSSSETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTR
                     TRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFA
                     ACPEHKTSDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKP
                     KVIIIQACRGEKQGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPD
                     NVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFRLQMPTADRVTL
                     TKRFYLFPGH"
     exon            208..474
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            475..537
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            538..650
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            651..824
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1059
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1200
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1310
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1414
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1513
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /note="hexamer: ATTAAA"
     polyA_site      1511
                     /gene="Casp1"
                     /gene_synonym="ICE; Il1bc"
                     /note="major polyA site"
ORIGIN      
        1 cttccaagtg ttgaagaaga atcatttccg cggttgaatc cttttcagac ttgagcattt
       61 aaacctaact ttaattaggg aaagaaacat gcgcacacag caattgtggt tatttctcaa
      121 tctgtattca cgccctgttg gaaaggaact aacaatatgc tttcagtttc agtagctctg
      181 cggtgtagaa aagaaacgcc atggctgaca agatcctgag ggcaaagagg aagcaattta
      241 tcaactcagt gagtataggg acaataaatg gattgttgga tgaactttta gagaagagag
      301 tgctgaatca ggaagaaatg gataaaataa aacttgcaaa cattactgct atggacaagg
      361 cacgggacct atgtgatcat gtctctaaaa aagggcccca ggcaagccaa atctttatca
      421 cttacatttg taatgaagac tgctacctgg caggaattct ggagcttcaa tcagctccat
      481 cagctgaaac atttgttgct acagaagatt ctaaaggagg acatccttca tcctcagaaa
      541 caaaggaaga acagaacaaa gaagatggca catttccagg actgactggg accctcaagt
      601 tttgcccttt agaaaaagcc cagaagttat ggaaagaaaa tccttcagag atttatccaa
      661 taatgaatac aaccactcgt acacgtcttg ccctcattat ctgcaacaca gagtttcaac
      721 atctttctcc gagggttgga gctcaagttg acctcagaga aatgaagttg ctgctggagg
      781 atctggggta taccgtgaaa gtgaaagaaa atctcacagc tctggagatg gtgaaagagg
      841 tgaaagaatt tgctgcctgc ccagagcaca agacttctga cagtactttc cttgtattca
      901 tgtctcatgg tatccaggag ggaatatgtg ggaccacata ctctaatgaa gtttcagata
      961 ttttaaaggt tgacacaatc tttcagatga tgaacacttt gaagtgccca agcttgaaag
     1021 acaagcccaa ggtgatcatt attcaggcat gccgtggaga gaaacaagga gtggtgttgt
     1081 taaaagattc agtaagagac tctgaagagg atttcttaac ggatgcaatt tttgaagatg
     1141 atggcattaa gaaggcccat atagagaaag attttattgc tttctgctct tcaacaccag
     1201 ataatgtgtc ttggagacat cctgtcaggg gctcactttt cattgagtca ctcatcaaac
     1261 acatgaaaga atatgcctgg tcttgtgact tggaggacat tttcagaaag gttcgatttt
     1321 catttgaaca accagaattt aggctacaga tgcccactgc tgatagggtg accctgacaa
     1381 aacgtttcta cctcttcccg ggacattaaa cgaagaatcc agttcattct tatgtaccta
     1441 tgctgagaat cgtgccaata agaagccaat acttccttag atgatgcaat aaatattaaa
     1501 ataaaacaaa acaaaaaaaa aaaaaaaaaa aaa
//
