LOCUS       NM_080643               4762 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CASK-interacting protein 2 (Caskin2), mRNA.
ACCESSION   NM_080643
VERSION     NM_080643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Bencsik,N., Pusztai,S., Borbely,S., Fekete,A., Dulk,M., Kis,V.,
            Pesti,S., Vas,V., Szucs,A., Buday,L. and Schlett,K.
  TITLE     Dendritic spine morphology and memory formation depend on
            postsynaptic Caskin proteins
  JOURNAL   Sci Rep 9 (1), 16843 (2019)
   PUBMED   31727973
  REMARK    GeneRIF: Dendritic spine morphology and memory formation depend on
            postsynaptic Caskin proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Tabuchi,K., Biederer,T., Butz,S. and Sudhof,T.C.
  TITLE     CASK participates in alternative tripartite complexes in which Mint
            1 competes for binding with caskin 1, a novel CASK-binding protein
  JOURNAL   J Neurosci 22 (11), 4264-4273 (2002)
   PUBMED   12040031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053083.1.
            
            On Jun 19, 2003 this sequence version replaced NM_080643.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053083.1, AK129297.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..4762
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /note="CASK-interacting protein 2"
                     /db_xref="GeneID:140721"
                     /db_xref="MGI:MGI:2157062"
     exon            1..79
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            80..575
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..4087
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /codon_start=1
                     /product="caskin-2"
                     /protein_id="NP_542374.2"
                     /db_xref="CCDS:CCDS25647.1"
                     /db_xref="GeneID:140721"
                     /db_xref="MGI:MGI:2157062"
                     /translation="MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKRLNINY
                     QDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL
                     RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGR
                     LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLKAGIEINRQ
                     TKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQL
                     LREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRV
                     GYFPPGIVEVVSKRVGIPVARLPSAPTPLRPSFSRISQPAADDPLPSVPYGQLPRVGL
                     SPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGTGLLIENAQPLPSASEDQGLP
                     GLHAPSPADNLSHRPLAGYRSGEIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAH
                     FLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLLEWL
                     CALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRG
                     LLHGEALGEGGRRMTRGPELMAIEGLENGEGPTTAGPRLLTFQGSELSPELQAAMAGG
                     GSEPLPLPPARSPSQESIGARSRGSGHSQEQPVPQPSVGDPSAPQERNLPEGTERPSK
                     LCSPLPGQGPAPYVFMCPQNLPSSPAPGPPPGVPRAFSYLAGSPAAPPDPPRPKRRSH
                     SLSRPGPAEGEAEGEAEGPVGSALGSYATLTRRPGRSTLARTSPSLTPTRGTPRSQSF
                     ALRARRKGPPPPPPKRLSSVSGSTEPPSLDGTSGPKEGATGPRRRTLSEPTGPSESPG
                     PSAPTGPVSDTEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP
                     PGLDFNLTESDTVKRRPKCKEREPLQTALLAFGVVGSDTPGPSNPLSTQAPCDPPSAS
                     SNPPQRSEPSVLPSQGTSASSLSSVTQSPGHPGPSAGPALANSTGSKPNVETEPPAPP
                     AALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQR
                     LEQTSSSLEAALRAAEKSIGTEERDGPTGTSTKHILDDISTMFDALADQLDAMLD"
     exon            576..627
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            628..725
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            726..871
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1098
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1207
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1316
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1411
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1673
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1795
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1856
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1945
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2056
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2158
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2297
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..3773
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3996
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4722
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4722
                     /gene="Caskin2"
                     /gene_synonym="1600028L06Rik; mKIAA1139"
                     /note="major polyA site"
ORIGIN      
        1 ggggacagtg agaaccagag tccagagtgc ctgagactga gcacagccag ccggaccccc
       61 ggcggggcgg ccgggagaga ccctcaggac ttgtccctgg ctgctgcctc acgccagagg
      121 gaatgctgac tgctctctgg gtgggcactg gtgcttctgc gctaacccag gaagattggc
      181 gggcccagtc ccagcccatt ccagggctgt cggaagctgc aagctgatct caggccagat
      241 ttccacacag cctccacccc accagggacc ggctttcctg cctgtggtgg cagctcccag
      301 agcaccttga gggaactata tctctgcctg acaagaagcc cattgcctga gacaccagac
      361 ttgttccccc aggaccagga gtcctccaaa gcattgaggc atggcgaact gacacttgac
      421 tgggccggtc ccttgcttct tcctggacct tgaagtccca gagcctgacc cggtaatcag
      481 aatgggtcgt gaacaggacc ttatccttgc cgtcaagaat ggagacgtga cctgcgtgca
      541 gaaactggtg gctaaagtga aggctgcaaa aacaaagctc ctgggctcca cgaagagact
      601 caacattaac taccaggatg ctgatggatt ctctgctctc caccacgctg ccttgggggg
      661 cagcctggaa ctcatagcct tgctgctgga ggctcaagcc actgtggaca tcaaggacag
      721 caatggcatg cgccccctac actatgcagc ctggcagggc cgcctggagc ccgtgagact
      781 gctgctccgg gcttccgccg ctgtcaacgc tgcctcgctg gatgggcaga tccccctgca
      841 cctggctgcg cagtacgggc attatgaggt gtcagaaatg cttctccagc accagtctaa
      901 cccatgccta gtcaacaagt tgaagaagac acccctagac ctagcctgtg aatttgggcg
      961 gctcaaggtg gcccagctgc ttttgaacag ccacttatgc gtggcactgc tagagggaga
     1021 ggcgaaggac ccatgtgacc ccaactacac cacacccctg cacttggctg ccaagaatgg
     1081 ccacagagaa gtcatcaggc agctcttgaa agctggtatt gagatcaacc gccagaccaa
     1141 gacaggcacc gcactccacg aggctgcgct gtatggcaag actgaggtgg tgcggctgct
     1201 cctggaggga ggtgtggacg tgaatatccg gaacacatat aaccagacgg cgctggacat
     1261 agtcaatcag ttcaccacct cccaggccag ccgggaaatc aagcagctac ttcgagaggc
     1321 ttcagggatc ttgaaggttc gagcgcttaa ggatttctgg aaccttcatg accccaccgc
     1381 tctcaatgtc cgagcaggag atgtcatcac ggtgctcgaa cagcaccccg atggccgctg
     1441 gaagggccac atccatgaga gccaaagggg cacagaccgt gttggctact tccccccggg
     1501 catcgtcgag gtggtcagca agcgggtggg catccctgtg gcccgcctcc cctctgcccc
     1561 cacccctctg cgaccaagct tctcccggat atcacaacct gcggccgacg atcccctgcc
     1621 atctgtcccc tacggccagc tccctcgggt gggcctcagc ccagacagtc cagcaggtga
     1681 caggaatagc gtgggcagcg agggtagcgt gggcagcatc cgcagtgctg gcagcgggca
     1741 gagctctgaa ggcaccaacg gccatggcac tggcctcctg attgagaacg ctcagccact
     1801 gccctctgcc agtgaggacc agggactgcc aggcctgcat gccccgtccc cagcagacaa
     1861 cctgagccac cgccctctgg ccggttaccg ctctggagag atcttcaccc aggatgtgag
     1921 accagagcag ctactggaag ggaaggatgc acaggccatt cataactggc taagtgagtt
     1981 ccagctagag ggctacactg cccacttcct gcaggctggc tacgatgtgc cgaccatcag
     2041 ccggatgaca cctgaggatt tgacggccat tggggtgacc aagcctggac acaggaagaa
     2101 gatcgcctcg gagattgccc agcttagcat tgctgagtgg ctgcccaatt atatcccggt
     2161 ggacttgctg gagtggctgt gtgcactggg gctgccgcag taccacaagc agctggtgag
     2221 cagcggctac gactctatgg ggctggtggc cgacctcacc tgggaggagc tgcaggagat
     2281 aggcgtgaac aagctggggc accagaagaa gctaatgcta ggtgtgaaac ggctggcaga
     2341 acttcggcgg ggcctgctgc atggagaagc cctgggtgaa ggcggacgcc ggatgaccag
     2401 gggtccagag ctgatggcca tcgaaggcct ggagaatggg gaaggcccaa ctacagctgg
     2461 ccctcgcctc ctcacctttc agggcagtga gctgagccca gagctacagg cagccatggc
     2521 agggggtggc tcagaaccac taccccttcc tccggcccgt tctcctagcc aggagagcat
     2581 tggcgcccgc tcacggggct ctggtcactc acaggaacag cctgttcccc agcccagtgt
     2641 tggtgacccc agcgccccac aggagaggaa ccttccggag ggtacagagc gcccctctaa
     2701 gctttgttct ccgctccctg gccaaggacc tgccccatat gtctttatgt gtccacagaa
     2761 cttaccctct agcccagccc cagggccacc tcctggtgtt ccccgggcct tctcctactt
     2821 ggctggctct ccggccgctc ctccagaccc acctcggccg aagcgccggt ctcacagctt
     2881 gagccgccct ggccctgctg agggggaagc tgaaggggag gctgaagggc cagtgggcag
     2941 tgccctgggc agttatgcca cgcttactcg gagaccagga cgcagcaccc ttgcccggac
     3001 tagtcctagc ctgaccccaa ctcgagggac cccccgaagc cagtcctttg ccctccgtgc
     3061 ccgtcgtaaa gggcccccac ccccaccccc caagcgcctc agttctgtct ctggctccac
     3121 cgagccacct tcactagacg gaacctcggg gcccaaggaa ggggccacag gtccccggag
     3181 gagaacactg agtgaaccaa ccggcccctc ggagtcccct ggtccttccg caccaactgg
     3241 ccctgtgtcg gacacagaag aggaacctgg ccctgaggga acacccccat ctcggggcag
     3301 ctcaggggaa ggcctgccat tcgcagagga ggggaacctg actatcaagc agcggccgaa
     3361 gccagccggt ccccctcccc gtgagacacc tgtgccccct ggccttgact tcaacctcac
     3421 agagtcagat actgtcaaac gcaggcccaa gtgcaaggag agagagccac tacagactgc
     3481 actgttggcc tttggggtag tgggcagtga taccccgggc ccctccaatc ccctgtccac
     3541 ccaagccccg tgtgaccctc cctcagcttc ctctaaccct ccacaacggt ctgagcccag
     3601 cgtccttcca tcgcaaggaa cttcagcctc ttctctcagc tctgtaactc agtcccctgg
     3661 gcacccaggg cccagtgctg gacccgctct ggcaaactcc acaggcagta agcccaatgt
     3721 ggagacggag cctccggctc ccccggccgc cctcctcaaa gtgcctggag caggaacagc
     3781 tcccaagcct gtgtctgtgg cctgcactca gctggcattt tcaggcccaa agctggcccc
     3841 ccggctcggt ccccgtccag taccccctcc aaggcccgag aataccgggc ctgtgtgtcc
     3901 aggtcgggcc caacagagac tggaacagac cagctcatcc ttggaagccg cactgagggc
     3961 agctgagaag agcattggca ccgaggaacg agacggcccc acagggacgt ctaccaagca
     4021 cattctggat gacattagca ctatgttcga tgccctggcg gaccagctgg atgctatgct
     4081 ggactgagca aaccttggcc tgtgactctc ccacctgcca gtgttcaccg ccctcggccc
     4141 agcgtggaag aagcccgtgc cacacaggga acaggcagag gtctggttgg gctggagaat
     4201 ccttccgtag cagaggcctc caatggcttc aagcagtggc tggcagtcac agacaggccg
     4261 agaggacttg tcagaacctg actgaggggc ctcagctgtg tgggagcgaa gctctccccg
     4321 tgagcagctg actgcacagc tatggcccct gaacagggac cctcgtagaa cattctcctc
     4381 taggaggagg tggtgacagg gatttgggga tgcacctcct tgccttgtct aaagtccctg
     4441 tggtctggga atttgtctgg ccaccactga gtcaccctag ggctctgtga ggctgcgtgg
     4501 ttggccagtc ccctccgtgc aagtgtacat aggagctgta aatacacagc aggggcatgc
     4561 cttcctgccg gtggcctttt ctgctcctgc ctggccatcc cacactggga ggcagcgctg
     4621 gctgggatcg ggcagtgagg taacagatcc ccagggccca gactcttaca actgtacata
     4681 atatttttca agcagagaga aatgcatata ttttaaatgg aaaaaaaaaa aaaaaaaaaa
     4741 aaaaaaaaaa aaaaaaaaaa aa
//
