LOCUS       NM_001284505            8358 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus calcium/calmodulin dependent serine protein kinase
            (Cask), transcript variant 3, mRNA.
ACCESSION   NM_001284505
VERSION     NM_001284505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8358)
  AUTHORS   Patel,P.A., LaConte,L.E.W., Liang,C., Cecere,T., Rajan,D.,
            Srivastava,S. and Mukherjee,K.
  TITLE     Genetic evidence for splicing-dependent structural and functional
            plasticity in CASK protein
  JOURNAL   J Med Genet 61 (8), 759-768 (2024)
   PUBMED   38670634
  REMARK    GeneRIF: Genetic evidence for splicing-dependent structural and
            functional plasticity in CASK protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8358)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   3  (bases 1 to 8358)
  AUTHORS   Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
            Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   4  (bases 1 to 8358)
  AUTHORS   Liu,X., Sun,P., Yuan,Q., Xie,J., Xiao,T., Zhang,K., Chen,X.,
            Wang,Y., Yuan,L. and Han,X.
  TITLE     Specific Deletion of CASK in Pancreatic beta Cells Affects Glucose
            Homeostasis and Improves Insulin Sensitivity in Obese Mice by
            Reducing Hyperinsulinemia Running Title: beta Cell CASK Deletion
            Reduces Hyperinsulinemia
  JOURNAL   Diabetes (2021) In press
   PUBMED   34957476
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 8358)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8358)
  AUTHORS   Hsueh,Y.P., Wang,T.F., Yang,F.C. and Sheng,M.
  TITLE     Nuclear translocation and transcription regulation by the
            membrane-associated guanylate kinase CASK/LIN-2
  JOURNAL   Nature 404 (6775), 298-302 (2000)
   PUBMED   10749215
  REMARK    Erratum:[Nature 2002 May 9;417(6885):205]
REFERENCE   7  (bases 1 to 8358)
  AUTHORS   Borg,J.P., Straight,S.W., Kaech,S.M., de Taddeo-Borg,M.,
            Kroon,D.E., Karnak,D., Turner,R.S., Kim,S.K. and Margolis,B.
  TITLE     Identification of an evolutionarily conserved heterotrimeric
            protein complex involved in protein targeting
  JOURNAL   J Biol Chem 273 (48), 31633-31636 (1998)
   PUBMED   9822620
REFERENCE   8  (bases 1 to 8358)
  AUTHORS   Laverty,H.G. and Wilson,J.B.
  TITLE     Murine CASK is disrupted in a sex-linked cleft palate mouse mutant
  JOURNAL   Genomics 53 (1), 29-41 (1998)
   PUBMED   9787075
REFERENCE   9  (bases 1 to 8358)
  AUTHORS   Wilson,J.B., Ferguson,M.W., Jenkins,N.A., Lock,L.F., Copeland,N.G.
            and Levine,A.J.
  TITLE     Transgenic mouse model of X-linked cleft palate
  JOURNAL   Cell Growth Differ 4 (2), 67-76 (1993)
   PUBMED   8494785
REFERENCE   10 (bases 1 to 8358)
  AUTHORS   Wilson,J.B., Weinberg,W., Johnson,R., Yuspa,S. and Levine,A.J.
  TITLE     Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin
            of transgenic mice induces hyperplasia and aberrant expression of
            keratin 6
  JOURNAL   Cell 61 (7), 1315-1327 (1990)
   PUBMED   1694724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y17138.1, CJ060796.1, AK136523.1, CJ317104.1, AL671117.6 and
            BU700766.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. This results
            in a shorter protein (isoform 3), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145620.1, SRR7652917.130684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               Y17138.1           3-148
            147-391             CJ060796.1         133-377
            392-1383            Y17138.1           394-1385
            1384-2209           AK136523.1         80-905
            2210-2469           Y17138.1           2230-2489
            2470-4009           AK136523.1         1097-2636
            4010-4432           CJ317104.1         12-434
            4433-7727           AL671117.6         46370-49664         c
            7728-8358           BU700766.1         1-631               c
FEATURES             Location/Qualifiers
     source          1..8358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 8.43 cM"
     gene            1..8358
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /note="calcium/calmodulin dependent serine protein kinase"
                     /db_xref="GeneID:12361"
                     /db_xref="MGI:MGI:1309489"
     exon            1..549
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..3253
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     peripheral plasma membrane protein CASK;
                     calcium/calmodulin-dependent serine protein kinase (MAGUK
                     family)"
                     /codon_start=1
                     /product="peripheral plasma membrane protein CASK isoform
                     3"
                     /protein_id="NP_001271434.1"
                     /db_xref="CCDS:CCDS72343.1"
                     /db_xref="GeneID:12361"
                     /db_xref="MGI:MGI:1309489"
                     /translation="MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVD
                     VAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFE
                     IVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKL
                     GGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLP
                     FYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
                     KERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSED
                     PTSSGAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQI
                     RNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEA
                     LRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCI
                     VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYR
                     TQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDL
                     IPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAME
                     KTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLG
                     AHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNE
                     YLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTI
                     TPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWV
                     PVSWVY"
     exon            550..662
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..768
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..846
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            847..919
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1022
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1198
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1321
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1405
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1505
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1627
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1705
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1786
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1975
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2054
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2140
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2209
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2278
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2314
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2511
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2627
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2708
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2789
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2992
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3076
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..8344
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /note="hexamer: AATATA"
     regulatory      4432..4437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /note="hexamer: ATTAAA"
     polyA_site      4432
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /note="major polyA site"
     polyA_site      4454
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
     regulatory      8321..8326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
                     /note="hexamer: AATAAA"
     polyA_site      8344
                     /gene="Cask"
                     /gene_synonym="DXPri1; DXRib1; LIN-2; mLin-2; Pals3"
ORIGIN      
        1 cgcggatcag ccgccaccac ctcccttcgc gacgatcctc cctccatggt gctgccgcgg
       61 ccccccctgt agcccgagct gccccgcgcc gcgccggagc cggtctcggg cagagggagc
      121 ggtcgcggcc tcgcggcccg cgcgggctga cgagcggaga gtgcggcgct tcgcggtccc
      181 cgagggtccg cacgccccgg cagcgcggtc gccagccacc gcgcgaggag cagcgggcgg
      241 gcgggcggcg ccgggcccgg gccgccctcg ctcccacgcc ccggccccgc cgcccgcgcc
      301 ggggcggcag ccggcagagg aaaggcgctg cagtctccgg gcctcacggc cccagtcgag
      361 cttcctcagc accgagggct tgcgggtcct gagtggagga cacgagcccg gagccgggca
      421 ctgagctctt gggcgccccc aacccagttt tcagaaccct ccacgctgcg gccgctgtcc
      481 ccttcggacc atggccgacg acgacgtgct gttcgaggat gtgtacgagc tatgcgaggt
      541 gatcggcaag ggtcccttca gtgttgtacg gcgatgtatc aacagagaaa ctgggcaaca
      601 atttgctgta aaaattgttg atgtagccaa gttcacatca agtccagggt taagtacaga
      661 agatctaaag cgggaagcca gtatctgtca tatgctgaag catccacaca ttgtagagct
      721 gttggagaca tatagctcag atgggatgct ttacatggtt tttgaattta tggatggagc
      781 agatctgtgt tttgaaatcg taaagcgagc tgatgctggt tttgtataca gtgaagctgt
      841 agccagccac tacatgagac agatactgga agctctgcgc tactgtcatg ataataacat
      901 aattcacagg gacgtgaagc cccactgtgt tctccttgcc tcaaaagaaa actcggcacc
      961 tgttaaactt gggggctttg gggtggccat tcagttagga gaatctggac ttgttgctgg
     1021 aggccgcgtt ggaacacctc actttatggc cccagaagtg gtcaagagag agccttacgg
     1081 aaagcctgtg gatgtctggg gctgtggtgt gatccttttc atcctgctca gtggctgttt
     1141 gcctttctac ggaaccaagg aaagattgtt tgaaggcatt attaaaggaa aatataagat
     1201 gaatccaagg cagtggagcc atatctctga aagtgccaaa gacctagtac gccgcatgct
     1261 gatgctggat cctgctgaaa ggatcactgt ttatgaagca ctgaatcacc catggcttaa
     1321 ggagcgggat cgttatgcct acaaaatcca tcttccagaa acagtagaac aactgaggaa
     1381 attcaatgca aggagaaaac taaagggtgc agtactagct gctgtgtcaa gtcacaaatt
     1441 caattccttc tatggggacc ctcctgaaga gttgccagat ttctccgaag accctacctc
     1501 ctcaggagcc gtctctcagg tgctggacag cctggaagag attcacgcac ttacagactg
     1561 cagtgaaaag gacctagatt ttctacacag tgttttccag gatcaacatc ttcacacact
     1621 gctggatctg tatgacaaaa ttaacacaaa gtcttcgcca caaatcagga atcctccaag
     1681 tgatgcagta cagagagcca aagaggtatt ggaagaaatt tcatgttacc ctgagaataa
     1741 tgatgcgaag gaactaaagc gtattttaac acaacctcat ttcatggcct tacttcagac
     1801 tcatgatgta gtggcacatg aagtttacag tgatgaagca ttaagggtca cacctccccc
     1861 gacttccccc tatttaaacg gtgattctcc agaaagtgca aacggagaca tggacatgga
     1921 gaatgtgacc agagttcggc tggtacagtt ccaaaagaac acggatgagc caatgggaat
     1981 cactttgaaa atgaatgagc taaatcattg tattgtcgca agaatcatgc atgggggtat
     2041 gattcacagg caaggtacac ttcatgttgg tgatgaaatc cgagaaatca atggcatcag
     2101 tgtcgctaac caaacagtgg aacagctaca gaaaatgctt agggaaatgc gagggagtat
     2161 taccttcaag attgtgccaa gctaccgcac tcagtcttcg tcctgtgaga gagattcccc
     2221 ctccacttcc agacagtccc ctgctaatgg tcatagcagc actaacaatt ctgtttcgga
     2281 cttgccatca accacccaac caaaaggacg acagatctat gtaagagcac aatttgaata
     2341 tgatccagcc aaggatgacc tcatcccctg caaagaagct ggcatccggt tccgagttgg
     2401 tgacatcatc cagattatta gtaaggatga ccacaactgg tggcagggta aactggaaaa
     2461 ctccaaaaat ggaactgcag gtctcattcc ttctcctgaa cttcaggaat ggcgagtagc
     2521 ttgcattgcc atggagaaga ccaaacaaga gcagcaggcc agctgtactt ggtttggcaa
     2581 gaaaaagaag cagtacaaag ataaatattt ggcaaagcac aacgcagtgt ttgatcaatt
     2641 agatcttgtc acatatgaag aagtagtcaa actgccagca ttcaaaagga aaacattagt
     2701 cttattaggt gcacatggtg ttggaagaag acacataaaa aataccctca tcacaaagca
     2761 cccggaccgg tttgcgtacc ctattccaca tacaaccaga cctccaaaga aagatgaaga
     2821 aaatggcaag aattattact ttgtatctca tgaccaaatg atgcaagaca tctcaaataa
     2881 cgaatacttg gagtatggca gccatgagga tgcaatgtac gggacaaaac tggagaccat
     2941 tcggaaaatc catgagcagg ggctgattgc gattctggac gtggagcctc aggcactgaa
     3001 ggtcctgagg actgcagagt ttgctccttt tgttgtcttc attgcggcgc caactatcac
     3061 tccaggttta aatgaggatg aatctcttca gcgcctgcag aaggagtccg atgtcttgca
     3121 gagaacatat gcacactact tcgatctcac aattatcaac aacgaaattg atgagacaat
     3181 cagacatctg gaagaagctg tcgagcttgt gtgcacagcc ccacagtggg tcccagtctc
     3241 ctgggtctat taggcttctc cttggctatc tgagtataaa actgggagcc acctcctacg
     3301 tggaaaaagc ctctttgtta tcggccttgt gtcagcaggt cgtggtccct agagactacc
     3361 tagttgtagt gtgacctaca tttataatta ttgtcatgtc cgaatagata ggaggagaaa
     3421 atcaattaca cactaattta aagagacagt atctttttta atcagttctc ctaaacttta
     3481 ataaaatgta tctttaaatg tatgtattat tcaatccttt ggaatgttat atttttggaa
     3541 atcatagctt tttatttcca aggcccctaa aaactgcaca aaatagatgc tgctttctat
     3601 aatctatttt aataataata aacaatgatt ctgttacctt gactgggggt ggaacactac
     3661 attcttttta gagtctgatt ttatggattg gaataccttt ctttccttta tttatttgaa
     3721 atgattagtc tagtgattac aaaacagtca taaattttta aaggcctgtt ttctctcttt
     3781 ttttaagtcc tttatgtaac atgcggatac tgtgatactg tctctttgaa gcaccctgta
     3841 aaccttttag agatttgaag ttgggtcttg actcttaatg catgtggaca gtcgcgagcg
     3901 tttatgctgt cggtgtgtct gtgttggaca aaacaatctg taattacagc caagtacatt
     3961 ccgttcacgg ggcacaccca ggggagtaag aataaattgc tattatgact aagttgtaaa
     4021 cctatgcaca tcccttgcat ttcgggcaac tttataaaac agaaaaaaaa aacctgattt
     4081 ttattaataa taatcatgta gtgaaatgtg tttgtaattt tgtctcaatt taatttgttg
     4141 taaggtggga gggggtattg ctggtttcgc catttcagat ctgtgttgtc taagagtatt
     4201 aacgttttaa ttaagcaaag aaatgcggat ttttaatctg tatgtaattg ttttaagcac
     4261 ccatttaaag agaatatact gtgcaatgaa gaaaccagtt taggcatttg ctacaaactg
     4321 aattattcca aaagaataat ctataacagc cctgtaaatt cctttaaaat gataactaac
     4381 aggacagtct gaccattttt tttaaatata cttcattgta tgtgttcaat aattaaatgc
     4441 ctttgggtcc ttcatttcat tatagatttg ttcaggtcca agctggtaat cttttaagtt
     4501 ctaaaatttg ttagatgctc actgacccat cgaaggccca ggaataagta tcggttggta
     4561 gggcaacaaa gcagcctgcc agggcacagc ttggaccaca tgtgactcac aaggccacct
     4621 gtggtctctc cttcctcttg ctctatccct tggcacaggg gagtcacctg tccttgttgc
     4681 tttaaaagca ttcaccatgt catcccccgc catgctgtca gaatcactag aggaggccca
     4741 ggctggggtt ctcagactgc cagaggtcac tagagtgttg ccccttcatg gatgagagaa
     4801 cagggcactg acatgactct ggtccttgga aacacaccat cgttttcatt tcttcagggt
     4861 tagctggcct ccatcacttt gtgccttggc agaatgagtt ctggcctgaa cagctcctct
     4921 taggcactga acagagaagg catttttgtg ttcatactcc tctcctgttt tcagcatctc
     4981 acccttccca actattatta catgatacca tttggtttct gtttgtagac cattctttgt
     5041 cagtgcccag atggtcacaa cttaccaaca agatactgtg agaataactt gtgttcggtc
     5101 ccacaagtaa gggtggccta acagcacacc agagacagac tcaacagtga gctcttgcta
     5161 ggtggaggga gaaaacttca ggagttgctt agggctgtgt agtgctgacc tcgatcctaa
     5221 tcagtgccca ggccagacat cattactgca gtagtactga gcataaggca cccttttcag
     5281 tggctcagta cctgctctac ctcttccagt aaagcacaac taaggtgtgg gaaaaaaaag
     5341 aaccattcct ccctctggta gaatccctta tgctccactt gctcttgaga gcacatctcc
     5401 agaaatgctg gcaaggcctg tgtgtgacca tctaccacgt ccccccagac agaatgagca
     5461 taggaaagtg aagccagctg aagttcaggt gagcacagac tgaaaaaggt actccaggac
     5521 tcggggacat ggggaacttc tgtcctcact ggccttctgg agtctgagag aagagcactg
     5581 gtggcatcct tcctgccctt atacaggtgg cgaaagcctg cacctagaac ccagcggctg
     5641 ccccagcagc tcacctgctc ttctccacta atacacagct ctaaagcagt gtgcttatga
     5701 cctacaggaa aacaatctct gaagtcagag tactatcagt acagccgtac cccgagcaat
     5761 cagaggaaat tgctcaaagc ttcttgactg cttccatttc atcggccaga acacacacac
     5821 acacacacac acacacacac acacacacac tagagcaaat taccagagat tgctaaatca
     5881 gtagtcagct gaaatgttgg aaagccagag tgcaggtcct ttctgccgcc ccagccctac
     5941 tccccacaac aggagaagga gtgtttggat ctcctaagtt cgttgcttaa aagatgaagt
     6001 gagctgattt tctaatcata aagcagtaat tacttctcac atgcatcgta ttcctatctg
     6061 aacactgaaa aggaatgtgt ccctcagctt aattcatctg gaagtttccc aatgtcgaga
     6121 taacattgga actgctttag cagcacccca tcagaggaga tggcttaaaa tatcagctca
     6181 gaaaggcaaa agaaagagtt gacctacttc ttgctatttg cattcagaag gcagagtctc
     6241 aggctattgg tggcagaata gataaagctg cagagttccc cagcaaagga agagtggcag
     6301 gaagcggtcc cttccctata tctaaggcct ggggcaggca ggccaagcat tcctttgaag
     6361 ctactgttat ctttttaagc tttttatctg tgagttctgt tttccaatca ggggtctctt
     6421 cattaaggtt accagggttt tggtttgttt tttttttttt tttttttttt tttttttttt
     6481 ttttttgcaa aaagttaaat caactgaacc accctccagg aaatggggag ctactcagaa
     6541 tggaaactgc tccttaaggg tgaggcagcc caaagcattc tcttgtctcc cactgatggg
     6601 atgttccttt agcatctcag gtcagtttct tacacggggg aaaaataagc ttagcttgtc
     6661 acaaacgcta tggagaaaat ggcttgatta gtgaattctt aatacaaatg tctccttgga
     6721 aagaatagag ggcacactgc taagcattcc aaaaatcaag cccctggcat gcctcatcac
     6781 ttcttgtttc aggtcagcat tctggtgggt agatagtggt ggctgtttgt cagaactgaa
     6841 cacagcctgc tccatctgtt ctcttcgcaa ggatgctgat gctgaggcac actgaagccc
     6901 ctgaacacat ctttcttgat gcctcgtttc ttcctatggc tttcagaagg gctgcatgtt
     6961 cttctcatcg ctgtttttat ttgggggcac ttgccctttt ctggcccttt tagaaatagg
     7021 gtctccctct ctgtgtggta ccactggcta aggaaaccgt acttgggagg cctcatttgt
     7081 aatcagctat gcctgggcac tgcacacgtc catttgcctt aaacttgtgg gaagtctcgg
     7141 gttgcccagc ttacagagtg aagttcagct cccacatcca tccggaagta ggggaaaaga
     7201 ggaagcgcgt ccaaccttcc tatctgcact tcctgttggt gccttcaggc cacagcagca
     7261 gtagcagcta taggcaaaga gcagcaccgt ctctgggacg ggcatccgca agtcttagct
     7321 gttagaggga tgggagagac cattcctgac ttcccactgt ttgtcacccg accctccatt
     7381 aactcccttg aatgaacctg tgcaaatgga ccaagcaaaa gaaaatggaa ggagatgttt
     7441 gcagccacat gggagaccac attgctggcc ccaagcacaa ctccagctct gtgtatgtgc
     7501 aaaaccttgg cacttggcta ctgcttagag ttcaatccat tctttatagc atgtgactga
     7561 gtaaggtccg gggatgatga gtcttttgga cccaggagag aatctcaaca gagggatttg
     7621 tgcttgggag tagaagtagg cattcctcca cagagagtgg cattgccttt atttttcatt
     7681 tggcagagac caagaattgg ggggtagggg ttgatttcca gtctttgatg tcgcctggga
     7741 tgtcctctgc aggcaggtgg tgctgagacc acagcatcgt gttccagtgc agtgtaggtg
     7801 cattgccatt cagactcagt tctggggtgg ttttgcataa agctttgcca atgtgttctt
     7861 tctttctgta tgtattattg cctttttata aaaggttttg aagtattgtc tcagtgataa
     7921 aaagagagag atgttaatgg ttgttgtata tttcaccgta tccgattgta agtattcgca
     7981 gggtacagca aagccttagc ttgcaagagg agctgaaggg gttggaaagg ttcggattct
     8041 ttgtaaatgt cctgcttttc tttctctctg tgtgtatcta tttacatgcc ttagcacatg
     8101 ccctcccatc ccaacccctt tgccctgtca cctgaacaac cacaagggtg gtggcaagcc
     8161 agcacagtac aagtcgaaac cctaatcagt tatctcgtgt gacaggggga gaagagaaac
     8221 tgcatagtat tctttgtaga atatacatac ctgtaggatg ctgtgtaatg ggaaaccata
     8281 gacttgggct tttgtcattt caaagttgga gaaatgtatg aataaaatgt ataaaacatg
     8341 aaaaaaaaaa aaaaaaaa
//
