LOCUS       NM_138660               3764 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus exon junction complex subunit (Casc3), mRNA.
ACCESSION   NM_138660
VERSION     NM_138660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Rehfeld,F., Maticzka,D., Grosser,S., Knauff,P., Eravci,M., Vida,I.,
            Backofen,R. and Wulczyn,F.G.
  TITLE     The RNA-binding protein ARPP21 controls dendritic branching by
            functionally opposing the miRNA it hosts
  JOURNAL   Nat Commun 9 (1), 1235 (2018)
   PUBMED   29581509
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Mao,H., Brown,H.E. and Silver,D.L.
  TITLE     Mouse models of Casc3 reveal developmental functions distinct from
            other components of the exon junction complex
  JOURNAL   RNA 23 (1), 23-31 (2017)
   PUBMED   27780844
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   Macchi,P., Kroening,S., Palacios,I.M., Baldassa,S., Grunewald,B.,
            Ambrosino,C., Goetze,B., Lupas,A., St Johnston,D. and Kiebler,M.
  TITLE     Barentsz, a new component of the Staufen-containing
            ribonucleoprotein particles in mammalian cells, interacts with
            Staufen in an RNA-dependent manner
  JOURNAL   J Neurosci 23 (13), 5778-5788 (2003)
   PUBMED   12843282
  REMARK    GeneRIF: data suggest that the mRNA transport machinery is
            conserved during evolution, and that mammalian Btz is an additional
            component of the dendritic ribonucleoprotein particles in
            hippocampal neurons
REFERENCE   7  (bases 1 to 3764)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3764)
  AUTHORS   Degot,S., Regnier,C.H., Wendling,C., Chenard,M.P., Rio,M.C. and
            Tomasetto,C.
  TITLE     Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein
            overexpressed in breast cancer
  JOURNAL   Oncogene 21 (28), 4422-4434 (2002)
   PUBMED   12080473
REFERENCE   9  (bases 1 to 3764)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139608.1, AK145886.1, AK037399.1 and BQ548016.1.
            
            On Nov 15, 2007 this sequence version replaced NM_138660.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139608.1, BC141296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-944               AK139608.1         40-983
            945-2518            AK145886.1         719-2292
            2519-3734           AK037399.1         1114-2329
            3735-3764           BQ548016.1         545-574
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.68 cM"
     gene            1..3764
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /note="exon junction complex subunit"
                     /db_xref="GeneID:192160"
                     /db_xref="MGI:MGI:2179723"
     exon            1..284
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2153
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /note="Barentsz; metastatic lymph node 51; mBtz; MLN 51
                     homolog; protein barentsz; metastatic lymph node gene 51
                     protein homolog; cancer susceptibility candidate gene 3
                     protein homolog; cancer susceptibility candidate 3"
                     /codon_start=1
                     /product="protein CASC3"
                     /protein_id="NP_619601.2"
                     /db_xref="CCDS:CCDS36302.1"
                     /db_xref="GeneID:192160"
                     /db_xref="MGI:MGI:2179723"
                     /translation="MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSVGGGGS
                     GSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEED
                     YSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVG
                     KKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHD
                     KFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQRDPNWIGDRSS
                     KSHRHQGPGGNLPPRTFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAGQHGG
                     RSAETLKHEASYRSRRLEQTPVRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAP
                     DRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPV
                     DSTTGGLEQDVAQLNIAEQSWSPSQPSFLQPRELRGVPNHIHMGAGPPPQFNRMEEMG
                     VQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQG
                     MIVQPEMHLPHPGLHPHQSPGPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMN
                     FGNPNYPYAPGALPPPPPPHLYPNTQAPPQVYGGVTYYNPAQQQVQPKPSPPRRTPQP
                     VSIKPPPPEVVSRGSS"
     exon            285..312
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            313..350
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            351..503
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            504..655
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            656..832
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1512
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1577
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1692
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1791
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2006
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2129
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2195
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..3742
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3718..3723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /note="hexamer: AATAAA"
     polyA_site      3742
                     /gene="Casc3"
                     /gene_synonym="Btz; Mln51"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcggcg ggcgtggtgc gtaaggagct gaccagcggt ggccgttctc cgtaagatgg
       61 cggaccggcg gcggcagcgc gcttcccagg acacggagga cgaggaatcc ggggcttcgg
      121 gttccgacag cggctctccg gcgcggggcg gcggcagctg cagcgggagc gtcggaggcg
      181 gcggcagtgg ctcgctgcct tctcagcgcg gcggccgcgg cgggggcctt cacctgcggc
      241 gggtggagag cgggggcgcc aagagcgccg aggagtctga gtgtgagagt gaagatggca
      301 tggaaggaga tgctgttctt tccgattatg aaagtgcaga agattcagaa ggtgaagaag
      361 actacagtga agaggagaat tccaaggtgg agctgaaatc agaagctaac gatgctgctg
      421 attcctctgc gaaagaaaag ggagaggaaa agcctgagtc taaaggcacg gtgactgggg
      481 agaggcagag cggcgatggg caggagagca cagagcctgt ggagaacaaa gtggggaaaa
      541 aaggccctaa gcacttggat gacgatgagg atcggaaaaa cccagcctac atccccagga
      601 aagggctctt ctttgagcac gatcttcgag gacagactca ggaggaggaa gtccgaccca
      661 agggacggca gcgaaagcta tggaaagatg agggtcgctg ggaacatgat aagttccgtg
      721 aggatgaaca ggccccgaaa tctcggcagg agctaattgc actttatggt tatgacattc
      781 ggtctgctca caatcctgat gacatcaaac cccgaagaat ccggaaacct cgatttggaa
      841 gttccccaca aagagatcca aactggattg gtgatcgatc aagcaaatcc catcgccacc
      901 agggtcctgg gggcaatcta ccacctagga catttattaa caggaacacg gcaggtactg
      961 gccgcatgtc tgcatccagg aattactctc gatctggggg cttcaaggat ggccgcacta
     1021 gtttcaggcc tgtggaggtt gctgggcagc atggtggccg gtctgctgag actcttaagc
     1081 atgaagctag ttaccggtca cggcgtctag agcagactcc tgtgagggat ccatctccag
     1141 agccagatgc tccattgctt ggaagtcctg agaaagaaga ggtggcctca gagacgccag
     1201 ctgctgtacc cgacatcacc ccaccagctc ctgacaggcc cattgagaag aagtcctatt
     1261 cccgggcaag aaggaccagg accaaagttg gggatgcagt caaagctgct gaggaggttc
     1321 ctcctccatc tgaagggctg gcctcaacag ccacagtccc cgaaacgact ccagctgcta
     1381 agactgggaa ctgggaggct ccagtagact ctaccacagg tggacttgag caagatgtgg
     1441 cgcagctaaa tatagcagaa caaagttgga gtccaagcca gccttcattc ttgcagccac
     1501 gggaacttcg aggtgtgcct aaccacatcc acatgggagc aggaccccca cctcagttta
     1561 accggatgga agaaatgggc gtccagagtg gtcgagctaa gcgttactca tcccagcggc
     1621 agagacctgt gccagagccc cctgctcctc ctgtgcatat cagtatcatg gagggacatt
     1681 actatgatcc attgcagttc cagggaccaa tctataccca tggtgacagc cctgccccac
     1741 tgcccccaca gggcatgatc gtacagccgg aaatgcacct tccccaccca ggtttacatc
     1801 cccaccagtc accaggacct ctgcccaacc cgggtctcta cccaccacca gtgtccatgt
     1861 ccccaggaca gccaccgccc cagcaactgc ttgctcctac ctacttttct gctccgggtg
     1921 tcatgaattt tggtaacccc aattaccctt atgctccggg agcattgcca cctcctccac
     1981 ctcctcatct gtatcctaac acgcaggctc caccacaggt gtatggagga gtgacttact
     2041 ataaccccgc ccagcagcag gtgcagccca agccctcccc accccggagg actccccagc
     2101 cggtctccat caagcccccc ccacctgagg ttgtaagcag gggttccagt taataagagt
     2161 tttcgaatat tttaagtata acatcatgtg aaaaagacag gagaggtgga aactcaggag
     2221 agaagggaaa tacagctggc tgtctactac tcagagggct tcaaaggtgt ggggtggccc
     2281 tgccagcagg cggaggatga ggccctcctt ctctgaggac gggtctgctg gagagagaag
     2341 aaacaggtgg ctgccttcca cctcactcct cacttgagct gcctggactc gaggagcaga
     2401 gactggacaa cccaggcgtc agaagcctgt ttcttactgt ctccccagag actcaagtgt
     2461 cttctgctcc caagggagtt ccttcctgct tgtttgtttg aatgttgatt ttttttttaa
     2521 agcttgattt acccttctta agttaatgtt tttagttttt tctccttttc cctgccctgc
     2581 cctgacttta catgaaacaa gttcagtttc gtttaccagc ctttctgggt tccctttgac
     2641 tcccctgcta accccacata attgagaatg ttttgaccaa gtgtaaaaat agctggcctt
     2701 ttccttgtga ttggtcttta ttagtctttt taatgcctct aaccctgtgg aagctgtctg
     2761 cacgcagtat cccactgtag aggagagctc agagtggggg agtaggagcc cttgcttggg
     2821 gtacaggttt tataaatctg agccttcaac agtacctctc ttctaatggg cttcagtcct
     2881 ccactgaggc agaatctctg ctgtggggag agagaacaaa ctggatgcta ttgtgagacg
     2941 ggagggtgga gtgagaccct ctgcgctgag tcctcagggc tgtcttggag gtaagtggaa
     3001 gtagtgggcc ctgcttcttt tctttgtagc cttccggcta catccccttc ccagttgtgg
     3061 accaatgcat ctctagagac agatactatc cagccatctg tctgccttgt cttttgcagt
     3121 acttctccat gccttccctg ctacaagtgt ttttagatgt tattactgta ctttccccaa
     3181 attctgctcc tgtacttgca aactgaaggt aactatacct agacttaaat cctaaggaag
     3241 caagttacct tctgggcaaa ggctgccttc ccacccttcc tttcacggca ccacactaca
     3301 tccccatgcc cctgtggaag tctgttactg cagcactgtg cctgccagag ttcccacagc
     3361 acccgaggga gaaggtgatg gctgtctctc tctagtaatg tccttgttct tattcttccc
     3421 tcctacagct ggcctaacca ctcttgagtc ggggtggggg taaccctcaa ggaggaggta
     3481 actaagaggc tcttccaggg gtagctggtg ggtgtgcttt tcataggctt ccctttgcct
     3541 taaacctgaa gatgtctcct caagcctgtg ggcagcatgc ccagattccc agactaagac
     3601 actgtgacag ttgtctgtcg gtccactgtg tttagttgca aagatttcac catgtgtgtt
     3661 gtttttgtta ctgtcttaaa gggtgcacat ttgtgatcag cattgtgact tggagataat
     3721 aaaatttaga ctgtagactt gaaaaaaaaa aaaaaaaaaa aaaa
//
