LOCUS       NP_598909                947 aa            linear   ROD 01-MAY-2025
DEFINITION  carnosine synthase 1 isoform 1 [Mus musculus].
ACCESSION   NP_598909 XP_907538 XP_924958
VERSION     NP_598909.2
DBSOURCE    REFSEQ: accession NM_134148.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 947)
  AUTHORS   Sakano,T., Egusa,A.S., Kawauchi,Y., Wu,J., Nishimura,T., Nakao,N.,
            Kuramoto,A., Kawashima,T., Shiotani,S., Okada,Y., Sato,K. and
            Yanai,N.
  TITLE     Pharmacokinetics and tissue distribution of orally administrated
            imidazole dipeptides in carnosine synthase gene knockout mice
  JOURNAL   Biosci Biotechnol Biochem 86 (9), 1276-1285 (2022)
   PUBMED   35641020
REFERENCE   2  (residues 1 to 947)
  AUTHORS   Wu,J., Egusa,A. and Nishimura,T.
  TITLE     Carnosine synthase deficiency in mice affects protein metabolism in
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 612, 22-29 (2022)
   PUBMED   35500438
REFERENCE   3  (residues 1 to 947)
  AUTHORS   Wang-Eckhardt,L., Bastian,A., Bruegmann,T., Sasse,P. and
            Eckhardt,M.
  TITLE     Carnosine synthase deficiency is compatible with normal skeletal
            muscle and olfactory function but causes reduced olfactory
            sensitivity in aging mice
  JOURNAL   J Biol Chem 295 (50), 17100-17113 (2020)
   PUBMED   33040025
  REMARK    GeneRIF: Carnosine synthase deficiency is compatible with normal
            skeletal muscle and olfactory function but causes reduced olfactory
            sensitivity in aging mice.
REFERENCE   4  (residues 1 to 947)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
REFERENCE   5  (residues 1 to 947)
  AUTHORS   Drozak,J., Veiga-da-Cunha,M., Vertommen,D., Stroobant,V. and Van
            Schaftingen,E.
  TITLE     Molecular identification of carnosine synthase as ATP-grasp
            domain-containing protein 1 (ATPGD1)
  JOURNAL   J Biol Chem 285 (13), 9346-9356 (2010)
   PUBMED   20097752
  REMARK    GeneRIF: carnosine synthase is identified as ATP-grasp
            domain-containing protein 1
REFERENCE   6  (residues 1 to 947)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109138.10.
            
            On or before Oct 11, 2009 this sequence version replaced
            XP_924958.3, XP_907538.3, NP_598909.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.86 cM"
     Protein         1..947
                     /product="carnosine synthase 1 isoform 1"
                     /EC_number="6.3.2.11"
                     /note="ATP-grasp domain-containing protein 1; ATP-grasp
                     domain containing 1"
                     /calculated_mol_wt=102007
     Region          531..611
                     /region_name="ATPgrasp_N"
                     /note="ATP-grasp N-terminal domain; pfam18130"
                     /db_xref="CDD:407962"
     Region          572..848
                     /region_name="AccC"
                     /note="Biotin carboxylase [Lipid transport and
                     metabolism]; COG0439"
                     /db_xref="CDD:440208"
     CDS             1..947
                     /gene="Carns1"
                     /gene_synonym="Atpgd1; mKIAA1394"
                     /coded_by="NM_134148.3:109..2952"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50350.1"
                     /db_xref="GeneID:107239"
                     /db_xref="MGI:MGI:2147595"
ORIGIN      
        1 mlcldplgte wdskdldgke epwksgaglp ptgcfpgpwr qdisldckgs peetearawt
       61 vyyygllqsc lqqaglpetq drsqaprtgc pgaevtlcil gspstflsll leggvqspgn
      121 mllclspawl mkvatpgqeg eavllvskav sfypggltfl ddfvpprhat yflaglgpes
      181 grgkeaaela rnltcptgts selsqllenr llmrwllsqq sgvavpatla ftyrppgllr
      241 ggdaspglrl velsgkegqe tlvkeeveaf vhsealgdas qvavrlsgcr wrgqqalplh
      301 lrvepstvvn tvlgllekle eeesvlveam cppvrlplpg gpapgpelav ricavvcriq
      361 gdrpllskvv cgvgrgdrpv rhhytlprtl rvalaqcgle eeaqvalleq gikeaaegal
      421 aavlaleagl sveqrggrqv htdflgvdlv ltvigrtltp vvlklnsglc leacgalegl
      481 wavprlrrsa eeaaaaplve tmlrrsgrhl mdgkqllvig aggvskkfvw eaardygltl
      541 hlvesdpnhf asqlvqtfih fdvtehrrde enalllaelv rarnlkldgc fsfwddclvl
      601 tallcrelgl pcsppaamcl akqksrtqlh llrcqgppwp stslhavacc pleneadver
      661 aiyqvplpgv mklefgsgav gvqlvkdgpq crehfsrilh dlqgeadhpg iglgwgnaml
      721 lmefvegteh dvdlvvfggr llaafvsdng ptrlpgftet aacmptglap eqeaqvvqaa
      781 frcclgcgll dgvfnvelkm tgagprliei nprmggfylr dwilelygvd lllastmvac
      841 glqpalpahp rargylvgim clvsqhlqll sspssretlq tlhdqgqlrl nlleealipg
      901 qyeepycnva cagpspaeac hrllgicqgl gidrpnypva hflshfk
//
