LOCUS       NM_026120               4524 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus carnosine N-methyltransferase 1 (Carnmt1), transcript
            variant 1, mRNA.
ACCESSION   NM_026120 XM_003946026 XM_006544724 XM_011238255 XM_916317
            XM_924220 XM_924223
VERSION     NM_026120.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Shimazu,T., Yoshimoto,R., Kotoshiba,K., Suzuki,T., Matoba,S.,
            Hirose,M., Akakabe,M., Sohtome,Y., Sodeoka,M., Ogura,A., Dohmae,N.
            and Shinkai,Y.
  TITLE     Histidine N1-position-specific methyltransferase CARNMT1 targets
            C3H zinc finger proteins and modulates RNA metabolism
  JOURNAL   Genes Dev 37 (15-16), 724-742 (2023)
   PUBMED   37612136
  REMARK    GeneRIF: Histidine N1-position-specific methyltransferase CARNMT1
            targets C3H zinc finger proteins and modulates RNA metabolism.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134906.3.
            
            On Dec 12, 2019 this sequence version replaced NM_026120.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043335.1, SRR7345562.4730611.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AC134906.3         78799-79242         c
            445-640             AC134906.3         72118-72313         c
            641-804             AC134906.3         70734-70897         c
            805-945             AC134906.3         59631-59771         c
            946-1124            AC134906.3         58406-58584         c
            1125-1238           AC134906.3         56239-56352         c
            1239-1342           AC134906.3         46537-46640         c
            1343-4524           AC134906.3         42800-45981         c
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.18 cM"
     gene            1..4524
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="carnosine N-methyltransferase 1"
                     /db_xref="GeneID:67383"
                     /db_xref="MGI:MGI:1914633"
     exon            1..444
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1444
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /EC_number="2.1.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0586 protein C9orf41 homolog"
                     /codon_start=1
                     /product="carnosine N-methyltransferase isoform 1"
                     /protein_id="NP_080396.2"
                     /db_xref="CCDS:CCDS29689.1"
                     /db_xref="GeneID:67383"
                     /db_xref="MGI:MGI:1914633"
                     /translation="MQRRQRAPPASQPAQDGGRSEDVEVQFSAGRLGSAAPAGPPARG
                     TAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPENQQKLLPQFPLHLDK
                     IRKCIDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDW
                     SETGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEVAMLGYACQG
                     NEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPILFPDVDPHSLPP
                     GSNFSMTAGDFQEIYSECNAWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGP
                     LLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECV
                     LFVVRKPQ"
     exon            445..640
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..804
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            805..945
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1124
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1238
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1342
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..4524
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1496..1501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1538
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="major polyA site"
     polyA_site      1545
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="major polyA site"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3994
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="major polyA site"
     regulatory      4501..4506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      4524
                     /gene="Carnmt1"
                     /gene_synonym="2410127L17Rik"
ORIGIN      
        1 agcccggcag cgaatgaacg cgggcggccg cggccttagc ctggtcgtcg gcgcgtgcgc
       61 gggtcccgaa accctggcgg agcgcagcgc gaatggaggc ctgagggcgg cgggggcggg
      121 gcgtgccgcg agcgggggcc tcggccgcgg ccggcgccgt ctagaggagg cccggccgtt
      181 cgccaccacg cactcgggag ccgggaagcg caggcgggtc acgccgtggg ccgcggcggc
      241 gatgcagcga cgacagcgcg ctccgcccgc gtctcaaccg gcccaggacg gcgggcgaag
      301 cgaggacgtg gaggtgcagt tctccgccgg gcgtttgggc tcggccgcgc ctgcggggcc
      361 cccggcgcgc ggcaccgccg aggacgagga gcggctggag cgcgagcact tctggaaggt
      421 catcaacgcg ttccgctact acggcaccag catgcatgaa cgagtgaaca gaacagaaag
      481 acagtttcgg tcccttccag agaaccagca gaaactgctt cctcagtttc ctcttcactt
      541 ggacaagatc cggaaatgca ttgaccataa tcaggaaata ctgctgacca ttgtgaatga
      601 ttgcatacat atgttcgaaa ataaagaata tggagaagat gccaatggaa agattatgcc
      661 agcatctaca tttgacatgg ataagttaaa atctacactg aaacagtttg taagagactg
      721 gagtgagacc gggaaagcag aaagggacgc ctgctataag ccaatcatta aagagattat
      781 caaaaatttt ccaaaggaga gatgggatcc ttctaaagta aatattctgg tacctggtgc
      841 tggactagga agattggcct gggaagtagc tatgctaggt tatgcttgtc aaggaaatga
      901 atggagtttt tttatgctct tttcttccaa ctttgtactc aacagatgtt ctgaaattaa
      961 caaatataaa ctttatccct ggatccatca gtttagcaat aatcggagat cagctgatca
     1021 gatccgaccc attcttttcc ctgatgttga cccccacagt cttcctcctg gttctaactt
     1081 ttccatgaca gcaggagact ttcaggagat ttactcagaa tgcaatgcct gggactgtat
     1141 tgccacctgc ttcttcatag acacagctca caatgtaatt gattatattg atacaatatg
     1201 gagaatactc aagccaggtg gaatctggat aaatcttggt cctctactat accattttga
     1261 aaatctggca aatgaactgt ctatagaatt gagctatgag gatattaaaa atgttgttct
     1321 tcagtatgga tttcagctag aggtggagaa agaatctgta ttgtcaacat atactgtgaa
     1381 tgatctctct atgatgaaat actactatga gtgtgttttg tttgtggtcc ggaagccaca
     1441 ataatggtct taagtgctat tacccagaaa aacatttaat aagagtaaat gatgaaataa
     1501 acaactcaga gtcaactatc ggtgacaaca ggacacaacc tcaaatcagt ggtgccttct
     1561 tattcctaac aaaatttaga aatagtgtct attttcttaa tgatgtctat tgcttttttc
     1621 agaaatatac tatgccgtgc aaatttatac cacacaagta aaaaaaaaaa aaaaaatgaa
     1681 gacattatct cccatgcaga tatctaatgg aggaactatc ttcaagtact tttttctttg
     1741 aagccctgaa ttgtctttaa gaaaataaac ataaactcca ggtttcatga agctattgcg
     1801 agtctgcaat agaatttgaa actattcttt catcattcaa aatagtttta ttttattttt
     1861 tagctcagcc gcatttagag aacatcaaac atgtcatgta tgaaatgcta aatcagttgt
     1921 atcacaggtt aaaactcatg aactacagta acagagaaag tctttgtcca tgttaaactg
     1981 aatcttatat caatcactgg atccctttga aatgtatgta aatataaata tttggaggtc
     2041 caaaagcttc ttttataaag cagtgttaag aaactggaaa aataagaata aaatctgccc
     2101 atctgaaata cataatttcg aattagaaat taattacaaa gcttgtcgtg tgatgtttac
     2161 aatgatgtgt tttataaagt atgtggctta tggaagcaag cactttttta gttaacatgt
     2221 attctagtga aaattataat agaattaatg tgagaagttc tgagtataaa attcagggat
     2281 aaattaatgc ctgtgttctg tgtcttccta ggcagcagcc attcatggaa tttcagatta
     2341 atactaattt tgtccccaga taagagttgg agctgaaaga gtatatgctg ctttaatttt
     2401 ctacctctag agaggcctgg tcagagggag ttttccttgt tagttgtaat gcttgttatt
     2461 ccgtttccat tagctaggaa agaagaggtg gaaggtgttt taacttctgc aggaaaagga
     2521 agttcttgct gagtgttgca caaatgtgtg acctctgtgg catctggatt agatggattt
     2581 aatatgtact ggtgacataa ctgccttgtt gccatgcttt aataggacgc cttactttaa
     2641 gtccttgagc ctttgtgttg cttaggtttg agtctgtagg atctggtatc tttctagttg
     2701 ggagaattct acacagtatg ggaatttttg tcatctgtcc ttccatcatg cagtacatgg
     2761 ctccacagag caaattttac ttcttaggct gtgtaaatcc atagtctagt ttttgtctaa
     2821 aatcatttct tgttcttcta ttgctcacta ctttacaaat gttcatttgg tggaaattct
     2881 tatcactata tacaaggggg gaatatctct cagaattatt tttttaaggg gaaaaaataa
     2941 cctaagaaat gtattttaaa agtcatccag tgaacagcga ggaatgcatg ctttttaagt
     3001 tgttatttag gaatgctttt attcatcgag tgttttttgt ttttttacaa aggtaagagc
     3061 agtctgacac cagagggttg gttttgttac ctaacgattt ttttttctgt tatgttttac
     3121 tctttaatgt tactacttac atttctaaat tatgtatttt acttaactct gaaatcagtt
     3181 atttcactta tttttttctt catatcatga acgttctaaa aatattcctt ataaatttgc
     3241 atcacttttt ctcttgtggc ttttgaagtt actatattct aaacttgaga agatggtata
     3301 aatcaataat agaagagtca ctggggagct ggtgagatgg ctcagtgggt aagagcactg
     3361 acttcttttc caaaggtact gaattcaaat cccagcaacc acatggtggc tcacagcctc
     3421 ccatagtgag atctgatgcc ctattctgat gtgtttgaag acagctacgg tgaacttata
     3481 ataataaata aatcttaaaa aaaaaaaaaa agaggtgtca ctggaggagt ttaattttgt
     3541 attttttata tttaggtcca gctattaaag tgtgtaagtc tgggaaattt aatttttttt
     3601 cttaaattag tgctatatac aaatgttctc agttttataa ggtgatcatg tgctttctgt
     3661 ttttaaattt acattttctg aggtggtgaa gacttaggtt ctgatcaata agcatgatag
     3721 ggcatgtaga ctatacggga aggctcctga gcccacagta tatagtgagc atgatagggc
     3781 atgtagacta tacgggaagg ctcccgagct cacagtatgc actggtcacg ccggggaact
     3841 gtagagtgta tgggctctgt gtgtaattca cgttctgaca tcgccagaaa gacgggactg
     3901 ggagcttcat gtctgcatga aacttcctat atctttaatg tgtgtataga cttacttttt
     3961 ctttaaatat taaagtctac caattgctac aacagttctt ggttgtttcc ctcaatgtaa
     4021 tgatggccat agtgggaatg ttatttgagc acatttctca attcttcatt agcctttttt
     4081 tttttttttt ttgtacgctt ctaggaactc aatgagcatt tgagctttga gtttgccgag
     4141 gtgtatagta tctattttca ctttgtttca ttcatgttca gtataatgaa cttggaatct
     4201 tccaagggaa aaagattagt cttgatcctt aattttgtta aatgatagaa taaactacaa
     4261 aggctaacag cagaaaaagt ttcaagaaga gcagttttat catctggggt cgcttctctg
     4321 aactcttctc aactgggcgg gtagtgtctc tgaggacttc tgccaggtga ctccacagtg
     4381 cctcagcagg tggctactgg gtgaggactt cactctgcat tctgacctgg tattttctcc
     4441 tcccctagtg ctttctctct gtattgtcaa ctttttattt ctatgacaac atacttttaa
     4501 agtaaaagga taatgggttt atta
//
