LOCUS       NM_001037747            1871 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus caspase recruitment domain family, member 9 (Card9),
            mRNA.
ACCESSION   NM_001037747 XM_285326 XM_914859
VERSION     NM_001037747.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Linnemann,L., Antwi-Ekwuruke,J., Gnanapragassam,V., Bang,C.,
            Ruhlemann,M., Ruland,J., Hartmann,W., Heepmann,L., Dorken,S.,
            Yunus,S.M., Viebrock,B., Schlosser,A., Lepenies,B. and Breloer,M.
  TITLE     The C-type lectin receptor MINCLE interferes with eosinophil
            function and protective intestinal immunity in Strongyloides
            ratti-infected mice
  JOURNAL   Mucosal Immunol (2024) In press
   PUBMED   39581231
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Wang,R., Oliveira,L.V.N., Hester,M.M., Carlson,D., Christensen,D.,
            Specht,C.A. and Levitz,S.M.
  TITLE     Protection against experimental cryptococcosis elicited by Cationic
            Adjuvant Formulation 01-adjuvanted subunit vaccines
  JOURNAL   PLoS Pathog 20 (7), e1012220 (2024)
   PUBMED   38976694
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Danne,C., Lamas,B., Lavelle,A., Michel,M.L., Da Costa,G.,
            Pham,H.P., Lefevre,A., Bridonneau,C., Bredon,M., Planchais,J.,
            Straube,M., Emond,P., Langella,P. and Sokol,H.
  TITLE     Dissecting the respective roles of microbiota and host genetics in
            the susceptibility of Card9-/- mice to colitis
  JOURNAL   Microbiome 12 (1), 76 (2024)
   PUBMED   38649950
  REMARK    GeneRIF: Dissecting the respective roles of microbiota and host
            genetics in the susceptibility of Card9[-/-] mice to colitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Brandt,M., Cao,Z., Krishna,C., Reedy,J.L., Gu,X., Dutko,R.A.,
            Oliver,B.A., Tusi,B.K., Park,J., Richey,L., Segerstolpe,A.,
            Litwiler,S., Creasey,E.A., Carey,K.L., Vyas,J.M., Graham,D.B. and
            Xavier,R.J.
  TITLE     Translational genetics identifies a phosphorylation switch in CARD9
            required for innate inflammatory responses
  JOURNAL   Cell Rep 43 (3), 113944 (2024)
   PUBMED   38489265
  REMARK    GeneRIF: Translational genetics identifies a phosphorylation switch
            in CARD9 required for innate inflammatory responses.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Gross,O., Grupp,C., Steinberg,C., Zimmermann,S., Strasser,D.,
            Hannesschlager,N., Reindl,W., Jonsson,H., Huo,H., Littman,D.R.,
            Peschel,C., Yokoyama,W.M., Krug,A. and Ruland,J.
  TITLE     Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1
            complex via Carma1 for NF-kappaB and MAPK activation to selectively
            control cytokine production
  JOURNAL   Blood 112 (6), 2421-2428 (2008)
   PUBMED   18192506
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Hara,H., Ishihara,C., Takeuchi,A., Imanishi,T., Xue,L.,
            Morris,S.W., Inui,M., Takai,T., Shibuya,A., Saijo,S., Iwakura,Y.,
            Ohno,N., Koseki,H., Yoshida,H., Penninger,J.M. and Saito,T.
  TITLE     The adaptor protein CARD9 is essential for the activation of
            myeloid cells through ITAM-associated and Toll-like receptors
  JOURNAL   Nat Immunol 8 (6), 619-629 (2007)
   PUBMED   17486093
  REMARK    GeneRIF: activation of lymphoid and myeloid cells through
            Immunoreceptor tyrosine-based activation motifs-associated
            receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and
            CARD9-Bcl-10, respectively
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   LeibundGut-Landmann,S., Gross,O., Robinson,M.J., Osorio,F.,
            Slack,E.C., Tsoni,S.V., Schweighoffer,E., Tybulewicz,V.,
            Brown,G.D., Ruland,J. and Reis e Sousa,C.
  TITLE     Syk- and CARD9-dependent coupling of innate immunity to the
            induction of T helper cells that produce interleukin 17
  JOURNAL   Nat Immunol 8 (6), 630-638 (2007)
   PUBMED   17450144
  REMARK    GeneRIF: signaling through Syk and CARD9 can couple innate to
            adaptive immunity independently of Toll-like receptor signals
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Hsu,Y.M., Zhang,Y., You,Y., Wang,D., Li,H., Duramad,O., Qin,X.F.,
            Dong,C. and Lin,X.
  TITLE     The adaptor protein CARD9 is required for innate immune responses
            to intracellular pathogens
  JOURNAL   Nat Immunol 8 (2), 198-205 (2007)
   PUBMED   17187069
  REMARK    GeneRIF: CARD9 has a critical function in Nod2-mediated activation
            of p38 and Jnk in innate immune responses to intracellular
            pathogens
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Gross,O., Gewies,A., Finger,K., Schafer,M., Sparwasser,T.,
            Peschel,C., Forster,I. and Ruland,J.
  TITLE     Card9 controls a non-TLR signalling pathway for innate anti-fungal
            immunity
  JOURNAL   Nature 442 (7103), 651-656 (2006)
   PUBMED   16862125
  REMARK    GeneRIF: Card9 is a key transducer of Dectin-1 signalling, where
            Dectin-1 is the major mammalian pattern recognition receptor for
            the fungal component zymosan, in antifungal immunity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732541.11.
            
            On Dec 5, 2019 this sequence version replaced NM_001037747.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1710886.1,
                                           SRR7345562.1720195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL732541.11        165416-165538
            124-319             AL732541.11        166766-166961
            320-457             AL732541.11        167374-167511
            458-762             AL732541.11        168310-168614
            763-942             AL732541.11        168681-168860
            943-1086            AL732541.11        168997-169140
            1087-1212           AL732541.11        169442-169567
            1213-1404           AL732541.11        170801-170992
            1405-1446           AL732541.11        171454-171495
            1447-1495           AL732541.11        171920-171968
            1496-1569           AL732541.11        173311-173384
            1570-1646           AL732541.11        173764-173840
            1647-1871           AL732541.11        173914-174138
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.87 cM"
     gene            1..1871
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /note="caspase recruitment domain family, member 9"
                     /db_xref="GeneID:332579"
                     /db_xref="MGI:MGI:2685628"
     exon            1..123
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            124..319
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1746
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 9"
                     /protein_id="NP_001032836.1"
                     /db_xref="CCDS:CCDS38084.1"
                     /db_xref="GeneID:332579"
                     /db_xref="MGI:MGI:2685628"
                     /translation="MSDYENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDD
                     EEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARV
                     FSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQER
                     VQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLM
                     KAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRN
                     SPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRK
                     DAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKA
                     DELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQL
                     SDKGVLADRESPEQPFMALNKEHLSLTHGMGPSSSEPPEKERRRLKESFENYRRKRAL
                     RKMQNSWRQGEGDRGNTTGSDNTDTEGS"
     exon            320..457
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            458..762
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            763..942
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1086
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1212
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1404
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1446
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1495
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1569
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1646
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1871
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /note="major polyA site"
ORIGIN      
        1 ctccttcatg gctccaccct tctccagtta gggaacccct ccacactccc agagacccag
       61 gctcctggta tgtccataac ccagacagca tctgctggca ggtagctctc acaagaccct
      121 gagcctacag aggacatgtc agactatgag aatgacgacg agtgctggag caccctggag
      181 agcttccggg tgaagctcat ctctgtcatt gacccctccc ggatcacacc ctatctacgc
      241 cagtgcaaag tcctgaaccc cgatgatgag gagcaggtgc tcagtgaccc caacctggtc
      301 atccgcaagc ggaaagtggg tgtgctcctg gacatcctgc agcggacagg ccacaagggc
      361 tacgtggctt tcctcgagag cctggagctc tactaccctc agttataccg gaaagtcact
      421 ggcaaggagc cagcacgcgt cttctccatg atcattgatg catcagggga gtctggcctg
      481 acgcagctgc tgatgacaga ggtcatgaag ctgcagaaga aggttcagga cctgacggcc
      541 cttctgagct ccaaggacga cttcatcaag gagctgaggg taaaggacag cctactgcgc
      601 aagcaccagg agcgggtgca gcggctcaag gaggagtgtg agctgagcag tgcggagctg
      661 aagcgctgca aggacgagaa ctatgagctg gccatgtgcc tggcacatct gagtgaagag
      721 aagggcgcag cactcatgcg gaaccgtgac ctgcagcttg aggtggaccg gctcaggcac
      781 agcctcatga aggccgagga tgactgcaag gtggagcgca aacacacact gaagctcagg
      841 cacgccatgg agcagcggcc tagtcaggag ctgctgtggg aactacagca ggaaaaggac
      901 ttgctgcagg cccgggtgca ggagctgcag gtctctgtgc aggagggtaa gctagacagg
      961 aatagtccat acattcaagt gctggaggag gactggcgtc aagcactgca ggaacaccag
     1021 aagcaggtca gcaccatctt ctccctacgg aaggacctcc gccaggctga gaccctccgg
     1081 gcccggtgca cggaagaaaa ggagatgttc gagctgcagt gcctggcctt gcgcaaggat
     1141 gccaagatgt acaaggaccg tatcgaggct atcctgctgc agatggagga ggtctccatt
     1201 gagagggacc aggctatggc ctccagggaa gagctgcatg cacagtgtac ccaaagcttt
     1261 caggacaaag ataagcttcg aaagctggtt cgagagctgg gtgagaaggc agatgagctg
     1321 cagctacagc tgttccagac ggagagccga ttactggccg ccgagggcag actcaagcag
     1381 cagcaattgg acatgctcat cctgagctct gacttggaag acagttcacc caggaactcc
     1441 caggagctct cactgcctca ggatctggag gaggatgccc agctctcaga caaaggtgta
     1501 ctggcagaca gggagagccc agagcagccc tttatggctc tgaacaagga gcatctttca
     1561 ctgacccatg gcatggggcc cagcagcagc gagcccccgg agaaggagcg gcggcgcctc
     1621 aaggagagct tcgagaacta ccgcaggaag cgggcgctcc gcaagatgca gaacagctgg
     1681 cggcagggag aaggggatcg cgggaatacg acaggcagcg acaacaccga caccgagggc
     1741 tcctagcgaa ccgcgccgag gctgagcatc tgtggaattg tgaaaggatg ctgcggtttt
     1801 tttttttttt tttttttttt tactgtatta gaattagaaa atgcaactaa ataaaataat
     1861 caccgagctg a
//
