LOCUS       NM_001163138            4531 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus caspase recruitment domain family, member 6 (Card6),
            mRNA.
ACCESSION   NM_001163138 XM_139295 XM_904712
VERSION     NM_001163138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4531)
  AUTHORS   Zhao M, He H and Yin J.
  TITLE     CARD6 protects against collagen-induced rheumatoid arthritis in
            mice through attenuating the inflammatory response and joint
            destruction via suppression of TNFR1/TRAF2 signaling
  JOURNAL   Biochem Biophys Res Commun 526 (4), 1092-1099 (2020)
   PUBMED   32317187
  REMARK    GeneRIF: CARD6 protects against collagen-induced rheumatoid
            arthritis in mice through attenuating the inflammatory response and
            joint destruction via suppression of TNFR1/TRAF2 signaling.
REFERENCE   2  (bases 1 to 4531)
  AUTHORS   Chen F, Li J, Tian G and Yuan Z.
  TITLE     Increased macrophage activation mediated by caspase recruitment
            domain 6 knockdown through negatively targeting AMPK
  JOURNAL   Biochem Biophys Res Commun 525 (2), 412-417 (2020)
   PUBMED   32102753
  REMARK    GeneRIF: Increased macrophage activation mediated by caspase
            recruitment domain 6 knockdown through negatively targeting AMPK.
REFERENCE   3  (bases 1 to 4531)
  AUTHORS   Wang JL, Luo X and Liu L.
  TITLE     Targeting CARD6 attenuates spinal cord injury (SCI) in mice through
            inhibiting apoptosis, inflammation and oxidative stress associated
            ROS production
  JOURNAL   Aging (Albany NY) 11 (24), 12213-12235 (2019)
   PUBMED   31841440
  REMARK    GeneRIF: Targeting CARD6 attenuates spinal cord injury (SCI) in
            mice through inhibiting apoptosis, inflammation and oxidative
            stress associated ROS production.
REFERENCE   4  (bases 1 to 4531)
  AUTHORS   Sun P, Zeng Q, Cheng D, Zhang K, Zheng J, Liu Y, Yuan YF and Tang
            YD.
  TITLE     Caspase Recruitment Domain Protein 6 Protects Against Hepatic
            Steatosis and Insulin Resistance by Suppressing Apoptosis
            Signal-Regulating Kinase 1
  JOURNAL   Hepatology 68 (6), 2212-2229 (2018)
   PUBMED   29729191
  REMARK    GeneRIF: Gain-of-function and loss-of-function Card6 mouse models
            demonstrated that Card6 protected mice from insulin resistance,
            hepatic steatosis, and inflammatory responses upon high-fat diet
            administration. Mechanistically, Card6 interacted with and
            inhibited apoptosis signal-regulating kinase 1 (Ask1) and its
            subsequent downstream c-Jun N-terminal kinase/p38 signaling.
REFERENCE   5  (bases 1 to 4531)
  AUTHORS   Qin JJ, Mao W, Wang X, Sun P, Cheng D, Tian S, Zhu XY, Yang L,
            Huang Z and Li H.
  TITLE     Caspase recruitment domain 6 protects against hepatic
            ischemia/reperfusion injury by suppressing ASK1
  JOURNAL   J Hepatol 69 (5), 1110-1122 (2018)
   PUBMED   29958938
  REMARK    GeneRIF: CARD6 is a novel protective factor against hepatic I/R
            injury that suppresses inflammation and liver cell death by
            inhibiting the ASK1 signaling pathway.
            Erratum:[J Hepatol. 2019 Mar;70(3):578-580. PMID: 30616986]
REFERENCE   6  (bases 1 to 4531)
  AUTHORS   Li L, Chen W, Zhu Y, Wang X, Jiang DS, Huang F, Wang L, Xiang F,
            Qin W, Wang Q, Zhang R, Zhu X, Li H and Chen X.
  TITLE     Caspase recruitment domain 6 protects against cardiac hypertrophy
            in response to pressure overload
  JOURNAL   Hypertension 64 (1), 94-102 (2014)
   PUBMED   24777975
  REMARK    GeneRIF: these data indicated that CARD6 serves as a novel
            cardioprotective factor via negative regulation of MEK
            kinase-1-dependent MEK-ERK1/2 and JNK1/2 signaling
REFERENCE   7  (bases 1 to 4531)
  AUTHORS   Dufner A, Duncan GS, Wakeham A, Elford AR, Hall HT, Ohashi PS and
            Mak TW.
  TITLE     CARD6 is interferon inducible but not involved in
            nucleotide-binding oligomerization domain protein signaling leading
            to NF-kappaB activation
  JOURNAL   Mol Cell Biol 28 (5), 1541-1552 (2008)
   PUBMED   18160713
REFERENCE   8  (bases 1 to 4531)
  AUTHORS   Dufner A, Pownall S and Mak TW.
  TITLE     Caspase recruitment domain protein 6 is a microtubule-interacting
            protein that positively modulates NF-kappaB activation
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 988-993 (2006)
   PUBMED   16418290
  REMARK    GeneRIF: CARD6 is a regulator of NF-kappaB activation that
            modulates the functions of RICK protein
REFERENCE   9  (bases 1 to 4531)
  AUTHORS   Stehlik C, Hayashi H, Pio F, Godzik A and Reed JC.
  TITLE     CARD6 is a modulator of NF-kappa B activation by Nod1- and
            Cardiak-mediated pathways
  JOURNAL   J Biol Chem 278 (34), 31941-31949 (2003)
   PUBMED   12775719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131919.13.
            
            On or before Jul 10, 2009 this sequence version replaced
            XM_904712.2, XM_139295.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.75882.1,
                                           SRR13948564.5119263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC131919.13        121397-121447       c
            52-340              AC131919.13        121002-121290       c
            341-874             AC131919.13        117817-118350       c
            875-4531            AC131919.13        110353-114009       c
FEATURES             Location/Qualifiers
     source          1..4531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.99 cM"
     gene            1..4531
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /note="caspase recruitment domain family, member 6"
                     /db_xref="GeneID:239319"
                     /db_xref="MGI:MGI:3032959"
     exon            1..51
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /inference="alignment:Splign:2.1.0"
     exon            52..340
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3585
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 6"
                     /protein_id="NP_001156610.1"
                     /db_xref="CCDS:CCDS49573.1"
                     /db_xref="GeneID:239319"
                     /db_xref="MGI:MGI:3032959"
                     /translation="MATEGASSELIEKKRTKLLSVLQQDPDSILDTLTSRSLISEKEY
                     ETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCLSNAFPESASTVGFKHEVPRQEAE
                     ETVGVNRNSEDPLSLGTIIPEIAELSEEKECLDLRALKFFTYKESGHRELAVSSRENQ
                     EGHGTPQVTAPHSVKRVEYEVPASITFLSNGQRYEEPDDSLYLEEGEHQEYLGFPEDV
                     ETVLEEEAGKDPQCFVYDNEEEWENEETMGFSSEASSCSEINFSLEEEEEKSAEERKR
                     VFQHVLSCLNMDRSRKLLPDSVKQFSTDRGREWTPETPGDLAWNFLMKVQALDSTARD
                     FTLRHKMVDEENKELLLARMEKLGIGDAQTIHPLDVLCACMLCADSSLQREVMSNMYH
                     CCFALPLLLPDAENNKSILMMGAMKDLKQHATQSSGGPPRETDASLSLMKMPVISFVR
                     LGHCSFSKSRILNTLLSSSRQKPHTFFLRRDLSVPVLPRQISDGLVEVMWHFPDDAEL
                     TVSPHVFQKPVAVANLRGDLESFWVQFGFLVEVSSAVFFLTDCLGEKERALLRFLGDD
                     AIERCYVILSPQAKESEEAQIFQKILKLRPSQLLFWEVEEAGDRRRAMEALQAALQEV
                     MSSPLKCVSLEDMACLARELGIQVDQDFEVIQDTQVSPRTIEGENQQPQSQTKSPSES
                     RTQKPLREPGTQCEDSQNAVIFHQTPVFMPYPAHPWPLPIEAGSNFYHVPLRAPRAIS
                     SHFRSQQKAEWFFPFPHQNTSVHSRGQNFAIKYLQPWRFYSRERFTRCSATPQQYHPN
                     GPFGRSQRQASPVQTHPKSRQMSRTLERSGTVVSRVGHGRSLGSQARRAAGKPQPEKA
                     CAQGLQLTKAAGKSIRTLPHIKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPADF
                     AFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKKPSHSRPSQAKPPH
                     LDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHP
                     QSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPT
                     HPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPK
                     PFQPRPTQPKSSKTKPSQARAFHPRAGRR"
     exon            341..874
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /inference="alignment:Splign:2.1.0"
     exon            875..4531
                     /gene="Card6"
                     /gene_synonym="D730008L15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgtg tttgtactct ctgttgtcct ctttgccctc tccaacaaca ggaagcaatg
       61 gctacagagg gtgcttcctc agaactcata gaaaaaaaac gtacgaagtt gctcagtgtc
      121 ctccaacaag atccggactc tatcttggac acgttaacct ctcggagcct gatttctgag
      181 aaggagtatg agactctgga ggaaatcaca gatcccctga agaaaagtcg gaagctgtta
      241 attttgatac agaaaaaagg agaggacagc tgtcggcgtt tcctccggtg tttgtctaat
      301 gcctttccag agtcagcgtc cacagtgggc ttcaagcacg aagttccacg gcaggaagct
      361 gaagagactg tgggggtgaa caggaattct gaagatcccc tttctcttgg gacaataatc
      421 ccggagatag cagagctctc agaagagaaa gaatgtctag atctgagagc tttgaagttc
      481 ttcacctaca aggaaagtgg ccacagggaa cttgcagtat cctcccggga gaaccaggaa
      541 gggcatggga caccgcaggt cacggctccc cattcagtca aaagagttga gtatgaagtc
      601 ccagcaagta tcaccttctt aagcaatgga cagagatacg aggagccaga tgattcgctg
      661 tacttagagg aaggggaaca tcaagagtac cttgggttcc ctgaagatgt cgagactgtc
      721 ttggaggaag aggccggcaa ggacccacag tgctttgtat atgataatga agaggaatgg
      781 gagaatgaag agaccatggg gttctccagt gaagccagta gctgttcaga gatcaatttc
      841 tcattggagg aggaggagga gaaaagcgct gaagagagaa aaagagtatt tcagcatgtt
      901 ctgtcttgtt tgaacatgga tagaagcagg aagcttctcc cagattctgt gaagcagttt
      961 tccacagacc gaggacgtga gtggacaccc gagaccccag gggacttagc ttggaatttc
     1021 ctgatgaagg ttcaggcttt agactcgaca gccagagatt ttacccttag gcacaagatg
     1081 gtggatgaag agaacaaaga actgctgctg gctagaatgg agaagttagg aattggagac
     1141 gcacaaacca tccatcccct ggatgtcctc tgcgcctgca tgctttgcgc agacagctct
     1201 ttgcaacgtg aagtcatgtc aaatatgtac cactgctgct ttgctcttcc cctgctactg
     1261 ccagatgcag agaacaacaa aagcatctta atgatggggg ccatgaagga cctaaagcag
     1321 cacgcaacgc agtcctcagg cgggcccccc agggaaacag acgcgtctct gagtctcatg
     1381 aagatgcctg tcatctcttt tgtgcgactg ggacactgca gcttctccaa gtccagaatt
     1441 ctgaacacac tgctcagctc ctctcgacag aaaccacaca cgtttttcct ccgtcgggac
     1501 ctgtcggtcc ctgtgctgcc tcggcaaatt tctgatggcc tggtggaagt gatgtggcac
     1561 tttcccgacg atgcagagct aacggtgagc ccacacgttt tccagaaacc tgttgctgtg
     1621 gccaaccttc gtggcgatct agaaagcttt tgggtgcaat ttgggtttct ggtggaagtt
     1681 tcctccgctg tgttcttcct cacagactgc ctcggggaga aggagcgggc cctgctgagg
     1741 ttcttaggag acgatgccat tgaaaggtgc tacgtcatcc tcagtcccca ggccaaggag
     1801 agtgaagagg ctcagatttt ccaaaagatc ctaaaactga ggccatcaca gctactgttt
     1861 tgggaagtag aggaagccgg ggatagaagg agggctatgg aggcccttca agctgccctc
     1921 caggaagtaa tgtcgtctcc actcaaatgt gtgtcccttg aagatatggc ctgtctggcc
     1981 agggagctgg ggattcaggt agaccaagac tttgaagtta ttcaagatac tcaagtttcc
     2041 cccagaacaa ttgaaggtga gaaccagcaa ccacagagtc agacaaaaag cccatctgaa
     2101 agccgaactc agaagccact cagagagcct ggaactcaat gtgaggacag ccagaatgct
     2161 gtaatcttcc atcagactcc agtattcatg ccttatccag cacacccatg gcccttgccc
     2221 attgaagctg gaagtaactt ttaccatgtt cctttgagag ccccccgggc tataagctcc
     2281 cactttagat cacagcagaa ggctgagtgg ttctttccat tcccccatca gaatacaagt
     2341 gttcacagca gaggtcaaaa ctttgctatt aaatacctcc aaccctggag attttattca
     2401 agggaaagat tcacaagatg ttcagcaact cctcagcagt atcacccgaa tggaccattt
     2461 gggagatcac agagacaggc ttctcctgta cagacccatc ctaagagcag gcagatgtcc
     2521 agaactcttg agaggtctgg gacagtggtc tctcgagtag gtcacggacg ttctcttggc
     2581 tcacaagcaa ggagagctgc agggaagcca caacctgaga aagcctgtgc gcaggggctg
     2641 cagctgacta aagcagctgg aaagtctata aggacactgc cccacattaa atatcctcac
     2701 cctcagccct gtcagccagc aggagccagt caagaacgga taatgccagt ctctcatcaa
     2761 ggagcccaac aaacaacaca gggaaggcct gcggattttg ctttcaaacc agggtctcaa
     2821 tctacatctg ggagtaaact ttcatctacc tcccagtcca gcgcccatca acccaaattc
     2881 cagagcaaac acttccagcc tcagccgttt caacccgtgc cttctcagaa aaaaccgtct
     2941 cactcccggc cctcccaagc taaaccccct catctggatc cctctcatgc aaaccttact
     3001 caggggcagc cttcccaagc tacacccact cactcccagg cctcccaagc taaacccact
     3061 cactctcaag ctaactctca tcatccacat ccctcccatg ctaaaccttc tcatcagaat
     3121 ccctctcatg ctaaccctac tcatccgcag tcctcccatg ctaagccctc tcatccgcag
     3181 tcctcccatg ctaagccctc tcatccacag tcctcccatg ctaagccctc tcatccacag
     3241 tcctcccatg ctaagccctc tcatccacag tcctcccaag ctaagccctc tcatccacag
     3301 tcctcccaag ctaagcccac tcatccacag tcctcccaag ctaactccca tcatccacag
     3361 gcctcccaag ctaagccctc tcatccacag tcctcccatg ctaagccctc tcatccgcat
     3421 ccctcccatg ctaagccctc cccatcccag tctactcagt gtaaggcaca taaagcccat
     3481 cagtcccaac ctaagccttt tcaaccgaga cccactcaac ctaaatcctc gaagactaag
     3541 ccttcacagg ccagggcctt ccacccaaga gcagggagac gttaaagaac atactctaga
     3601 gatctaggat gtgtgatctt tgcttaagct attcttccca tataacagtc tgaagaaaag
     3661 tttcagtgaa agtgataaaa atagccaaac aaaaaaatat gcaaagtctt aagtgcatag
     3721 cagagtttct aagtgtggga actgtgaaag cagttatcag tagggtctgg ctgggcaagg
     3781 tggcacacac ctacagggtt tagcatgagg gctgtgtcat cccaattcag gagaagcagg
     3841 cagatctctg tgtgtaggcc agtctggtct acataacaat gacatagcaa gttctagatc
     3901 agccagagta cataatgaga ccctgtctgc acagaaggtt tggatctagc atcaaaccaa
     3961 agagttcagt cagtattcca gaagacatca ttaattacac tcagtgggtt acccaaacca
     4021 aaccaaacca aaccaaacca aaccaaacca aaccaaacca acgactaacc ctcctaagga
     4081 gcgggaagga gtgggtaggg gtcaggctga gcaggaaggg agaagagctg aggatggata
     4141 tgatcattgt atacacatat gaagctgcca aatcatacgt gcaagatgag gaaagagcag
     4201 gatctaagga tacatgaact cactgagccc agccctcact atccgatggt gtggggtttg
     4261 aacccaggga gtggagtctg tgtgattgta aaatgatgaa aatatggagc tcaccttatc
     4321 tcagtgttga agaaaagcag cttcagaggt gccttggttt gggtttatta tcaggcactg
     4381 agcagataga cagtctgcac cattggtaca gttaaatcag cttgcttctg ctaacagcca
     4441 cagtagtcat gcctgataat actatctcat ttagccctta cacacagaaa taatgaatgt
     4501 tcaataaaac atacttttac attaaccttg g
//
