LOCUS       NM_026738                774 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus caspase recruitment domain family, member 19 (Card19),
            transcript variant 1, mRNA.
ACCESSION   NM_026738
VERSION     NM_026738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 774)
  AUTHORS   Zheng,Y., Yu,M., Chen,Y., Xue,L., Zhu,W., Fu,G., Morris,S.W.,
            Wen,R. and Wang,D.
  TITLE     CARD19, a Novel Regulator of the TAK1/NF-kappaB Pathway in
            Self-Reactive B Cells
  JOURNAL   J Immunol 210 (9), 1222-1235 (2023)
   PUBMED   36961449
  REMARK    GeneRIF: CARD19, a Novel Regulator of the TAK1/NF-kappaB Pathway in
            Self-Reactive B Cells.
REFERENCE   2  (bases 1 to 774)
  AUTHORS   Rios,K.E., Zhou,M., Lott,N.M., Beauregard,C.R., McDaniel,D.P.,
            Conrads,T.P. and Schaefer,B.C.
  TITLE     CARD19 Interacts with Mitochondrial Contact Site and Cristae
            Organizing System Constituent Proteins and Regulates Cristae
            Morphology
  JOURNAL   Cells 11 (7), 1175 (2022)
   PUBMED   35406738
  REMARK    GeneRIF: CARD19 Interacts with Mitochondrial Contact Site and
            Cristae Organizing System Constituent Proteins and Regulates
            Cristae Morphology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 774)
  AUTHORS   Bjanes,E., Sillas,R.G., Matsuda,R., Demarco,B., Fettrelet,T.,
            DeLaney,A.A., Kornfeld,O.S., Lee,B.L., Rodriguez Lopez,E.M.,
            Grubaugh,D., Wynosky-Dolfi,M.A., Philip,N.H., Krespan,E., Tovar,D.,
            Joannas,L., Beiting,D.P., Henao-Mejia,J., Schaefer,B.C., Chen,K.W.,
            Broz,P. and Brodsky,I.E.
  TITLE     Genetic targeting of Card19 is linked to disrupted NINJ1
            expression, impaired cell lysis, and increased susceptibility to
            Yersinia infection
  JOURNAL   PLoS Pathog 17 (10), e1009967 (2021)
   PUBMED   34648590
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 774)
  AUTHORS   Rios,K.E., Kashyap,A.K., Maynard,S.K., Washington,M., Paul,S. and
            Schaefer,B.C.
  TITLE     CARD19, the protein formerly known as BinCARD, is a mitochondrial
            protein that does not regulate Bcl10-dependent NF-kappaB activation
            after TCR engagement
  JOURNAL   Cell Immunol 356, 104179 (2020)
   PUBMED   32763502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140284.3.
            
            On Mar 21, 2023 this sequence version replaced NM_026738.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703786.1, BI654722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC140284.3         111681-111739       c
            60-202              AC140284.3         103748-103890       c
            203-356             AC140284.3         100936-101089       c
            357-416             AC140284.3         99673-99732         c
            417-488             AC140284.3         99462-99533         c
            489-774             AC140284.3         98694-98979         c
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.15 cM"
     gene            1..774
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /note="caspase recruitment domain family, member 19"
                     /db_xref="GeneID:68480"
                     /db_xref="MGI:MGI:1915730"
     exon            1..59
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..604
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Bcl10-interacting protein with Card; bcl10-interacting
                     CARD protein; caspase recruitment domain-containing
                     protein 19"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 19
                     isoform 1"
                     /protein_id="NP_081014.1"
                     /db_xref="CCDS:CCDS49260.1"
                     /db_xref="GeneID:68480"
                     /db_xref="MGI:MGI:1915730"
                     /translation="MTDQTYCDRLVQDTPFLTGQGRLSEQQVDRIILQLNRYYPQILT
                     NKEAEKFRNPKASLRVRLCDLLSHLQQRGERHCQEFYRALYIHAQPLHSHLPSRYSPQ
                     NSDCRELDWGIESRELSDRGPMSFLAGLGLAAGLALLLYCCPPDPKVLPGTRRVLAFS
                     PVIIDRHVSRYLLAFLADDLGGL"
     exon            60..202
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     exon            203..356
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     exon            357..416
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     exon            417..488
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     exon            489..774
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /inference="alignment:Splign:2.1.0"
     regulatory      756..761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /note="hexamer: ATTAAA"
     polyA_site      774
                     /gene="Card19"
                     /gene_synonym="1110007C09Rik; Bincard"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgggcg gcggacagcc gaggacgacg gggcggcgcc gtgtcctccg ccatgacaga
       61 tcagacctac tgtgaccggc tggtacagga cactcctttc ctgacgggac agggtcgcct
      121 gagcgagcaa caagtggaca ggatcatcct ccagctgaac cgttactacc cacagatcct
      181 taccaacaag gaggctgaaa agttccggaa ccccaaggca tccctgcgcg tacggctctg
      241 tgacctcctg agccatctac agcagcgtgg ggaacggcac tgtcaggaat tttaccgagc
      301 tctgtacatc catgcccagc ccctgcacag ccacctgccc agccgctact ctcctcaaaa
      361 ctcagattgc agagagctgg actggggcat cgagagccgt gagctgagtg acaggggacc
      421 catgagcttc ctggcaggcc tgggcctggc agcgggcctg gccctcctcc tctactgctg
      481 ccctccagac cccaaagtgc tgcccggaac ccggcgcgtc cttgccttct cacctgtcat
      541 cattgaccgg catgtcagcc gctacctgct ggctttcctg gcagatgacc tcggaggact
      601 ctgatgaacc cagatcccgg gccttacctg ctgcttaacc aaagagtccc ctggctgccc
      661 atcgtggggc ctgtatttct ttttctaaat acttattttt cattatttat aatttctacg
      721 agaacacatc accttcactc tgtaaggtgc ttaatattaa atgttccagc tgca
//
