LOCUS       NM_130886               4210 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus caspase recruitment domain family, member 14 (Card14),
            mRNA.
ACCESSION   NM_130886 XM_006532376
VERSION     NM_130886.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4210)
  AUTHORS   Yoshikawa,T., Takeichi,T., Hirabayashi,T., Muro,Y., Miyasaka,Y.,
            Ohno,T. and Akiyama,M.
  TITLE     Hyperactivation of the IL-17 Axis and IL-36 Signaling in
            Card14-Mutant Pityriasis Rubra Pilaris Mouse Model
  JOURNAL   J Invest Dermatol 145 (2), 427-432 (2025)
   PUBMED   39159782
REFERENCE   2  (bases 1 to 4210)
  AUTHORS   O'Sullivan,P.A., Aidarova,A., Afonina,I.S., Manils,J.,
            Thurston,T.L.M., Instrell,R., Howell,M., Boeing,S., Ranawana,S.,
            Herpels,M.B., Chetian,R., Bassa,M., Flynn,H., Frith,D.,
            Snijders,A.P., Howes,A., Beyaert,R., Bowcock,A.M. and Ley,S.C.
  TITLE     CARD14 signalosome formation is associated with its endosomal
            relocation and mTORC1-induced keratinocyte proliferation
  JOURNAL   Biochem J 481 (18), 1143-1171 (2024)
   PUBMED   39145956
  REMARK    GeneRIF: CARD14 signalosome formation is associated with its
            endosomal relocation and mTORC1-induced keratinocyte proliferation.
REFERENCE   3  (bases 1 to 4210)
  AUTHORS   DeVore,S.B., Schuetz,M., Alvey,L., Lujan,H., Ochayon,D.E.,
            Williams,L., Chang,W.C., Filuta,A., Ruff,B., Kothari,A., Hahn,J.M.,
            Brandt,E., Satish,L., Roskin,K., Herr,A.B., Biagini,J.M.,
            Martin,L.J., Cagdas,D., Keles,S., Milner,J.D., Supp,D.M. and
            Khurana Hershey,G.K.
  TITLE     Regulation of MYC by CARD14 in human epithelium is a determinant of
            epidermal homeostasis and disease
  JOURNAL   Cell Rep 43 (8), 114589 (2024)
   PUBMED   39110589
REFERENCE   4  (bases 1 to 4210)
  AUTHORS   Del Rio Oliva,M., Mellett,M. and Basler,M.
  TITLE     Immunoproteasome inhibition attenuates experimental psoriasis
  JOURNAL   Front Immunol 13, 1075615 (2022)
   PUBMED   36591277
  REMARK    Erratum:[Front Immunol. 2024 Jan 16;14:1335691. doi:
            10.3389/fimmu.2023.1335691.. PMID: 38292479]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4210)
  AUTHORS   Manils,J., Webb,L.V., Howes,A., Janzen,J., Boeing,S., Bowcock,A.M.
            and Ley,S.C.
  TITLE     CARD14E138A signalling in keratinocytes induces TNF-dependent skin
            and systemic inflammation
  JOURNAL   Elife 9, e56720 (2020)
   PUBMED   32597759
  REMARK    GeneRIF: CARD14(E138A) signalling in keratinocytes induces
            TNF-dependent skin and systemic inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4210)
  AUTHORS   Van Nuffel,E., Afonina,I.S. and Beyaert,R.
  TITLE     Psoriasis Plays a Wild CARD
  JOURNAL   J Invest Dermatol 138 (9), 1903-1905 (2018)
   PUBMED   30143077
REFERENCE   7  (bases 1 to 4210)
  AUTHORS   Mellett,M., Meier,B., Mohanan,D., Schairer,R., Cheng,P.,
            Satoh,T.K., Kiefer,B., Ospelt,C., Nobbe,S., Thome,M., Contassot,E.
            and French,L.E.
  TITLE     CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive
            IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo
  JOURNAL   J Invest Dermatol 138 (9), 2010-2023 (2018)
   PUBMED   29689250
  REMARK    GeneRIF: hyperactivation of CARD14 alone is sufficient to
            orchestrate the complex immunopathogenesis that drives T helper
            type 17-mediated psoriasis skin disease in vivo.
REFERENCE   8  (bases 1 to 4210)
  AUTHORS   Wang,M., Zhang,S., Zheng,G., Huang,J., Songyang,Z., Zhao,X. and
            Lin,X.
  TITLE     Gain-of-Function Mutation of Card14 Leads to Spontaneous
            Psoriasis-like Skin Inflammation through Enhanced Keratinocyte
            Response to IL-17A
  JOURNAL   Immunity 49 (1), 66-79 (2018)
   PUBMED   29980436
  REMARK    GeneRIF: Caspase recruitment domain family member 14
            (Card14)(E138A/+) and Card14(DeltaQ136/+) mice develop spontaneous
            psoriasis-like skin inflammation, resulted from constitutively
            activated CARMA2 via self-aggregation leading to the enhanced
            activation of the IL-23-IL-17A cytokine axis. Card14(-/-) mice
            display attenuated skin inflammation in the imiquimod-induced
            psoriasis model due to impaired IL-17A signaling in keratinoc...
REFERENCE   9  (bases 1 to 4210)
  AUTHORS   Tanaka,M., Kobiyama,K., Honda,T., Uchio-Yamada,K.,
            Natsume-Kitatani,Y., Mizuguchi,K., Kabashima,K. and Ishii,K.J.
  TITLE     Essential Role of CARD14 in Murine Experimental Psoriasis
  JOURNAL   J Immunol 200 (1), 71-81 (2018)
   PUBMED   29150564
  REMARK    GeneRIF: in experimental models of psoriasis induced by either
            imiquimod cream or recombinant IL-23 injection, the psoriasiform
            skin inflammation was abrogated in Card14(-/-) mice
REFERENCE   10 (bases 1 to 4210)
  AUTHORS   McAllister-Lucas,L.M., Inohara,N., Lucas,P.C., Ruland,J.,
            Benito,A., Li,Q., Chen,S., Chen,F.F., Yamaoka,S., Verma,I.M.,
            Mak,T.W. and Nunez,G.
  TITLE     Bimp1, a MAGUK family member linking protein kinase C activation to
            Bcl10-mediated NF-kappaB induction
  JOURNAL   J Biol Chem 276 (33), 30589-30597 (2001)
   PUBMED   11387339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645911.14.
            
            On or before Jul 4, 2018 this sequence version replaced
            XM_006532376.1, NM_130886.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC029102.1, AF363457.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380, SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL645911.14        14703-14872
            171-362             AL645911.14        21644-21835
            363-471             AL645911.14        23727-23835
            472-783             AL645911.14        23940-24251
            784-921             AL645911.14        28758-28895
            922-1247            AL645911.14        29513-29838
            1248-1415           AL645911.14        31066-31233
            1416-1535           AL645911.14        32373-32492
            1536-1661           AL645911.14        32990-33115
            1662-1811           AL645911.14        33567-33716
            1812-1928           AL645911.14        35411-35527
            1929-2071           AL645911.14        38172-38314
            2072-2160           AL645911.14        38464-38552
            2161-2221           AL645911.14        40482-40542
            2222-2414           AL645911.14        40733-40925
            2415-2541           AL645911.14        44627-44753
            2542-2779           AL645911.14        45170-45407
            2780-2843           AL645911.14        45807-45870
            2844-2955           AL645911.14        46510-46621
            2956-3129           AL645911.14        47926-48099
            3130-3251           AL645911.14        50078-50199
            3252-3367           AL645911.14        50830-50945
            3368-4210           AL645911.14        51472-52314
FEATURES             Location/Qualifiers
     source          1..4210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.36 cM"
     gene            1..4210
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /note="caspase recruitment domain family, member 14"
                     /db_xref="GeneID:170720"
                     /db_xref="MGI:MGI:2386258"
     exon            1..170
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            171..362
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..471
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..783
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             573..3572
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /note="bcl10-interacting MAGUK protein 2"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     14"
                     /protein_id="NP_570956.1"
                     /db_xref="CCDS:CCDS25715.1"
                     /db_xref="GeneID:170720"
                     /db_xref="MGI:MGI:2386258"
                     /translation="MAELCRMDSTLTALDEEMLWDMLESHRCRIVQSICPSRLTPYLR
                     QAKVLGQLDEEEILHSSRFTNSAMRVGHLLDLLKARGKNGAIAFLESLKFHNPDVYTL
                     VTGLQSDIDFSTFSGLMETSKLTECLAGAISSLQEELAQEKAQKEVLLRRCQQLKERL
                     GLAEAHAEGLRQLEVDHSRMKREVSTHFHEVLKLKDEMLNLSLHYSNALREKELAATR
                     CHSLQEELYLVKQELQRASLVSSCERESRERSLKMASNLEPQGEELNRLKEENEKLRS
                     MTFSLVEKDILEQSLDEARESKQELVDRIHSLRERAVAAERQQKQYWEEKEQTLLQFR
                     KTQVDCELYKEKMTMLQGQVAELQKERDQAYTARDRAQMEISQRLVEKDALRRRVFEL
                     TEQVCELRTQLRRLQAEAPGGPKQEAGARELCLRGKQRLVRMHAVCPPDDSDCSLLSS
                     TESRLWWDLNSTSSREQMDSFRSSSPMPPSQQSLYKRVAEDFLEDPESLSFPEVLEMR
                     LQGATVDDTDTDLEFEMIDGADLSQTEDSLQGSSRSLNVSESSVPVRRRPARKILSQV
                     TVLAFQGDALLEQIGVIGGNLTGIFIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSL
                     RATLENTTLEQAVGLLRRVNGSCYLSVKINTEGYKNLIQDLDAKVVTSGDSFYIRVNL
                     AMQRGGDGELQTHCNDILHVTDTMFQGRSCWHAHHVNPYTMKDMEPGTIPNYSQAQQQ
                     LLALIQDMTQRCTVPRKPPGGPQKLVRIVSVDKAAVSPLTSSFDQSQWDSGKEEGGPS
                     VCFWSESCFTLAPYTLVHPHRPARPRPVLFVPRLVGRILGKKLCLLQGFKQCSAEYLS
                     QEEYATWSQRGDIIQEGESIGDHHWITRHAVESLMNMSTHALLDVRLDSVRVLHRMDM
                     FPIIIHVSVNEKTAKKLRKGLHRLGSSEEQFLEVARQEEGELDRVPCLYSSLAPDSWS
                     DLDSLLSCVRLAIADEQKKVVWTESPC"
     exon            784..921
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1247
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1415
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1535
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1661
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1811
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1928
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2071
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2160
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2221
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2414
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2541
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2779
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2843
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2955
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3129
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3251
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3367
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..4210
                     /gene="Card14"
                     /gene_synonym="Bimp2; CARMA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgactgt gccatcaaac ctgctcctca cttgctgtac agcccagccc agcctaagac
       61 tgagcctccg accatcactg ctacaggaca ggaaggcaaa tgcagagtct gtcccaccag
      121 aaccagtcag catgccagag ggactgtgga caggtcagga caatggacag tctttggcgc
      181 tggactttga gttttggagc acgtcacatg gtttgaagta acttcatagc ccttcctgcc
      241 tggccctgcc caccacagcc tgtagagaaa aagccattgg cggtttgcac cggccagatt
      301 ggagacacca gactccagcc agctacaagg aggccccgaa gaagcagctc tgggcacctc
      361 tgatcctgac cggtttttat tgtcatcttg ggttaatgaa gtcctgggcc atgagcaaca
      421 aatgactaat gtggtttact gacaccagct gaagctgcct gcctgccaga gcagtgtgga
      481 gccaagaggg ctggagcaga aaactccctg gccttggaag tccaagcgca gtctttcatc
      541 gaacccctat cccagcgtct cagagttcag gtatggcaga actgtgccgc atggattcca
      601 cactgactgc tctggacgag gagatgctct gggatatgct ggagagtcac cgatgcagga
      661 ttgtgcagag catctgccct agccggctca ccccctacct gcgccaggcc aaggtgctgg
      721 gccagctgga cgaggaggag atcctgcata gctcccgttt caccaacagt gccatgagag
      781 ttgggcactt gctggatctg ctaaaggccc gagggaagaa tggagccatt gcctttctgg
      841 aaagcctgaa gttccacaac cctgatgtct acaccctggt cactgggctg cagtctgaca
      901 ttgacttcag cactttcagc ggtctcatgg agacatccaa gctgaccgag tgtctggctg
      961 gggccatcag cagcctgcag gaggagctgg cccaggagaa ggcacagaag gaggttctgc
     1021 tccggagatg ccagcagctg aaggagcgcc tgggcttggc tgaggctcac gcagaaggtc
     1081 tgcgccagct ggaggtcgac cacagccgca tgaaacgtga ggtcagcacc cacttccacg
     1141 aggtcctgaa actgaaggac gagatgctga acctgtcact gcactacagc aacgcactca
     1201 gagagaagga gctggctgcc acacgctgcc acagccttca ggaagagctc tacctggtga
     1261 agcaggaact ccagcgagca agccttgtat cgtcatgtga aagagaatct cgagagaggt
     1321 ccctgaagat ggccagcaac ctggagcctc agggagaaga actaaatcgg cttaaggagg
     1381 agaatgagaa actccgctcc atgaccttca gcctggtgga gaaggacatt ctggaacaga
     1441 gtctggatga ggccagggag agcaagcaag agctggtgga ccgcatccac tcactgcggg
     1501 agagagcagt ggccgcggag aggcagcaga agcagtactg ggaggagaag gaacagaccc
     1561 tactccagtt ccggaagaca caggtggact gtgaactata caaagaaaag atgaccatgc
     1621 ttcagggcca ggtggctgag ctgcagaagg aacgtgacca ggcatacaca gcaagggaca
     1681 gggcccagat ggagatttct cagcgcctgg tggagaagga tgcccttcgc aggagagtgt
     1741 tcgagctgac ggagcaggtc tgtgagctgc gtactcagct gcgcaggctg caggcggagg
     1801 ccccaggagg acccaagcag gaagccggag ccagggaact ctgcctccgg gggaagcaga
     1861 ggcttgtgcg gatgcatgct gtgtgcccac cagatgacag tgactgcagc ctcctcagct
     1921 ccacagagtc ccggctgtgg tgggacctga attccacatc cagccgggag cagatggaca
     1981 gcttccgctc cagcagcccc atgcctccca gccagcagtc cctgtacaag cgggtggcag
     2041 aggacttcct ggaagacccc gagtctctaa gcttcccaga agtccttgag atgcgccttc
     2101 aaggggctac agtggacgac acagacacag acctggagtt tgagatgatt gacggagcag
     2161 acctctctca gacagaagac agcctgcagg ggtcttcccg gagcctgaat gtctcagaaa
     2221 gcagtgtccc cgtgaggagg aggccagccc gcaagatcct aagccaggtc acggtgctgg
     2281 cgttccaagg ggacgcgttg ctggaacaga ttggtgtcat cggtgggaac ctcactggga
     2341 tcttcattca ccgtgtcacc cccggctctg cagcagatga gatggccctg cgccctggta
     2401 cccagatcat gatggtggac tataaaccta ccaagccatc attaagggcc actctggaga
     2461 atacaacgct ggagcaggct gtgggccttc tcaggagggt gaatggctcc tgctacttgt
     2521 ctgtgaagat caacactgaa ggttataaga acctcatcca ggacctagat gccaaagtgg
     2581 taacgtctgg ggattccttc tacatccgtg tcaacctggc catgcagagg ggaggggacg
     2641 gagaactgca aactcactgc aatgacatcc tgcatgtcac tgacaccatg ttccaaggcc
     2701 gcagctgctg gcatgcccac catgtgaacc cctacaccat gaaagacatg gagcctggca
     2761 ccatccccaa ctattcacag gctcagcagc agcttctggc cctcatccag gacatgactc
     2821 aacggtgcac agtcccccgc aagcctcctg gaggaccaca gaagttagta cgaattgtca
     2881 gtgtggacaa agccgctgtc agtcctctga cttcatcctt tgaccaaagc cagtgggatt
     2941 ctggcaagga ggaaggtggt cctagcgtgt gcttctggtc agagagctgc ttcaccctgg
     3001 caccgtacac cctggtgcac ccccacaggc ctgcccggcc ccggcctgtg ctgtttgtgc
     3061 ctagattagt tggaaggatc ctgggtaaaa agctgtgtct cctccaaggt tttaagcaat
     3121 gttcagcaga gtacttgagc caggaggagt atgccacctg gagtcagaga ggggacatca
     3181 tccaggaggg agagtcaata ggtgaccacc actggatcac ccggcatgct gtggagtccc
     3241 tcatgaatat gagcacccac gccctgctgg atgtgcggct ggacagcgtc cgagtcctac
     3301 ataggatgga catgtttccc attatcatcc atgtctctgt caatgagaag acagcaaaga
     3361 aactcaggaa gggcctgcat cggcttggca gctcggagga gcagttcctg gaggtggccc
     3421 ggcaggagga gggagagctg gacagagtgc cgtgtctgta cagcagcctg gcccccgaca
     3481 gctggagtga tctggacagc ctgctcagct gtgtgcgcct ggccattgca gatgagcaga
     3541 agaaggtggt gtggacagag agcccctgct gaagcccaga cctggcttgg gactgtgggg
     3601 acctctgtgt gtctgtcaat gctgtcagca aacaacccca cttccttctc tggtcggggt
     3661 ctgacctcag gtgcccccag aaatcaaggt gtaaatgacg aagccacctt cacacagcat
     3721 ggcctgggct gatggaggac cggaaaatat tctgccgtgt gggggtactc cctgagacct
     3781 gctcagagcc agtgccccaa cctcctgtga caacaggaat agctttgtgg gttctggccc
     3841 ttccttttat gtttctgatg tcaaaggaac cttgcaagct cgctggagca gtccttcctg
     3901 cccagggcgg gggcctgact ctggagcacc gtgggcacag ctgactcagc tgctaacagc
     3961 caagtgctgc cacagacatc tgcaaatgaa ggtgctgtag tgcacagact tgagtggctc
     4021 tttgactcac tgcctctgtg cctaacccca aaccccaggt tgctttggtg catatcccag
     4081 agccaactga cccttcatga gcaaagaact ctctctcaaa actgacattt cccccagtcc
     4141 ttcccaggct gcattgcgcc acacttgggt gaagccccca tctagccata aactgagtca
     4201 ttttgacacg
//
