LOCUS       NM_175362               4112 bp    mRNA    linear   ROD 28-MAR-2023
DEFINITION  Mus musculus caspase recruitment domain family, member 11 (Card11),
            mRNA.
ACCESSION   NM_175362 XM_981066
VERSION     NM_175362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4112)
  AUTHORS   Masle-Farquhar E, Jeelall Y, White J, Bier J, Deenick EK, Brink R,
            Horikawa K and Goodnow CC.
  TITLE     CARD11 gain-of-function mutation drives cell-autonomous
            accumulation of PD-1+ ICOShigh activated T cells, T-follicular,
            T-regulatory and T-follicular regulatory cells
  JOURNAL   Front Immunol 14, 1095257 (2023)
   PUBMED   36960072
  REMARK    GeneRIF: CARD11 gain-of-function mutation drives cell-autonomous
            accumulation of PD-1[+] ICOS[high] activated T cells, T-follicular,
            T-regulatory and T-follicular regulatory cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4112)
  AUTHORS   Pomerantz JL, Milner JD and Snow AL.
  TITLE     Elevated IgE from attenuated CARD11 signaling: lessons from atopic
            mice and humans
  JOURNAL   Curr Opin Immunol 79, 102255 (2022)
   PUBMED   36334349
  REMARK    GeneRIF: Elevated IgE from attenuated CARD11 signaling: lessons
            from atopic mice and humans.
            Review article
REFERENCE   3  (bases 1 to 4112)
  AUTHORS   Kameda T, Shide K, Kamiunten A, Kogure Y, Morishita D, Koya J,
            Tahira Y, Akizuki K, Yokomizo-Nakano T, Kubota S, Marutsuka K,
            Sekine M, Hidaka T, Kubuki Y, Kitai Y, Matsuda T, Yoda A, Ohshima
            T, Sugiyama M, Sashida G, Kataoka K, Ogawa S and Shimoda K.
  TITLE     CARD11 mutation and HBZ expression induce lymphoproliferative
            disease and adult T-cell leukemia/lymphoma
  JOURNAL   Commun Biol 5 (1), 1309 (2022)
   PUBMED   36446869
  REMARK    GeneRIF: CARD11 mutation and HBZ expression induce
            lymphoproliferative disease and adult T-cell leukemia/lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4112)
  AUTHORS   McGuire MH, Dasari SK, Yao H, Wen Y, Mangala LS, Bayraktar E, Ma W,
            Ivan C, Shoshan E, Wu SY, Jonasch E, Bar-Eli M, Wang J, Baggerly KA
            and Sood AK.
  TITLE     Gene Body Methylation of the Lymphocyte-Specific Gene CARD11
            Results in Its Overexpression and Regulates Cancer mTOR Signaling
  JOURNAL   Mol Cancer Res 19 (11), 1917-1928 (2021)
   PUBMED   34348992
  REMARK    GeneRIF: Gene Body Methylation of the Lymphocyte-Specific Gene
            CARD11 Results in Its Overexpression and Regulates Cancer mTOR
            Signaling.
REFERENCE   5  (bases 1 to 4112)
  AUTHORS   Hutcherson SM, Bedsaul JR and Pomerantz JL.
  TITLE     Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent
            Development of High IgE in Mice Heterozygous for a
            CADINS-Associated Dominant NegativeCARD11 Allele
  JOURNAL   J Immunol 207 (4), 1150-1164 (2021)
   PUBMED   34341167
  REMARK    GeneRIF: Pathway-Specific Defects in T, B, and NK Cells and
            Age-Dependent Development of High IgE in Mice Heterozygous for a
            CADINS-Associated Dominant Negative CARD11 Allele.
REFERENCE   6  (bases 1 to 4112)
  AUTHORS   Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L,
            Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H,
            Xu F, Salvesen G and Godzik A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   7  (bases 1 to 4112)
  AUTHORS   Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem
            M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh
            WC, Baier G, Rottapel R and Penninger JM.
  TITLE     The MAGUK family protein CARD11 is essential for lymphocyte
            activation
  JOURNAL   Immunity 18 (6), 763-775 (2003)
   PUBMED   12818158
REFERENCE   8  (bases 1 to 4112)
  AUTHORS   Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook
            MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA,
            Glynne RJ, Nelms KA and Goodnow CC.
  TITLE     Identifying the MAGUK protein Carma-1 as a central regulator of
            humoral immune responses and atopy by genome-wide mouse mutagenesis
  JOURNAL   Immunity 18 (6), 751-762 (2003)
   PUBMED   12818157
REFERENCE   9  (bases 1 to 4112)
  AUTHORS   Pomerantz JL, Denny EM and Baltimore D.
  TITLE     CARD11 mediates factor-specific activation of NF-kappaB by the T
            cell receptor complex
  JOURNAL   EMBO J 21 (19), 5184-5194 (2002)
   PUBMED   12356734
REFERENCE   10 (bases 1 to 4112)
  AUTHORS   Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS,
            Nunez G, Bertin J and Lin X.
  TITLE     A requirement for CARMA1 in TCR-induced NF-kappa B activation
  JOURNAL   Nat Immunol 3 (9), 830-835 (2002)
   PUBMED   12154356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131134.1.
            
            [WARNING] On Apr 20, 2023 this sequence was replaced by
            NM_175362.3.
            
            On Nov 27, 2007 this sequence version replaced NM_175362.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131134.1, BC096592.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..4112
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /note="caspase recruitment domain family, member 11"
                     /db_xref="GeneID:108723"
                     /db_xref="MGI:MGI:1916978"
     exon            1..190
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..328
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..3786
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /note="carma 1; CARD-containing MAGUK protein 1"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     11"
                     /protein_id="NP_780571.2"
                     /db_xref="CCDS:CCDS51686.1"
                     /db_xref="GeneID:108723"
                     /db_xref="MGI:MGI:1916978"
                     /translation="MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTP
                     YLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPEL
                     YKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLE
                     DEKKQLSLIRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMA
                     VMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPRKEQVLELERENEML
                     KTKIQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNKIYNLQEEVRQAE
                     ELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQ
                     YSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDNGSLDQSLP
                     RHLPATIISQNLGDTSPRTNGQEADDSSTSEESPEDSKYFLPYHPPRRRMNLKGIQLQ
                     RAKSPISMKQASEFQVKGHEEDFTDGSPSSSRSLPVTSSFSKMQPHRSRSSIMSITAE
                     PPGNDSIVRRCKEDAPHRSTVEEDNDSCGFDALDLDDENHERYSFGPPSIHSSSSSHQ
                     SEGLDAYDLEQVNLMLRKFSLERPFRPSVTSGGHVRGTGPLVQHTTLNGDGLITQLTL
                     LGGNARGSFIHSVKPGSLAERAGLREGHQLLLLEGCIRGERQSVPLDACTKEEARWTI
                     QRCSGLITLHYKVNHEGYRKLLKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKCD
                     DVVHVLDTMYQDRHEWLCARVDPFTDQDLDTGTIPSYSRAQQLLLVKLQRLVHRGNRE
                     EADSAHHTLRSLRNTLQPEEMLSTSDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMN
                     SNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPENELSRNLTLIPYSLVRAFHCE
                     RRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVTRDEFLRKQKTETIIYSREKN
                     PNTFECIVPANIEAVAAKNKHCLLEAGIGCVRDLIKCKVYPIVLLIRVSEKNIKRFRK
                     LLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKT
                     IWVDEDQL"
     exon            329..541
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..679
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1005
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1185
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1338
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1464
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1662
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1839
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1891
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1974
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2075
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2128
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2261
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2463
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2590
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2831
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2928
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3024
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3160
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3340
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3465
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3581
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..4112
                     /gene="Card11"
                     /gene_synonym="0610008L17Rik; 2410011D02Rik; BIMP3;
                     CARMA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctcctc cccttgagtt ttctgatctc tggactcctg gcgcctcgca tccctacggg
       61 tcaccaaggc ccagggaggg tggcagcctc aggcaggtgc atgctggagc ccagagccca
      121 gtgctggagg aagttggaga gcagcgtgga ggaagcgcct cgccgagcct gtggagcatg
      181 agcaccccag attctgccca gatccactcc agatccaaca tcagcctggc tcgaaagagg
      241 acagcgggca gccagaaagt gtgaccgtca catccggata acagttccac ggctcttgtg
      301 tatagagtgc caaccgaccg tatgccagga ggagggccag ctatggatga ctacatggag
      361 acgctgaagg atgaagagga ggccctatgg gataacgtgg aatgcaaccg gcacatgctg
      421 agccgttaca tcaaccccgc caagctcacc ccctacctgc gccagtgcaa ggtcatcgat
      481 gagcaagatg aagacgaggt gctcaatgcg cccatgctgc cgtccaagat caaccgtgca
      541 ggccgattgt tggacattct tcacaccaag ggacaaaggg gctatgtggt cttcctggag
      601 agcctggagt tttactaccc agaactttac aaactggtga ctggaaagga acccacccgg
      661 agattctcca ccattgtggt ggaggaaggc catgagggcc tcacacactt cctgatgaac
      721 gaggtcatca aactgcagca gcaagtgaaa gccaaggacc ttcagcgctg tgagctgctg
      781 gccaagtccc ggcaactgga ggatgagaag aagcagctga gcctgatacg ggtggagctg
      841 ctgaccttcc aggagcgata ctacaagatg aaggaggagc gggacagcta caatgacgag
      901 ctcgtcaagg tcaaggacga caactacaac ttagccatgc gctacgccca gctcagtgag
      961 gagaaaaaca tggcggtgat gaggagccgc gacctccaac tcgagatcga ccagctcaaa
     1021 caccgactga acaagatgga ggaggaatgc aagctggaga gaaatcagtc cctcaagctc
     1081 aagaatgaca tcgagaaccg gcccaggaag gagcaggtcc tggagctgga gcgggagaat
     1141 gagatgctga agacgaaaat tcaggagctg cagtccatca tccaggctgg caagcgcagc
     1201 ctccctgact cagacaaggc catcttggac atcctggaac atgaccggaa ggaggcgcta
     1261 gaggaccggc aggaactggt caacaaaatt tacaacctac aagaggaagt ccgccaggcg
     1321 gaggagctgc gggataagta cctggaggag aaggaagacc tggaactcaa gtgttcaacc
     1381 ctggggaagg actgtgaaat gtacaagcac cgcatgaaca cagttatgct gcagctggag
     1441 gaggtggagc gggagcggga ccaggccttc cactcccgag atgaggcaca gacacagtac
     1501 tcacagtgct taatcgagaa ggacaagtac cggaagcaga tccgggagct ggaggagaag
     1561 aacgatgaga tgcgtattga gatggtgagg agggaggcct gtattgtcaa cctggaaagc
     1621 aagctccggc gcctgtccaa ggacaacggc agcctcgacc agagtctgcc tagacacctt
     1681 ccagccacca tcatctcaca gaaccttgga gacaccagcc ccaggaccaa tggccaggaa
     1741 gctgatgatt cttcaacctc agaagagtct cccgaagaca gcaagtactt tctgccttac
     1801 cacccacccc ggcgccggat gaacctaaag ggcatccagc tgcagagagc caaatccccc
     1861 atcagcatga agcaagcatc tgagtttcaa gtcaaggggc acgaagagga tttcacagac
     1921 ggcagcccca gttcctcccg ctcgctgcct gtcaccagct ctttctccaa gatgcaaccc
     1981 catcggagcc gcagcagcat catgtcaatc acggcagagc ccccgggaaa tgactccata
     2041 gtcagacgct gtaaggaaga tgcgccacac cggagcacgg tggaagaaga caacgatagc
     2101 tgtgggtttg atgccttaga ccttgacgat gaaaatcacg aacgttattc ctttggacct
     2161 ccctccatcc actcctcctc ctcttcacac cagtcagagg gactggatgc ctacgacctg
     2221 gagcaggtca acctcatgtt acgaaagttc tctttggaaa ggcccttccg gccatcggtc
     2281 acatctgggg gtcacgtgcg gggcaccggg cccttggtcc agcacacaac tctgaatggc
     2341 gatgggctca tcacgcagct cacccttctg ggcggcaatg cacgcgggag cttcattcac
     2401 tctgtcaagc caggctcact ggctgagagg gccggactgc gtgagggcca ccaactcctg
     2461 ctgctggaag gttgcatccg aggcgaaagg cagagcgttc cactggatgc gtgcacaaaa
     2521 gaagaggccc gttggaccat ccagaggtgc agtggcctca tcactctgca ttacaaggtc
     2581 aaccatgaag gataccggaa gctgctgaag gagatggagg atggtctgat cacatcaggg
     2641 gactcgttct atatccgcct gaacctgaac atctccagcc agctggatgc ctgctccatg
     2701 tccctcaagt gtgacgacgt ggtgcatgtc ctagacacca tgtaccagga caggcacgag
     2761 tggctgtgtg cacgagtcga ccccttcact gaccaagacc tggacacggg caccatcccc
     2821 agctacagcc gggctcaaca gcttctcctg gtgaagctcc agcggttggt tcacagaggc
     2881 aaccgggaag aggcagacag cgctcaccac accctgcgca gcctccggaa caccctgcag
     2941 cccgaagaga tgctttcgac gagcgacccc cgagtcagcc cccgcctctc cagagcgagt
     3001 ttcttctttg gccagctcct gcagtttgtc agccggtcag aaaacaagta caaaagaatg
     3061 aacagcaatg agcgcgtgag aatcatctct gggagtcccc tggggagcct ctcccggtcc
     3121 tcgctggatg ccaccaaact cctgaccgag aagcatgaag aactggatcc tgagaatgag
     3181 ctcagccgga acctcaccct gatcccttac agcctggtgc gcgctttcca ctgtgagcgc
     3241 cgcaggcctg tgctcttcac gcccaccatg ctggccaaga cattggtgca gaagctgctc
     3301 aactcagggg gtgccatgga gttcaccatc tgcaagtcag atattgtcac aagagatgag
     3361 ttcctccgaa agcagaagac agagaccatc atctactccc gggaaaagaa ccccaacacc
     3421 tttgaatgca tcgtccctgc caacattgag gctgtggcag ccaagaacaa acactgcctg
     3481 ctggaggctg ggatcggctg tgtgcgcgac ctgatcaagt gcaaggtgta ccccatagtg
     3541 ctgctcatcc gggtgagcga gaagaacatc aaacggttca ggaagctgct gccgcggcca
     3601 gagacggaag aggaattcct gcgagtgtgc aggctcaaag agaaggagct ggaggcgctg
     3661 ccctgcctct acgccaccgt ggaagctgag atgtggagca gcgtggagga gctgctgcga
     3721 gtcctcaaag acaagattgt agaggagcag cgcaagacca tctgggtgga cgaggaccag
     3781 ctgtgagctt gtctgggtct gacctacaca cagacacacc ggggtcctga gcccctagca
     3841 acaaagttac cagacaccag acgcctggtg gaaggtcagg ctctgctggc gtgaacagag
     3901 atgagcaacc ccagagcctg gggcccaagg ccagcaacca gagcagcagt tgaatgtaaa
     3961 ctcacgggac agggacgggt aaactgcctg caggcctcca gcagccacag tggctgccag
     4021 cccaagaaga agcacgaaac atgcgtccca ggctggggag acaggactcc tcctatgccg
     4081 ttctttttct tgcattaaaa ttcctccagt tc
//
