LOCUS       NM_130859               4731 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus caspase recruitment domain family, member 10 (Card10),
            mRNA.
ACCESSION   NM_130859 XM_912015
VERSION     NM_130859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4731)
  AUTHORS   Yao,Y., Cao,Y., Xu,Y., Chen,G., Liu,Y., Jiang,H., Fan,R., Qin,W.,
            Wang,X., Chai,H., Chen,X., Qiu,Z. and Chen,W.
  TITLE     CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal
            Aortic Aneurysm Development Interacting Between Endoplasmic
            Reticulum and Mitochondria
  JOURNAL   Can J Cardiol 39 (10), 1449-1462 (2023)
   PUBMED   37030515
  REMARK    GeneRIF: CARMA3 Deficiency Aggravates Angiotensin II-Induced
            Abdominal Aortic Aneurysm Development Interacting Between
            Endoplasmic Reticulum and Mitochondria.
REFERENCE   2  (bases 1 to 4731)
  AUTHORS   Wu,Y., Qi,Y., Qiu,Z. and Chen,W.
  TITLE     Deficiency of CARMA3 attenuates the development of bleomycin
            induced pulmonary fibrosis
  JOURNAL   Biochem Biophys Res Commun 581, 81-88 (2021)
   PUBMED   34656852
  REMARK    GeneRIF: Deficiency of CARMA3 attenuates the development of
            bleomycin induced pulmonary fibrosis.
REFERENCE   3  (bases 1 to 4731)
  AUTHORS   Shyamsunder,P., Sankar,H., Mayakonda,A., Han,L., Nordin,H.B.M.,
            Woon,T.W., Shanmugasundaram,M., Dakle,P., Madan,V. and
            Koeffler,H.P.
  TITLE     CARD10, a CEBPE target involved in granulocytic differentiation
  JOURNAL   Haematologica 103 (8), 1269-1277 (2018)
   PUBMED   29773596
  REMARK    GeneRIF: Card10 is expressed in granulocytes and is a direct target
            of CEBPE with functions extending to myeloid differentiation.
REFERENCE   4  (bases 1 to 4731)
  AUTHORS   Jiang,C., Zhou,Z., Quan,Y., Zhang,S., Wang,T., Zhao,X.,
            Morrison,C., Heise,M.T., He,W., Miller,M.S. and Lin,X.
  TITLE     CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and
            Antiviral Responses against Viral Infection
  JOURNAL   Cell Rep 14 (10), 2389-2401 (2016)
   PUBMED   26947079
  REMARK    GeneRIF: CARMA3 is gradually turned over following vesicular
            stomatitis virus infection, which may serve as a mechanism to turn
            off NF-kB activation, it releases MAVS to form functional
            aggregates to induce interferon regulatory factor 3 activation.
REFERENCE   5  (bases 1 to 4731)
  AUTHORS   Causton,B., Ramadas,R.A., Cho,J.L., Jones,K., Pardo-Saganta,A.,
            Rajagopal,J., Xavier,R.J. and Medoff,B.D.
  TITLE     CARMA3 Is Critical for the Initiation of Allergic Airway
            Inflammation
  JOURNAL   J Immunol 195 (2), 683-694 (2015)
   PUBMED   26041536
  REMARK    GeneRIF: CARMA3 is critical for the initiation of allergic airway
            inflammation.
REFERENCE   6  (bases 1 to 4731)
  AUTHORS   Medoff,B.D., Landry,A.L., Wittbold,K.A., Sandall,B.P., Derby,M.C.,
            Cao,Z., Adams,J.C. and Xavier,R.J.
  TITLE     CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion
            by bronchial epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 40 (3), 286-294 (2009)
   PUBMED   18757306
  REMARK    GeneRIF: Data demonstrate that lysophosphatidic acid stimulates
            thymic stromal lymphopoietin and CCL20 expression in bronchial
            epithelial cells via CARMA3-mediated NF-kappaB activation.
REFERENCE   7  (bases 1 to 4731)
  AUTHORS   Grabiner,B.C., Blonska,M., Lin,P.C., You,Y., Wang,D., Sun,J.,
            Darnay,B.G., Dong,C. and Lin,X.
  TITLE     CARMA3 deficiency abrogates G protein-coupled receptor-induced
            NF-{kappa}B activation
  JOURNAL   Genes Dev 21 (8), 984-996 (2007)
   PUBMED   17438001
  REMARK    GeneRIF: Together, results provide the genetic evidence that CARMA3
            is required for G protein-coupled receptor-induced NF-kappaB
            activation.
REFERENCE   8  (bases 1 to 4731)
  AUTHORS   McAllister-Lucas,L.M., Ruland,J., Siu,K., Jin,X., Gu,S., Kim,D.S.,
            Kuffa,P., Kohrt,D., Mak,T.W., Nunez,G. and Lucas,P.C.
  TITLE     CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates
            angiotensin II-responsive inflammatory signaling in nonimmune cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 139-144 (2007)
   PUBMED   17101977
  REMARK    GeneRIF: CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates
            angiotensin II-responsive inflammatory signaling in hepatocytes.
REFERENCE   9  (bases 1 to 4731)
  AUTHORS   McAllister-Lucas,L.M., Inohara,N., Lucas,P.C., Ruland,J.,
            Benito,A., Li,Q., Chen,S., Chen,F.F., Yamaoka,S., Verma,I.M.,
            Mak,T.W. and Nunez,G.
  TITLE     Bimp1, a MAGUK family member linking protein kinase C activation to
            Bcl10-mediated NF-kappaB induction
  JOURNAL   J Biol Chem 276 (33), 30589-30597 (2001)
   PUBMED   11387339
REFERENCE   10 (bases 1 to 4731)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592169.14.
            
            On Jun 22, 2022 this sequence version replaced NM_130859.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL592169.14        121941-122131
            192-443             AL592169.14        122354-122605
            444-581             AL592169.14        123216-123353
            582-907             AL592169.14        125565-125890
            908-1099            AL592169.14        129586-129777
            1100-1255           AL592169.14        130978-131133
            1256-1381           AL592169.14        131975-132100
            1382-1573           AL592169.14        133754-133945
            1574-1699           AL592169.14        135130-135255
            1700-1815           AL592169.14        136149-136264
            1816-1844           AL592169.14        137112-137140
            1845-1968           AL592169.14        137507-137630
            1969-2128           AL592169.14        143352-143511
            2129-2240           AL592169.14        143802-143913
            2241-2484           AL592169.14        144266-144509
            2485-2554           AL592169.14        144675-144744
            2555-2648           AL592169.14        145498-145591
            2649-2807           AL592169.14        146630-146788
            2808-2923           AL592169.14        146912-147027
            2924-3036           AL592169.14        147409-147521
            3037-4731           AL592169.14        148156-149850
FEATURES             Location/Qualifiers
     source          1..4731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..4731
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /note="caspase recruitment domain family, member 10"
                     /db_xref="GeneID:105844"
                     /db_xref="MGI:MGI:2146012"
     exon            1..191
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..443
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            444..581
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..907
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1099
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1255
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1381
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1573
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1699
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1815
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1844
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1968
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2128
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2240
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2484
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2554
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2648
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2807
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2923
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3036
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..4731
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /note="hexamer: ATTAAA"
     polyA_site      4731
                     /gene="Card10"
                     /gene_synonym="Bimp1; Carma3"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgcggc tggcccgcag agcggccggg aggacgaccg gagcgcagcg ggtcgcgggc
       61 aatgttgggt ggcccgggag gccgccgggc tgggggcgga gccaatgacc ccgaaggcac
      121 cgccccgtcg cgcctccgga gccgtcggcc gagcacagag ccgggagctc agggcagctg
      181 cagcgcccgt ggctcggagg acgcggccat gcagggccgg gcggacgcgg gcgaggctga
      241 cgaggaggct ggggcgggtt cggggtcgga ggccgaagag gacgcgctgt gggagcggat
      301 cgagggcgtc cggcaccgac tgacgcgcgc cctgaatccg gccaagctca cgccgtatct
      361 gcgccagtgc cgcgtcctgg acgaacagga cgaggaggag gtgctcagca cctaccgttt
      421 cccgtgccgc gctaaccgta ccgggcgcct catagacatt ttacgctgcc ggggcaagag
      481 gggcttcgag gccttcctgg aagccctgga attctactac ccagaacact tcacgctgct
      541 cactggccag gaacctgccc aacgctgctc catgatcctt gatgaggagg gtcccgaggg
      601 cctgactcag ttcttgatga ctgaggtccg gaggcttcgg gaagctcgga agagccaatt
      661 gcaccgagag cagcaactgc aggcccgggg ccgggccctg gaggaggagc gggcagggct
      721 agagcagagg cttcgggagc agcagcaggc acaggagcgc tgccagcgac tgcgggagga
      781 ctgggaggct ggcagcctgg agctgctgcg cctcaaggat gagaactaca tgatcgccat
      841 gcgcctggct cagctcagcg aggagaagaa ttcggctgtg ctgcgcagcc gagacctgca
      901 gctggcggtg gaccagctca agctcaaggt cagccggctg gaggaagagt gtgcgctgct
      961 gaggagggcc aggggcccac cgcctggggc tgaggagaag gagagggagc cagatggcgc
     1021 tgatcttctc tctgagcttc gtgcagagaa ccagcggctg acggcttcac tgcaggagct
     1081 tcaggaaggt cttcagcagg agatgagccg gccaggagct gcaggctctg aacgtatcct
     1141 actggacata ctggagcacg actggaggga ggcgcaggac agcaggcagg agctgtgtca
     1201 gaagcttcat gctgtgcagg gcgagctaca gtgggcagag gagctgcggg acaagtacct
     1261 gcaagagatg gaggatctgc ggctcaaaca tcgaacgctg ctgaaggact gtgacctcta
     1321 taagcaccgc atggccactg tgttggccca gctggaggag attgagaaag agcgggacca
     1381 ggcaatccag agccgagacc ggatccagct gcagtattct cagagcctca ttgagaagga
     1441 ccagtaccgc aagcaggtgc gggggctgga ggcggagcgc gatgagctgc tcaccacagt
     1501 caccagcctg gaggggacca aggccatgct ggaggcacag ctgcagcgga cacagggggg
     1561 ttcctgtctc aaggcctgtg cctcctccca ctccctgtgc tccaacctca gcagcacctg
     1621 gagcctcagc gagttcccat cgcccctggg aggcccagaa gctacaggag aagccggggg
     1681 atctgagccc cacacctcgg aggaagccac agacagcgag aaggagatca accggctctc
     1741 tatcctgcct ttcccaccca gtgctggttc catactccgc cggcagcgtg aggaagaccc
     1801 ggagccccct aagaggtctt ttagcagcat gtcggatatc acagggagtg tgacccttaa
     1861 gccatggtcc cctggcctct cttcatcatc ctcgtctgac agtgtgtggc ctttgggaaa
     1921 gccggaaggc ctcctggctc ggggctgtgg cctggacttc ctcaataggt ctctggccat
     1981 ccgagtgtcc ggctggagtc cccccgcagg cctggatccc caggataaga gtccagatag
     2041 catgccgggc cttggagaca ggtggtctgg ggcggtggtg cgaagggtgt tgtctgggcc
     2101 tgggtcagcc aggacagaac agaaagagcc gagggcggaa ggcactggtc tggagggggc
     2161 aggcctggaa gcggaggccc agcagaggac cttgccctgg aaccagagct ccaccctccc
     2221 cttcctgctg gactcaaagg cctgtcattc cttccatgag gccctggatg cctgggcaaa
     2281 gggaccgggt gccgagccct tctacattcg agccaacttc tccctgcccg agcggtcgga
     2341 tccccatgcc ctttgtgtga aagcccaaga gatcctgcgg ttggtggacc cagcccacaa
     2401 gcggaggcag gagtggttct gtactcgagt ggacaccctc accttacggg acctggaccg
     2461 gggcaccgtg cccaattatc agagagctca gcagctccta gaagtccagg aaaaatactt
     2521 gatctccagc agacaccgaa gtcctcgaag caacctgaag aagcgagccc tagggttggt
     2581 gaggcccaag cctgcagggg gcactgcagg agactcagca gaacagctcc ctgcagagcc
     2641 ctgctcagag ctagaacgaa gcctaaaacc ctacagcctg gtgcgaccgc tgttggtgtc
     2701 tgccttgagg cctgtggtcc tcctgcctga gtgcctggcg cctcgcctca tccgtaacct
     2761 gctggatctg ccaagctcca ggctggattt ccaagtgtgc ccagcagaga gcctctctgg
     2821 ggaggaacag tgtacgtcct cagctcccgg agcccccaaa gcctggccgg ccactgctgg
     2881 gctaggcagc aggatccgtg ccatccagga gtctgtcggg aagaagcact gcctgttgga
     2941 gctgggtgca cggggagtgc gggagttggt gcacagcgag gtctacccca ttgtcatcca
     3001 cgtggaggtg actgagaaga atgtccgtga gatcaggggc ctgttgggcc ggccgggctg
     3061 gcgggattca gaactgctcc gtcagtgtcg gggctcagaa cagtggctct ggggactgcc
     3121 gtgttcctgg gtgcaggtgc ctgcgcatgc gtggggccat gcagaggagc tggccaaggt
     3181 ggtgcgtggc cgaatcttgc aggaacaggc tcgccttgtg tgggtggagc gaggcagcag
     3241 cagagggggc agtggcagca gtagtgaggc ctgaggaccc atctgatgcc caggctcttc
     3301 cagccactgt ctagacctcc tccatcagat gcctaggcct cctccatcag atacctgggc
     3361 ctcctccatc agatgtctgg gcctcctcca tcagatgcct aggcctcctc catcagatgt
     3421 ctgggcctcc tccatcagat gcctaggcct cctccatcag atgcctgggc ctcctccatc
     3481 agatgtctgg gcctcctcca tcagatgtct gggcctcctc catcagatgc ttgggcctcc
     3541 tccatcagat gcctgggcct cctccatcag atgtctgggc ctcctccatc agatgcctgg
     3601 gcctcctcca tcagatgcct gggcctcctc catcagatgt ctaggcctcc tccatcagat
     3661 gcctgggcct cctccatcag atgcctaggc ctcctccatc agatgtctgg gcctcctcca
     3721 tcagatgcct gggcctcctc catcagatgc ctgggcctcc tccatcagat gtctgggcct
     3781 cctccatcag atgcctgggc ctcctccatc agatgtctgg gcctcctcca tcagatgcct
     3841 gggcctcctc catcagatgt ctgggcctcc tccatcagat gcctgggcct cctccagctg
     3901 gtgcctgggc ctcctccatc agatgcctgg gcctcctcca tcagatgtct gggcctcctc
     3961 cagctggtgc ctggacattc accgtttata catgggctca cacccgtgtg agcagaggag
     4021 accctgtgtt ttcagtggaa tcagatcttc ctcagttggg gccttccttg tccccccgtg
     4081 gactctccaa tgtgggacct cggtcctggg ctctcaccgg ggtctgtcat tggctctgca
     4141 caggctgcat gaacccacgc acctgtccct gacctgctgc tctggtctcc tcactagctc
     4201 caatgttccc atgtttccat ttgtgtgtct tatacgtgta tgtgtgccct ctccttacat
     4261 acacaccctg gaatagagtt ctcacaccgt tcaattttgc acatatgtcc tcatggatcc
     4321 ccagttttgt ccctccactt gggcacacga ggtctcaggg gtcctcaacc tgggtctgtg
     4381 cccccagctg tgcccagcac cacgggacct ccacagtcca atggcattgc ctgtgtgtgc
     4441 tgtcatgaag ataccacggc tgttctggtc agctcctacc cttacatctc tgtgtgtgtc
     4501 gtccctcatc ccgtgtaaat atcaccatcc ttgtgacact ggcactaagc aatgtgtgct
     4561 ctgcccagca cacctggaca tgttctctcg gctggctttc tgttccccgc ctgcctccag
     4621 gaggccaggg tggtggtgct gctaggccat cccaatgtta ggcttgtggg tgattccccg
     4681 ggccttttca ttcaagctgc acacaatgag tcattaaagt ttgtcataga a
//
