LOCUS       NM_139305               1959 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus carbonic anhydrase 9 (Car9), mRNA.
ACCESSION   NM_139305
VERSION     NM_139305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Grajek,J. and Poleszczuk,J.
  TITLE     Carbonic Anhydrase IX Suppression Shifts Partial Response to
            Checkpoint Inhibitors into Complete Tumor Eradication: Model-Based
            Investigation
  JOURNAL   Int J Mol Sci 24 (12), 10068 (2023)
   PUBMED   37373220
  REMARK    GeneRIF: Carbonic Anhydrase IX Suppression Shifts Partial Response
            to Checkpoint Inhibitors into Complete Tumor Eradication:
            Model-Based Investigation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Jazwiec,P.A., Patterson,V.S., Ribeiro,T.A., Yeo,E., Kennedy,K.M.,
            Mathias,P.C.F., Petrik,J.J. and Sloboda,D.M.
  TITLE     Paternal obesity induces placental hypoxia and sex-specific
            impairments in placental vascularization and offspring
            metabolismdagger
  JOURNAL   Biol Reprod 107 (2), 574-589 (2022)
   PUBMED   35377412
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Guda,M.R., Tsung,A.J., Asuthkar,S. and Velpula,K.K.
  TITLE     Galectin-1 activates carbonic anhydrase IX and modulates glioma
            metabolism
  JOURNAL   Cell Death Dis 13 (6), 574 (2022)
   PUBMED   35773253
  REMARK    GeneRIF: Galectin-1 activates carbonic anhydrase IX and modulates
            glioma metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Kirschner,K.M., Kelterborn,S., Stehr,H., Penzlin,J.L.T.,
            Jacobi,C.L.J., Endesfelder,S., Sieg,M., Kruppa,J., Dame,C. and
            Sciesielski,L.K.
  TITLE     Adaptation of the Oxygen Sensing System during Lung Development
  JOURNAL   Oxid Med Cell Longev 2022, 9714669 (2022)
   PUBMED   35242281
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Leppilampi,M., Parkkila,S., Karttunen,T., Gut,M.O., Gros,G. and
            Sjoblom,M.
  TITLE     Carbonic anhydrase isozyme-II-deficient mice lack the duodenal
            bicarbonate secretory response to prostaglandin E2
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15247-15252 (2005)
   PUBMED   16217040
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Leppilampi,M., Karttunen,T.J., Kivela,J., Gut,M.O., Pastorekova,S.,
            Pastorek,J. and Parkkila,S.
  TITLE     Gastric pit cell hyperplasia and glandular atrophy in carbonic
            anhydrase IX knockout mice: studies on two strains C57/BL6 and
            BALB/C
  JOURNAL   Transgenic Res 14 (5), 655-663 (2005)
   PUBMED   16245156
  REMARK    GeneRIF: although CA IX-deficiency is not a tumor-promoting factor
            per se, it induces glandular atrophy in the body mucosa, a lesion
            which is considered to be a preneoplastic alteration in the stomach
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Hilvo,M., Rafajova,M., Pastorekova,S., Pastorek,J. and Parkkila,S.
  TITLE     Expression of carbonic anhydrase IX in mouse tissues
  JOURNAL   J Histochem Cytochem 52 (10), 1313-1322 (2004)
   PUBMED   15385577
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Zat'ovicova,M., Tarabkova,K., Svastova,E., Gibadulinova,A.,
            Mucha,V., Jakubickova,L., Biesova,Z., Rafajova,M., Ortova Gut,M.,
            Parkkila,S., Parkkila,A.K., Waheed,A., Sly,W.S., Horak,I.,
            Pastorek,J. and Pastorekova,S.
  TITLE     Monoclonal antibodies generated in carbonic anhydrase IX-deficient
            mice recognize different domains of tumour-associated
            hypoxia-induced carbonic anhydrase IX
  JOURNAL   J Immunol Methods 282 (1-2), 117-134 (2003)
   PUBMED   14604546
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Gut,M.O., Parkkila,S., Vernerova,Z., Rohde,E., Zavada,J.,
            Hocker,M., Pastorek,J., Karttunen,T., Gibadulinova,A., Zavadova,Z.,
            Knobeloch,K.P., Wiedenmann,B., Svoboda,J., Horak,I. and
            Pastorekova,S.
  TITLE     Gastric hyperplasia in mice with targeted disruption of the
            carbonic anhydrase gene Car9
  JOURNAL   Gastroenterology 123 (6), 1889-1903 (2002)
   PUBMED   12454846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136579.1.
            
            On Apr 12, 2007 this sequence version replaced NM_139305.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136579.1, AJ245857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1959              AK136579.1         2-1960
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..1959
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /note="carbonic anhydrase 9"
                     /db_xref="GeneID:230099"
                     /db_xref="MGI:MGI:2447188"
     exon            1..370
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1344
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /EC_number="4.2.1.1"
                     /note="CA-IX; carbonic anhydrase IX; carbonate dehydratase
                     IX; membrane antigen MN homolog"
                     /codon_start=1
                     /product="carbonic anhydrase 9 precursor"
                     /protein_id="NP_647466.2"
                     /db_xref="CCDS:CCDS18099.1"
                     /db_xref="GeneID:230099"
                     /db_xref="MGI:MGI:2447188"
                     /translation="MASLGPSPWAPLSTPAPTAQLLLFLLLQVSAQPQGLSGMQGEPS
                     LGDSSSGEDELGVDVLPSEEDAPEEADPPDGEDPPEVNSEDRMEESLGLEDLSTPEAP
                     EHSQGSHGDEKGGGHSHWSYGGTLLWPQVSPACAGRFQSPVDIRLERTAFCRTLQPLE
                     LLGYELQPLPELSLSNNGHTVQLTLPPGLKMALGPGQEYRALQLHLHWGTSDHPGSEH
                     TVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLE
                     EISEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQ
                     LHTLSVSLWGPRDSRLQLNFRATQPLNGRTIEASFPAAEDSSPEPVHVNSCFTAGDIL
                     ALVFGLLFAVTSIAFLLQLRRQHRHRSGTKDRVSYSPAEMTETGA"
     exon            371..400
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            401..571
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            572..714
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            715..807
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            808..874
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1032
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1168
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1195
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1277
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1959
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /note="hexamer: AATATA"
     polyA_site      1949
                     /gene="Car9"
                     /gene_synonym="Ca9; CAIX; MN/CA9"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgtcct gggacacccc agtcagctgc atggcctccc tgggccccag cccctgggcc
       61 cctttgtcga ccccagcccc tactgcacag ctgctgctgt tcctgctgct ccaagtgtct
      121 gctcagcccc agggcctgtc cgggatgcag ggggagccct ccttgggaga cagttcatct
      181 ggggaggatg agctgggcgt ggatgttctg cccagtgaag aggatgcacc tgaagaggcg
      241 gatccacccg atggggagga tccacctgaa gttaattctg aagacaggat ggaggagtcc
      301 cttgggttag aggatctatc gactcccgag gctcctgagc acagtcaagg ttcccacggg
      361 gatgaaaaag ggggtggcca cagtcattgg agctatggag gcaccctact ctggccccag
      421 gtgtccccag cctgtgctgg ccgctttcag tccccggtag acatccgcct ggagcgcacc
      481 gcattctgcc gcactctgca acccctggaa cttctgggtt atgagctcca gcctctcccg
      541 gaactgagcc tatccaacaa tggccacacg gtacagctga ctctgccgcc ggggctgaag
      601 atggctctgg gacctgggca ggaataccgg gccttgcagt tgcatctaca ctggggaact
      661 tcagatcacc caggctcaga acacacagtc aatggtcacc gtttccctgc tgagatccac
      721 gtggtgcacc tcagtactgc tttctccgaa cttcatgaag ccttgggccg cccaggaggc
      781 ctggcagttt tggctgcctt tctgcaggag agcccagaag aaaacagtgc ttacgaacag
      841 ttgctgtccc atttggaaga aatctcggag gaaggctcca agattgagat cccaggtttg
      901 gatgtatctg cactgttgcc ctcggacctc agccgctact accgatatga agggtctctg
      961 accacacctc cctgcagcca gggggtcatc tggactgtgt tcaatgagac agtgaaactg
     1021 agcgctaagc agctccatac tctctccgtt tccttgtggg gacctcgtga ttctcggcta
     1081 caactgaact tccgagccac gcaacccttg aatgggcgaa cgattgaggc ttccttccct
     1141 gctgcagagg atagcagccc tgagccagtc catgtgaatt cctgcttcac tgctggtgac
     1201 atcctagcct tggtgtttgg ccttctcttt gctgtcacca gcatcgcctt cctcctacag
     1261 ctgaggaggc agcacaggca cagaagtggg accaaagata gagttagcta cagtccggca
     1321 gagatgacag aaactggagc ctaataagga gaaaccagct aaaggaatct ggaaaccttg
     1381 tcctgtcctg cctgttatac agcctccttt ttaaccacta cgaaatcatt tccatctttt
     1441 taactttctt ctttccttaa agtactgtga taggagctaa ccgtgaaaaa acaagattgg
     1501 gctcaattct tgctgggttt tgatggtttt gaagacaggg tttctctgtg tagccctggc
     1561 tgtcctggga ctcactctgt agcctaggct ggccttgaac tcagagatcc gattgcctct
     1621 gccttcttag tgccaggact gagggtatgt accactacca ccgccacccc gcaattcttg
     1681 cttttattct gcagtcaaat gctctaccac tgagctacac acccctccat cttactatgc
     1741 aggcagactg gccttgcatt gtgtatgtat ggtgatggag tttgaagcca gggtcttacc
     1801 tactaggcaa gcgttctatc actgacctaa gcctctctag tcccttctct tgaaccctct
     1861 attctcctgt cccagcctct tgaatgctgg gattacagga atgcaccatc atgcttggtc
     1921 atcccaatta tttaaaaaaa atatataaat cttcctagt
//
