LOCUS       NM_007592               5722 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus carbonic anhydrase 8 (Car8), mRNA.
ACCESSION   NM_007592
VERSION     NM_007592.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5722)
  AUTHORS   Aditi, Downing SM, Schreiner PA, Kwak YD, Li Y, Shaw TI, Russell HR
            and McKinnon PJ.
  TITLE     Genome instability independent of type I interferon signaling
            drives neuropathology caused by impaired ribonucleotide excision
            repair
  JOURNAL   Neuron 109 (24), 3962-3979 (2021)
   PUBMED   34655526
REFERENCE   2  (bases 1 to 5722)
  AUTHORS   Fujiwara Y, Yamane S, Harada N, Ikeguchi-Ogura E, Usui R, Nakamura
            T, Iwasaki K, Suzuki K, Yabe D, Hayashi Y and Inagaki N.
  TITLE     Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion
            from enteroendocrine cells in response to long-chain fatty acids
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (4), G617-G626 (2021)
   PUBMED   33533304
REFERENCE   3  (bases 1 to 5722)
  AUTHORS   Miterko LN, Lin T, Zhou J, van der Heijden ME, Beckinghausen J,
            White JJ and Sillitoe RV.
  TITLE     Neuromodulation of the cerebellum rescues movement in a mouse model
            of ataxia
  JOURNAL   Nat Commun 12 (1), 1295 (2021)
   PUBMED   33637754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5722)
  AUTHORS   Kim J, Kim K, Mo JS and Lee Y.
  TITLE     Atm deficiency in the DNA polymerase beta null cerebellum results
            in cerebellar ataxia and Itpr1 reduction associated with alteration
            of cytosine methylation
  JOURNAL   Nucleic Acids Res 48 (7), 3678-3691 (2020)
   PUBMED   32123907
REFERENCE   5  (bases 1 to 5722)
  AUTHORS   Yorgan TA, Peters S, Amling M and Schinke T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   6  (bases 1 to 5722)
  AUTHORS   Taniuchi K, Nishimori I, Takeuchi T, Ohtsuki Y and Onishi S.
  TITLE     cDNA cloning and developmental expression of murine carbonic
            anhydrase-related proteins VIII, X, and XI
  JOURNAL   Brain Res Mol Brain Res 109 (1-2), 207-215 (2002)
   PUBMED   12531530
  REMARK    GeneRIF: Results describe the tissue distribution of carbonic
            anhydrase-related proteins VIII, X, and XI and their developmental
            expression in the murine embryonic brain.
REFERENCE   7  (bases 1 to 5722)
  AUTHORS   Sjoblom B, Elleby B, Wallgren K, Jonsson BH and Lindskog S.
  TITLE     Two point mutations convert a catalytically inactive carbonic
            anhydrase-related protein (CARP) to an active enzyme
  JOURNAL   FEBS Lett 398 (2-3), 322-325 (1996)
   PUBMED   8977131
REFERENCE   8  (bases 1 to 5722)
  AUTHORS   Kelly C, Nogradi A, Walker R, Caddy K, Peters J and Carter N.
  TITLE     Lurching, reeling, waddling and staggering in mice--is carbonic
            anhydrase (CA) VIII a candidate gene?
  JOURNAL   Biochem Soc Trans 22 (3), 359S (1994)
   PUBMED   7821612
REFERENCE   9  (bases 1 to 5722)
  AUTHORS   Skaggs LA, Bergenhem NC, Venta PJ and Tashian RE.
  TITLE     The deduced amino acid sequence of human carbonic anhydrase-related
            protein (CARP) is 98% identical to the mouse homologue
  JOURNAL   Gene 126 (2), 291-292 (1993)
   PUBMED   8482548
REFERENCE   10 (bases 1 to 5722)
  AUTHORS   Kato K.
  TITLE     Sequence of a novel carbonic anhydrase-related polypeptide and its
            exclusive presence in Purkinje cells
  JOURNAL   FEBS Lett 271 (1-2), 137-140 (1990)
   PUBMED   2121526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004896.1, BE647642.1 and AL772336.5.
            
            [WARNING] On Apr 24, 2023 this sequence was replaced by
            NM_007592.4.
            
            On Feb 3, 2006 this sequence version replaced NM_007592.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.197635.1, AK004896.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AK004896.1         2-940
            940-1082            BE647642.1         160-302
            1083-5722           AL772336.5         6103-10742          c
FEATURES             Location/Qualifiers
     source          1..5722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 3.53 cM"
     gene            1..5722
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /note="carbonic anhydrase 8"
                     /db_xref="GeneID:12319"
                     /db_xref="MGI:MGI:88253"
     exon            1..190
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..963
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /EC_number="4.2.1.1"
                     /note="CA-VIII; carbonic anhydrase VIII; CA-RP VIII;
                     carbonic anhydrase-like sequence 1"
                     /codon_start=1
                     /product="carbonic anhydrase-related protein"
                     /protein_id="NP_031618.2"
                     /db_xref="CCDS:CCDS17954.1"
                     /db_xref="GeneID:12319"
                     /db_xref="MGI:MGI:88253"
                     /translation="MADLSFIEDAVAFPEKEEDEEEEEEEGVEWGYEEGVEWGLVFPD
                     ANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSG
                     GPLPQGQEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGK
                     PHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWV
                     YEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHVKGAELVEGCDGILGDNFR
                     PTQPLSDRVIRAAFQ"
     exon            191..382
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            383..507
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            508..603
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            604..666
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            667..715
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            716..828
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            829..998
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
     exon            999..5722
                     /gene="Car8"
                     /gene_synonym="Ca8; Cals; Cals1; Carp; wdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctcgcg ctcgcgggga ctgccacgct cagtgcggtc cccagccccg cgcctgccgc
       61 tcccgcaccc gtgtcgcaga gctgcccatg gctgacctga gcttcattga ggatgcagtc
      121 gccttccccg agaaggagga agacgaggaa gaggaggagg aggagggcgt ggagtggggt
      181 tacgaggaag gtgttgagtg gggcttagtg tttcctgatg ctaatgggga gtaccagtca
      241 cctatcaacc taaactccag agaagccagg tatgacccct cactgctgga tgtccgcctg
      301 tctccaaatt atgtggtgtg ccgggactgt gaagtcacca acgatggaca caccattcaa
      361 gtcatcctga agtcaaaatc agtcttgtca ggaggaccac tgcctcaggg acaggagttt
      421 gagctgtatg aagttagatt tcactgggga agagaaaacc agcgtggttc tgagcacacg
      481 gtcaatttca aagcctttcc catggagctc cacctgatcc actggaattc cacactgttt
      541 ggcagcatcg atgaggcggt tgggaagccc catggtatcg ccatcattgc actatttgtt
      601 cagatcggga aggaacatgt tggcttgaag gctgtgactg agatcctcca ggatattcaa
      661 tataagggaa aatccaaaac aattccatgc tttaatccta acactttatt accagaccct
      721 cttctgcggg attactgggt ctatgaagga tctcttacta tcccaccttg cagcgaagga
      781 gttacctgga tattattccg atacccttta actatatccc agatgcagat agaagaattt
      841 cgaaggctga ggacacatgt caagggggca gaactggtgg agggctgcga tgggattttg
      901 ggagacaatt tccgacctac ccagcccctg agtgatagag tcatccgagc ggcctttcag
      961 tagccagaga gaccgggaac aaacccatct gcatcagtga agaagacagt ggtcccacgg
     1021 agtcctttga tgaggagtgg aaactcctga gtggcagctt tgttttaacc ctcaagcctg
     1081 cattatcttc agttactgca gtgttgatgg atatctgtga ccattgtctg tatacatgct
     1141 gttatgaaat attagaagtg gctgttcatt ttaaagaaac acagtgtgtg tgtgcacaca
     1201 ccacagcttc tggaattcat acttttgcac atactgcttg ttgcttatgt gtagaaagaa
     1261 tgaaagtagt tttcagacat actaatatga ctgtattata tatcaatatg agataagaaa
     1321 agcacattcc cagagccaag tcatttattt cctgtctgta ttagaaaata tgctcactag
     1381 tgtatttctt gataataaag caagatgttt gatctacaac agcttagaac atcaaaatac
     1441 aatatgaagg agtcataaaa attatctcgt gttgtttttg caataattgc accaaattta
     1501 atgtcaaact ggtttgtcat ggaaaaaatt ttgaagttaa tgcaaagata ctttatatat
     1561 tatttttaaa aagaatttaa ttgaatctaa tatacttatg gcatatctga atgtatggct
     1621 tctaaggagt taagaatagc ataaaaatag ataggaggaa agatggggac agcataccag
     1681 taatagcttt gtttccataa tagaaataaa aatccactag tatactatgt taatttagta
     1741 ttgtatactt tttaagtctt caaaatacgt tatagattgc acatctgtag tgggataaga
     1801 taagggtcaa ccataccctt cttttcagtt aagctcatct tcagtcatat ctcagttcaa
     1861 tgtgacagaa tggtgtaaaa tggtagagat aatggaagaa agcaactact tcccaaataa
     1921 attttattga ctgttttaat tgttgcactc tcaatttgga gggattgtgt gctggtagct
     1981 agaataagca ccgatttaga ggttttagat ctgttggtaa agggaaacaa tacaaaaaaa
     2041 aaaaaaatca caagagatct ccctgaaaac agaagcaaag gaagttcaac atagagtctt
     2101 gggcaggaag gaaaactaga gccattgtcc tgagggaagt gggatacagg aagattcagt
     2161 atccctggaa cacaacagaa cagccacacg cagggtctct gatgacagag agagtgcctg
     2221 catcctgcct ctttgaagtt tttagtattt gctaaaatga aaatgttaaa atataggcta
     2281 aacaaacaaa caaaatgaac cctgaaattg aaatctttat agcttccaag ctagcaagca
     2341 ctatgaaatc catgttcagc catgactatg gggatgtcat agtttatagc taatagacta
     2401 gactgaaagg ccgtcatggg gtgtcagtta catggttctc ctggtgatac tttggtagta
     2461 cagtgcttgg gacacagtca tgcagagagg tctatgtctc cactcctaca gagttgacct
     2521 agacttgcat tttcatgtct catccttcct atagtcttca tccatcttac tctgaaacat
     2581 ataaagtgga aaatgaaatg taatgaaaaa cctaccgtga ttgtcttcca gaatgatatc
     2641 tagacgtcat aagaatttca taaagcaacc aaatttattt tttgcgtttt ttttttctta
     2701 aatgaccatt taagattagt atccatggtg aattttgtag agcaatttta atccagcaac
     2761 gtggctgttc tggaaagaaa tcatattgaa agactttctt ggtctgggca atccacacct
     2821 ataatccctc tggctagaat acagatatgc ccttagtgca catcctgaat ctgaaacaat
     2881 gtaggcaatg ttagtttgca gaaggaagca actaaaagtg atgtctcatt gaggggtaga
     2941 caaagttaca aatcagagaa agatttggca gaacaaatca gatgtaggat accccaactc
     3001 taaggagcac aggagaggtg ggggggtcgg ggggggggcg agcagttcag tgagcacagt
     3061 tcagttgagt tcaggcaacg cagtgttgtg cagttgagtg cggtttgctg tagttgagat
     3121 gaatgccgtt gagttcagtt gagtttgtgc agttctgctt agttccattc agttcctgcc
     3181 ggcaatacag ttcagtttgg ggaaattcaa gaggcagttt ttccaagcag agcaattcag
     3241 agagaagcca agagaatccc gtcttgaatt agtcactttg gagaggagtt tgagtcagaa
     3301 cagctgagtt gaatgagcta ggcagagttc agagagaagt agaaaaggtg atttattcag
     3361 caataaggct ccgagatgac agttacatct ggtgaataaa aggtactttt acagagcctt
     3421 tgtattcttt ctatcttttg cccccccccc ccttttttga gttttttgag acagggtttc
     3481 tctgtgtagc tctgtctgtc ctggaactca ctttgtacac caggctggcc tcgaactcag
     3541 aaatcctcct gcctctgcct cccgagtgct ttggctcccc cccccctttt tttgagaaaa
     3601 gttttcacca catagctctg gtggtcttgc acatctctgt gtagaccaga ctggccttca
     3661 tctcacagag atcttcctgg gtctgttgga attgatgtgt accactaagc ccaaccaata
     3721 tttttatgta tgaaaacccc ctcaaaatgc taattgcatc tgattcagaa tagaaacatt
     3781 actgtgtgtt tgtatgaatg gatttgaaag tctaattcgt ccatcaataa aactttaaat
     3841 aactattctc aaatctatgt tgctttgatg atgactgaga aagaaaattc aaagcattgc
     3901 aatgagatat gagccttctg gaagtgaggg aagccattaa ctaggaatac atggtgactt
     3961 ccacaagtct tgagatttag ggtaaaggca acaagctgaa gtgcctttcc atgtaaaagt
     4021 gtatctgagt tgtggtcatt aatgacctta atggtgtgtg aggggatatt gtcttagaag
     4081 gtttgtcagc caagacactt tcagaattta aatgagaaaa aaaatgttcg tttgtatgtg
     4141 tgtggatata cacatgccac acggtgcacg tggcggtcag agaaccgctt ccagaagttg
     4201 gctctctctt tgtaccatgc aggtcctagg gataggatca aaaattgatc atcaggcttg
     4261 gcagcaagtg ccaccaccca ctgaaccgtt ttcctggggt cttttgttgg ttattattct
     4321 gtctatccga agataattct gttaattgtt ctaaagaact gaactcggat tttgtggctt
     4381 tttttttttt ttttgaattg tgcttctgat gtagtctgca ttttctttcc ttccttgatg
     4441 cttactgtgg atctgaactc tgctgtttcc attatcttaa agggtaaatt aggttatttc
     4501 attgatacgt tagtttcaca tcaggatatt tgcagttgta agtttgtctt aaattttgaa
     4561 atgacacttt tacattttct ttcacttcat cttatgctcc ccaattttca gtgctatgtt
     4621 gaatccaatt gtcccttatt cccgtggtgt ctaatttgta caaatatctg agtttctaag
     4681 tttttccatt cactaatgat ttcacttctt gtggttaggc aatctatttg gcaggatccg
     4741 gatccattaa aagttatgtg ccctttcttg tctcacggag aacaatatgg agatgttgaa
     4801 cacggatgct tttttttttg ttttccattt gtgcagtgtc ttttatagat gtttatttat
     4861 cctagttgac ttacatcttt ggttaactct tcaatttcct tgtcaagctt ttgcttatta
     4921 ttgaaagtaa atattgaagt ctttaactac tattgttaaa ttattctttt attattttct
     4981 ttgcgcattt tagaactctg ttgttaaagg tatacatatt tataactgtt taattactat
     5041 taaattgttc ctattttagt ttatattctt agtgttctag gaatatatat cagaaactag
     5101 aatattagtt attgagaact gaatttagat ttataccaac ttgattatta tgatctactt
     5161 attccaaaat agctccatgg cttctctttt tgtgctataa ttgtgtgtgt gtgtgtatgc
     5221 atatatactt atatatatat atgcatatat atttatatgt gcatatatat acatacatat
     5281 atgtatgcat gttatccttt tcatatgtcc aaagatatca tcttaaacat caattaaaga
     5341 tgtatcaaaa atatatttta gaattattaa tctgtatatg tatatactaa agaatctaag
     5401 aaaagagagt aaatgcacat tcacagagtt tcttagtctt atttgttgat atccttattt
     5461 tcatttcatt ccagtgattc aagttactga ctgtcatttt ctcactctaa ttttgctttg
     5521 ttcccatctg cctctgtgct gttattgtga agggagctgt gtatgtgtgt attgaagctc
     5581 taatcgttca ataatacagt attgtcttat atagttgcct tttgatataa gtaagaaatg
     5641 cccatttagc actcctttat agtgacctaa ttacattttc tgatgttttg ttgttgtgtt
     5701 aataaaggtt ctgtctatca ca
//
