LOCUS       NM_053070               1538 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus carbonic anhydrase 7 (Car7), transcript variant 1,
            mRNA.
ACCESSION   NM_053070 XM_134293
VERSION     NM_053070.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1538)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1538)
  AUTHORS   Bertling,E., Blaesse,P., Seja,P., Kremneva,E., Gateva,G.,
            Virtanen,M.A., Summanen,M., Spoljaric,I., Uvarov,P., Blaesse,M.,
            Paavilainen,V.O., Vutskits,L., Kaila,K., Hotulainen,P. and
            Ruusuvuori,E.
  TITLE     Carbonic anhydrase seven bundles filamentous actin and regulates
            dendritic spine morphology and density
  JOURNAL   EMBO Rep 22 (4), e50145 (2021)
   PUBMED   33719157
REFERENCE   3  (bases 1 to 1538)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1538)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1538)
  AUTHORS   Ruusuvuori,E., Huebner,A.K., Kirilkin,I., Yukin,A.Y., Blaesse,P.,
            Helmy,M., Kang,H.J., El Muayed,M., Hennings,J.C., Voipio,J.,
            Sestan,N., Hubner,C.A. and Kaila,K.
  TITLE     Neuronal carbonic anhydrase VII provides GABAergic excitatory drive
            to exacerbate febrile seizures
  JOURNAL   EMBO J 32 (16), 2275-2286 (2013)
   PUBMED   23881097
  REMARK    GeneRIF: Neuronal carbonic anhydrase VII provides GABAergic
            excitatory drive to exacerbate febrile seizures.
REFERENCE   6  (bases 1 to 1538)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1538)
  AUTHORS   Pan,P.W., Rodriguez,A. and Parkkila,S.
  TITLE     A systematic quantification of carbonic anhydrase transcripts in
            the mouse digestive system
  JOURNAL   BMC Mol Biol 8, 22 (2007)
   PUBMED   17362527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1538)
  AUTHORS   Earnhardt,J.N., Qian,M., Tu,C., Lakkis,M.M., Bergenhem,N.C.,
            Laipis,P.J., Tashian,R.E. and Silverman,D.N.
  TITLE     The catalytic properties of murine carbonic anhydrase VII
  JOURNAL   Biochemistry 37 (30), 10837-10845 (1998)
   PUBMED   9692974
REFERENCE   9  (bases 1 to 1538)
  AUTHORS   Lakkis,M.M., Bergenhem,N.C. and Tashian,R.E.
  TITLE     Expression of mouse carbonic anhydrase VII in E. coli and
            demonstration of its CO2 hydrase activity
  JOURNAL   Biochem Biophys Res Commun 226 (1), 268-272 (1996)
   PUBMED   8806625
REFERENCE   10 (bases 1 to 1538)
  AUTHORS   Selbert,S., Fischer,P., Menke,A., Jockusch,H., Pongratz,D. and
            Noegel,A.A.
  TITLE     Annexin VII relocalization as a result of dystrophin deficiency
  JOURNAL   Exp Cell Res 222 (1), 199-208 (1996)
   PUBMED   8549664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130543.3.
            
            On Aug 21, 2007 this sequence version replaced NM_053070.2.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY075021.1, BC094913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC130543.3         12469-12587         c
            120-317             AC130543.3         9787-9984           c
            318-436             AC130543.3         5589-5707           c
            437-532             AC130543.3         5113-5208           c
            533-595             AC130543.3         4947-5009           c
            596-751             AC130543.3         4302-4457           c
            752-1538            AC130543.3         3051-3837           c
FEATURES             Location/Qualifiers
     source          1..1538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1538
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="carbonic anhydrase 7"
                     /db_xref="GeneID:12354"
                     /db_xref="MGI:MGI:103100"
     exon            1..119
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..874
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /EC_number="4.2.1.1"
                     /note="isoform a is encoded by transcript variant 1;
                     CA-VII; carbonate dehydratase VII; carbonic anhydrase VII"
                     /codon_start=1
                     /product="carbonic anhydrase 7 isoform a"
                     /protein_id="NP_444300.1"
                     /db_xref="CCDS:CCDS22581.1"
                     /db_xref="GeneID:12354"
                     /db_xref="MGI:MGI:103100"
                     /translation="MTGHHCWGYGQDDGPSNWHKLYPIAQGDRQSPINIISSQAVYSP
                     SLQPLELFYEACMSLSITNNGHSVQVDFNDSDDRTVVSGGPLEGPYRLKQLHFHWGKK
                     RDMGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPSMN
                     RLTDALYMVRFKDTKAQFSCFNPKCLLPTSRHYWTYPGSLTTPPLSESVTWIVLREPI
                     RISERQMEKFRSLLFTSEDDERIHMVDNFRPPQPLKGRVVKASFQA"
     exon            120..317
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            318..436
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            437..532
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            533..595
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..751
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1538
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1516..1521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="hexamer: AATAAA"
     polyA_site      1538
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="major polyA site"
ORIGIN      
        1 gggccgtagc cggagccgca gacagagcga gcggacagaa cggagccggc aggtgcagag
       61 ccgcggggac agcagcggca tgaccggcca ccactgttgg ggctacggcc aggacgacgg
      121 cccttcaaat tggcacaagc tgtatcccat tgcccaggga gaccgccagt cacccatcaa
      181 tatcatatcc agccaggctg tgtactcgcc cagcctgcag ccactggaac ttttctatga
      241 ggcctgcatg tccctcagca tcaccaacaa tggccactct gtccaggtgg acttcaatga
      301 cagtgatgac agaaccgtgg tgtctggggg ccccctggaa gggccctatc gtctcaagca
      361 gctccacttc cactggggca agaagcgcga catgggctca gagcacacag tggacggcaa
      421 gtccttcccc agcgagctac atctggttca ctggaacgcc aagaagtaca gcacttttgg
      481 ggaggcggct gcagcccctg atggcctggc tgtggttggt gtcttcctgg agacaggaga
      541 tgagcaccca agcatgaacc gcctgacaga cgccctctac atggttcgat ttaaggacac
      601 caaggcccag ttcagctgct tcaaccccaa gtgcctgctg cccaccagcc gacactactg
      661 gacctatcct ggctccctga ccacaccccc actcagtgag agtgtcactt ggattgtgct
      721 tcgggagccc atcaggatct ccgagaggca gatggagaaa ttccggagcc tgcttttcac
      781 ctcagaggat gatgagagga tccatatggt ggacaacttc cggccaccac agccgctgaa
      841 gggccgagtg gtcaaagcat ccttccaggc ctgaacttcc cacctcccca gccagccact
      901 ggggtaccat cctcccaagg gcttccatgt cagcagacac caaaccatct gaggctcgct
      961 cccagttagg ggagggtgct acggccctcc ttcagctggc ttgctccttg accacattga
     1021 agggttcttg atggaaccct tgagttgggg gtaccctcca gctgccctgg tggggagggg
     1081 ctggaagaac aggaactgag cagagtccaa acctgggctg cctccgttcc tccagatcca
     1141 aaggcccctg agaatctcct cctgtcttcc ctgctggctg catcagcagc cccaactgga
     1201 gttcacactg tgatggccaa gacacagccc ctgccccgcg gggcgggatt ggcagctgtc
     1261 tctgccataa agactcaagc aataattaga ggtgggcaga gctgcccact ctgcattacc
     1321 tcttctgcag gcctctgcca tacatgcacc tcactgccag gccattacaa tagcacccag
     1381 acgctggagg cgatgtggcc ccctccagtc atctgctgcc acgggcaggc cctggcttta
     1441 gcttctatat gatctccctt tgttcctacc cagccaccaa agccacctac ataacaatcc
     1501 actcatgtac tagcaaataa attcatttat tcatggaa
//
