LOCUS       NM_001416666            1610 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus carbonic anhydrase 7 (Car7), transcript variant 4,
            mRNA.
ACCESSION   NM_001416666 XM_030243264
VERSION     NM_001416666.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Bertling,E., Blaesse,P., Seja,P., Kremneva,E., Gateva,G.,
            Virtanen,M.A., Summanen,M., Spoljaric,I., Uvarov,P., Blaesse,M.,
            Paavilainen,V.O., Vutskits,L., Kaila,K., Hotulainen,P. and
            Ruusuvuori,E.
  TITLE     Carbonic anhydrase seven bundles filamentous actin and regulates
            dendritic spine morphology and density
  JOURNAL   EMBO Rep 22 (4), e50145 (2021)
   PUBMED   33719157
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Ruusuvuori,E., Huebner,A.K., Kirilkin,I., Yukin,A.Y., Blaesse,P.,
            Helmy,M., Kang,H.J., El Muayed,M., Hennings,J.C., Voipio,J.,
            Sestan,N., Hubner,C.A. and Kaila,K.
  TITLE     Neuronal carbonic anhydrase VII provides GABAergic excitatory drive
            to exacerbate febrile seizures
  JOURNAL   EMBO J 32 (16), 2275-2286 (2013)
   PUBMED   23881097
  REMARK    GeneRIF: Neuronal carbonic anhydrase VII provides GABAergic
            excitatory drive to exacerbate febrile seizures.
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Pan,P.W., Rodriguez,A. and Parkkila,S.
  TITLE     A systematic quantification of carbonic anhydrase transcripts in
            the mouse digestive system
  JOURNAL   BMC Mol Biol 8, 22 (2007)
   PUBMED   17362527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Earnhardt,J.N., Qian,M., Tu,C., Lakkis,M.M., Bergenhem,N.C.,
            Laipis,P.J., Tashian,R.E. and Silverman,D.N.
  TITLE     The catalytic properties of murine carbonic anhydrase VII
  JOURNAL   Biochemistry 37 (30), 10837-10845 (1998)
   PUBMED   9692974
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Lakkis,M.M., Bergenhem,N.C. and Tashian,R.E.
  TITLE     Expression of mouse carbonic anhydrase VII in E. coli and
            demonstration of its CO2 hydrase activity
  JOURNAL   Biochem Biophys Res Commun 226 (1), 268-272 (1996)
   PUBMED   8806625
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Selbert,S., Fischer,P., Menke,A., Jockusch,H., Pongratz,D. and
            Noegel,A.A.
  TITLE     Annexin VII relocalization as a result of dystrophin deficiency
  JOURNAL   Exp Cell Res 222 (1), 199-208 (1996)
   PUBMED   8549664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130543.3.
            
            On Feb 14, 2023 this sequence version replaced XM_030243264.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.567298.1,
                                           SRR17784651.260386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC130543.3         11791-11981         c
            192-389             AC130543.3         9787-9984           c
            390-508             AC130543.3         5589-5707           c
            509-604             AC130543.3         5113-5208           c
            605-667             AC130543.3         4947-5009           c
            668-823             AC130543.3         4302-4457           c
            824-1610            AC130543.3         3051-3837           c
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1610
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="carbonic anhydrase 7"
                     /db_xref="GeneID:12354"
                     /db_xref="MGI:MGI:103100"
     exon            1..191
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            192..389
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..946
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /EC_number="4.2.1.1"
                     /note="isoform b is encoded by transcript variant 4;
                     CA-VII; carbonate dehydratase VII; carbonic anhydrase VII"
                     /codon_start=1
                     /product="carbonic anhydrase 7 isoform b"
                     /protein_id="NP_001403595.1"
                     /db_xref="GeneID:12354"
                     /db_xref="MGI:MGI:103100"
                     /translation="MSLSITNNGHSVQVDFNDSDDRTVVSGGPLEGPYRLKQLHFHWG
                     KKRDMGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPS
                     MNRLTDALYMVRFKDTKAQFSCFNPKCLLPTSRHYWTYPGSLTTPPLSESVTWIVLRE
                     PIRISERQMEKFRSLLFTSEDDERIHMVDNFRPPQPLKGRVVKASFQA"
     exon            390..508
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            509..604
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            605..667
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            668..823
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1610
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="hexamer: AATAAA"
     polyA_site      1610
                     /gene="Car7"
                     /gene_synonym="Ca7"
                     /note="major polyA site"
ORIGIN      
        1 agagggaggg cacttcggga cacaatggga acgtctgggt gtccacaccc gggagagtgt
       61 ttcagctcgt cctaagtgag tggggccatg ggtgctgggt ctggcctgga ggaccgctcc
      121 tccattctgc ctcagtttcc tcggcataca gagagagtat ggaagaagcc ggtgagccag
      181 acagcttgag tgcccttcaa attggcacaa gctgtatccc attgcccagg gagaccgcca
      241 gtcacccatc aatatcatat ccagccaggc tgtgtactcg cccagcctgc agccactgga
      301 acttttctat gaggcctgca tgtccctcag catcaccaac aatggccact ctgtccaggt
      361 ggacttcaat gacagtgatg acagaaccgt ggtgtctggg ggccccctgg aagggcccta
      421 tcgtctcaag cagctccact tccactgggg caagaagcgc gacatgggct cagagcacac
      481 agtggacggc aagtccttcc ccagcgagct acatctggtt cactggaacg ccaagaagta
      541 cagcactttt ggggaggcgg ctgcagcccc tgatggcctg gctgtggttg gtgtcttcct
      601 ggagacagga gatgagcacc caagcatgaa ccgcctgaca gacgccctct acatggttcg
      661 atttaaggac accaaggccc agttcagctg cttcaacccc aagtgcctgc tgcccaccag
      721 ccgacactac tggacctatc ctggctccct gaccacaccc ccactcagtg agagtgtcac
      781 ttggattgtg cttcgggagc ccatcaggat ctccgagagg cagatggaga aattccggag
      841 cctgcttttc acctcagagg atgatgagag gatccatatg gtggacaact tccggccacc
      901 acagccgctg aagggccgag tggtcaaagc atccttccag gcctgaactt cccacctccc
      961 cagccagcca ctggggtacc atcctcccaa gggcttccat gtcagcagac accaaaccat
     1021 ctgaggctcg ctcccagtta ggggagggtg ctacggccct ccttcagctg gcttgctcct
     1081 tgaccacatt gaagggttct tgatggaacc cttgagttgg gggtaccctc cagctgccct
     1141 ggtggggagg ggctggaaga acaggaactg agcagagtcc aaacctgggc tgcctccgtt
     1201 cctccagatc caaaggcccc tgagaatctc ctcctgtctt ccctgctggc tgcatcagca
     1261 gccccaactg gagttcacac tgtgatggcc aagacacagc ccctgccccg cggggcggga
     1321 ttggcagctg tctctgccat aaagactcaa gcaataatta gaggtgggca gagctgccca
     1381 ctctgcatta cctcttctgc aggcctctgc catacatgca cctcactgcc aggccattac
     1441 aatagcaccc agacgctgga ggcgatgtgg ccccctccag tcatctgctg ccacgggcag
     1501 gccctggctt tagcttctat atgatctccc tttgttccta cccagccacc aaagccacct
     1561 acataacaat ccactcatgt actagcaaat aaattcattt attcatggaa
//
