LOCUS       NM_009802               1380 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carbonic anhydrase 6 (Car6), mRNA.
ACCESSION   NM_009802
VERSION     NM_009802.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Ohshima,K., Ohshima,T., Meyer,K., Takai,E., Yoshizawa,S.,
            Shiraki,K. and Maeda,N.
  TITLE     Proteome analysis of high affinity mouse saliva proteins to
            hydroxyapatite
  JOURNAL   Heliyon 8 (8), e10077 (2022)
   PUBMED   36033281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Xu,J., Xu,X., Wang,B., Ma,Y., Zhang,L., Xu,H., Hu,Y., Wu,J. and
            Cao,X.
  TITLE     Nuclear carbonic anhydrase 6B associates with PRMT5 to
            epigenetically promote IL-12 expression in innate response
  JOURNAL   Proc Natl Acad Sci U S A 114 (32), 8620-8625 (2017)
   PUBMED   28739930
  REMARK    GeneRIF: the nuclear localized CA-VI B selectively promotes IL-12
            expression by interaction with protein arginine N-methyltransferase
            5 (PRMT5), which reduces symmetric dimethylation of histone H3
            arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate
            chromatin accessibility, selectively enhancing c-Rel binding to the
            Il12b promoter.
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Patrikainen,M.S., Pan,P., Barker,H.R. and Parkkila,S.
  TITLE     Altered gene expression in the lower respiratory tract of Car6
            (-/-) mice
  JOURNAL   Transgenic Res 25 (5), 649-664 (2016)
   PUBMED   27209317
  REMARK    GeneRIF: he altered biological processes included antigen transport
            by M-cells, potassium transport, muscle contraction, and thyroid
            hormone synthesis. Immunohistochemical staining confirmed the
            absence of CA VI in the submandibular gland of Car6 (-/-) mice
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Pan,P.W., Rodriguez,A. and Parkkila,S.
  TITLE     A systematic quantification of carbonic anhydrase transcripts in
            the mouse digestive system
  JOURNAL   BMC Mol Biol 8, 22 (2007)
   PUBMED   17362527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Sok,J., Wang,X.Z., Batchvarova,N., Kuroda,M., Harding,H. and Ron,D.
  TITLE     CHOP-Dependent stress-inducible expression of a novel form of
            carbonic anhydrase VI
  JOURNAL   Mol Cell Biol 19 (1), 495-504 (1999)
   PUBMED   9858573
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Wang,X.Z., Kuroda,M., Sok,J., Batchvarova,N., Kimmel,R., Chung,P.,
            Zinszner,H. and Ron,D.
  TITLE     Identification of novel stress-induced genes downstream of chop
  JOURNAL   EMBO J 17 (13), 3619-3630 (1998)
   PUBMED   9649432
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Fernley,R.T., Darling,P., Aldred,P., Wright,R.D. and Coghlan,J.P.
  TITLE     Tissue and species distribution of the secreted carbonic anhydrase
            isoenzyme
  JOURNAL   Biochem J 259 (1), 91-96 (1989)
   PUBMED   2497732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132599.1, AK161216.1 and AI323978.1.
            
            On Oct 6, 2007 this sequence version replaced NM_009802.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079835.1, AK132599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               AK132599.1         2-666
            666-929             AK161216.1         662-925
            930-1365            AK132599.1         931-1366
            1366-1380           AI323978.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.12 cM"
     gene            1..1380
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /note="carbonic anhydrase 6"
                     /db_xref="GeneID:12353"
                     /db_xref="MGI:MGI:1333786"
     exon            1..99
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..980
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /EC_number="4.2.1.1"
                     /note="carbonic anhydrase VI; CA-VI; carbonate dehydratase
                     VI; salivary carbonic anhydrase; secreted carbonic
                     anhydrase"
                     /codon_start=1
                     /product="carbonic anhydrase 6 precursor"
                     /protein_id="NP_033932.2"
                     /db_xref="CCDS:CCDS51386.1"
                     /db_xref="GeneID:12353"
                     /db_xref="MGI:MGI:1333786"
                     /translation="MRALVSVVSLFFLGIQAHSDWSYSGDDGVGESQWSEQYPSCGGE
                     RQSPIDVKTEEVMFNPSLKPLSLVNYEKENLEFTMTNNGHTVSIDLPPSMYLETSDGT
                     EFISKAFHFHWGGRDWELSGSEHTIDGIRSIMEAHFVHFNKEYGTYENAKDQKNGLAV
                     LAVLFKIDEYAENTYYSDIISALKNIEKPGETTTLKDTTIRNLLPKDVHHYYTYPGSL
                     TTPPCTENVQWFVLRDKVTLSKAQVVTIENSVMDHNNNTIQNGYRSTQPNNHRVVEAN
                     FLNVQDMYSSYHLYLKNMQKEILQPKKQKKTKKNRHFWSRK"
     exon            100..282
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..431
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..524
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..594
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..752
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..876
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1370
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1338..1343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /note="hexamer: AATAAA"
     polyA_site      1370
                     /gene="Car6"
                     /gene_synonym="Ca6; DOC1"
                     /note="major polyA site"
ORIGIN      
        1 ctgcattcag ggctacagca tctgccatga gggccctggt gagcgtggtg tccctgttct
       61 tcctgggcat ccaggcccac agtgattgga gctattcagg ggatgatggc gtgggagaaa
      121 gtcagtggtc tgagcagtat ccttcctgcg gcggggaaag gcagtcgccc atcgacgtga
      181 agacggagga ggtgatgttc aatccctcct tgaagcccct gagcttggtg aactatgaga
      241 aggagaacct ggagttcact atgactaaca acggacacac agtatcgatc gatctgccgc
      301 cctccatgta ccttgaaacc tctgacggca ctgagttcat ctcaaaggcc tttcactttc
      361 actggggggg tcgggactgg gaactcagcg gctctgaaca caccattgat gggatcagga
      421 gtataatgga ggctcacttt gttcacttca ataaggaata cgggacctat gagaatgcca
      481 aggatcaaaa aaacggccta gctgtgttag ccgtcttgtt taagattgac gagtatgccg
      541 aaaacactta ctacagcgac atcatttctg ccttgaagaa catcgagaag ccaggagaaa
      601 ctacaactct gaaagacacg accattagga acttgttgcc taaggacgtc caccactatt
      661 acacctaccc aggctcgctc accacacccc cctgcacaga gaatgtccag tggtttgtgc
      721 ttagagacaa agtcactttg tccaaggccc aggtggtgac catagaaaac tctgttatgg
      781 atcacaacaa caacaccatt caaaatggtt accgcagcac acagcccaac aaccacaggg
      841 tggtggaagc caatttcctg aacgtccagg atatgtactc ttcgtaccac ctttacctaa
      901 aaaacatgca gaaggagatt ctacaaccta agaaacagaa gaaaacaaag aagaaccggc
      961 acttttggag ccggaaatga cacactggcc ccagggctca ccctgcccct tgtctaagga
     1021 atcctggaat gtgggtctcc ttgctgcctt cagcgagtct ctgattaacc cagagggagt
     1081 tctcctccga gagaagaagt ggagctacgt tagccagaag agaaagggat gtgggtgaga
     1141 gggaaaagac ttcgacggac gtgcaaagaa atcaagcctt tcataattcc ctgtcaatca
     1201 ttcacctaaa gttggggtcc acagatgcag ctcatggtag agagcttgtc acaaccttgg
     1261 gtttgacccc cagcgccgaa aaaagaaaac cattcacctt gatctacgtt ataaatcagc
     1321 ctttagcatt tagatgtaat aaagtgattt tggaaatttt catttttaaa aaaaaaaaaa
//
