LOCUS       NM_007608               1248 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus carbonic anhydrase 5a, mitochondrial (Car5a), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_007608
VERSION     NM_007608.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1248)
  AUTHORS   Aspatwar,A., Supuran,C.T., Waheed,A., Sly,W.S. and Parkkila,S.
  TITLE     Mitochondrial carbonic anhydrase VA and VB: properties and roles in
            health and disease
  JOURNAL   J Physiol 601 (2), 257-274 (2023)
   PUBMED   36464834
  REMARK    GeneRIF: Mitochondrial carbonic anhydrase VA and VB: properties and
            roles in health and disease.
            Review article
REFERENCE   2  (bases 1 to 1248)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1248)
  AUTHORS   Price,T.O., Sheibani,N. and Shah,G.N.
  TITLE     Regulation of high glucose-induced apoptosis of brain pericytes by
            mitochondrial CA VA: A specific target for prevention of diabetic
            cerebrovascular pathology
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (4), 929-935 (2017)
   PUBMED   28131914
  REMARK    GeneRIF: In this report, genetic knockdown and overexpression
            studies confirm that mitochondrial CA VA regulates respiration in
            pericytes, whereas mitochondrial CA VB does not contribute
            significantly. Identification of mitochondrial CA VA as a sole
            regulator of respiration provides a specific target to develop new
            drugs with fewer side effects that may be better tolerated and can
            protect the brain from diabetic injury.
REFERENCE   4  (bases 1 to 1248)
  AUTHORS   Shah,G.N., Rubbelke,T.S., Hendin,J., Nguyen,H., Waheed,A.,
            Shoemaker,J.D. and Sly,W.S.
  TITLE     Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB
            implicates both enzymes in ammonia detoxification and glucose
            metabolism
  JOURNAL   Proc Natl Acad Sci U S A 110 (18), 7423-7428 (2013)
   PUBMED   23589845
  REMARK    GeneRIF: both Car5A and Car5B contribute to both ammonia
            detoxification (ureagenesis) and regulation of fasting blood sugar
            (gluconeogenesis).
REFERENCE   5  (bases 1 to 1248)
  AUTHORS   Wu,L., Sagong,B., Choi,J.Y., Kim,U.K. and Bok,J.
  TITLE     A systematic survey of carbonic anhydrase mRNA expression during
            mammalian inner ear development
  JOURNAL   Dev Dyn 242 (3), 269-280 (2013)
   PUBMED   23233153
REFERENCE   6  (bases 1 to 1248)
  AUTHORS   Lakkis,M.M., Venta,P.J. and Tashian,R.E.
  TITLE     Localization of the mitochondrial carbonic anhydrase V gene, Car5,
            on mouse chromosome 8
  JOURNAL   Mamm Genome 8 (3), 225-226 (1997)
   PUBMED   9069129
REFERENCE   7  (bases 1 to 1248)
  AUTHORS   Boriack-Sjodin,P.A., Heck,R.W., Laipis,P.J., Silverman,D.N. and
            Christianson,D.W.
  TITLE     Structure determination of murine mitochondrial carbonic anhydrase
            V at 2.45-A resolution: implications for catalytic proton transfer
            and inhibitor design
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 10949-10953 (1995)
   PUBMED   7479916
REFERENCE   8  (bases 1 to 1248)
  AUTHORS   Nagao,Y., Srinivasan,M., Platero,J.S., Svendrowski,M., Waheed,A.
            and Sly,W.S.
  TITLE     Mitochondrial carbonic anhydrase (isozyme V) in mouse and rat: cDNA
            cloning, expression, subcellular localization, processing, and
            tissue distribution
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10330-10334 (1994)
   PUBMED   7937950
REFERENCE   9  (bases 1 to 1248)
  AUTHORS   Heck,R.W., Tanhauser,S.M., Manda,R., Tu,C., Laipis,P.J. and
            Silverman,D.N.
  TITLE     Catalytic properties of mouse carbonic anhydrase V
  JOURNAL   J Biol Chem 269 (40), 24742-24746 (1994)
   PUBMED   7929150
REFERENCE   10 (bases 1 to 1248)
  AUTHORS   Amor-Gueret,M. and Levi-Strauss,M.
  TITLE     Nucleotide and derived amino-acid sequence of a cDNA encoding a new
            mouse carbonic anhydrase
  JOURNAL   Nucleic Acids Res 18 (6), 1646 (1990)
   PUBMED   2109313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI314393.1, AI314492.1, AI098626.1, AI132225.1 and AI527458.1.
            
            On Aug 12, 2006 this sequence version replaced NM_007608.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030174.2, X51971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AI314393.1         1-18
            19-560              AI314492.1         1-542
            561-684             AI098626.1         477-600
            685-808             AI132225.1         441-564             c
            809-1236            AI527458.1         1-428               c
            1237-1248           AI132225.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.81 cM"
     gene            1..1248
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /note="carbonic anhydrase 5a, mitochondrial"
                     /db_xref="GeneID:12352"
                     /db_xref="MGI:MGI:101946"
     exon            1..243
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            244..441
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            442..560
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            561..656
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            657..719
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            720..875
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1248
                     /gene="Car5a"
                     /gene_synonym="Ca5a; Car5; CAV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggttcag aggttttaat gagttcctca aaaggacaga gatgcaccta actctgaggt
       61 ggccctgacc aaagcaaggg catacagtgg gccactaccc cgtgctgctc agagccaaga
      121 tgctcaggag agacccccgc aagcccttag ccatcctcag gcatgtggga cttctctgtg
      181 ccacagggcc acagcgctgg cgtttccagc attcctgtgc agaggaacac agcaactgtg
      241 cccgacaccc cctctggact ggcccagtgt cctcagcaga aggcacccgg cagtctccca
      301 tcaacatcca gtggaaggac agtgtgtatg acccgcagct ggcaccactc agggtctcct
      361 atgatgccgc gtcctgcaga tacctctgga acactggcta cttcttccag gtggagtttg
      421 acgattcctg tgaggattca gggatcagcg gtgggcctct gggaaaccac tacaggctga
      481 agcagtttca tttccactgg ggagcaacag atgaatgggg ctcagagcac gcagtggacg
      541 gccataccta cccagctgag ctccatctgg ttcactggaa ttccacgaaa tatgaaaatt
      601 acaagaaagc ctccgtgggg gagaacgggc tggcggtcat cggcgtgttt ctgaagctcg
      661 gggcgcatca ccaggccctg cagaagctgg tggatgtctt gccggaagta agacacaagg
      721 atacacaggt ggccatggga ccctttgacc cctcttgtct gctgcctgcc tgccgggatt
      781 actggaccta ccctggctcc ctcaccaccc cgccacttgc tgagtcagtc acctggattg
      841 tgcagaagac gcctgttgag gtgtccccga gccagctatc cacgttccgc acactcttgt
      901 tctccgggcg aggtgaggaa gaggatgtga tggtgaacaa ctaccgcccg ctccagcccc
      961 tcagggaccg caaacttcgc tcgtccttcc ggcttgatcg gaccaagatg aggtcttaat
     1021 ctcaggatga agtctgtaag gataggcaga gcagaccgga aagggggccc gagtttccag
     1081 ggtgccacgt ggcacgacga gccggggcgg cagtggcgca cgcctttaat cccagcacat
     1141 gggaggcaga ggcaggcaga tttctgagtt cgaggccagc ctggtctaca gagtgagttc
     1201 caggacagcc aggactacac agagaaaccc tgtcccgaaa aaaaaaaa
//
