LOCUS       NM_007607               1316 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus carbonic anhydrase 4 (Car4), mRNA.
ACCESSION   NM_007607
VERSION     NM_007607.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Hutchison,V., Lynch,A., Gutierrez-Gamez,A.M. and Chen,J.
  TITLE     Inducible tricolor reporter mouse for parallel imaging of
            lysosomes, mitochondria, and microtubules
  JOURNAL   J Cell Biol 223 (1) (2024)
   PUBMED   37917008
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Shay,T.F., Sullivan,E.E., Ding,X., Chen,X., Ravindra Kumar,S.,
            Goertsen,D., Brown,D., Crosby,A., Vielmetter,J., Borsos,M.,
            Wolfe,D.A., Lam,A.W. and Gradinaru,V.
  TITLE     Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1
            enable blood-brain barrier crossing by engineered viral vectors
  JOURNAL   Sci Adv 9 (16), eadg6618 (2023)
   PUBMED   37075114
  REMARK    GeneRIF: Primate-conserved carbonic anhydrase IV and
            murine-restricted LY6C1 enable blood-brain barrier crossing by
            engineered viral vectors.
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Zhang,Z. and Zhou,B.
  TITLE     Generation of Plvap-CreER and Car4-CreER for genetic targeting of
            distinct lung capillary populations
  JOURNAL   J Genet Genomics 49 (12), 1093-1100 (2022)
   PUBMED   36028133
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Gupta,S.C., Ghobbeh,A., Taugher-Hebl,R.J., Fan,R., Hardie,J.B.,
            LaLumiere,R.T. and Wemmie,J.A.
  TITLE     Carbonic anhydrase 4 disruption decreases synaptic and behavioral
            adaptations induced by cocaine withdrawal
  JOURNAL   Sci Adv 8 (46), eabq5058 (2022)
   PUBMED   36383659
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Brion,L.P., Cammer,W., Satlin,L.M., Suarez,C., Zavilowitz,B.J. and
            Schuster,V.L.
  TITLE     Expression of carbonic anhydrase IV in carbonic anhydrase
            II-deficient mice
  JOURNAL   Am J Physiol 273 (2 Pt 2), F234-F245 (1997)
   PUBMED   9277584
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Hurt,J.D., Tu,C., Laipis,P.J. and Silverman,D.N.
  TITLE     Catalytic properties of murine carbonic anhydrase IV
  JOURNAL   J Biol Chem 272 (21), 13512-13518 (1997)
   PUBMED   9153196
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Tamai,S., Waheed,A., Cody,L.B. and Sly,W.S.
  TITLE     Gly-63-->Gln substitution adjacent to His-64 in rodent carbonic
            anhydrase IVs largely explains their reduced activity
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13647-13652 (1996)
   PUBMED   8942988
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Tamai,S., Cody,L.B. and Sly,W.S.
  TITLE     Molecular cloning of the mouse gene coding for carbonic anhydrase
            IV
  JOURNAL   Biochem Genet 34 (1-2), 31-43 (1996)
   PUBMED   8935991
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Brion,L.P., Suarez,C., Zhang,H. and Cammer,W.
  TITLE     Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of
            mice genetically deficient in carbonic anhydrase II
  JOURNAL   J Neurochem 63 (1), 360-366 (1994)
   PUBMED   8207439
  REMARK    Erratum:[J Neurochem 1998 Apr;70(4):1777]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669859.5, AK165399.1 and BM935015.1.
            
            [WARNING] On Jun 5, 2024 this sequence was replaced by NM_007607.3.
            
            On Jun 11, 2009 this sequence version replaced NM_007607.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154754.1, BC012704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL669859.5         12741-12813
            74-659              AK165399.1         2-587
            660-1285            AK165399.1         589-1214
            1286-1316           BM935015.1         540-570
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..1316
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /note="carbonic anhydrase 4"
                     /db_xref="GeneID:12351"
                     /db_xref="MGI:MGI:1096574"
     exon            1..188
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1051
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /EC_number="4.2.1.1"
                     /note="carbonate dehydratase IV; carbonic anhydrase IV;
                     CA-IV"
                     /codon_start=1
                     /product="carbonic anhydrase 4 precursor"
                     /protein_id="NP_031633.1"
                     /db_xref="CCDS:CCDS25190.1"
                     /db_xref="GeneID:12351"
                     /db_xref="MGI:MGI:1096574"
                     /translation="MQLLLALLALAYVAPSTEDSGWCYEIQTKDPRSSCLGPEKWPGA
                     CKENQQSPINIVTARTKVNPRLTPFILVGYDQKQQWPIKNNQHTVEMTLGGGACIIGG
                     DLPARYEAVQLHLHWSNGNDNGSEHSIDGRHFAMEMHIVHKKLTSSKEDSKDKFAVLA
                     FMIEVGDKVNKGFQPLVEALPSISKPHSTSTVRESSLQDMLPPSTKMYTYFRYNGSLT
                     TPNCDETVIWTVYKQPIKIHKNQFLEFSKNLYYDEDQKLNMKDNVRPLQPLGKRQVFK
                     SHAPGQLLSLPLPTLLVPTLTCLVANFLQ"
     exon            189..242
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            243..398
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..544
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..625
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            626..692
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..856
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1300
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /note="hexamer: AATAAA"
     polyA_site      1290
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /note="major polyA site"
ORIGIN      
        1 cccacgtcta gccgtccggg ctcccttagg tcgtggctct gctataaagc ctccaccagc
       61 atgatcgcga cgcctagggt ggcttcattg gtgattgacc ctaggctggg cagcgtcttt
      121 cccctcaagc accatgcagc tccttcttgc tctgctggcg ctggcatacg tggccccctc
      181 tactgaagac tcaggctggt gctatgagat tcaaaccaag gatcctagaa gcagttgctt
      241 ggggcctgag aagtggcctg gagcctgtaa ggagaatcag cagtccccca tcaacattgt
      301 cactgctagg acaaaggtga accccagact gacacccttc atcctcgtcg gctatgacca
      361 aaagcaacag tggccaatta agaacaatca acacacagtg gagatgacgc tggggggagg
      421 tgcgtgcatt atcggaggag acctgcccgc ccggtacgag gctgtacagt tgcacctgca
      481 ctggtcaaat gggaatgaca acggttcaga gcacagtatt gatgggagac actttgccat
      541 ggagatgcac atcgtgcaca agaagttgac atctagcaag gaggactcga aggacaagtt
      601 tgcagtgctg gcatttatga ttgaggtagg agacaaggtg aacaagggct tccagcccct
      661 ggtggaagca ctgcccagta tctccaaacc ccattcaacc tctacagtga gggagagcag
      721 tttgcaggac atgcttcccc cgagcaccaa aatgtatacc tacttccgtt acaatggctc
      781 actaaccaca ccaaactgtg atgagactgt catctggact gtgtacaaac aacccatcaa
      841 gatccacaaa aaccagttcc tggaattctc aaaaaatctg tactatgacg aagatcagaa
      901 gttgaacatg aaggacaatg tgaggcccct gcagccgctg ggaaaacgcc aggtgttcaa
      961 gtcccatgcc ccaggacagc tgctgtcttt gcccctgccc actctgttgg tccccacact
     1021 cacctgcctg gtagccaact tcctccagta atggcccact tctggatatc tgacctctga
     1081 cctcagcctt tagaggacat ggcttatctt tcttaatctt tccaggttga actttgggga
     1141 ctattaaaat atgaggaact ggctgtggtg tgcacacctt taatcccagc cttgggggtg
     1201 gagggagggt gacagggaca tgtggatctc tgacctcctc cccagccccc caattaaatg
     1261 aaataaaata tggatatgtt tttagaaaaa cccttggcaa aaaaaaaaaa aaaaaa
//
