LOCUS       NM_007606               1537 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus carbonic anhydrase 3 (Car3), mRNA.
ACCESSION   NM_007606
VERSION     NM_007606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Tan,Z., Chen,P., Dong,X., Guo,S., Leung,V.Y.L., Cheung,J.P.Y.,
            Chan,D., Richardson,S.M., Hoyland,J.A., To,M.K.T. and Cheah,K.S.E.
  TITLE     Progenitor-like cells contributing to cellular heterogeneity in the
            nucleus pulposus are lost in intervertebral disc degeneration
  JOURNAL   Cell Rep 43 (6), 114342 (2024)
   PUBMED   38865240
REFERENCE   2  (bases 1 to 1537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1537)
  AUTHORS   Rose,K.P., Manilla,G., Milon,B., Zalzman,O., Song,Y., Coate,T.M.
            and Hertzano,R.
  TITLE     Spatially distinct otic mesenchyme cells show molecular and
            functional heterogeneity patterns before hearing onset
  JOURNAL   iScience 26 (10), 107769 (2023)
   PUBMED   37720106
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1537)
  AUTHORS   Johnston,S.N., Silagi,E.S., Madhu,V., Nguyen,D.H., Shapiro,I.M. and
            Risbud,M.V.
  TITLE     GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells
            of the intervertebral disc
  JOURNAL   JCI Insight 8 (8), e164883 (2023)
   PUBMED   36917198
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1537)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   6  (bases 1 to 1537)
  AUTHORS   Lowe,N., Edwards,Y.H., Edwards,M. and Butterworth,P.H.
  TITLE     Physical mapping of the human carbonic anhydrase gene cluster on
            chromosome 8
  JOURNAL   Genomics 10 (4), 882-888 (1991)
   PUBMED   1916821
REFERENCE   7  (bases 1 to 1537)
  AUTHORS   Stanton,L.W., Ponte,P.A., Coleman,R.T. and Snyder,M.A.
  TITLE     Expression of CA III in rodent models of obesity
  JOURNAL   Mol Endocrinol 5 (6), 860-866 (1991)
   PUBMED   1922100
REFERENCE   8  (bases 1 to 1537)
  AUTHORS   Lyons,G.E., Buckingham,M.E., Tweedie,S. and Edwards,Y.H.
  TITLE     Carbonic anhydrase III, an early mesodermal marker, is expressed in
            embryonic mouse skeletal muscle and notochord
  JOURNAL   Development 111 (1), 233-244 (1991)
   PUBMED   1901785
REFERENCE   9  (bases 1 to 1537)
  AUTHORS   Beechey,C., Tweedie,S., Spurr,N., Ball,S., Peters,J. and Edwards,Y.
  TITLE     Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the
            homologous region of mouse chromosome 3 and human chromosome 8
  JOURNAL   Genomics 6 (4), 692-696 (1990)
   PUBMED   2111277
REFERENCE   10 (bases 1 to 1537)
  AUTHORS   Tweedie,S. and Edwards,Y.
  TITLE     Mouse carbonic anhydrase III: nucleotide sequence and expression
            studies
  JOURNAL   Biochem Genet 27 (1-2), 17-30 (1989)
   PUBMED   2496681
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC123747.26.
            
            On Nov 17, 2006 this sequence version replaced NM_007606.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011129.1, AK003671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC123747.26        155420-155487
            69-266              AC123747.26        156132-156329
            267-385             AC123747.26        158685-158803
            386-478             AC123747.26        160231-160323
            479-541             AC123747.26        161117-161179
            542-697             AC123747.26        161924-162079
            698-1537            AC123747.26        163424-164263
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.22 cM"
     gene            1..1537
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /note="carbonic anhydrase 3"
                     /db_xref="GeneID:12350"
                     /db_xref="MGI:MGI:88270"
     exon            1..68
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..817
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /EC_number="4.2.1.1"
                     /note="CA-III; carbonic anhydrase III; carbonate
                     dehydratase III"
                     /codon_start=1
                     /product="carbonic anhydrase 3"
                     /protein_id="NP_031632.2"
                     /db_xref="CCDS:CCDS17250.1"
                     /db_xref="GeneID:12350"
                     /db_xref="MGI:MGI:88270"
                     /translation="MAKEWGYASHNGPDHWHELYPIAKGDNQSPIELHTKDIKHDPSL
                     QPWSASYDPGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLSGPYRLRQFHLHWGSSDD
                     HGSEHTVDGVKYAAELHLVHWNPKYNTFGEALKQPDGIAVVGIFLKIGREKGEFQILL
                     DALDKIKTKGKEAPFTHFDPSCLFPACRDYWTYHGSFTTPPCEECIVWLLLKEPMTVS
                     SDQMAKLRSLFSSAENEPPVPLVGNWRPPQPVKGRVVRASFK"
     exon            69..266
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     exon            267..385
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..478
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..541
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..697
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1537
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /note="hexamer: CATAAA"
     polyA_site      1457
                     /gene="Car3"
                     /gene_synonym="Ca3; Car-3"
                     /note="major polyA site"
ORIGIN      
        1 agctgtccag cgctgagaaa cacgaaaggt gaccatggct aaggagtggg gctacgccag
       61 ccacaatggt cctgatcact ggcatgaact ttatccaatt gccaaagggg acaaccagtc
      121 acccattgaa ctgcatacta aagacatcaa gcatgacccc tctctgcagc cctggtcagc
      181 atcttatgac cctggctctg ctaagaccat cctgaacaat gggaagacct gcagagttgt
      241 gtttgatgat acttatgaca ggtctatgct gaggggtggt cctctctctg gaccctaccg
      301 acttcgccaa ttccatcttc actggggctc ctctgatgac cacggctctg agcacaccgt
      361 ggacggagta aaatacgctg ctgagcttca cctggttcac tggaatccaa agtataacac
      421 ctttggagag gctctgaagc agcctgatgg catcgctgtg gttggcattt tcctgaagat
      481 aggacgggag aaaggcgagt tccagattct tcttgatgcc ctggacaaaa ttaagacgaa
      541 gggcaaggag gcccctttta cacactttga cccatcatgc ctgttccctg cttgccggga
      601 ctattggacc tatcacggct ccttcaccac gccgccctgc gaggagtgca ttgtgtggct
      661 gctgctcaaa gagcccatga ctgtgagctc agaccagatg gccaagctgc gcagcctctt
      721 ctccagcgca gagaatgagc ccccggtgcc tctggtgggg aattggcgcc ctcctcagcc
      781 tgtcaagggc agggtggtga gggcctcctt caagtaaggc tctgagcttg ccctcttcgg
      841 gcaagaaact ctgcccctga agagcctgct tgtctcctcc tggtgctccc tactccaagc
      901 tgtccgacaa cacctagagg aagaggagaa gcagtcacat gcaaccgcag tgccttttga
      961 catgatctca cccagaagca tgaatttcac acctaacatt cttaataacc acctgttcta
     1021 aaaaaaaata ataataatta gtatttctag tatgaattca gtgaggaaga aatagatgga
     1081 aaaatagcga tagagaacag tggctcactg agcatattag actcagaatc tcagcactcc
     1141 tactttcagg ctgagttaca aatactacag aagtgatggg cccatgctat gtatccgggt
     1201 atggaggagt atgcggacct taccacactt aagtgaaaac acacgttaac atcattgtag
     1261 atctcaaaaa ctgaattcat aatgtgtttt acttcaaata ataccagcga taatccatca
     1321 ctcgttaaaa atttgcctac taccaagttt gcctggtttt agtcacctat aaaacacacc
     1381 catgaagcca ggtgttttaa aatgtttgat ccagcattta aatttcttct tcataaagat
     1441 ggttttcttt gcccaaagta gagccattta ttttttattt cactacttta atctttgcat
     1501 gcctattaaa aacaaaaaca aacaaacaaa aaaaaaa
//
