LOCUS       NM_009801               1945 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus carbonic anhydrase 2 (Car2), transcript variant 1,
            mRNA.
ACCESSION   NM_009801
VERSION     NM_009801.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Barone,S., Zahedi,K., Brooks,M. and Soleimani,M.
  TITLE     Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts
            Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC
  JOURNAL   Int J Mol Sci 25 (9), 4772 (2024)
   PUBMED   38731991
  REMARK    GeneRIF: Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney
            Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in
            TSC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Oh,Y., Kasu,M., Bottoms,C.J., Douglas,J.C., Sekulovski,N.,
            Hayashi,K. and MacLean Ii,J.A.
  TITLE     Rhox8 homeobox gene ablation leads to rete testis abnormality and
            male subfertility in micedagger
  JOURNAL   Biol Reprod 109 (4), 520-532 (2023)
   PUBMED   37471646
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Whyte,M.P.
  TITLE     Carbonic anhydrase II deficiency
  JOURNAL   Bone 169, 116684 (2023)
   PUBMED   36709914
  REMARK    GeneRIF: Carbonic anhydrase II deficiency.
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Babochkina,T.I., Gerlinskaya,L.A., Anisimova,M.V., Kontsevaya,G.V.,
            Feofanova,N.A., Stanova,A.K., Moshkin,M.P. and Moshkin,Y.M.
  TITLE     Mother-Fetus Immune Cross-Talk Coordinates 'Extrinsic'/'Intrinsic'
            Embryo Gene Expression Noise and Growth Stability
  JOURNAL   Int J Mol Sci 23 (20), 12467 (2022)
   PUBMED   36293324
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Gao,C., Chen,L., Chen,E., Tsilosani,A., Xia,Y. and Zhang,W.
  TITLE     Generation of Distal Renal Segments Involves a Unique Population of
            Aqp2 + Progenitor Cells
  JOURNAL   J Am Soc Nephrol 32 (12), 3035-3049 (2021)
   PUBMED   34667084
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Marshall,J.D., Mu,J.L., Cheah,Y.C., Nesbitt,M.N., Frankel,W.N. and
            Paigen,B.
  TITLE     The AXB and BXA set of recombinant inbred mouse strains
  JOURNAL   Mamm Genome 3 (12), 669-680 (1992)
   PUBMED   1477475
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Githens,S., Schexnayder,J.A. and Frazier,M.L.
  TITLE     Carbonic anhydrase II gene expression in mouse pancreatic duct
            cells
  JOURNAL   Pancreas 7 (5), 556-561 (1992)
   PUBMED   1381098
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Elliott,R.W.
  TITLE     Use of two-dimensional electrophoresis to identify and map new
            mouse genes
  JOURNAL   Genetics 91 (2), 295-308 (1979)
   PUBMED   447069
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Eicher,E.M., Stern,R.H., Womack,J.E., Davisson,M.T., Roderick,T.H.
            and Reynolds,S.C.
  TITLE     Evolution of mammalian carbonic anhydrase loci by tanden
            duplication: close linkage of Car-1 and Car-2 to the centromere
            region of chromosome 3 of the mouse
  JOURNAL   Biochem Genet 14 (7-8), 651-660 (1976)
   PUBMED   825106
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Davisson,M.T., Eicher,E.M. and Green,M.C.
  TITLE     Genes on chromosome 3 of the mouse
  JOURNAL   J Hered 67 (3), 155-156 (1976)
   PUBMED   820740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123747.26, AK002333.1 and CD774528.1.
            
            On Oct 26, 2017 this sequence version replaced NM_009801.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055291.1, AK146015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               AC123747.26        178170-178579
            411-1701            AK002333.1         8-1298
            1702-1945           CD774528.1         1-244               c
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.23 cM"
     gene            1..1945
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /note="carbonic anhydrase 2"
                     /db_xref="GeneID:12349"
                     /db_xref="MGI:MGI:88269"
     exon            1..499
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1248
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /EC_number="4.2.1.1"
                     /EC_number="4.2.1.69"
                     /note="carbonic anhydrase II; carbonate dehydratase II;
                     cyanamide hydratase CA2"
                     /codon_start=1
                     /product="carbonic anhydrase 2"
                     /protein_id="NP_033931.4"
                     /db_xref="CCDS:CCDS17251.1"
                     /db_xref="GeneID:12349"
                     /db_xref="MGI:MGI:88269"
                     /translation="MSHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPAL
                     QPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDG
                     QGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVL
                     EALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVS
                     SEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK"
     exon            500..697
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     exon            698..816
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     exon            817..909
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     exon            910..972
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1128
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1928
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1910..1915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="Car2"
                     /gene_synonym="Ca2; CAII; Car-2; Ltw-5; Lvtw-5"
                     /note="major polyA site"
ORIGIN      
        1 cgcgtgcgtg cgggccgcgg ccgggtggcc ggctggcccg ccagctctgg gaagcggagc
       61 cccgctgtgc gggcgggtga ccaggtcggt gctcacaatg gggctgggga gtaggggcgc
      121 cggcccgcga ggctgcgcag cgccggggcg agctggagag cgcgcagctg ctgcagagcg
      181 ggtcggacgc agaagcggag agcagccgga gggcgccccg ccccaagcaa ggtgcggggg
      241 ccctcgaaca ccgaggcctc cgcctgtcac ctctgcctgt cacctccgtc cgccacctcc
      301 acggtctcct ccccttgctc aggtccactc ggtccctccc ctgggccgcc cagagcacca
      361 agttggcggg agcctataaa agccggacgg tgcgacccgc gacacacact gcaggaccgc
      421 tagacggacg acaacttctg ctctgcccca atcaccggcg tgaccatgtc ccaccactgg
      481 ggatacagca agcacaacgg accagagaac tggcacaagg acttccccat tgccaatgga
      541 gaccggcagt cccctgtgga cattgacaca gcaactgccc agcatgaccc tgccctacag
      601 cctctgctca tatcttatga taaagctgcg tccaagagca ttgtcaacaa cggccactcc
      661 tttaacgttg agtttgatga ctctcaggac aatgcagtgc tgaaaggagg acccctcagt
      721 gactcctaca gattgatcca gtttcacttt cactggggct catctgatgg ccagggctct
      781 gagcacactg tgaacaaaaa aaaatatgct gcagagcttc acttggttca ctggaacacc
      841 aaatatgggg actttggaaa agctgtgcag caaccggatg gattggctgt tttgggtatt
      901 tttttgaaga ttggacctgc ctcacaaggc cttcagaaag tccttgaagc actgcattcc
      961 attaaaacaa aggggaagcg tgcggccttt gctaacttcg atccttgctc ccttcttcct
     1021 ggaaacttgg actactggac ataccctggc tctctgacca ctccgcctct gctggaatgt
     1081 gtgacctgga tcgtgctcag ggagcccatt actgtcagca gcgagcagat gtctcatttc
     1141 cgtacgctga acttcaatga ggagggggat gctgaagaag cgatggtgga caactggcgt
     1201 ccagctcagc cgctaaagaa tagaaagatc aaagcgtcct ttaagtaaaa caaccctgca
     1261 gcaggggtcc gaagggcaca agtgtgaccg cctctctgta gctaagcaca gttaggctgg
     1321 gtgatttgga tcccgactcg catctggtat tgtagacctt ttacctctca tccgttgtgc
     1381 ttactaacaa aatgtgaaaa gcaagaccca ggtgtctcat gtggtggcag cacagtggca
     1441 ggccagtggt caacttaggg catcttttct ctgccacggc agcgcaatgc aaagagcaga
     1501 catggcctct tgcttctctt cacagccata ggataatgaa tactcaggcc tgtttgttaa
     1561 aatgctattt ttaaaaccat atgaaggtag gataattaat tacaagtcca catcatgaga
     1621 caaactgaag taacttaggc aaaacaggta aaacagtcat agttttgtga ttataaatga
     1681 gatgaatgtt cacccttcca agatcttata ttaaagaaaa aattttaaaa agcttatata
     1741 tttgtagcaa agttattctt aaatatgaat tatgttataa cttagtgact tttgatttct
     1801 agaggtgtaa atgaggatgt aaaaattgat atagttgtga tacagagtat atttcccttc
     1861 agataacata ccacaacaca atggataatg tattttagat atattctcta ataaaattga
     1921 gaactctaaa aaaaaaaaaa aaaaa
//
