LOCUS       NM_030558               1125 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus carbonic anhydrase 15 (Car15), mRNA.
ACCESSION   NM_030558
VERSION     NM_030558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Naganuma,H., Miike,K., Ohmori,T., Tanigawa,S., Ichikawa,T.,
            Yamane,M., Eto,M., Niwa,H., Kobayashi,A. and Nishinakamura,R.
  TITLE     Molecular detection of maturation stages in the developing kidney
  JOURNAL   Dev Biol 470, 62-73 (2021)
   PUBMED   33197428
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Wu,L., Sagong,B., Choi,J.Y., Kim,U.K. and Bok,J.
  TITLE     A systematic survey of carbonic anhydrase mRNA expression during
            mammalian inner ear development
  JOURNAL   Dev Dyn 242 (3), 269-280 (2013)
   PUBMED   23233153
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Pan,P.W., Waheed,A., Sly,W.S. and Parkkila,S.
  TITLE     Carbonic anhydrases in the mouse harderian gland
  JOURNAL   J Mol Histol 41 (6), 411-417 (2010)
   PUBMED   20820888
  REMARK    GeneRIF: Car2, Car3, Car7, and Car15 mRNAs were barely within the
            detection limits in the mouse harderian gland.
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Saari,S., Hilvo,M., Pan,P., Gros,G., Hanke,N., Waheed,A., Sly,W.S.
            and Parkkila,S.
  TITLE     The most recently discovered carbonic anhydrase, CA XV, is
            expressed in the thick ascending limb of Henle and in the
            collecting ducts of mouse kidney
  JOURNAL   PLoS One 5 (3), e9624 (2010)
   PUBMED   20224780
  REMARK    GeneRIF: CA XV is expressed in the thick ascending limb of Henle
            and in the collecting ducts of mouse kidney and may have a role in
            the regulation of acid-base homeostasis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Hilvo,M., Salzano,A.M., Innocenti,A., Kulomaa,M.S., Scozzafava,A.,
            Scaloni,A., Parkkila,S. and Supuran,C.T.
  TITLE     Cloning, expression, post-translational modifications and
            inhibition studies on the latest mammalian carbonic anhydrase
            isoform, CA XV
  JOURNAL   J Med Chem 52 (3), 646-654 (2009)
   PUBMED   19193158
  REMARK    GeneRIF: cloning & purification of CA XV; the enzyme shows a
            moderate catalytic activity for the physiologic reaction, similarly
            to the physiologically relevant isoforms CA I, IV, VI, XII, and
            XIV, and it is susceptible to inhibition by sulfonamides and
            sulfamates
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Hilvo,M., Innocenti,A., Monti,S.M., De Simone,G., Supuran,C.T. and
            Parkkila,S.
  TITLE     Recent advances in research on the most novel carbonic anhydrases,
            CA XIII and XV
  JOURNAL   Curr Pharm Des 14 (7), 672-678 (2008)
   PUBMED   18336313
  REMARK    GeneRIF: Mouse carbonic anhydrase XV, absent in humans, is a
            moderately active enzyme which may play a physiological role at
            least in the kidney.  [review]
            Review article
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Pan,P.W., Rodriguez,A. and Parkkila,S.
  TITLE     A systematic quantification of carbonic anhydrase transcripts in
            the mouse digestive system
  JOURNAL   BMC Mol Biol 8, 22 (2007)
   PUBMED   17362527
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Hilvo,M., Tolvanen,M., Clark,A., Shen,B., Shah,G.N., Waheed,A.,
            Halmi,P., Hanninen,M., Hamalainen,J.M., Vihinen,M., Sly,W.S. and
            Parkkila,S.
  TITLE     Characterization of CA XV, a new GPI-anchored form of carbonic
            anhydrase
  JOURNAL   Biochem J 392 (Pt 1), 83-92 (2005)
   PUBMED   16083424
  REMARK    GeneRIF: CA XV is the first member of the alpha-CA gene family that
            is expressed in several species, but not in humans and chimpanzees.
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC019975.1.
            
            On Jun 19, 2003 this sequence version replaced NM_030558.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019975.1, AF231122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.05 cM"
     gene            1..1125
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /note="carbonic anhydrase 15"
                     /db_xref="GeneID:80733"
                     /db_xref="MGI:MGI:1931324"
     exon            1..146
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1054
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /EC_number="4.2.1.1"
                     /note="carbonic anhydrase-like sequence 2; CA-XV; carbonic
                     anhydrase XV; carbonate dehydratase XV"
                     /codon_start=1
                     /product="carbonic anhydrase 15 precursor"
                     /protein_id="NP_085035.1"
                     /db_xref="CCDS:CCDS49784.1"
                     /db_xref="GeneID:80733"
                     /db_xref="MGI:MGI:1931324"
                     /translation="MWALDFLLSFLLIQLAAQVDSSGTWCYDSQDPKCGPAHWKELAP
                     ACGGPTQSPINIDLRLVQRDYTLKPFIFQGYDSAPQDPWVLENDGHTVLLRVNSCQQN
                     CPAIRGAGLPSPEYRLLQLHFHWGSPGHQGSEHSLDEKHGSMEMHMVHMNTKYQSMED
                     ARSQPDGFAILAVLLVEEDRDNTNFSAIVSGLKNLSSPGVAVNLTSTFALASLLPSAL
                     RLLRYYRYSGSLTTPGCEPAVLWTVFENTVPIGHAQVVQFQAVLQTGPPGLHPRPLTS
                     NFRPQQPLGGRRISASPEASVRSSVSTLPCLHLALVGLGVGLRLWQGP"
     exon            147..182
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..353
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..514
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..607
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..674
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..841
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1105
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /note="hexamer: AATAAA"
     polyA_site      1105
                     /gene="Car15"
                     /gene_synonym="Ca15; Cals2"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcagc cttctaagta gcctggctgt acattcctca tccactttgc agttctccgg
       61 agtcagccac tgcagcatca tgtgggccct ggacttcttg ctcagcttcc tccttataca
      121 actggcggca caggtggact ccagtggtac ctggtgctac gactcccaag acccaaagtg
      181 tggccctgcc cactggaagg aactagcacc tgcctgtggg ggcccaaccc agtcccctat
      241 caacattgac cttcgattgg tccagcggga ctacactctt aagcccttca tctttcaagg
      301 ctatgattca gcccctcaag atccttgggt cctggagaac gatggccaca cagtgctact
      361 tcgagtaaat tcctgtcagc agaactgccc agccatccga ggggctgggc tcccgtcacc
      421 agagtaccgg ctactgcagc tgcacttcca ctggggcagc ccagggcacc aaggctccga
      481 gcacagcctg gatgagaagc atggctctat ggagatgcac atggtccaca tgaacacaaa
      541 gtaccagagc atggaggatg cacggagcca accagatggg tttgctatac tggctgtgct
      601 gttggtggag gaagacaggg acaataccaa tttctctgcc attgtgtctg gcctgaaaaa
      661 tttatcttca cctggggtag ctgtgaatct gacgtccacc tttgcactgg cctctctgct
      721 gccaagtgct ttgcggctct tgcggtacta ccgatactct gggtctctga ccacgccggg
      781 ctgtgagcca gcggtgctct ggactgtctt tgaaaacacc gtacccattg ggcatgcgca
      841 ggtagtccag ttccaggccg tgcttcagac tgggccacca ggtttgcacc ccagaccact
      901 cacgagtaat ttccgccccc agcagcctct tggagggcgc aggatatcag cctctcccga
      961 agcatccgtc cgatcatcag tctctaccct gccctgtttg cacctggctc ttgtgggctt
     1021 gggagttggc ctgagactct ggcagggtcc ctaggtccag caatgattct acaatagtat
     1081 ttccccaata aatcgtgcat agtgaaaaaa aaaaaaaaaa aaaaa
//
