LOCUS       NM_011797               1703 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus carbonic anhydrase 14 (Car14), transcript variant 1,
            mRNA.
ACCESSION   NM_011797
VERSION     NM_011797.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Oh,Y., Kasu,M., Bottoms,C.J., Douglas,J.C., Sekulovski,N.,
            Hayashi,K. and MacLean Ii,J.A.
  TITLE     Rhox8 homeobox gene ablation leads to rete testis abnormality and
            male subfertility in micedagger
  JOURNAL   Biol Reprod 109 (4), 520-532 (2023)
   PUBMED   37471646
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Qian,J., Shen,Q., Zhang,T., Chen,J., Chen,L., Dong,Y., Yan,R. and
            Chen,Z.
  TITLE     Carbonic anhydrase 14 protects the liver against the cytotoxicity
            of bile acids in a biliary bicarbonate umbrella-related manner
  JOURNAL   Life Sci 310, 121117 (2022)
   PUBMED   36302497
  REMARK    GeneRIF: Carbonic anhydrase 14 protects the liver against the
            cytotoxicity of bile acids in a biliary bicarbonate
            umbrella-related manner.
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Zhou,Z., Qian,J., Kini,A., Riederer,B., Romermann,D., Gros,G. and
            Seidler,U.
  TITLE     Loss of luminal carbonic anhydrase XIV results in decreased biliary
            bicarbonate output, liver fibrosis, and cholangiocyte proliferation
            in mice
  JOURNAL   Pflugers Arch 474 (5), 529-539 (2022)
   PUBMED   35119514
  REMARK    GeneRIF: Loss of luminal carbonic anhydrase XIV results in
            decreased biliary bicarbonate output, liver fibrosis, and
            cholangiocyte proliferation in mice.
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Supuran,C.T.
  TITLE     Carbonic anhydrases as drug targets--an overview
  JOURNAL   Curr Top Med Chem 7 (9), 825-833 (2007)
   PUBMED   17504127
  REMARK    Review article
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Shah,G.N., Ulmasov,B., Waheed,A., Becker,T., Makani,S., Svichar,N.,
            Chesler,M. and Sly,W.S.
  TITLE     Carbonic anhydrase IV and XIV knockout mice: roles of the
            respective carbonic anhydrases in buffering the extracellular space
            in brain
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16771-16776 (2005)
   PUBMED   16260723
  REMARK    GeneRIF: studies on hippocampal slices on these KO mice showed that
            either CA can mediate buffering after synaptic transmission in
            hippocampal slices in the absence of the other, but that
            eliminating both is as effective in blocking the buffering seen in
            WT mice
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Nagelhus,E.A., Mathiisen,T.M., Bateman,A.C., Haug,F.M.,
            Ottersen,O.P., Grubb,J.H., Waheed,A. and Sly,W.S.
  TITLE     Carbonic anhydrase XIV is enriched in specific membrane domains of
            retinal pigment epithelium, Muller cells, and astrocytes
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 8030-8035 (2005)
   PUBMED   15901897
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Whittington,D.A., Grubb,J.H., Waheed,A., Shah,G.N., Sly,W.S. and
            Christianson,D.W.
  TITLE     Expression, assay, and structure of the extracellular domain of
            murine carbonic anhydrase XIV: implications for selective
            inhibition of membrane-associated isozymes
  JOURNAL   J Biol Chem 279 (8), 7223-7228 (2004)
   PUBMED   14660577
  REMARK    GeneRIF: carbonic anhydrase XIV has a role in selective inhibition
            of membrane-associated isozymes
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Parkkila,S., Kivela,A.J., Kaunisto,K., Parkkila,A.K., Hakkola,J.,
            Rajaniemi,H., Waheed,A. and Sly,W.S.
  TITLE     The plasma membrane carbonic anhydrase in murine hepatocytes
            identified as isozyme XIV
  JOURNAL   BMC Gastroenterol 2, 13 (2002)
   PUBMED   12033992
  REMARK    GeneRIF: The presence of CA XIV in the hepatocyte plasma membrane
            places it at a strategic site to control pH regulation and ion
            transport between the hepatocytes, sinusoids and bile canaliculi.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Mori,K., Ogawa,Y., Ebihara,K., Tamura,N., Tashiro,K., Kuwahara,T.,
            Mukoyama,M., Sugawara,A., Ozaki,S., Tanaka,I. and Nakao,K.
  TITLE     Isolation and characterization of CA XIV, a novel membrane-bound
            carbonic anhydrase from mouse kidney
  JOURNAL   J Biol Chem 274 (22), 15701-15705 (1999)
   PUBMED   10336468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39.
            
            On Sep 27, 2017 this sequence version replaced NM_011797.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046995.1, AB005450.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AC092855.39        81243-81608         c
            367-387             AC092855.39        79034-79054         c
            388-567             AC092855.39        78016-78195         c
            568-710             AC092855.39        77166-77308         c
            711-806             AC092855.39        76854-76949         c
            807-873             AC092855.39        76663-76729         c
            874-1031            AC092855.39        76354-76511         c
            1032-1152           AC092855.39        76147-76267         c
            1153-1173           AC092855.39        75900-75920         c
            1174-1258           AC092855.39        75724-75808         c
            1259-1703           AC092855.39        74691-75135         c
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.48 cM"
     gene            1..1703
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /note="carbonic anhydrase 14"
                     /db_xref="GeneID:23831"
                     /db_xref="MGI:MGI:1344341"
     exon            1..366
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            367..387
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            388..567
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            568..710
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            711..806
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            807..873
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1031
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1152
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1173
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1258
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1703
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /note="hexamer: ATTAAA"
     polyA_site      1703
                     /gene="Car14"
                     /gene_synonym="CA-XIV; Ca14"
                     /note="major polyA site"
ORIGIN      
        1 accggtttcg agccacctta aaagcgggag gcaactgtga agttgctggc cagtaagtgg
       61 tgtggagatt acgaagggac atacggagag ggcagagaga ggaagagaga gaaagtgaga
      121 gaggaagaaa tttatcctgg gatccagaag ttcgtgttaa cctgtggaaa atcaagtccc
      181 tggaagtctg cagagacaga gacaagaaga aaagagatag aacgccagaa actcctctct
      241 ctccctccct ctccacctct ctcttctaaa ccccaaattc ctggtccctt gtaccccatt
      301 gtggggataa tatgttgttc ttcgctctcc tgttaaaggt gacttggatc ctggctgcag
      361 atgggggtca ccactggaca tatgaaggcc cacacggtca ggaccattgg ccaacctctt
      421 atcctgagtg tggaggcgat gcccagtccc ccatcaatat ccagacagac agtgtgatat
      481 ttgaccccga tctgcctgct gtacagcccc atggatatga ccagcttggg actgagcctt
      541 tggatctaca caataatggc catacagtgc agctttccct gcccccaacc ctgcacctgg
      601 gtggactgcc ccgaaaatac acagcagccc agctccacct gcactggggt cagagaggat
      661 ccctcgaggg atcagagcac cagatcaaca gtgaagccac ggctgcggag ctccacgtgg
      721 ttcactatga ctcccagtcc tacagcagct tgagtgaggc agctcagaag ccacagggcc
      781 tggctgtcct aggcatcctc attgaggtgg gcgagactga gaatccagct tatgatcaca
      841 ttctgagtcg tctacatgaa ataagataca aagatcagaa gacctctgtg cctcccttca
      901 gcgtgagaga gctgttcccc caacagctgg agcaattctt ccgctacaac ggctcactca
      961 caactccccc ctgctaccag agtgtgctct ggacagtctt caacagaagg gcccagattt
     1021 caatgggaca gttagagaag ctccaggaga cattgtcctc tacagaagag gacccctctg
     1081 agccccttgt acagaactac agagtccccc agcctctcaa ccagaggacc atctttgctt
     1141 ctttcatcca agcaggacca ctgtatacca caggagagat gctgggtcta ggtgtgggaa
     1201 tcttggctgg atgtctttgc cttctgctgg ctgtttattt catcgctcaa aaaattagga
     1261 agaagcggct gggaaacagg aaaagtgtgg ttttcacctc tgctcgggct accacagagg
     1321 cgtgaactct gtctcaagat gctgcagatg cctccctctc ctcctgccag ggagcctctc
     1381 tgagggctgc aggcactgga cgaccagttg taggcaggca cgtgtcctgc taggtaaccc
     1441 tctctataca ccagggaccc cagctcttca ggaagggctg agcctttggc cttcaaagct
     1501 gtggatgagg agattccctg tcctcatgct tggttggaag aagctgagga taaactgcca
     1561 tctttcacct cacaccgcca tgttctctcc cttagatata cgttgtagtt tttttttttc
     1621 ctctaggaaa aaagggctgc tgctgggatt ttaattattt tttgctcaat atatgtttgg
     1681 aaattaaaag tttttgatct taa
//
