LOCUS       NM_024495               2299 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus carbonic anhydrase 13 (Car13), mRNA.
ACCESSION   NM_024495
VERSION     NM_024495.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   Wiwatpanit,T., Lorenzen,S.M., Cantu,J.A., Foo,C.Z., Hogan,A.K.,
            Marquez,F., Clancy,J.C., Schipma,M.J., Cheatham,M.A., Duggan,A. and
            Garcia-Anoveros,J.
  TITLE     Trans-differentiation of outer hair cells into inner hair cells in
            the absence of INSM1
  JOURNAL   Nature 563 (7733), 691-695 (2018)
   PUBMED   30305733
  REMARK    Erratum:[Nature. 2019 Jan;565(7737):E2. doi:
            10.1038/s41586-018-0795-6.. PMID: 30518865]
REFERENCE   4  (bases 1 to 2299)
  AUTHORS   Reibring,C.G., El Shahawy,M., Hallberg,K., Kannius-Janson,M.,
            Nilsson,J., Parkkila,S., Sly,W.S., Waheed,A., Linde,A. and
            Gritli-Linde,A.
  TITLE     Expression patterns and subcellular localization of carbonic
            anhydrases are developmentally regulated during tooth formation
  JOURNAL   PLoS One 9 (5), e96007 (2014)
   PUBMED   24789143
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2299)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2299)
  AUTHORS   Wu,L., Sagong,B., Choi,J.Y., Kim,U.K. and Bok,J.
  TITLE     A systematic survey of carbonic anhydrase mRNA expression during
            mammalian inner ear development
  JOURNAL   Dev Dyn 242 (3), 269-280 (2013)
   PUBMED   23233153
  REMARK    GeneRIF: During inner ear development, transcripts of four
            cytosolic isozymes (Car1, Car2, Car3, and Car13), two
            membrane-bound isozymes (Car12 and Car14), and two CA-related
            proteins (Car8 and Car11) were expressed at higher levels than
            other isozymes.
REFERENCE   7  (bases 1 to 2299)
  AUTHORS   Pan,P.W., Waheed,A., Sly,W.S. and Parkkila,S.
  TITLE     Carbonic anhydrases in the mouse harderian gland
  JOURNAL   J Mol Histol 41 (6), 411-417 (2010)
   PUBMED   20820888
  REMARK    GeneRIF: Car5b and Car13 showed the highest signals in the mouse
            harderian gland.
REFERENCE   8  (bases 1 to 2299)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2299)
  AUTHORS   Pan,P.W., Rodriguez,A. and Parkkila,S.
  TITLE     A systematic quantification of carbonic anhydrase transcripts in
            the mouse digestive system
  JOURNAL   BMC Mol Biol 8, 22 (2007)
   PUBMED   17362527
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2299)
  AUTHORS   Lehtonen,J., Shen,B., Vihinen,M., Casini,A., Scozzafava,A.,
            Supuran,C.T., Parkkila,A.K., Saarnio,J., Kivela,A.J., Waheed,A.,
            Sly,W.S. and Parkkila,S.
  TITLE     Characterization of CA XIII, a novel member of the carbonic
            anhydrase isozyme family
  JOURNAL   J Biol Chem 279 (4), 2719-2727 (2004)
   PUBMED   14600151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162621.1 and AK151978.1.
            
            On Jun 18, 2009 this sequence version replaced NM_024495.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150871.1, AK152124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1744              AK162621.1         1-1744
            1745-2299           AK151978.1         1695-2249
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.12 cM"
     gene            1..2299
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /note="carbonic anhydrase 13"
                     /db_xref="GeneID:71934"
                     /db_xref="MGI:MGI:1931322"
     exon            1..119
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..871
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /EC_number="4.2.1.1"
                     /note="CA-XIII; carbonic anhydrase XIII; carbonate
                     dehydratase XIII"
                     /codon_start=1
                     /product="carbonic anhydrase 13"
                     /protein_id="NP_078771.1"
                     /db_xref="CCDS:CCDS17247.1"
                     /db_xref="GeneID:71934"
                     /db_xref="MGI:MGI:1931322"
                     /translation="MARLSWGYGEHNGPIHWNELFPIADGDQQSPIEIKTKEVKYDSS
                     LRPLSIKYDPASAKIISNSGHSFNVDFDDTEDKSVLRGGPLTGNYRLRQFHLHWGSAD
                     DHGSEHVVDGVRYAAELHVVHWNSDKYPSFVEAAHESDGLAVLGVFLQIGEHNPQLQK
                     ITDILDSIKEKGKQTRFTNFDPLCLLPSSWDYWTYPGSLTVPPLLESVTWIVLKQPIS
                     ISSQQLARFRSLLCTAEGESAAFLLSNHRPPQPLKGRRVRASFY"
     exon            120..317
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     exon            318..436
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     exon            437..532
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     exon            533..595
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     exon            596..751
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     exon            752..2299
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /note="hexamer: ATTAAA"
     polyA_site      1689
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /note="major polyA site"
     polyA_site      1918
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
     polyA_site      2028
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
                     /note="hexamer: AATAGA"
     polyA_site      2073
                     /gene="Car13"
                     /gene_synonym="2310075C21Rik; Ca13"
ORIGIN      
        1 acccaggccc gcccagctcc ttggcgcggg cgccctgcca caggtccaca gtgtccctgc
       61 cacaggctct ccatcgagga ccatggcgag gctgagctgg gggtacggcg agcacaacgg
      121 tcccattcac tggaatgaat tgttccctat tgctgatggt gatcagcagt ctccaattga
      181 gattaaaacc aaagaagtga aatacgactc ctcactccga cctctcagta tcaagtatga
      241 tcctgcctca gctaaaatca tcagcaatag tggccattcc ttcaacgttg actttgacga
      301 cacggaggac aaatcagttc tgcgtggagg tcctctcact gggaactaca ggttgcggca
      361 gttccatttg cactgggggt cagcagatga tcatggctca gagcatgtgg tagacggagt
      421 gaggtatgct gcagagctgc atgttgtcca ctggaattca gacaaatacc cgagctttgt
      481 agaggcagct catgagtccg atgggctggc tgtcctggga gtatttctac agattgggga
      541 acacaatcct caactgcaaa agatcactga tattttggat tccataaagg aaaagggtaa
      601 acaaacacgg ttcacaaatt ttgacccgtt atgcttgctt ccatcatctt gggactactg
      661 gacataccct ggctctctga cagttccacc tcttcttgag agtgtcacgt ggattgtttt
      721 aaaacaacct ataagtatca gctctcaaca gctggccaga ttccgaagcc tcttgtgcac
      781 agctgaggga gagagtgcgg cttttttgtt aagcaatcac cgtccaccac agcccttgaa
      841 gggccgcaga gtgagagcat ctttctatta gcagtcacca gtgggtcaac ccaatcggaa
      901 cacggaggta gcaaatacaa cggaactcag acattccaat aatggctttt cgagaatttc
      961 acgtttgtgg attctacttg tccagcacct ctggcacggc agagaaaacc agaagtctga
     1021 aataacttag cccatcactc ctagatttgc cccaatgtat gtccaattgc taaatatggg
     1081 atgtaattaa aatcacaaag tatacctgct tcagccttcc tgacaataat gtcagcctta
     1141 ccaacctcag actgtactaa actttatggt gggcttagac tgagcctatc ccattctaga
     1201 tagtgtttga taaaaacttt aaattcactt tgaactgata ttattcccaa acaagcagtt
     1261 cttacagtct tgataatttt ctgattaatc aagagtatat atttccttta atacattttc
     1321 tcagattctc attttatgta ctgtaatata gcacataaga caaaacacac acagactagg
     1381 atagaacaat gtggctactc ctgtgattaa agtaacctac agttttagtg aagcattcct
     1441 caggctaaga acagcttttt aagacactat tccacgtaat atattcaccc aagaatgtta
     1501 atgactacca gggtgatgac atagtgtgag gctcatgata ttaacgtgat tcagaccagc
     1561 aatgtatacg ataccactgc agcagaactg ccccgagctg gtgaacagct tcctacaaac
     1621 agagtgggac gctatcctat atctgctgtt ttttctgtca cccattaaaa agatgaacca
     1681 cgtcttgcat aaatgcctaa gccattcatt gcattttcta ggaagagctt atttcccatt
     1741 tgtacatgtt aactaagctg tttcatgatt ttataagatg ccatttgtta ctaactttag
     1801 actattctat ctggagaggt tttcttttgt attcattgaa ggaagacagg caccacattc
     1861 cttttgcttt gccattgtaa ggtgattcta tactcaataa ccacacttaa gacttgaata
     1921 tttgttatac ttttggtatt ttgtgagact gtgtccctgg gtttcttaag tttaataatt
     1981 tgtttcagat ctctctcatc ttctaaatgt aaagttaatt actgaaaact ttcttcatat
     2041 tcttcttaat agaataactt tattttgagt aaattgtact tgataatgtc tactgtcaca
     2101 taagatgaga gcccaaagat tagaatgaac accttagcca gtgttctccc ctgccgagtc
     2161 cactctaagg cttagaggaa gacctacata tcataaatat tttatgagct ggatagttaa
     2221 aagatttatt taattatctt gataactgcc atctatctga gataaaatgc agccaagtta
     2281 ataaaataat taaaatagg
//
