LOCUS       NM_178396               3720 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carbonic anhydrase 12 (Car12), transcript variant 1,
            mRNA.
ACCESSION   NM_178396
VERSION     NM_178396.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Seifinejad,A., Li,S., Mikhail,C., Vassalli,A., Pradervand,S.,
            Arribat,Y., Pezeshgi Modarres,H., Allen,B., John,R.M., Amati,F. and
            Tafti,M.
  TITLE     Molecular codes and in vitro generation of hypocretin and melanin
            concentrating hormone neurons
  JOURNAL   Proc Natl Acad Sci U S A 116 (34), 17061-17070 (2019)
   PUBMED   31375626
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Silagi,E.S., Batista,P., Shapiro,I.M. and Risbud,M.V.
  TITLE     Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic
            Marker, is Hypoxia-responsive and Confers Protection from Oxidative
            Stress-induced Cell Death
  JOURNAL   Sci Rep 8 (1), 4856 (2018)
   PUBMED   29559661
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Kallio,H., Pastorekova,S., Pastorek,J., Waheed,A., Sly,W.S.,
            Mannisto,S., Heikinheimo,M. and Parkkila,S.
  TITLE     Expression of carbonic anhydrases IX and XII during mouse embryonic
            development
  JOURNAL   BMC Dev Biol 6, 22 (2006)
   PUBMED   16719910
  REMARK    GeneRIF: CA12 may regulate ion and pH homeostasis within the
            developing embryo.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Hynninen,P., Hamalainen,J.M., Pastorekova,S., Pastorek,J.,
            Waheed,A., Sly,W.S., Tomas,E., Kirkinen,P. and Parkkila,S.
  TITLE     Transmembrane carbonic anhydrase isozymes IX and XII in the female
            mouse reproductive organs
  JOURNAL   Reprod Biol Endocrinol 2, 73 (2004)
   PUBMED   15488153
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Halmi,P., Lehtonen,J., Waheed,A., Sly,W.S. and Parkkila,S.
  TITLE     Expression of hypoxia-inducible, membrane-bound carbonic anhydrase
            isozyme XII in mouse tissues
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 277 (1), 171-177 (2004)
   PUBMED   14983512
  REMARK    GeneRIF: High expression in the kidney and colon suggests a role
            for carbonic anhydrase XII in the maintenance of body ion and pH
            homeostasis in the mouse.
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Whittington,D.A., Grubb,J.H., Waheed,A., Shah,G.N., Sly,W.S. and
            Christianson,D.W.
  TITLE     Expression, assay, and structure of the extracellular domain of
            murine carbonic anhydrase XIV: implications for selective
            inhibition of membrane-associated isozymes
  JOURNAL   J Biol Chem 279 (8), 7223-7228 (2004)
   PUBMED   14660577
REFERENCE   10 (bases 1 to 3720)
  AUTHORS   Kyllonen,M.S., Parkkila,S., Rajaniemi,H., Waheed,A., Grubb,J.H.,
            Shah,G.N., Sly,W.S. and Kaunisto,K.
  TITLE     Localization of carbonic anhydrase XII to the basolateral membrane
            of H+-secreting cells of mouse and rat kidney
  JOURNAL   J Histochem Cytochem 51 (9), 1217-1224 (2003)
   PUBMED   12923247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY236613.1, AK052639.1,
            BU700194.1, AC134429.3, CX240181.1, BX513273.1, AK009873.1 and
            AI414285.1.
            
            On Apr 15, 2015 this sequence version replaced NM_178396.4.
            
            Summary: This gene encodes a membrane-bound member of the alpha
            carbonic anhydrase family of enzymes that catalyze the reversible
            hydration of carbon dioxide to bicarbonate. These proteins
            participate in a variety of biological processes, including
            respiration, calcification, acid-base balance, bone resorption, and
            the formation of aqueous humor, cerebrospinal fluid, saliva, and
            gastric acid. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035941.1, AK170859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY236613.1         1-41
            42-1512             AK052639.1         2-1472
            1513-1847           BU700194.1         18-352              c
            1848-2283           AC134429.3         10290-10725         c
            2284-2982           CX240181.1         1-699
            2983-3072           BX513273.1         448-537
            3073-3715           AK009873.1         823-1465
            3716-3720           AI414285.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.09 cM"
     gene            1..3720
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /note="carbonic anhydrase 12"
                     /db_xref="GeneID:76459"
                     /db_xref="MGI:MGI:1923709"
     exon            1..248
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1228
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /EC_number="4.2.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carbonic anhydrase XII; carbonate dehydratase
                     XII; CA XII"
                     /codon_start=1
                     /product="carbonic anhydrase 12 isoform 1 precursor"
                     /protein_id="NP_848483.3"
                     /db_xref="CCDS:CCDS23306.1"
                     /db_xref="GeneID:76459"
                     /db_xref="MGI:MGI:1923709"
                     /translation="MPHRSLRATVVLLLVILKKQPSSSAPLNGSKWTYVGPAGEKNWS
                     KKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNS
                     DMYIQGLQPHHYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFST
                     ASDKSEGLAVLAVLIEIGSANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGE
                     YYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPTPREMINNFR
                     QVQKFDERLVYISFRQGLLTNTGLSLGIILSVALAGVLGISIVLAVSIWLFKRKKSKK
                     GDNKGVIYKPAIKKEAEVHA"
     exon            249..269
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            270..449
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..595
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            596..691
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            692..755
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            756..913
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1040
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1070
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1158
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..3716
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3695..3700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /note="hexamer: AATAAA"
     polyA_site      3716
                     /gene="Car12"
                     /gene_synonym="2310047E01Rik; CA-XII; Ca12"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgcggc attaaaaagc agcctacagg cagccacgag tctacacaac caacgtgcac
       61 gtcttggtcc caggctaagt gcacactgtg ctggtgcgcc gctgccagct ccgagcgccc
      121 cacagctccg agtgagtggc agctttgagt cgccaggaca aagatgcctc accgcagcct
      181 gcgcgcgact gtcgtcctcc tgttggtgat ccttaagaag cagccttcca gctcagcccc
      241 actcaacgga tccaagtgga cctatgttgg tcctgctggg gaaaagaact ggtccaagaa
      301 gtacccatcg tgtggaggcc tcctgcagtc cccgatagac ctacatagcg acatccttca
      361 gtatgatgct agcctcgcac ccctccagtt ccaaggttac aatgtgtctg ttgaaaagct
      421 gttgaacctg accaatgatg gccattcagt gagactgaat ctgaactcag acatgtacat
      481 ccagggtctc cagcctcacc actacagagc agagcagctg cacttgcact gggggaaccg
      541 caatgacccc catggctctg aacacaccgt gagtgggaag cactttgctg ccgagctgca
      601 cattgtccat tataactcag acctgtaccc tgacttcagc accgccagtg acaagtccga
      661 aggcctcgct gtccttgctg ttcttattga gataggctcc gccaatccat catatgacaa
      721 gatcttcagc catcttcaac atgttaagta taaaggccaa caagtgctca tcccaggctt
      781 caacattgaa gaacttctgc ccgagagccc tggcgagtat taccgctatg aagggtccct
      841 gactacacct ccttgctacc ctaccgtgct ctggacagtt ttccgaaacc ctgtgcagat
      901 ttcccaggag cagctgctgg ctttggagac agctctgtac ttcacacaca tggatgatcc
      961 tacccccaga gaaatgatca acaacttccg gcaggtccag aagttcgatg agaggctggt
     1021 gtatatctcc ttccgacaag gactgcttac caacacagga ctgagtttgg gtatcatcct
     1081 ttcagtggcc ctggctggcg ttcttggcat ctccattgtt ctggcagtgt ctatttggct
     1141 cttcaaaagg aagaagagca aaaaaggtga caacaaggga gtcatttata aaccagccat
     1201 caagaaggag gctgaggtcc acgcctgagg tccctggcag tctcagacat ccaaggaagg
     1261 accttgcttt ggacactcca tactttggct ctctggacac ttgaaatacc tccagctgtt
     1321 ctcttgagct cacctgtatc ccctcccccc agactcttgt gaggttccag ctgggcctcc
     1381 cctgctctgc tgtcacagcc accccagggt gaccagtgag tgggatgaac tgaactaggg
     1441 ggcaggagtt ttgagtggat ttctccagct gtatgagatg gctaaagatt ctgaattttg
     1501 ggtcacaaac ctaacctgct ggtgggccat tgtggtttgg aaaacacttc catcctgggt
     1561 tcttcctggt ccatctccag ggccctgaac attctagcta ttctctgacc ttccagacta
     1621 gaacatgtac cctttgctta ggtgacactt ttgaaactca gcttcatccc tcagggagca
     1681 gttgtcttcc ttggctttcc ttctgctctg acagactgcc agcaagcctg gcctcacacc
     1741 taacggggaa gaactgagac aggaagtatg aaattatcag aaagaaagga caactataat
     1801 aaactagggc atttttacag tcccatcttt tgggttacag acattgacca agcctcactc
     1861 aagttttatt ccttagtggg gatgaaaggg agacagagaa tgagggaagc agagggaaca
     1921 ggaaggcgta cattgtccag gagtcttcct ttgtagtcag aactggaacc aagatataat
     1981 gtggggggaa aagtctatgt tatcacttac ttggcctcag gaagaggaca gttacacttt
     2041 atattccact ccattacttg aaaatgaatt actccctctg tcttgtagta gatgtgagtt
     2101 ctggaataat ctaccctgtt ttgaacccat gggaaacaga caaaagcaga ctacgggaca
     2161 gctctgcctc ctttgcccaa atgtcagttt taccttgtct gatcttcctc ctgcccactc
     2221 attgtcagga ctgtctactc ctctggctgt ggagaggtct aaataatgtt taggtaaaat
     2281 gtattttcat actatcaaag cagaaagcta tctgtgtaga actaagcttg gtcctggtat
     2341 ttaagtcctg aaaccaatag catgtttcta agaatctccc tgttcttccc cctcagtccc
     2401 atggtttctg ggaatgctta ttcccttctt catgttcttt ccatagaggt gagaaccctg
     2461 tggagagcag tcagttccat ggctcaaaag aagtctcagc caccagcccc taattgctag
     2521 ctccttgcag ttcataggga gttctctgat ttagtctcat tttgacagca tggaatgtcc
     2581 tcttgaagaa caaggtttat atattttttt ccttcttcta tccctccctc cttctgactt
     2641 gataaaaatc tcttctgcta tcagaatgtt tcatggtggc agctgtgtgt gcaggatacg
     2701 tgcatgcaca caaaacctct gacagtcttg gagtctgggt ggcaccctag ccttgggacc
     2761 aatggcgtca ccacagtaag gacaagcctc aagaagaagc aacacaattt agtttcctga
     2821 gcttggtcca ggattgtcgg ccaagagctg gcataaagca gtccagggca gcaagactgt
     2881 cctaaagaag tgtatacact aacaagttat ctgagagtgc agcgtggtca tcatagctgg
     2941 cacgaggact ggtcagaaaa ggagaggtgc taggaggcaa aaacagtggt gtttctcctt
     3001 ccctcttccc cttcagcacg gtccagctat tcagtgctcg ttcaaccctc atggctgaga
     3061 caaaacaaag ccaaggaggc agaaagagtg ctccaagaat cagcgctgtc aacctttaac
     3121 tcctgaagat gcagattcaa aatcattctg tgaacacctg gccaccactg agggaaacca
     3181 gtgctgtggt atttgatgca cagctcgcct tgcgctcctt aactctgccg tgcgaggtgc
     3241 aaggtgggtg cctaggagaa cctgggtggg cacagggctg ggcacagggc aggtggagat
     3301 gaccaacaca atgcgtgggt ggatgggggc acacactggg gacccgagga aggcactggc
     3361 ttctgcaatg tttcttctgc ctcttacagg agaacttgag tctctgttct tttttagtat
     3421 ccatcttctg ttatcgtaaa tcctgtatcc atggctttaa tagacattct aaaagttgct
     3481 gcactgacag tcttaataat atttctatcc ctctccctct caatactctt tgaagacctc
     3541 ctgattggcc ctgaggaagt atccagggta acagtattcc tgggtccctg tccctcagcc
     3601 cataggccac tgtgataatt gtctgctcag catttccata tttattgtac caatgattgt
     3661 aatgaaaata tacactgaaa gtttaagaga ttataataaa aacgtttttc acatcaaaaa
//
