LOCUS       NM_001361708            3337 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus carbonic anhydrase 10 (Car10), transcript variant 2,
            mRNA.
ACCESSION   NM_001361708 XM_006534319
VERSION     NM_001361708.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Norrie,J.L., Lupo,M.S., Xu,B., Al Diri,I., Valentine,M., Putnam,D.,
            Griffiths,L., Zhang,J., Johnson,D., Easton,J., Shao,Y., Honnell,V.,
            Frase,S., Miller,S., Stewart,V., Zhou,X., Chen,X. and Dyer,M.A.
  TITLE     Nucleome Dynamics during Retinal Development
  JOURNAL   Neuron 104 (3), 512-528 (2019)
   PUBMED   31493975
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Sterky,F.H., Trotter,J.H., Lee,S.J., Recktenwald,C.V., Du,X.,
            Zhou,B., Zhou,P., Schwenk,J., Fakler,B. and Sudhof,T.C.
  TITLE     Carbonic anhydrase-related protein CA10 is an evolutionarily
            conserved pan-neurexin ligand
  JOURNAL   Proc Natl Acad Sci U S A 114 (7), E1253-E1262 (2017)
   PUBMED   28154140
  REMARK    GeneRIF: CA10 directly binds in a cis configuration to a conserved
            membrane-proximal, extracellular sequence of alpha- and
            beta-neurexins.
            Erratum:[Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2984. doi:
            10.1073/pnas.1703198114.. PMID: 28320946]
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Nishino,J., Kim,S., Zhu,Y., Zhu,H. and Morrison,S.J.
  TITLE     A network of heterochronic genes including Imp1 regulates temporal
            changes in stem cell properties
  JOURNAL   Elife 2, e00924 (2013)
   PUBMED   24192035
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3337)
  AUTHORS   Wu,L., Sagong,B., Choi,J.Y., Kim,U.K. and Bok,J.
  TITLE     A systematic survey of carbonic anhydrase mRNA expression during
            mammalian inner ear development
  JOURNAL   Dev Dyn 242 (3), 269-280 (2013)
   PUBMED   23233153
REFERENCE   7  (bases 1 to 3337)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 3337)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3337)
  AUTHORS   Woo,D.D. and Kurtz,I.
  TITLE     Mapping blood pressure loci in (A/J x B6)F2 mice
  JOURNAL   Physiol Genomics 15 (3), 236-242 (2003)
   PUBMED   14612590
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3337)
  AUTHORS   Taniuchi,K., Nishimori,I., Takeuchi,T., Ohtsuki,Y. and Onishi,S.
  TITLE     cDNA cloning and developmental expression of murine carbonic
            anhydrase-related proteins VIII, X, and XI
  JOURNAL   Brain Res Mol Brain Res 109 (1-2), 207-215 (2002)
   PUBMED   12531530
  REMARK    GeneRIF: Results describe the tissue distribution of carbonic
            anhydrase-related proteins VIII, X, and XI and their developmental
            expression in the murine embryonic brain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713960.17, AL683819.19, AL731849.5, AL731728.10 and AL954830.7.
            
            On Mar 29, 2018 this sequence version replaced XM_006534319.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB080741.1, SRR1660817.143460.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AL713960.17        152010-152366
            358-998             AL713960.17        153290-153930
            999-1073            AL683819.19        37277-37351
            1074-1216           AL731849.5         21965-22107
            1217-1402           AL731728.10        95316-95501
            1403-1498           AL954830.7         38755-38850
            1499-1571           AL954830.7         43037-43109
            1572-1726           AL954830.7         57202-57356
            1727-1901           AL954830.7         59313-59487
            1902-3337           AL954830.7         60405-61840
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.43 cM"
     gene            1..3337
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /note="carbonic anhydrase 10"
                     /db_xref="GeneID:72605"
                     /db_xref="MGI:MGI:1919855"
     exon            1..357
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            358..998
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     CDS             938..1924
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /note="carbonic anhydrase-related protein 10; CARP X;
                     carbonic anhydrase-related protein X; CA-RP X"
                     /codon_start=1
                     /product="carbonic anhydrase-related protein 10 precursor"
                     /protein_id="NP_001348637.1"
                     /db_xref="CCDS:CCDS25244.1"
                     /db_xref="GeneID:72605"
                     /db_xref="MGI:MGI:1919855"
                     /translation="MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFV
                     PVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTG
                     RHVSLRLDKEHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIH
                     YNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQ
                     GLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPS
                     QIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK"
     exon            999..1073
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1216
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1402
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1498
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1571
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1726
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1901
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..3337
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2833..2838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /note="hexamer: AATAAA"
     polyA_site      2855
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /note="major polyA site"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
                     /note="hexamer: AATAAA"
     polyA_site      3337
                     /gene="Car10"
                     /gene_synonym="2700029L05Rik; Ca10"
ORIGIN      
        1 gagagagccg cgcgctgggc aagagtgcgc gcgcgccggc ttgctggggg aaaatctcct
       61 tccctggaag ctgctgagtg tcgctgaccg agagtatccc ggggtccatc aaaagccacc
      121 aaagcgtttg agagcttttc taaagaaaaa cggtgaaaga aaaacaagaa gggaaacccg
      181 tttcccggga ggcctgggtt tccgatggta tcggattctc ccgtagctgc tctgataggg
      241 atgcggttgg cggccgctgg tacccggact tagagtgtcc gttgcgagag gagggaggtg
      301 agggacttgc gggcaagagt tgcacctgat cagggaatct gcgaagagaa ctgtggggag
      361 aactggcctg atcagagaca gcagtcaccc tttgaccatg ccccggtgaa ggggggcgga
      421 cttcgagggc aacttgtcgc ggactacctg ggctcagcta gcctacggaa agagagcaag
      481 agcccagaac tctacagctc ggcccagcgg ggggctgttg tctatgtctt cttggggcgc
      541 ccggcggatc ggggtctcgg ttttgcagga aaagcccagt gctgttggct tcaggtggct
      601 gccgccgccg ccaccgcggt cgccgcaagt gccatttctg ccactggtga gaggagcaga
      661 gatacaagag aggggagacc tccgaggcaa cgaggcatcg gacatgtgtc agcacatctg
      721 gggagtacat ccgaagagcc cgaggggaga tttgccgaaa caattcaaac tgcgttattg
      781 atcttggggg tgcctgtccc tggccggctg tcgggtggga gcgcgagtgt gcgctctctg
      841 gagagagtgt gcgtgtgtgt atgtgtgtac cgtgtcgggc tccccccttc ccccctgttt
      901 tcccgtcgag tgatgcacct ggaatgagaa tcagaggatg gaaatagtct gggaggtgct
      961 ttttcttctt caagccaatt tcatcgtctg catatcagct caacagaatt caccaaaaat
     1021 ccatgaaggc tggtgggcat acaaggaggt ggtccaggga agctttgttc cagttccttc
     1081 tttctgggga ttggtgaact cagcttggaa tctttgctct gtggggaagc gtcagtcccc
     1141 tgtcaacata gaaaccagtc acatgatctt cgaccccttt ctgacacctc ttcgcatcaa
     1201 cactgggggc aggaaggtca gtgggaccat gtacaacact ggaaggcatg tctccctccg
     1261 cctggacaaa gagcacttgg tcaatatttc aggagggccc atgacataca gtcaccgcct
     1321 ggaagaaatc cggctacact ttgggagtga ggacagccaa gggtctgagc acctcctcaa
     1381 tggacaggcc ttctccgggg aggtacaact catccactat aaccacgagc tatacacaaa
     1441 tgtcacagaa gctgcgaaga gcccgaatgg attggtggta gtttctatat ttataaaagt
     1501 ttctgattca tcaaacccat ttcttaatcg aatgctcaac agagatacta tcacaagaat
     1561 aacatataaa aatgatgcat acttactaca gggacttaat atagaggaac tgtatccaga
     1621 gacctctagt ttcatcactt atgatgggtc gatgactatc ccgccctgct atgagacagc
     1681 aagttggata ataatgaaca agcctgtgta cataaccagg atgcagatgc attccctacg
     1741 cctcctcagc cagaatcagc catcgcagat ctttctgagc atgagtgaca acttcaggcc
     1801 tgtccagcca ctcaataatc gctgtattcg caccaacatc aacttcagtt tacaggggaa
     1861 ggactgtcct aacaacaggg cccagaagct acagtacaga gtaaacgaat ggctcctcaa
     1921 gtagggaact aagccaagaa gaatcccacc tcagtgaaat tctacaactg tgaattgacg
     1981 caacccagaa tgcccccctt ccctgtcctt cctcccctaa gcctttcact ctttggattg
     2041 gccccttttt catgaaaatt gtctgaaaaa atgtttcaga ggagtgcatc tgtctctctc
     2101 tctctctaca cacacacact cacacacaca ctcatacaca catatacaca tacacagaca
     2161 catatacaca cacataaata caaatgcaca cactcataca cacataaaca caagtacaca
     2221 tgcacacaca cacacacaca cacacacaca cacacacaca caccacctcc atgatgaaaa
     2281 agccaagttt cagaaaaaaa ggttcattca tcaaaggtct tagaagaaaa caaccagtta
     2341 acctgattac aattttgata ctgttttcct gaactaataa ctcaacccaa tgagacttct
     2401 cagcctttgt atatacaaaa ttcttccaaa agagagtggg gggggggggg aaaccaccgt
     2461 tctgacagca tcaagcggac tcggcatctc accatccctg acagtgtcct gggttactcc
     2521 gagggtgctg tgacaggtga ccaggacaaa gctgaccaag gacacttatt tctagattac
     2581 gattcttctg tttactcaat gatttaaaaa gaaaatcttc aaaaataaat aaataaataa
     2641 ataaataaat aaatggacag acatcaaaga gctatacgtt gtatatattt atcaccacag
     2701 actataagaa tggaattatt tccctctttg tcacataact gtactaggac ttgcccgaga
     2761 tcagaatcga tccattcgct gtttcttgtt ttccgaaggt catacattgt gtttggttat
     2821 tgttaacagc ccaataaatg tgtttaatgc gttgatttca tttttttctg gctttgatct
     2881 gttctccttc ctgccaacct aagccctagc cccacgctat cttcttggct ctcccatgtc
     2941 ccttcatctc catgttttgt tcatttgcag ccagttttac tgagtttgtg gcaagcagga
     3001 atgcatttgc taagcaggta tatctatctt tcactccact ccatggctcg atccttcatc
     3061 ccaggtgagc tacgcccgac ctagcaggca acagattcct tgcgtttcaa aactgccatt
     3121 tcccccaccc cccaacccct gtgatgctcc caaaggaatg cactttgact tgtaaattcc
     3181 tgggaaattg gggtatcttt tctctccagg tgcagccaga tctcacaaaa tacaaaagaa
     3241 tgcctttctt ttcttgttta taatggtcac tcactgtgtt tggttactgt aaaaaaaaaa
     3301 aaaaaaaatc aataaatgtg tttaacaagt tgcccaa
//
