LOCUS       NM_001083957            1184 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus carbonic anhydrase 1 (Car1), transcript variant 2,
            mRNA.
ACCESSION   NM_001083957
VERSION     NM_001083957.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Cheng,K., Wang,Y., He,Y., Tian,Y., Li,J., Chen,C., Xu,X., Wu,Z.,
            Yu,H., Chen,X., Wu,Y., Song,W., Dong,Z., Xu,H. and Xie,P.
  TITLE     Upregulation of carbonic anhydrase 1 beneficial for depressive
            disorder
  JOURNAL   Acta Neuropathol Commun 11 (1), 59 (2023)
   PUBMED   37013604
  REMARK    GeneRIF: Upregulation of carbonic anhydrase 1 beneficial for
            depressive disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Tetteh,P.W., Kretzschmar,K., Begthel,H., van den Born,M.,
            Korving,J., Morsink,F., Farin,H., van Es,J.H., Offerhaus,G.J. and
            Clevers,H.
  TITLE     Generation of an inducible colon-specific Cre enzyme mouse line for
            colon cancer research
  JOURNAL   Proc Natl Acad Sci U S A 113 (42), 11859-11864 (2016)
   PUBMED   27708166
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Henry,E.K., Sy,C.B., Inclan-Rico,J.M., Espinosa,V., Ghanny,S.S.,
            Dwyer,D.F., Soteropoulos,P., Rivera,A. and Siracusa,M.C.
  TITLE     Carbonic anhydrase enzymes regulate mast cell-mediated inflammation
  JOURNAL   J Exp Med 213 (9), 1663-1673 (2016)
   PUBMED   27526715
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   McClelland,K.S., Bell,K., Larney,C., Harley,V.R., Sinclair,A.H.,
            Oshlack,A., Koopman,P. and Bowles,J.
  TITLE     Purification and Transcriptomic Analysis of Mouse Fetal Leydig
            Cells Reveals Candidate Genes for Specification of Gonadal
            Steroidogenic Cells
  JOURNAL   Biol Reprod 92 (6), 145 (2015)
   PUBMED   25855264
REFERENCE   5  (bases 1 to 1184)
  AUTHORS   Walker,E.M., Thompson,C.A. and Battle,M.A.
  TITLE     GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation
            during development
  JOURNAL   Dev Biol 392 (2), 283-294 (2014)
   PUBMED   24929016
REFERENCE   6  (bases 1 to 1184)
  AUTHORS   Sowden,J., Edwards,M., Morrison,K., Butterworth,P.H. and
            Edwards,Y.H.
  TITLE     Erythroid expression and DNAaseI-hypersensitive sites of the
            carbonic anhydrase 1 gene
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 545-551 (1992)
   PUBMED   1463458
REFERENCE   7  (bases 1 to 1184)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   8  (bases 1 to 1184)
  AUTHORS   Lowe,N., Edwards,Y.H., Edwards,M. and Butterworth,P.H.
  TITLE     Physical mapping of the human carbonic anhydrase gene cluster on
            chromosome 8
  JOURNAL   Genomics 10 (4), 882-888 (1991)
   PUBMED   1916821
REFERENCE   9  (bases 1 to 1184)
  AUTHORS   Eicher,E.M., Stern,R.H., Womack,J.E., Davisson,M.T., Roderick,T.H.
            and Reynolds,S.C.
  TITLE     Evolution of mammalian carbonic anhydrase loci by tanden
            duplication: close linkage of Car-1 and Car-2 to the centromere
            region of chromosome 3 of the mouse
  JOURNAL   Biochem Genet 14 (7-8), 651-660 (1976)
   PUBMED   825106
REFERENCE   10 (bases 1 to 1184)
  AUTHORS   Davisson,M.T., Eicher,E.M. and Green,M.C.
  TITLE     Genes on chromosome 3 of the mouse
  JOURNAL   J Hered 67 (3), 155-156 (1976)
   PUBMED   820740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162331.1 and AV374892.1.
            
            Transcript Variant: This variant (2) has a different 5' UTR
            compared to transcript variant 1. Both transcript variants (1 and
            2) encode the same protein. This variant represents use of an
            alternate downstream promoter and results in colon epithelia cell
            expression.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162331.1, AK033719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1182              AK162331.1         1-1182
            1183-1184           AV374892.1         255-256
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.18 cM"
     gene            1..1184
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /note="carbonic anhydrase 1"
                     /db_xref="GeneID:12346"
                     /db_xref="MGI:MGI:88268"
     exon            1..113
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..862
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /EC_number="4.2.1.1"
                     /EC_number="4.2.1.69"
                     /note="CA-I; carbonic anhydrase I; carbonate dehydratase
                     I; cyanamide hydratase CA1"
                     /codon_start=1
                     /product="carbonic anhydrase 1"
                     /protein_id="NP_001077426.1"
                     /db_xref="CCDS:CCDS17248.1"
                     /db_xref="GeneID:12346"
                     /db_xref="MGI:MGI:88268"
                     /translation="MASADWGYGSENGPDQWSKLYPIANGNNQSPIDIKTSEANHDSS
                     LKPLSISYNPATAKEIVNVGHSFHVIFDDSSNQSVLKGGPLADSYRLTQFHFHWGNSN
                     DHGSEHTVDGTRYSGELHLVHWNSAKYSSASEAISKADGLAILGVLMKVGPANPSLQK
                     VLDALNSVKTKGKRAPFTNFDPSSLLPSSLDYWTYFGSLTHPPLHESVTWVICKDSIS
                     LSPEQLAQLRGLLSSAEGEPAVPVLSNHRPPQPLKGRTVRASF"
     exon            114..311
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..430
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..526
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..589
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..745
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1184
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /note="hexamer: AATAAA"
     polyA_site      1177
                     /gene="Car1"
                     /gene_synonym="Ca1; Car-1"
                     /note="major polyA site"
ORIGIN      
        1 tgctgcaggt gtaagtgcag ttagtcattt cacatatcat ttctctttac aggaatcaca
       61 acctaaataa gagaaaatgg caagtgcaga ctggggatat ggaagcgaaa atggtcctga
      121 ccaatggagc aagctgtatc ccattgccaa tggaaacaac cagtctccta ttgatattaa
      181 aaccagtgaa gccaatcatg actcctctct gaaaccactc agcatctcct ataatcctgc
      241 aactgccaaa gaaattgtta acgtgggaca ttctttccat gtaatttttg atgacagtag
      301 caaccaatct gttctgaaag gtggccctct tgctgatagc tatcggctca ctcagttcca
      361 ttttcactgg ggcaactcaa acgaccatgg ctctgagcac accgtggatg gaactagata
      421 ttctggagag cttcacttag ttcactggaa ttctgcaaag tactccagtg cttctgaagc
      481 catctccaag gctgatggcc tggcaatcct tggcgttttg atgaaggttg gtccagccaa
      541 cccaagcctg cagaaagtac ttgatgctct aaactcagtt aaaactaagg gaaaacgagc
      601 cccattcaca aattttgacc catccagtct gcttccttca tctctggatt actggaccta
      661 ctttggctct ctgactcacc ctcctcttca tgaaagtgtg acctgggtga tctgcaagga
      721 tagcatcagt ctaagcccag agcagctggc ccagctccgt ggtcttctgt caagtgcaga
      781 gggagagcct gcagttccag ttctgagcaa ccaccgtcca ccccaacccc tgaagggcag
      841 aacagtcaga gcctcatttt gagtcccagc aaggaatgag tcctcaatta ggacctggcc
      901 ccctctacag cagcatccaa taaagggatc acgattaaga aacagaatta tgtcagtgct
      961 aagacagtat acctgcaaat ttaatccaca gaactaaaat gctttcattt taattcctga
     1021 tacttaatgc aaatactcta taagtttgcc tactgtaatt tttatgcatt cgtttttgct
     1081 taaatacacc tttttgtgga atcgttcata attacaacta agtgattcat tctctttctg
     1141 ctctcttcac tttaaataaa ccaataaaat ggctttacct cctc
//
