LOCUS       NM_009798               1676 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus capping actin protein of muscle Z-line subunit beta
            (Capzb), transcript variant 2, mRNA.
ACCESSION   NM_009798
VERSION     NM_009798.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Ye,Z., Wang,D., Lu,Y., He,Y., Yu,J., Wei,W., Chen,C., Wang,R.,
            Zhang,L., Zhang,L., Le,M.T.N., Cho,W.C., Yang,M., Zhang,H. and
            Yue,J.
  TITLE     Vacuolin-1 inhibits endosomal trafficking and metastasis via
            CapZbeta
  JOURNAL   Oncogene 40 (10), 1775-1791 (2021)
   PUBMED   33564074
  REMARK    GeneRIF: Vacuolin-1 inhibits endosomal trafficking and metastasis
            via CapZbeta.
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Jo,Y.J., Jang,W.I., Namgoong,S. and Kim,N.H.
  TITLE     Actin-capping proteins play essential roles in the asymmetric
            division of maturing mouse oocytes
  JOURNAL   J Cell Sci 128 (1), 160-170 (2015)
   PUBMED   25395583
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Kim,T., Cooper,J.A. and Sept,D.
  TITLE     The interaction of capping protein with the barbed end of the actin
            filament
  JOURNAL   J Mol Biol 404 (5), 794-802 (2010)
   PUBMED   20969875
  REMARK    GeneRIF: Capping protein interacts with both actin protomers at the
            barbed end of the filament, and the amphipathic helix at the
            C-terminus of the beta-subunit binds to the hydrophobic cleft on
            actin.
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Davis,D.A., Wilson,M.H., Giraud,J., Xie,Z., Tseng,H.C., England,C.,
            Herscovitz,H., Tsai,L.H. and Delalle,I.
  TITLE     Capzb2 interacts with beta-tubulin to regulate growth cone
            morphology and neurite outgrowth
  JOURNAL   PLoS Biol 7 (10), e1000208 (2009)
   PUBMED   19806181
  REMARK    GeneRIF: Capzb2 plays an important role in growth cone formation
            and neurite outgrowth and that the underlying mechanism may involve
            direct interaction between Capzb2 and microtubules.
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Geyer,C.B., Inselman,A.L., Sunman,J.A., Bornstein,S., Handel,M.A.
            and Eddy,E.M.
  TITLE     A missense mutation in the Capza3 gene and disruption of F-actin
            organization in spermatids of repro32 infertile male mice
  JOURNAL   Dev Biol 330 (1), 142-152 (2009)
   PUBMED   19341723
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   von Bulow,M., Rackwitz,H.R., Zimbelmann,R. and Franke,W.W.
  TITLE     CP beta3, a novel isoform of an actin-binding protein, is a
            component of the cytoskeletal calyx of the mammalian sperm head
  JOURNAL   Exp Cell Res 233 (1), 216-224 (1997)
   PUBMED   9184090
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Marks,P.W. and Kwiatkowski,D.J.
  TITLE     Genomic organization and chromosomal location of murine Cdc42
  JOURNAL   Genomics 38 (1), 13-18 (1996)
   PUBMED   8954774
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Schafer,D.A., Korshunova,Y.O., Schroer,T.A. and Cooper,J.A.
  TITLE     Differential localization and sequence analysis of capping protein
            beta-subunit isoforms of vertebrates
  JOURNAL   J Cell Biol 127 (2), 453-465 (1994)
   PUBMED   7929588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY033332.1, AK168738.1 and
            BY415700.1.
            
            On Sep 27, 2012 this sequence version replaced NM_009798.3.
            
            Summary: This gene encodes the beta subunit of a highly conserved
            filamentous actin capping protein that binds the barbed end of
            filamentous actin to stabilize it and terminate elongation.
            Interaction of this protein with the barbed end of the actin
            filament occurs through binding of the amphipathic helix at the
            C-terminus to the hydrophobic cleft on the actin molecule. This
            gene is required for a variety of dynamic actin-mediated processes
            including organization of lamellipodia and filopodia, growth cone
            morphology and neurite outgrowth in hippocampal neurons, and
            asymmetric spindle migration and polar body extrusion during oocyte
            maturation. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region, which results in translation extending to a
            distinct 3' coding region compared to variant 1. The encoded
            isoform (b) is shorter than and has a distinct C-terminus compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156778.1, AK168738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BY033332.1         1-73
            74-1672             AK168738.1         2-1600
            1673-1676           BY415700.1         300-303
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.59 cM"
     gene            1..1676
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:12345"
                     /db_xref="MGI:MGI:104652"
     exon            1..130
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..220
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..342
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..456
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..598
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..715
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..781
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..858
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1676
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /note="hexamer: AATAAA"
     polyA_site      1122
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /note="major polyA site"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /note="hexamer: AATAAA"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
                     /note="hexamer: AAGAAA"
     polyA_site      1669
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
     polyA_site      1674
                     /gene="Capzb"
                     /gene_synonym="1700120C01Rik; Cappb1; CPB1; CPB2; CPbeat2;
                     CPbeta1; CPbeta2"
ORIGIN      
        1 ggggggggag gggggcgctg acccggatgt tcactcttgg gcacccgggg aagtggaagc
       61 gcagggccct gctgcggggg ggagagccac agacgccggg acagggaccg tcgccgccgc
      121 cgccaccatg agcgatcagc agctggactg cgccttggac ctgatgaggc gcctgcctcc
      181 acagcagatt gagaagaacc tcagcgatct gatcgacctg gtccccagtc tgtgtgaaga
      241 tctcctgtca tctgttgacc agcccctgaa aattgccaga gacaaggtgg tgggcaagga
      301 ttaccttttg tgtgactaca acagagacgg ggactcctat aggtcaccgt ggagtaacaa
      361 gtatgaccct cctttggaag atggggccat gccatctgct cggctcagaa agctggaggt
      421 agaggccaac aatgccttcg accaataccg agacctgtat tttgaaggtg gggtctcatc
      481 agtctacctc tgggatcttg atcatggctt tgctggagtg atcctcataa agaaagctgg
      541 agatggatcc aagaagatca aaggctgctg ggattccatc cacgtggtgg aagtgcagga
      601 gaagtccagc ggccgtactg cccattacaa gttgacctcc acggtgatgc tatggctgca
      661 aaccaacaaa tccggctcgg gcaccatgaa cctgggaggc agcctaacca gacagatgga
      721 gaaagacgaa actgtgagtg actgttcccc acacatagcc aacatcgggc gcctggtgga
      781 ggacatggaa aacaaaatcc gaagcacgct gaatgagatc tactttggaa aaacaaagga
      841 catcgtcaac gggctgaggt ctgtgcagac gtttgcagac aaatcaaagc aagaagcgct
      901 taagaacgac ctggtggagg ccttgaagag aaagcagcag tgttgaagac ctctgcttca
      961 cgctaaccgg acacgccatg cactcgttag gttcctttct ttagaaaact cgttttctgc
     1021 tccttttccc tcttcctttc ccgccctgac aggtcacata acagtttgca tcgaccacgc
     1081 agcgccatct ctcccccaaa ataaagtccg ataaccaccc tcctctggct ccaaggcctg
     1141 cttcccacga cgtttccata gagaccgtgt ggttttgttc gcctgtcccc cttccttccc
     1201 ttgcccattt ataggcacag atacactgtc tgacaccgct ccctccatct ttttgttaca
     1261 ttggtgtaaa aaatgtaaaa caaaaaattt tatgaactaa ctggtgtgtg agagaagaaa
     1321 ctggagatct gatccgtgtg tgtgtgggag ttgcttggag tcagggctgg ggacagggga
     1381 cagcagtgga ggaaggagtg atgtcctcag cactgtcctg cacaggtgga cccttgtccc
     1441 aaggagacca tgctggggtg gggtggggct ggcgaccggc tgctcttcag gccaggtgct
     1501 tttctgtcaa tttttatgga atgcaaaagg agttttttgt tttattttgg tttttttttg
     1561 taaagcttaa acagacaaaa aaatctacat cttctacttg agcctccata cttaaaaaaa
     1621 aaaaaaaagg aaaaaaaaga acaaaaaaat aaataaaaag aaactgggac acaatc
//
