LOCUS       NM_007605               1281 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus capping actin protein of muscle Z-line subunit alpha 3
            (Capza3), mRNA.
ACCESSION   NM_007605
VERSION     NM_007605.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Crapster,J.A., Rack,P.G., Hellmann,Z.J., Le,A.D., Adams,C.M.,
            Leib,R.D., Elias,J.E., Perrino,J., Behr,B., Li,Y., Lin,J., Zeng,H.
            and Chen,J.K.
  TITLE     HIPK4 is essential for murine spermiogenesis
  JOURNAL   Elife 9, e50209 (2020)
   PUBMED   32163033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Sosnik,J., Buffone,M.G. and Visconti,P.E.
  TITLE     Analysis of CAPZA3 localization reveals temporally discrete events
            during the acrosome reaction
  JOURNAL   J Cell Physiol 224 (3), 575-580 (2010)
   PUBMED   20458735
  REMARK    GeneRIF: to understand actin-mediated change in protein
            localization during acrosome reaction, distribution of CAPZA3 was
            analyzed; like IZUMO1, CAPZA3 shows dynamic pattern of
            localization; movements follow different temporal pattern than
            changes seen with IZUMO1
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Geyer,C.B., Inselman,A.L., Sunman,J.A., Bornstein,S., Handel,M.A.
            and Eddy,E.M.
  TITLE     A missense mutation in the Capza3 gene and disruption of F-actin
            organization in spermatids of repro32 infertile male mice
  JOURNAL   Dev Biol 330 (1), 142-152 (2009)
   PUBMED   19341723
  REMARK    GeneRIF: These observations strongly suggest the missense mutation
            in Capza3 is responsible for the mutant phenotype of
            repro32/repro32 sperm and regulation of F-actin dynamics
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Robledo,R.F., Ciciotte,S.L., Gwynn,B., Sahr,K.E., Gilligan,D.M.,
            Mohandas,N. and Peters,L.L.
  TITLE     Targeted deletion of alpha-adducin results in absent beta- and
            gamma-adducin, compensated hemolytic anemia, and lethal
            hydrocephalus in mice
  JOURNAL   Blood 112 (10), 4298-4307 (2008)
   PUBMED   18723693
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Ben-Yosef,T., Eden,A. and Benvenisty,N.
  TITLE     Characterization of murine BCAT genes: Bcat1, a c-Myc target, and
            its homolog, Bcat2
  JOURNAL   Mamm Genome 9 (7), 595-597 (1998)
   PUBMED   9657861
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Ben-Porath,I., Kozak,C.A. and Benvenisty,N.
  TITLE     Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3),
            genes encoding membrane proteins related to Pmp22
  JOURNAL   Genomics 49 (3), 443-447 (1998)
   PUBMED   9615230
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Mapping of the mouse actin capping protein alpha subunit genes and
            pseudogenes
  JOURNAL   Genomics 39 (3), 264-270 (1997)
   PUBMED   9119363
REFERENCE   9  (bases 1 to 1281)
  AUTHORS   Matsui,M., Ichihara,H., Kobayashi,S., Tanaka,H., Tsuchida,J.,
            Nozaki,M., Yoshimura,Y., Nojima,H., Rochelle,J.M., Nishimune,Y.,
            Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of six germ-cell-specific genes to mouse chromosomes
  JOURNAL   Mamm Genome 8 (11), 873-874 (1997)
   PUBMED   9337410
REFERENCE   10 (bases 1 to 1281)
  AUTHORS   Tanaka,H., Yoshimura,Y., Nishina,Y., Nozaki,M., Nojima,H. and
            Nishimune,Y.
  TITLE     Isolation and characterization of cDNA clones specifically
            expressed in testicular germ cells
  JOURNAL   FEBS Lett 355 (1), 4-10 (1994)
   PUBMED   7957958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158625.9.
            
            On Feb 8, 2019 this sequence version replaced NM_007605.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK016391.1, BC049620.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1281              AC158625.9         109113-110393
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 69.77 cM"
     gene            1..1281
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 3"
                     /db_xref="GeneID:12344"
                     /db_xref="MGI:MGI:106221"
     exon            1..1281
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1020
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /note="capping protein alpha 3; capZ alpha-3; germ
                     cell-specific protein 3; cp alpha3; capping protein (actin
                     filament) muscle Z-line, alpha 3"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-3"
                     /protein_id="NP_031631.3"
                     /db_xref="CCDS:CCDS20672.1"
                     /db_xref="GeneID:12344"
                     /db_xref="MGI:MGI:106221"
                     /translation="MSLSVLSRKEKEKVIHRLLVQAPPGEFVNAFDDLCLLIRDEKLM
                     HHQGECAGHQHCQKYCVPLCIDGNPVLLSHHNVMGDFRFFDYQSKLSFRFDLLQNQLR
                     DIQSHGIIRNETEYLRSVVMCALKLYVNDHYPNGNCNVLRKTVKSKEFLIACIEDHSY
                     DNGECWNGLWKSKWIFQVNPFLTQVTGRIFVQAHFFRCVNLHIEVSKDLKESLEVVNQ
                     AQLALSFARLVEEQENKFQAAVIEELQELSNEALRKILRRDLPVTRTLIDWQRILSDL
                     NLVMYPKLGYVIYSRSVLCNWII"
     regulatory      1016..1021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /note="hexamer: TATAAA"
     polyA_site      1038
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /note="major polyA site"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
                     /note="hexamer: AATACA"
     polyA_site      1230
                     /gene="Capza3"
                     /gene_synonym="510-4; Cappa3; Gsg3; repro32; Tex8"
ORIGIN      
        1 agcatactgc tctaaagctt gaatgagtaa caccttgaat gggcaaggta tcccatggac
       61 cgttttctca ccctgtgagc acccttcatt tcagaagctt tgcttctgct gccactggcc
      121 atgtcactca gcgtcttgag taggaaagag aaagagaaag tcatccacag gctcttagtc
      181 caggctcctc ctggggaatt tgtgaatgcc tttgacgatc tctgtctgct tatccgagat
      241 gaaaagctta tgcaccatca gggtgagtgc gcaggccatc agcactgcca aaaatactgt
      301 gtcccactct gcatcgacgg caacccagtc ctcctgtctc accacaatgt gatgggtgac
      361 ttccgcttct ttgactacca gagcaaactt tctttcaggt ttgacctact ccagaatcaa
      421 ctgagggata tccaaagtca cggaatcatt cggaatgaga ccgagtacct aagatccgtt
      481 gttatgtgtg ccttaaaact ctatgtgaat gatcactacc caaatggaaa ttgcaatgtg
      541 ctgagaaaaa cagtcaaaag caaagaattc ttaatagctt gcattgaaga ccacagctat
      601 gacaatggag agtgttggaa cggtctttgg aagtctaagt ggatcttcca ggtaaacccg
      661 tttctaaccc aagtcacagg gagaattttt gtgcaagctc acttctttag gtgtgtcaac
      721 cttcatattg aagtctccaa ggacctaaag gagagcttgg aggtggtcaa tcaagcccag
      781 ttggctctca gtttcgcaag gcttgtggaa gaacaagaga ataagtttca agctgctgtc
      841 atagaagaac tacaggagtt gtctaacgaa gccctgagaa aaatattacg gagggatctt
      901 ccagtgacac gcactttgat tgactggcaa cggatcctct ctgacttgaa tctggtgatg
      961 taccccaagt tagggtatgt tatttactca agaagtgtgt tgtgcaactg gataatataa
     1021 aaggttgctg ctcctggtta tcggctcaag ctaaagtgtt ttctggggag taagtgcttg
     1081 gatagagttg ggaagctcct ggactcgtaa taagcctttc tttagtcctg tgccagtttg
     1141 aaaaggggga agaataagaa atcgtgttat acagtcagta ttcaccaaca cagcaaaaag
     1201 ggtaaataca tttcataacg ttaactgtca caaactcaga ggtttttatt agagcctaaa
     1261 ataatttacg aggtggccat g
//
