LOCUS       NM_007604               2541 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus capping actin protein of muscle Z-line subunit alpha 2
            (Capza2), mRNA.
ACCESSION   NM_007604
VERSION     NM_007604.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Crapster,J.A., Rack,P.G., Hellmann,Z.J., Le,A.D., Adams,C.M.,
            Leib,R.D., Elias,J.E., Perrino,J., Behr,B., Li,Y., Lin,J., Zeng,H.
            and Chen,J.K.
  TITLE     HIPK4 is essential for murine spermiogenesis
  JOURNAL   Elife 9, e50209 (2020)
   PUBMED   32163033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Thomas,J.W., Touchman,J.W., Blakesley,R.W., Bouffard,G.G.,
            Beckstrom-Sternberg,S.M., Margulies,E.H., Blanchette,M.,
            Siepel,A.C., Thomas,P.J., McDowell,J.C., Maskeri,B., Hansen,N.F.,
            Schwartz,M.S., Weber,R.J., Kent,W.J., Karolchik,D., Bruen,T.C.,
            Bevan,R., Cutler,D.J., Schwartz,S., Elnitski,L., Idol,J.R.,
            Prasad,A.B., Lee-Lin,S.Q., Maduro,V.V., Summers,T.J., Portnoy,M.E.,
            Dietrich,N.L., Akhter,N., Ayele,K., Benjamin,B., Cariaga,K.,
            Brinkley,C.P., Brooks,S.Y., Granite,S., Guan,X., Gupta,J.,
            Haghighi,P., Ho,S.L., Huang,M.C., Karlins,E., Laric,P.L.,
            Legaspi,R., Lim,M.J., Maduro,Q.L., Masiello,C.A., Mastrian,S.D.,
            McCloskey,J.C., Pearson,R., Stantripop,S., Tiongson,E.E.,
            Tran,J.T., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D.,
            Wiggins,L.S., Young,A.C., Zhang,L.H., Osoegawa,K., Zhu,B., Zhao,B.,
            Shu,C.L., De Jong,P.J., Lawrence,C.E., Smit,A.F., Chakravarti,A.,
            Haussler,D., Green,P., Miller,W. and Green,E.D.
  TITLE     Comparative analyses of multi-species sequences from targeted
            genomic regions
  JOURNAL   Nature 424 (6950), 788-793 (2003)
   PUBMED   12917688
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   Thomas,J.W., Lee-Lin,S.Q. and Green,E.D.
  TITLE     Human-mouse comparative mapping of the genomic region containing
            CDK6: localization of an evolutionary breakpoint
  JOURNAL   Mamm Genome 10 (7), 764-767 (1999)
   PUBMED   10384057
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Mapping of the mouse actin capping protein alpha subunit genes and
            pseudogenes
  JOURNAL   Genomics 39 (3), 264-270 (1997)
   PUBMED   9119363
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Vertebrates have conserved capping protein alpha isoforms with
            specific expression patterns
  JOURNAL   Cell Motil Cytoskeleton 38 (2), 120-132 (1997)
   PUBMED   9331217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY232398.1, BC082589.1, BM204346.2 and CX734558.1.
            
            On Feb 14, 2018 this sequence version replaced NM_007604.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150751.1, BC082589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BY232398.1         4-91
            89-2072             BC082589.1         1-1984
            2073-2423           BM204346.2         82-432              c
            2424-2541           CX734558.1         114-231
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 7.96 cM"
     gene            1..2541
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 2"
                     /db_xref="GeneID:12343"
                     /db_xref="MGI:MGI:106222"
     exon            1..151
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..973
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="capZ alpha-2; capping protein alpha 2; capping
                     protein (actin filament) muscle Z-line, alpha 2"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-2"
                     /protein_id="NP_031630.1"
                     /db_xref="CCDS:CCDS19926.1"
                     /db_xref="GeneID:12343"
                     /db_xref="MGI:MGI:106222"
                     /translation="MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDN
                     LLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLR
                     KEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIES
                     HQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTV
                     SNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILS
                     YKIGKEMQNA"
     exon            152..215
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..267
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..331
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..538
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..618
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..697
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..769
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..832
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..2510
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="hexamer: AATATA"
     polyA_site      2072
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="major polyA site"
     regulatory      2239..2244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="hexamer: AATAAA"
     polyA_site      2262
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="major polyA site"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="hexamer: AATATA"
     polyA_site      2363
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="major polyA site"
     regulatory      2487..2492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="hexamer: AGTAAA"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
                     /note="hexamer: ACTAAA"
     polyA_site      2506
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
     polyA_site      2510
                     /gene="Capza2"
                     /gene_synonym="1110053K06Rik; Cappa2"
ORIGIN      
        1 gcggcggggc ccctcccttg gcgggggcgc gcggcgcgga agaccgctcg gaaaggggga
       61 agtcaggtgg ccgctgctgc caccagcgcc acggtctgtc gccagaagga agatggcgga
      121 tctggaggag cagttgtccg atgaggagaa ggttcgtata gcagcaaaat tcatcattca
      181 cgcccctcct ggagaattta atgaggtttt taatgatgtt cgattattgc ttaataatga
      241 taatcttctc agggaaggag ccgcacatgc atttgcacag tataacctgg accagtttac
      301 accagtaaaa attgaaggct atgaagatca ggttttgata acagaacatg gagacttggg
      361 aaatggaaaa tttttggatc caaaaaacag aatctgtttc aaatttgatc atttaagaaa
      421 ggaagcaact gatccaaggc cctacgaagc agaaaatgcc attgaatcct ggagaacttc
      481 agtagaaact gcactgcgag cttatgtaaa agagcattat ccgaatgggg tctgcactgt
      541 gtatggcaaa aaagtagatg ggcagcaaac cattattgca tgcatagaaa gccatcagtt
      601 tcaagcaaaa aacttttgga atggtcgttg gaggtcagag tggaagttta cagtcactcc
      661 ttccaccaca caggtggttg gcattttgaa aattcaggtt cattattatg aagatggtaa
      721 tgttcagcta gtgagtcata aagatataca agattccctc acagtatcta atgaggtgca
      781 aacagcaaaa gaatttataa agattgtaga agctgcagaa aatgaatacc agactgccat
      841 cagtgagaat tatcagacga tgtcggacac taccttcaaa gccttacgtc gacagttgcc
      901 agtgacacgt actaagatcg actggaacaa gatccttagc tacaagattg gcaaagagat
      961 gcagaatgca taaatgaaaa ttgcatgagc agattgtttt agtgtcttcg cgttacaaaa
     1021 attattgcaa aagtattctg agctgacagc tgcccagtga ggtgggctgt tgcatctaag
     1081 atcactgtaa ttaagtagtg tggttagagc acagagctta gctaataacc tgttccattt
     1141 cctttgttca gagggttgga catgagttta gataagtatc ttactctgtt cctcctttcg
     1201 aagtctctct ctctctctct ttctttctct ctctctctgt tccttctcct acaatgaaga
     1261 ggtgatccct ctgggtcatg tctaaagggt ttgaaatatc tcaaaagtac cttctttact
     1321 gtaaccctga agttgtcttt ggcttgtgaa aggggcagct tttgatgtta gcccaggtag
     1381 ttttagtggg gtcagtcagt aatgggcact ctagttaagg tggttgatgg acttagccat
     1441 gtatgctgct aaagaaattg tctacctttt cctttcacct cttccagcat ggaagatgga
     1501 gattagaggg agagcatttt ctaacgagtt acgttaaacc ttctcagcaa ggttatttag
     1561 ctagcttagt gtctaactaa acttttttaa aacaaggcca aggtctgttg ctgttttgag
     1621 attctgaaat taaatgagaa tacttatttc agaaatgcat ttaatgcttt tttcttgtga
     1681 cagttatgca aattagcttg aattccatat gttcctgagt tatttttatc acaaagccac
     1741 aagtgtatta taaggcagat tgtaatatat atataatcct gaactcatga acatgtctca
     1801 gttgattctc cctccccttg gattggaaac tgaatatcag tgtgacatta aaatggcaac
     1861 atttggtatt tatttgagta aaaaaaaaat caccagtgaa tcatacacta ttttaaaata
     1921 ctttctttgt atattgtcat tcttaacaag ttgtaaatta gaaaatttgg gagtccacat
     1981 ggtatgcaac tgcatctttt gttctccatt ttcctatgca tcataagcat gtttgtaata
     2041 ctttaaaaat atatctactg ccaccacagg aattcacgcc tcggtgaatg ttagcgttta
     2101 ctgtaaggag ttggtggatt tgtggtttca ttcagtagct ctgctgctta tactcgagtg
     2161 gaatccattc ctcacgtact cctgcagaca tctgggcctg gaattttttt ttttttaaac
     2221 accactttta ctatgtataa taaaatattt cattagcttg aattgtatag atttttaaaa
     2281 attcaataag agcatgttgt ttaatttctt tttaaaatca ctgttgggct ttgaaagcat
     2341 tgcaaatata tgacattgtg acagttttgg ctaatttcct ctttagcttt tagtcttggc
     2401 atcaggattt ttaaggaaaa tgaactgata acattaattc tatgtctaga tttttaaaac
     2461 acgtacttaa attttgatga ttctgaagta aatactaaat aagtaactaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa a
//
