LOCUS       NM_009797               3191 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus capping actin protein of muscle Z-line subunit alpha 1
            (Capza1), transcript variant 1, mRNA.
ACCESSION   NM_009797
VERSION     NM_009797.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3191)
  AUTHORS   Zhu,H., Wang,D., Ye,Z., Huang,L., Wei,W., Chan,K.M., Zhang,R.,
            Zhang,L. and Yue,J.
  TITLE     The temporal association of CapZ with early endosomes regulates
            endosomal trafficking and viral entry into host cells
  JOURNAL   BMC Biol 22 (1), 12 (2024)
   PUBMED   38273307
  REMARK    GeneRIF: The temporal association of CapZ with early endosomes
            regulates endosomal trafficking and viral entry into host cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3191)
  AUTHORS   McConnell,P., Mekel,M., Kozlov,A.G., Mooren,O.L., Lohman,T.M. and
            Cooper,J.A.
  TITLE     Comparative Analysis of CPI-Motif Regulation of Biochemical
            Functions of Actin Capping Protein
  JOURNAL   Biochemistry 59 (11), 1202-1215 (2020)
   PUBMED   32133840
  REMARK    GeneRIF: Comparative Analysis of CPI-Motif Regulation of
            Biochemical Functions of Actin Capping Protein.
REFERENCE   4  (bases 1 to 3191)
  AUTHORS   Johnston,A.B., Hilton,D.M., McConnell,P., Johnson,B., Harris,M.T.,
            Simone,A., Amarasinghe,G.K., Cooper,J.A. and Goode,B.L.
  TITLE     A novel mode of capping protein-regulation by twinfilin
  JOURNAL   Elife 7, e41313 (2018)
   PUBMED   30351272
  REMARK    GeneRIF: Here, the authors discover that the C-terminal tail of
            Twinfilin harbors a capping protein-interacting (CPI) motif,
            identifying it as a novel CPI-motif protein. Twinfilin binds
            competitively with CARMIL to capping protein, protecting capping
            protein from barbed-end displacement by CARMIL.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3191)
  AUTHORS   Pyle,W.G., La Rotta,G., de Tombe,P.P., Sumandea,M.P. and
            Solaro,R.J.
  TITLE     Control of cardiac myofilament activation and PKC-betaII signaling
            through the actin capping protein, CapZ
  JOURNAL   J Mol Cell Cardiol 41 (3), 537-543 (2006)
   PUBMED   16870209
  REMARK    GeneRIF: CapZ is an important component in anchoring PKC-beta(II)
            at the myofilaments, and for mediating the effects of PKC-beta(II)
            on myofilament function
REFERENCE   6  (bases 1 to 3191)
  AUTHORS   Yang,C., Pring,M., Wear,M.A., Huang,M., Cooper,J.A., Svitkina,T.M.
            and Zigmond,S.H.
  TITLE     Mammalian CARMIL inhibits actin filament capping by capping protein
  JOURNAL   Dev Cell 9 (2), 209-221 (2005)
   PUBMED   16054028
  REMARK    GeneRIF: Mouse homolog of the adaptor protein CARMIL (mCARMIL)
            binds CP with high affinity and decreases its affinity for the
            barbed end
REFERENCE   7  (bases 1 to 3191)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   8  (bases 1 to 3191)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   9  (bases 1 to 3191)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Mapping of the mouse actin capping protein alpha subunit genes and
            pseudogenes
  JOURNAL   Genomics 39 (3), 264-270 (1997)
   PUBMED   9119363
REFERENCE   10 (bases 1 to 3191)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Vertebrates have conserved capping protein alpha isoforms with
            specific expression patterns
  JOURNAL   Cell Motil Cytoskeleton 38 (2), 120-132 (1997)
   PUBMED   9331217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161370.1, BC085506.1, U16740.1, AK147049.1 and BY442029.1.
            
            On Sep 20, 2017 this sequence version replaced NM_009797.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161370.1, AK147049.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK161370.1         2-126
            126-2365            BC085506.1         1-2240
            2366-3023           U16740.1           2236-2893
            3024-3187           AK147049.1         2913-3076
            3188-3191           BY442029.1         381-384
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.88 cM"
     gene            1..3191
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 1"
                     /db_xref="GeneID:12340"
                     /db_xref="MGI:MGI:106227"
     exon            1..166
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..230
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..282
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..346
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..553
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..633
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..712
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..784
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..847
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..3191
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /note="hexamer: AATACA"
     polyA_site      3039
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /note="major polyA site"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
                     /note="hexamer: AGTAAA"
     polyA_site      3190
                     /gene="Capza1"
                     /gene_synonym="Cappa1; CAPZ; capZ alpha-1; CAZ1"
ORIGIN      
        1 gacatggcgc cctcttggcc tgagcttccg ggcggctcct tccgacggcc cctcggtgat
       61 tccgccactc agcttccttc ccggcctgcc tcgcgccggc ccgccgggct gggccagagc
      121 agccaagatg gccgactttg aggatcgggt gtcggatgaa gagaaggtcc gcatagccgc
      181 taaattcatc acccatgcac ccccagggga gtttaatgaa gtattcaatg atgtccggct
      241 actgcttaac aatgacaatc tcctcaggga aggggcagca catgcatttg cccagtataa
      301 catggatcag ttcacacccg tgaagataga aggctacgat gaccaggtct taattacaga
      361 gcatggtgac cttggtaaca gcagattttt agatccaaga aaccaaattt cctttaagtt
      421 tgatcattta cggaaagaag caagtgaccc gcagccagag gatgtggatg gaggcttgaa
      481 gtcttggagg gagtcgtgtg acagtgctct gagagcctat gtgaaagatc attattccaa
      541 cggcttctgt actgtttacg ctaaaactat agatgggcaa cagaccatta ttgcatgtat
      601 tgaaagccac cagtttcaac caaaaaactt ctggaatggt cgctggagat cagagtggaa
      661 gttcaccatt acaccacctt cagcccaggt ggttggagta ctcaagattc aggttcatta
      721 ttatgaagat ggcaatgttc agctggttag tcataaagat gtgcaggact cagtaactgt
      781 ttctaatgaa atccaaacta ccaaggagtt tattaaaatc atagagagtg cagaaaatga
      841 gtatcagaca gcaattagtg aaaattacca aactatgtca gacaccacgt tcaaggcctt
      901 gcgccggcag cttccagtta cccgcaccaa aatcgactgg aacaagatac tcagttacaa
      961 gattggcaaa gaaatgcaga atgcttaaag gccgtctcta ggagtctcca gtacatggaa
     1021 agaaaaggat tcaacacggt gtggtcatat gacgaataag tgatttataa acaaacaaga
     1081 gtgatatttt gctagttaac aaagttaaca gatcttctag cctcatggaa tactgttgaa
     1141 cctacagcac tgtcttgatt cttttgtgtg tgttctttgc tttgtaattt tctgttatca
     1201 ctatatctac ttgtaaatct ttttttttaa ttctgctaca tttaatgtcg aagagctata
     1261 tcctgaagtc attttactgt ttagaacatt tcctagccat gcagtcctag gactggtttt
     1321 tacagagtat ctgttgagta ctttttaccc ctgtgcttta aagcacttcc agtgcttcag
     1381 tggcttttag tgatccacca attgctgaag aggctatgct accaagagct aagtggacaa
     1441 cacactcctt ctctgtccga ctgctttggt catttacagc atctcacaat tgtagatttc
     1501 agacatttgg attggggctt ttggggtcca tgttgggagg caaagtttcc tggaaattcc
     1561 atggcagcag cttctctagg gtcttgattt taaatccaaa gacttgaacc acatcccctg
     1621 ctgcacatga atgtttgctt actttcattt tctcattgtc tcctcccatc tggttctgtt
     1681 gtaaccatgg atgtctgtag gaagaacagc ctagagaaag cactgggaaa ccagggttgt
     1741 cagtcccatg ggtctgtttc cctcagtgga aggaagtgaa ggatgcctga tgactagtat
     1801 gctggagtgc tgtgctcaga cagcctgatg agcctctgct cactgtgaag gaccagcctc
     1861 cacctcaatc tctctcaccc accccatgtt ctgagcaatg tttagaccct aatactggcc
     1921 tttgtctctc agtgagtaga acttatgccg attcatatcc ttcctctctg ggccctcgtc
     1981 ctaagttctg tttttcagtc aatagagttc atgtttattg taaaggtcac aggtgcttta
     2041 ctaccttgca agggacttta gatgtagccg gccctgaagc tttgttataa gagttgtcac
     2101 acagagactt ttccccagag ttctactatg tttaaatgtg tggaaaaatt aaaacatagg
     2161 atcagagtcc agaagtcttg atccagtctg accaagtctg gctataccaa gttttcattc
     2221 ttatccatcc tgggtccact tttcctgcca gtggcaatac ctgcagaaac gcctcaacag
     2281 atgttggcat ttttagaaga gttttgccca ttagtattgc tctttcatag ttgagaactg
     2341 ctgacatact atcaatgtag tagaatataa aacttgaaaa cacagacatt gaaggaatca
     2401 taggtatttt tgctttatgc tctctggcag gattgttctg taagcagacg aataaatagc
     2461 tgtgtccctc acaaagctgg aatgaaccaa agtgaaaagg acggttccca ggcagcatct
     2521 gtcagtatgt cagagtgcta gtgcttcctt ctaaacagga tgaccaagtc attccagttc
     2581 atcttttcca tcatcctacc tgcctagaac tcatgtgtaa ctgtgatata gctaccttcc
     2641 caggtatatt ggcaggtgtg tgtgtgtgtg tgtgatctca gaacacacag gtaatgtgat
     2701 gtgacctatg acaactggta atggtggatt catttacatt gtttacactt ctatgaccag
     2761 gccttagggg aaggtcagtt ttttaaaaac caagtagtgt cttcctacct gtccccaagt
     2821 acaaggtaaa acagaaggct gttggcttca gctttctttt cttttttgct cagtaatact
     2881 gtcaagcagg agtttgtttg caaatgaaag ctgtgtaagc atttttgttt atttcaaata
     2941 aaatatattt gtattatttg tcattcatac tatccatcca tgccacactg tcttctgtac
     3001 caggtagccc aatagaaata cacctgtttt gttctaaaat tgtgtctgtc ctttctgtcc
     3061 tgtcaacctt tgttctcaag gtgagatatt caactataat caatctattt gttgagattc
     3121 ttcaaggttt ctgaaattgt atcctacttt ggactagtat agactcagta aatatgcaaa
     3181 gacttgtaaa g
//
