LOCUS       NM_001310675            2838 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus calcyphosphine 2 (Caps2), transcript variant 2, mRNA.
ACCESSION   NM_001310675 XM_006513819
VERSION     NM_001310675.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Fujima,S., Yamaga,R., Minami,H., Mizuno,S., Shinoda,Y.,
            Sadakata,T., Abe,M., Sakimura,K., Sano,Y. and Furuichi,T.
  TITLE     CAPS2 Deficiency Impairs the Release of the Social Peptide
            Oxytocin, as Well as Oxytocin-Associated Social Behavior
  JOURNAL   J Neurosci 41 (20), 4524-4535 (2021)
   PUBMED   33846232
  REMARK    GeneRIF: CAPS2 Deficiency Impairs the Release of the Social Peptide
            Oxytocin, as Well as Oxytocin-Associated Social Behavior.
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Ratai,O., Schirra,C., Rajabov,E., Brunk,I., Ahnert-Hilger,G.,
            Chitirala,P., Becherer,U., Stevens,D.R. and Rettig,J.
  TITLE     An Alternative Exon of CAPS2 Influences Catecholamine Loading into
            LDCVs of Chromaffin Cells
  JOURNAL   J Neurosci 39 (1), 18-27 (2019)
   PUBMED   30389842
  REMARK    GeneRIF: Epigenetic tuning of CAPS variants may allow modulation of
            endocrine adrenaline and noradrenaline release
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Yagishita,K., Suzuki,R., Mizuno,S., Katoh-Semba,R., Sadakata,T.,
            Sano,Y., Furuichi,T. and Shinoda,Y.
  TITLE     CAPS2 deficiency affects environmental enrichment-induced adult
            neurogenesis and differentiation/survival of newborn neurons in the
            hippocampal dentate gyrus
  JOURNAL   Neurosci Lett 661, 121-125 (2017)
   PUBMED   28963059
  REMARK    GeneRIF: that CAPS2 deficiency strongly impairs hippocampal adult
            neurogenesis and maturation of newborn neurons
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Mishima,Y., Shinoda,Y., Sadakata,T., Kojima,M., Wakana,S. and
            Furuichi,T.
  TITLE     Lack of stress responses to long-term effects of corticosterone in
            Caps2 knockout mice
  JOURNAL   Sci Rep 5, 8932 (2015)
   PUBMED   25754523
  REMARK    GeneRIF: These results suggest that Caps2 KO mice have altered
            endocrine responses to CORT administration, while maintaining
            CORT-induced anxiety/depressive-like behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Nguyen Truong,C.Q., Nestvogel,D., Ratai,O., Schirra,C.,
            Stevens,D.R., Brose,N., Rhee,J. and Rettig,J.
  TITLE     Secretory vesicle priming by CAPS is independent of its
            SNARE-binding MUN domain
  JOURNAL   Cell Rep 9 (3), 902-909 (2014)
   PUBMED   25437547
  REMARK    GeneRIF: Naturally occurring splice variants of CAPS2 in
            CAPS1/CAPS2-deficient cells were studied and found that CAPS2
            primes vesicles independently of its MUN domain.
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Sadakata,T., Sekine,Y., Oka,M., Itakura,M., Takahashi,M. and
            Furuichi,T.
  TITLE     Calcium-dependent activator protein for secretion 2 interacts with
            the class II ARF small GTPases and regulates dense-core vesicle
            trafficking
  JOURNAL   FEBS J 279 (3), 384-394 (2012)
   PUBMED   22111578
  REMARK    GeneRIF: CAPS family proteins exert dual roles in DCV trafficking,
            mediating trafficking at both the secretion site for exocytosis and
            at the Golgi complex for biogenesis
REFERENCE   7  (bases 1 to 2838)
  AUTHORS   Shinoda,Y., Sadakata,T., Nakao,K., Katoh-Semba,R., Kinameri,E.,
            Furuya,A., Yanagawa,Y., Hirase,H. and Furuichi,T.
  TITLE     Calcium-dependent activator protein for secretion 2 (CAPS2)
            promotes BDNF secretion and is critical for the development of
            GABAergic interneuron network
  JOURNAL   Proc Natl Acad Sci U S A 108 (1), 373-378 (2011)
   PUBMED   21173225
  REMARK    GeneRIF: CAPS2 promotes activity-dependent brain-derived
            neurotrophic factor secretion during the postnatal period that is
            critical for the development of hippocampal GABAergic networks.
REFERENCE   8  (bases 1 to 2838)
  AUTHORS   Sadakata,T. and Furuichi,T.
  TITLE     Ca(2+)-dependent activator protein for secretion 2 and
            autistic-like phenotypes
  JOURNAL   Neurosci Res 67 (3), 197-202 (2010)
   PUBMED   20302894
  REMARK    GeneRIF: CAPS2 KO mice will be a useful animal model to study the
            aspects of the neuropathology and behavior characteristics of
            neurodevelopmental disorders
            Review article
REFERENCE   9  (bases 1 to 2838)
  AUTHORS   Sadakata,T. and Furuichi,T.
  TITLE     Developmentally regulated Ca2+-dependent activator protein for
            secretion 2 (CAPS2) is involved in BDNF secretion and is associated
            with autism susceptibility
  JOURNAL   Cerebellum 8 (3), 312-322 (2009)
   PUBMED   19238500
  REMARK    GeneRIF: The CAPS2-deficient mice show reduced secretion of BDNF
            and NT-3. And the cerebella of these mice exhibit developmental
            deficits, such as delayed development.
            Review article
REFERENCE   10 (bases 1 to 2838)
  AUTHORS   Wang,S., Chen,J.Z., Zhang,Z., Huang,Q., Gu,S., Ying,K., Xie,Y. and
            Mao,Y.
  TITLE     Cloning, characterization, and expression of calcyphosine 2, a
            novel human gene encoding an EF-hand Ca(2+)-binding protein
  JOURNAL   Biochem Biophys Res Commun 291 (2), 414-420 (2002)
   PUBMED   11846421
  REMARK    GeneRIF: Discusses cloning of the human homolog of mouse Caps2
            (GeneID: 353025).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085286.1 and AC166263.9.
            
            On Jul 16, 2015 this sequence version replaced XM_006513819.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (2) with a shorter N-terminus, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1561              AK085286.1         2-1562
            1562-1614           AC166263.9         179914-179966
            1615-1711           AC166263.9         182660-182756
            1712-2838           AC166263.9         186992-188118
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 60.18 cM"
     gene            1..2838
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /note="calcyphosphine 2"
                     /db_xref="GeneID:353025"
                     /db_xref="MGI:MGI:2441980"
     exon            1..68
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            69..186
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            187..236
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1887
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcyphosin-2; calcyphosine 2"
                     /codon_start=1
                     /product="calcyphosin-2 isoform 2"
                     /protein_id="NP_001297604.1"
                     /db_xref="CCDS:CCDS78896.1"
                     /db_xref="GeneID:353025"
                     /db_xref="MGI:MGI:2441980"
                     /translation="MVPPLDLGSLVDSDEEDNFSQTARGTVHVHLNPPRSEPALGWVL
                     PCQRPNSQHRLQEVEQDVIPEDLPAPTGKYRLKYQQYASEMKDGYKQYIQRSTEKPKA
                     ASRPEATEKVEGASLDDLMTLDRKALLQQGYADSPYGRQSITRKSDVETVAIEKKKQT
                     VAEQMMMDHLSRAVISDPEQDLNTKNQESSRVPPDSERAPLRVRRRTLHETKIRTNSA
                     LTENDLSQKVEFDGRVLSRNGRDACRELIGFFFAHDQSLTVYEYRMFGKNRTSVLPFI
                     KKDIYHHQCGRRKGKQYELGDVYTGATLTFLSCDQPSLPKTIKENALLRLRITNIDQV
                     ALNSLKAASAEHGEEEAVSPEAHDQLVLQAIQDKLKEQLHKKGARILTGLGRYFQGLD
                     KEGNGLLEKADFQQALKTFHLEVSEQDFESFWLILQGYGHSKNKVDYGEFKRAIFGEM
                     NEYRKSFVRKAFMQLDFNKTGIVSVIDIRKCYCAKKHPRVISGHSTEEEIKSSFLETL
                     KGTCSKCDEVSYGEFEDYYEGLSIGVAGDEDFVNILRIPWRI"
     exon            237..282
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..408
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            409..567
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            568..681
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            682..749
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..869
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..944
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1040
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1134
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1253
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1333
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1488
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1614
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1711
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2838
                     /gene="Caps2"
                     /gene_synonym="D630005B03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctagcaac cagagactct ggtctagact gttgtgtttt ctgggacctg ctcctgagtt
       61 tgccaaggaa tatagcacat tgcacgggaa acacaaacat tcgaatggat ttagaggtaa
      121 aaggagtggc tgcctcaaga agccagactc ggctattttc tggaagaaag aattcactgc
      181 aagtatcaag gatggacttc tagatcatgg acaaaccaaa attcctgcct acctatggtc
      241 ccaccacttg atctgggaag ccttgttgac tctgatgagg aggataattt ttcacaaaca
      301 gcacgtggta cagtccatgt tcatcttaac ccaccgcggt cagagcctgc tctgggctgg
      361 gttctgccat gtcaaagacc taacagtcag catcgactac aggaagtgga acaggacgta
      421 atacctgagg atttgccagc gccaacaggc aaatacaggc taaagtacca gcagtacgca
      481 agtgaaatga aagacggcta caagcagtat attcagagga gtacagagaa gccaaaggca
      541 gccagcaggc cagaggcaac cgagaaggtg gaaggagcca gtctggatga cctcatgact
      601 ttggatagga aggccctctt acagcaaggt tacgcagata gcccttacgg tagacagagc
      661 atcacgagga aatcagatgt ggagactgtg gctatagaga agaagaaaca gaccgttgca
      721 gagcagatga tgatggacca cttatccagg gctgtcatca gcgacccaga acaagattta
      781 aacaccaaga accaagagag ttctcgtgtc cctccagact cagagagggc gccacttcgc
      841 gtcaggagac gaactctgca tgaaacgaag ataagaacca actctgcatt aacagagaat
      901 gacctttctc agaaagtaga atttgacggg agggtcttat caagaaatgg acgcgatgcc
      961 tgccgggaac taattgggtt tttctttgcc cacgaccagt ccctaactgt gtatgaatat
     1021 cggatgttcg ggaaaaacag aacaagtgtg cttcctttta ttaaaaaaga catttatcat
     1081 catcagtgtg gacgaagaaa aggaaagcaa tatgagcttg gtgacgtcta tactggtgca
     1141 actttgacat ttttgagctg tgatcaacct agccttccaa agaccataaa agaaaatgca
     1201 ttgcttagac ttcgaattac aaatattgat caagtagctt tgaattctct gaaagctgcc
     1261 tctgcggaac atggggaaga agaggcagtc agtccggagg ctcatgatca gttggtgcta
     1321 caggccattc aggataaatt gaaagaacaa ctgcacaaga agggtgctcg tattttgact
     1381 ggattgggaa gatacttcca aggtttggac aaggaaggga atgggctttt agaaaaggca
     1441 gattttcagc aagctctgaa aacctttcac ttggaagtgt ctgaacagga ctttgagtct
     1501 ttctggctaa ttctgcaagg atatggccat agcaagaaca aggttgacta tggagaattc
     1561 aaacgtgcca tttttggtga aatgaatgaa tataggaagt catttgttcg caaggccttc
     1621 atgcaactgg attttaacaa aaccggcatt gtgtctgtaa tagacataag aaagtgttac
     1681 tgcgccaaga agcatccacg tgtgatctca gggcattcaa cagaggagga aatcaaatca
     1741 tctttcctag agacgttaaa aggcacctgc agcaagtgcg atgaagtttc atacggagaa
     1801 ttcgaagatt actatgaagg cctaagtata ggggtagcag gcgatgaaga ctttgtcaac
     1861 atcttacgta ttccgtggag aatttagttt tcaataacgc tccttctcgc tggcaccaag
     1921 tatcttatag ataatatgca ttttatataa aatatgaaaa ccttgtaata tattttctag
     1981 gattctttat aatttgtttc caaagtggag tctagaaagg ccaatttgga aatagatgtg
     2041 tgcttttgag aacatatgca tgccatatgc ttataaaggt agttcttttt gctcattctt
     2101 atcttatact tattatatat cttatttatt atacttacag ttcttacagt tatcatatcc
     2161 ttatcctaca aggataaggt ggtccttatc ttatccttat accttataca tcttatactt
     2221 atcttagaaa agtagttaaa aaattagcct tagtagaaaa ctaacatttt tagtaaacta
     2281 tatgacggct tgtatatagt gatcattttc tgtccattct cagttttctt ataacgtgtc
     2341 tctagaatac agttgtcacc attctcaatt taatgacatg ggattcagat caaggctgaa
     2401 gtagtgcaac ttgtttgaaa cttatgaaaa tattcaatta tctgcaaaag caacattaaa
     2461 ttcagtatga ttataggtgt tttctatgca ttatattttg aatggttggt gtttactcct
     2521 caatgtttct ttaaagagaa ttatcattta tttttgtctt caaaattata tactgttctt
     2581 tgttcactgg gagaattaca gtgtattttc tattttaact gtcatattgt ctgcatacaa
     2641 aatgtttctt atgtgtaaag aacaaaatgt aggaaccttg gagtgtacaa atgttccctt
     2701 agaccattaa atgaagaatt caaagataat tcaatgattt ttgtacaaaa tgtgaaagca
     2761 tcctttatat cataaaataa agatgtgaca ttctgagcaa ccctttttgg aacaataaac
     2821 aaccagaaca ttttcttc
//
