LOCUS       NM_001411635            3692 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus caprin family member 2 (Caprin2), transcript variant
            3, mRNA.
ACCESSION   NM_001411635
VERSION     NM_001411635.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Nakazawa,K., Shichino,Y., Iwasaki,S. and Shiina,N.
  TITLE     Implications of RNG140 (caprin2)-mediated translational regulation
            in eye lens differentiation
  JOURNAL   J Biol Chem 295 (44), 15029-15044 (2020)
   PUBMED   32839273
  REMARK    GeneRIF: Implications of RNG140 (caprin2)-mediated translational
            regulation in eye lens differentiation.
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Dash,S., Dang,C.A., Beebe,D.C. and Lachke,S.A.
  TITLE     Deficiency of the RNA binding protein caprin2 causes lens defects
            and features of Peters anomaly
  JOURNAL   Dev Dyn 244 (10), 1313-1327 (2015)
   PUBMED   26177727
  REMARK    GeneRIF: functions in distinct morphological events in mammalian
            eye development
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   Shiina,N. and Tokunaga,M.
  TITLE     RNA granule protein 140 (RNG140), a paralog of RNG105 localized to
            distinct RNA granules in neuronal dendrites in the adult vertebrate
            brain
  JOURNAL   J Biol Chem 285 (31), 24260-24269 (2010)
   PUBMED   20516077
  REMARK    GeneRIF: RNG140 has roles in the maintenance of the dendritic
            structure in the adult vertebrate brain through localizing to a
            kind of RNA granules that are distinct from RNG105-containing
            granules
REFERENCE   7  (bases 1 to 3692)
  AUTHORS   Loren,C.E., Schrader,J.W., Ahlgren,U. and Gunhaga,L.
  TITLE     FGF signals induce Caprin2 expression in the vertebrate lens
  JOURNAL   Differentiation 77 (4), 386-394 (2009)
   PUBMED   19275872
  REMARK    GeneRIF: The authors have isolated and characterized mouse
            cytoplasmic activation/proliferation-associated protein-2
            (Caprin2), with domains belonging to both the Caprin family and the
            C1q and tumour necrosis factor (TNF) super-family
REFERENCE   8  (bases 1 to 3692)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134542.3.
            
            Summary: This gene encodes a member of the caprin family. The
            encoded protein may function as an RNA-binding protein that induces
            the formation of RNA granules and plays an important role in brain
            function. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.1316192.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC134542.3         166621-166785       c
            166-435             AC134542.3         165540-165809       c
            436-498             AC134542.3         161212-161274       c
            499-585             AC134542.3         154051-154137       c
            586-824             AC134542.3         148345-148583       c
            825-907             AC134542.3         147056-147138       c
            908-1063            AC134542.3         143611-143766       c
            1064-1107           AC134542.3         141216-141259       c
            1108-1764           AC134542.3         139592-140248       c
            1765-1887           AC134542.3         136433-136555       c
            1888-1957           AC134542.3         134106-134175       c
            1958-2022           AC134542.3         133007-133071       c
            2023-2124           AC134542.3         131090-131191       c
            2125-2265           AC134542.3         129204-129344       c
            2266-2434           AC134542.3         121878-122046       c
            2435-2620           AC134542.3         118709-118894       c
            2621-2721           AC134542.3         116756-116856       c
            2722-2785           AC134542.3         115775-115838       c
            2786-3692           AC134542.3         113095-114001       c
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.62 cM"
     gene            1..3692
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /note="caprin family member 2"
                     /db_xref="GeneID:232560"
                     /db_xref="MGI:MGI:2448541"
     exon            1..165
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            166..435
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..3354
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /note="isoform 1 is encoded by transcript variant 3; C1q
                     domain containing 1; caprin-2; RNA granule protein 140;
                     C1q domain-containing protein 1; cytoplasmic
                     activation/proliferation-associated protein 2; adiponectin
                     r"
                     /codon_start=1
                     /product="caprin-2 isoform 1"
                     /protein_id="NP_001398564.1"
                     /db_xref="GeneID:232560"
                     /db_xref="MGI:MGI:2448541"
                     /translation="MKSAKSQVNQDQQGENQRALSPLQSTLSSAASPSQAYETYIDNG
                     LICLKHKIRNIEKKKLKLEDYKDRLKNGEQLNPDQLEAVEKYEEVLHNLEFAKELQKT
                     FSALSQDLLKAQKKAQRREHMLKLETEKKKLRTMLQIQYVLQNLTQEHVQKDFKGGLN
                     GAMYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKTVVGTTYK
                     HVKDLLSKLLHSGYFESVPVLRNSKEKAEEVLMQSEMKKQLLKSESIKESESLTELVQ
                     PEIQPQEFLNRRYMTEVKFSRKQENVEQSWEADYARKPSLLKCWNTLPEPDGQEKKKE
                     SLESWKSSLKTQEVSKPVVSLVQGKLRPTLQEEQKQQVPITPVSQWKPESPKSKVGSP
                     QEEQNVQETPKPWVVQSQKEQDPKKLPPGSWAVSVQSEQSGSRSWTTPVCREQASVQP
                     GTPVSWENNAENQKHSLVPQSQISLKSWGAASAGLLPNGQVLTRKLNVEPKDVPKPLP
                     QPIDSSSALPKDPVLRKEKLQDLMSQIQGTYNFMQESVLDFDKPSSAIPSSQPPSACP
                     VSTVSAEQNLSNQSDFLQEPSQASSPVTCSSNACLVTTDQASSGSETEFTTSETPEMV
                     VSPCKPKPASALASPNPPLSKSFQLPPASGSSEAISTAPFQAMQTVFNVNAPLPPRKE
                     QEMKEPPYSSGYNQNFTSSSTQTVSQCQLPAVHIDQTTQPPETGAGYHPDGTVQVSNG
                     SLAFYPAPTSMFPRPAQPFISSRGTLRGCSHGGRLLMSSYQSPGGYKGFDSYRGLPSV
                     SSGNYSQLQLQAREYSGTAYSQRDNFQQCYKRSGTSSGLQANSRAGWSDSSQVSSPER
                     DSETFNSGDSGLGDSRSMTPVDVPVTSPAAAILPVHIYPLPQQMRVAFSAARTSNLAP
                     GTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNE
                     EVLVSAYANDGAPDHETASNHAVLQLLQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQ
                     D"
     exon            436..498
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            499..585
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            586..824
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            825..907
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1063
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1107
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1764
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1887
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1957
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2022
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2124
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2265
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2434
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2620
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2721
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2785
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3692
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /note="hexamer: AATAAA"
     polyA_site      3692
                     /gene="Caprin2"
                     /gene_synonym="Adir; C1qdc1; Eeg1; rng140"
                     /note="major polyA site"
ORIGIN      
        1 agcttgggcg cgagcagcgg agttggctgg gtgcactgtc ggcggtggcc gcaggctaag
       61 ctgaggcggg aggaagggac gcggggggag aagggagtgc ggggtggagt tcgcccactt
      121 tgcagcgcgc aggactcccg cgcgctttcg gaggcagccg gggagcctca tctgtttcag
      181 tggtgcaact ctctccatcc cttttcggtt accagtcacc ttcaggccgg ccattcagag
      241 gagggaaaag tgggaagtat gaagtcagcc aagtcccaag tgaaccagga tcagcaaggg
      301 gaaaaccagc gggctctgag ccccctgcag tctactctca gttctgctgc atctccttcc
      361 caggcatatg aaacctatat tgataatgga cttatatgcc ttaaacacaa aattaggaac
      421 atcgagaaga agaagctcaa actggaagat tataaagatc gccttaaaaa tggagagcag
      481 cttaacccag accagttgga agcagtagaa aagtatgaag aagtacttca taatttggaa
      541 tttgccaagg agcttcagaa aactttttct gcactgagcc aagatctgct gaaagcgcag
      601 aaaaaggccc agagaaggga gcatatgctg aaacttgaga ctgagaagaa aaagcttcga
      661 actatgcttc aaattcagta tgtattacag aatttgacac aagaacatgt acaaaaagac
      721 ttcaaagggg gcttgaatgg tgcaatgtat ttgccttcaa aagaacttga ctacctcatt
      781 aaattctcaa aactgacctg ccctgaaaga aatgaaagtc tgagtgttga agaccagatg
      841 gagcagtcat ccttgtactt ttgggacctt ttggaaggta gtgaaaaaac agtggtagga
      901 acaacatata aacatgtgaa agacctgctg tctaaattgc tgcactcagg ttattttgaa
      961 agtgtcccag ttctcaggaa ttctaaggaa aaagcagaag aagtgctaat gcaatcagaa
     1021 atgaaaaaac agttactgaa gagtgagtct atcaaagagt cagaatctct tacggaactt
     1081 gtacaaccag agatacagcc acaagagttt cttaacagac gctatatgac agaagtaaaa
     1141 ttttcaagaa aacaagaaaa tgtagaacaa tcctgggaag cagattatgc taggaaacca
     1201 agtctcctca aatgctggaa tacacttcca gagccagatg gtcaggagaa gaagaaagag
     1261 tccttggagt cctggaagtc ttctcttaag actcaggagg tatcaaagcc tgtggtttcc
     1321 ttagtacagg ggaaactcag gccaacattg caggaagagc agaagcagca ggttcctata
     1381 acacctgtca gtcagtggaa gccagaaagc cctaagtcca aagtgggcag tcctcaagaa
     1441 gagcagaatg tacaggagac accaaagcca tgggtggttc agtcacagaa agaacaagat
     1501 ccaaagaagc tgcctcctgg atcctgggca gtatctgtgc agagtgaaca gagtggcagc
     1561 agatcctgga ccacccctgt gtgcagagaa caggcttcag tgcagcctgg gactccagta
     1621 tcctgggaaa acaatgctga gaaccagaaa cactccttag taccacaatc acagatttct
     1681 ctaaagtcct ggggagcagc ttcagcaggc ctcttaccaa atggccaagt cctgacgagg
     1741 aagttaaatg tagaacccaa agatgtgcct aagcccctgc ctcagcctat agactcttct
     1801 tctgcccttc caaaggatcc agtattgagg aaagaaaaac tgcaggacct catgagccag
     1861 attcaaggaa cttataactt tatgcaagag tctgttctag attttgacaa accctcaagt
     1921 gcaattccat catcacagcc gccttcagct tgtccagtct ctacagtatc tgcagaacaa
     1981 aacttgtcca accaaagtga ttttcttcaa gaaccatcac aggcctcttc tccggttact
     2041 tgtagctcaa atgcttgctt ggtgactact gatcaggctt cttcgggatc tgaaacagag
     2101 tttacgacct cagagacccc tgagatggtg gtctccccct gcaagccaaa gccagcttct
     2161 gcacttgctt ctccaaatcc tcccctgtca aagagcttcc agttacctcc tgcaagtggg
     2221 agttcagaag ccattagcac agcacctttt caggccatgc agacagtgtt taatgttaat
     2281 gcacctctgc ctccacggaa agaacaagaa atgaaagaac ctccttattc atctggctac
     2341 aatcaaaatt ttacttcatc aagtacacag acagtatccc aatgccagct cccagctgta
     2401 cacatagacc agacaactca gcctccagag actggtgcag gttatcatcc tgatggaact
     2461 gttcaagtaa gcaatggcag ccttgccttt tacccagcac ccacgagtat gtttcccaga
     2521 cctgctcagc catttatcag tagtcggggg actctgagag ggtgttcaca tggagggagg
     2581 ttactaatga gttcctatca gtctcctggt ggctacaaag gttttgatag ttacagagga
     2641 cttccttcag tttcaagtgg gaattacagc cagctgcagc tgcaagctag agaatattct
     2701 ggaacagctt actctcaaag ggataatttc cagcagtgtt ataaaagatc agggacatct
     2761 agtggtcttc aggcaaattc aagagcaggg tggagtgact cctctcaggt gagcagccca
     2821 gaaagagaca gcgagacttt taacagtgga gactctgggc taggagactc tcggagcatg
     2881 accccagtgg atgtgccagt gacaagccca gcagccgcca tcctgccagt ccatatctat
     2941 cccctgcctc agcaaatgcg agttgccttc tcagctgcca gaacatccaa tctggctcct
     3001 ggaactttag accaacctat tgtgtttgat cttctcctga acaacttggg agagaccttt
     3061 gatcttcagc ttggtagatt caattgccca gtgaatggca cttacgtgtt catttttcac
     3121 atgctaaagc tggctgtgaa tgtaccactg tatgtcaacc tgatgaagaa tgaggaggtc
     3181 ttggtgtcag cctatgccaa cgatggtgct ccagaccatg agacagcaag caaccatgcc
     3241 gttctccagc tcctccaggg agaccagata tggctgcgct tacacagggg agcgatttat
     3301 ggaagtagct ggaaatactc tacattttca ggctatcttc tttatcaaga ttaaaattca
     3361 gttcagaata aaagaatgaa gttctcacta gtggatctaa ggaaaagcag tccttgccct
     3421 agtgattgac tggttgggaa aaatattttt gttcctagag aaagaaggag gtcctcactt
     3481 ttttgttttc cattttatgt gaagactttg aagcagaatg ataattagca ctaactttat
     3541 aaattgtgat gtagccttgc tagtcacaca gcgaatgtgt attgtttgca cttaatcctg
     3601 aactgtgtta atggtcagct tactgaattg aatgcctcaa cttcagataa gttaccatgc
     3661 ctcgttgtgc ctcaataaaa atttaaactg ca
//
