LOCUS       NM_001412568            6127 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cell cycle associated protein 1 (Caprin1), transcript
            variant 6, mRNA.
ACCESSION   NM_001412568
VERSION     NM_001412568.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6127)
  AUTHORS   Viegas,J.O., Azad,G.K., Lv,Y., Fishman,L., Paltiel,T.,
            Pattabiraman,S., Park,J.E., Kaganovich,D., Sze,S.K., Rabani,M.,
            Esteban,M.A. and Meshorer,E.
  TITLE     RNA degradation eliminates developmental transcripts during murine
            embryonic stem cell differentiation via CAPRIN1-XRN2
  JOURNAL   Dev Cell 57 (24), 2731-2744 (2022)
   PUBMED   36495875
  REMARK    GeneRIF: RNA degradation eliminates developmental transcripts
            during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
REFERENCE   2  (bases 1 to 6127)
  AUTHORS   Nolan,L.S., Chen,J., Goncalves,A.C., Bullen,A., Towers,E.R.,
            Steel,K.P., Dawson,S.J. and Gale,J.E.
  TITLE     Targeted deletion of the RNA-binding protein Caprin1 leads to
            progressive hearing loss and impairs recovery from noise exposure
            in mice
  JOURNAL   Sci Rep 12 (1), 2444 (2022)
   PUBMED   35165318
  REMARK    GeneRIF: Targeted deletion of the RNA-binding protein Caprin1 leads
            to progressive hearing loss and impairs recovery from noise
            exposure in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6127)
  AUTHORS   Valdez-Sinon,A.N., Lai,A., Shi,L., Lancaster,C.L., Gokhale,A.,
            Faundez,V. and Bassell,G.J.
  TITLE     Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons
            through an FMRP-Dependent Mechanism
  JOURNAL   iScience 23 (5), 101132 (2020)
   PUBMED   32434143
REFERENCE   4  (bases 1 to 6127)
  AUTHORS   Nakayama,K., Ohashi,R., Shinoda,Y., Yamazaki,M., Abe,M.,
            Fujikawa,A., Shigenobu,S., Futatsugi,A., Noda,M., Mikoshiba,K.,
            Furuichi,T., Sakimura,K. and Shiina,N.
  TITLE     RNG105/caprin1, an RNA granule protein for dendritic mRNA
            localization, is essential for long-term memory formation
  JOURNAL   Elife 6, e29677 (2017)
   PUBMED   29157358
  REMARK    GeneRIF: Thus, RNG105 has an essential role, as a key regulator of
            dendritic mRNA localization, in long-term memory formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6127)
  AUTHORS   Kedersha,N., Panas,M.D., Achorn,C.A., Lyons,S., Tisdale,S.,
            Hickman,T., Thomas,M., Lieberman,J., McInerney,G.M., Ivanov,P. and
            Anderson,P.
  TITLE     G3BP-Caprin1-USP10 complexes mediate stress granule condensation
            and associate with 40S subunits
  JOURNAL   J Cell Biol 212 (7), 845-860 (2016)
   PUBMED   27022092
  REMARK    Erratum:[J Cell Biol. 2020 Jan 6;219(1):e20150802809202019c. doi:
            10.1083/jcb.20150802809202019c.. PMID: 31851327]
REFERENCE   6  (bases 1 to 6127)
  AUTHORS   Shiina,N., Shinkura,K. and Tokunaga,M.
  TITLE     A novel RNA-binding protein in neuronal RNA granules: regulatory
            machinery for local translation
  JOURNAL   J Neurosci 25 (17), 4420-4434 (2005)
   PUBMED   15858068
REFERENCE   7  (bases 1 to 6127)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 6127)
  AUTHORS   Grill,B., Wilson,G.M., Zhang,K.X., Wang,B., Doyonnas,R.,
            Quadroni,M. and Schrader,J.W.
  TITLE     Activation/division of lymphocytes results in increased levels of
            cytoplasmic activation/proliferation-associated protein-1:
            prototype of a new family of proteins
  JOURNAL   J Immunol 172 (4), 2389-2400 (2004)
   PUBMED   14764709
  REMARK    GeneRIF: Overexpression of a fusion protein of enhanced green
            fluorescent protein and caprin-1 induces dose-dependent suppression
            of the proliferation of NIH-3T3 cells, consistent with the notion
            that caprin-1 plays a role in cellular activation or proliferation.
REFERENCE   9  (bases 1 to 6127)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6127)
  AUTHORS   Gessler,M., Klamt,B., Tsaoussidou,S., Ellis,J.A. and Luzio,J.P.
  TITLE     The gene encoding the GPI-anchored membrane protein p137GPI (M11S1)
            maps to human chromosome 11p13 and is highly conserved in the mouse
  JOURNAL   Genomics 32 (1), 169-170 (1996)
   PUBMED   8786113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX537331.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.156214.1,
                                           SRR7345562.2014531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               BX537331.2         161723-161861       c
            140-349             BX537331.2         160991-161200       c
            350-412             BX537331.2         147403-147465       c
            413-499             BX537331.2         147216-147302       c
            500-738             BX537331.2         143593-143831       c
            739-821             BX537331.2         143424-143506       c
            822-959             BX537331.2         142223-142360       c
            960-1012            BX537331.2         140365-140417       c
            1013-1099           BX537331.2         140194-140280       c
            1100-1255           BX537331.2         139870-140025       c
            1256-1364           BX537331.2         139677-139785       c
            1365-1426           BX537331.2         137994-138055       c
            1427-1537           BX537331.2         137234-137344       c
            1538-1687           BX537331.2         136929-137078       c
            1688-1838           BX537331.2         135957-136107       c
            1839-2033           BX537331.2         133695-133889       c
            2034-2134           BX537331.2         133063-133163       c
            2135-2210           BX537331.2         132666-132741       c
            2211-6127           BX537331.2         127207-131123       c
FEATURES             Location/Qualifiers
     source          1..6127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..6127
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="cell cycle associated protein 1"
                     /db_xref="GeneID:53872"
                     /db_xref="MGI:MGI:1858234"
     exon            1..139
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2275
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="isoform d is encoded by transcript variant 6;
                     cytoplasmic activation/proliferation-associated protein 1;
                     GPI-anchored membrane protein 1; RNA granule protein 105;
                     p137GPI; GPI-p137; GPI-anchored protein p137; membrane
                     component chromosome 11 surface marker 1; cytoplasmic
                     activation- and proliferation-associated protein 1"
                     /codon_start=1
                     /product="caprin-1 isoform d"
                     /protein_id="NP_001399497.1"
                     /db_xref="GeneID:53872"
                     /db_xref="MGI:MGI:1858234"
                     /translation="MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGT
                     GAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTN
                     NLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDD
                     DVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEG
                     KEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPTVEDQVAEAEPE
                     PAEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWTVETVEVVNSLQQQPQAASP
                     SVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQP
                     MNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPS
                     HATEQRPQKEPMDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNA
                     APFQSMQTVFNMNAPVPPANEPETLKQQSQYQATYNQSFSSQPHQVEQTELQQDQLQT
                     VVGTYHGSQDQPHQVPGNHQQPPQQNTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYR
                     GPANGFRGGYDGYRPSFSNTPNSGYSQSQFTAPRDYSGYQRLVFQDGYQQNFKRGSGQ
                     SGPRGAPRGRGGPPRPNRGMPQMNTQQVN"
     exon            140..349
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            350..412
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            413..499
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            500..738
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            739..821
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            822..959
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1012
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1099
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1255
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1364
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1426
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1537
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1687
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1838
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2033
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2134
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2210
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..6127
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="hexamer: AATAAG"
     polyA_site      4061
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="major polyA site"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="hexamer: ATTAAA"
     polyA_site      4933
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
     polyA_site      6052
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
     regulatory      6106..6111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
                     /note="hexamer: AATAAA"
     polyA_site      6127
                     /gene="Caprin1"
                     /gene_synonym="Caprin-1; Gpiap; Gpiap1; Mmgpip137; P137;
                     rng105"
ORIGIN      
        1 actaggagca gctcagagcc gcggggacag ggcgaagcgg cctgcgccca cggagcgcac
       61 gtctctgttc tcaacgcagc accacccttg cccccctcgg ctgcccactc cagacgtcca
      121 gcggctccgc gcgcgcacga tgccctcggc caccagccac agcggaagcg gcagcaaatc
      181 gtcgggaccg ccgccgccgt ccggttcctc cgggagtgag gcggcggccg gggcagctgc
      241 gccggcttct cagcatccgg caaccggcac cggcgccgtc cagaccgagg ccatgaagca
      301 gattctcggc gtaatcgaca agaaacttcg gaacctggag aagaaaaagg gtaaacttga
      361 tgattaccag gaacgaatga ataaagggga aaggctcaat caagaccagc tggatgccgt
      421 atctaagtac caggaagtca caaataattt ggagtttgca aaggaattac agaggagttt
      481 catggcatta agtcaagata ttcagaaaac aataaagaag acagcacgtc gggaacagct
      541 tatgagagaa gaagcagaac agaagcgctt aaaaactgta cttgagttac agtatgtatt
      601 ggataagctg ggagatgatg atgtgagaac agatctgaaa caaggtttga gtggagtgcc
      661 aatattgtct gaggaggagt tgtcattgct ggatgagttc tacaagctcg tagatcctga
      721 gcgtgacatg agtttaaggt taaatgagca gtatgaacat gcctcaattc acttgtggga
      781 tttgctggaa gggaaagaaa agcctgtgtg tggaacaacc tataaagctc taaaggaaat
      841 tgttgagcgt gttttccagt caaactactt tgatagcact cacaatcatc aaaatgggtt
      901 gtgtgaggag gaagaggcgg cttcagcgcc cacagtggag gaccaggtag ctgaagctga
      961 acctgagcca gcggaagaat acacagagca aagtgaggtt gaatcaacag agtatgtcaa
     1021 taggcagttc atggcagaaa cacagttcag cagtggtgag aaggagcaag tggatgagtg
     1081 gacagttgaa acagttgagg ttgtaaactc actccagcag caacctcagg ctgcgtcccc
     1141 ttcagtccca gagccccact ctttgactcc agtggctcag tcagatccac ttgtgagaag
     1201 gcagcgtgta caagatctta tggcacaaat gcaagggccc tataatttca tacaggattc
     1261 aatgttggat tttgaaaatc agacgcttga tcctgccatt gtatccgcac agcctatgaa
     1321 ccctacccag aacatggata tgcctcagct ggtttgccct caggttcatt ctgaatctag
     1381 acttgcccaa tctaatcaag ttcctgtaca accagaagcc acacaggttc ctttggtttc
     1441 atccacaagt gaggggtata cagcatctca gcccttgtac cagccatctc atgctacgga
     1501 gcagcggccg cagaaagagc caatggatca gattcaggca acaatatctt tgaatacaga
     1561 ccagactaca gcatcctcat cccttcctgc tgcttctcag cctcaagtgt tccaggctgg
     1621 gacaagtaaa cctttgcaca gcagtggaat caatgtaaat gcagctccat tccagtccat
     1681 gcaaacggtg ttcaatatga atgctccagt ccctcctgct aatgaaccag aaacgttaaa
     1741 acaacagagt cagtaccagg ccacttataa ccagagtttt tccagtcagc ctcaccaagt
     1801 ggaacaaaca gagcttcaac aagaccaact gcaaacggtg gttggcactt accatggatc
     1861 ccaggaccag cctcatcaag tgcctggtaa ccaccagcaa cccccacagc agaacactgg
     1921 ctttccacgt agcagtcagc cttattacaa cagtcgtggg gtatctcgag gagggtctcg
     1981 tggtgccaga ggcttgatga atggatacag gggccctgcc aatggattta gaggaggata
     2041 tgatggttac cgcccttcat tctcgaacac tccaaacagt ggttattcac agtctcagtt
     2101 cactgctccc cgggactact ctggttacca gcggcttgtc tttcaggatg gatatcagca
     2161 gaatttcaag cgaggctctg ggcagagtgg accacgggga gccccacgag gtcgtggagg
     2221 gcccccaaga cccaacagag ggatgccgca aatgaacact cagcaagtga attaatgtga
     2281 tacacaggat tatgtttaat cgccaaaaac acactggcca gtgtaccata atatgttacc
     2341 agaagagtta ttatctattt gttctccctt tcaggaaact tattgtaaag ggactgtttt
     2401 catcccataa agacaggact gcaattgtca gctttacatt acctggatat ggaaggaaac
     2461 tatttttatt ctgcatgttc tgtcctaagc gtcatcttga gccttgcaca caatacaata
     2521 ctcagattcc tcacccttgc ttaggagtaa aacattatat acttatgggg tgataatatc
     2581 tccatagtta gttgaagtgg cttggaaaaa aaatgcaaga ttgaattttt gaccttggat
     2641 aaaatctaca atcagcccta gaactattca gtggtaattg acaaagttaa agcattttct
     2701 ttgaaaggaa gatggaagga gtggagtgtg gtttagcaaa actgcatttc atagctttcc
     2761 cattaaattg gagcaccgac agattaaaag cataccaaat tatgcatggg tccttactca
     2821 cacaagtgag gctggctacc agccttgaca tagcactcac tagtcttctg gccaaacgac
     2881 tgtgattaaa acacatgtaa attgctcttt agtagtggat actgtgtaag acaaagccaa
     2941 attgcaaatc aggctttgat tggctcttct ggaaaatatg catcaaatat gggggataat
     3001 ctggatgggc tgctgctgtg ctcaatgtga actatttaga tacctttgga acacttaaca
     3061 gtttctctga acaatgactt acatggggat tggtcctgtt tgtcattcct caccataatt
     3121 gcattgtcat cactaatcct tggatcttgc tgtattgtta ctcaaattgg taataggtac
     3181 tgatggaaat cgctaatgga tggataatca taacactttt ggtcacatgt tttctcctgc
     3241 agcctgaaag ttcttaaaga aaaagatatc aaatgcctgc tgctaccacc cttttaaatt
     3301 gctatcttta gaaaagcacc ggtatgtgtt ttagattcat ttccctgttt tagggaaatg
     3361 acaggcagta gtttcagttc tgatggcaaa acaaataaaa acatgtttct aaaagttgta
     3421 tcttgaaaca ctggtgttca acagctagca gctaaagtaa ttcaacccat gcattgctag
     3481 tgtcacagcc tttggttatg tctagtagct gtttctgaag tattttcatt tatcttttgt
     3541 caaatttaac cctgtttgaa ttctctcctt tcctcaagga gacacttatg ttcaaagtgt
     3601 tgattctttg ccttaggtgc atagagagta gacagtttgg agatggaaag gttagcagtg
     3661 acttagccat atgttctgtg ttggaatttg tgctagcagt ttgagcacta gctctgcgtg
     3721 cctatgaact gaatgctgct tgtcccattc cattttatgt catggagaaa taattccact
     3781 tggtaacaca aaggctaagt taatgttatt ttctgtacag aaattaaatt ttacttttag
     3841 ccttttgtaa actttttttt tttttttcca agccggtatc agctactcaa aacaattctc
     3901 agatattcat cattagacaa ctggagtttt tgctggtttt gtagcctact aaaactgctg
     3961 aggctgttga acattccaca ttcaaaagtt ttgtagggtg gtggataatg gggaagcttc
     4021 aatgtttatt ttaaaataaa taaaataagt tcttgacttt tctcatgtgt ggttatggta
     4081 catcatattg gaagggttat ctgtttactt ttgccaagac tattttgcca gcacctacac
     4141 ttgtgtgctt taaaagacaa ctacctggga tgtaccacaa ccatatgtta attgtatttt
     4201 attgggatgg ataaaatgtt tgtggtttat tggataatcc ctagatggtg tgttacgtgt
     4261 gtagaatata attttatgat agtaagaaag caaaattgaa gaaaataagt ttagtattga
     4321 atttgagttc tgaagtgaat tcagggaatg tctcacgttt cgggcttcta cccaaagtgt
     4381 agggcagaag gtgtaaaagt tgtttgtagt ttgacttgtt tattttttaa gttgcttatt
     4441 cctttcaaca gcaacatatc attagctgtc attctaccat tgcagttcta gtgagtttta
     4501 acgtctgcat tcaagactgt tttaaaagca acctcactgg acagagaact gctaaagtct
     4561 tttccttaag atctgagtct ttgttactca gtatcttcta taatatgcaa atgcttgtct
     4621 agaggcagaa gaccttttgt ttggtcaagt gtgtatttta ccagagtaca gggaactgat
     4681 ggtcctacat gtctcttagt gtagtaagac tataaaatct tttgtacatg cacaattcac
     4741 agtatgttta gataccacgt gtataatgcc cccccctccc ccaggtagca tgccattgat
     4801 gactttttgc ttagggccat tttattacca gggccttaat attcctaaaa agatgatttt
     4861 ttttcatcct ttctcctctt ttgatcattg tatcttgata ttaaaaacat gaccttccaa
     4921 tgattgtagt aaattaactt ctatagttct tttgtctcta tatgtattca tatatatgct
     4981 attgtataga gacttcaagg agacatggag atgcatgctt attctcaggt tcattcacta
     5041 aggtgcttgg cagacaacca gtttctaagt gcagaatgta gttaagcagc ttcatatatg
     5101 tgccaggcaa tttgttttgt taaattttca tctacttaag gaaatagggt attgtagctt
     5161 aggctgatca tacccttcat ttcaacctta agctctcaac ctgcatccat ccgacttgag
     5221 ctattaagta ctttagtttt atcgagtata agttaacaga aaaagtaaat taagctttgc
     5281 ctttactatt ttgaatttat atacattctg gaaaaactta gaaactgttg tatatttcat
     5341 tagattaaat tatatgaaaa tgtgattgtt tatagcaaag cctgtgagtt gcatacaccc
     5401 taaggaaaac tccttaagtg ctccttgaag agagaagaaa caattctggg tctggtcttt
     5461 ttaagaacaa agctagacta ctgtatgtta gcactgtaca ttaatagtct gttgtgaagc
     5521 ttgagcagtt tcctgcatag ccttgatcct tcaccgttgg cattgaaaat agcagtatcc
     5581 ctgatgtact taaaacttaa agtcaggttt tggtatattt atttgtaagt cttaatttcc
     5641 tctaaatact atatctcttt agcgagacaa cctgaaattt attagcacat ttgggtatct
     5701 cttgcttggc attatggcca gtgttaacta ttcagtggtg aaaaaattac ccctcaagac
     5761 actggagtga ccccagatgt gtgtagtaag tggcatggtt caactgtgtg gttaatgata
     5821 aatatatgac ttagtcggta tgatctggaa agacttgatt gaaagataat tcagctgaca
     5881 taaggatgag tgaggagtgg caaactggat aaaagagtca agagacctgt attccagtga
     5941 ctcctgtttt gtttaagcat tagcaagatc tgtctgggga aactggatag ggcagttttc
     6001 ttccatgttt agtttttgtc tcaacatttg gaagctattg aaggttttaa aatggtgtgt
     6061 attgtttttt tttggggggg gggtggccag aatagtgggt catctaataa aactgccatt
     6121 taaaaga
//
