LOCUS       NM_009796               3662 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus calpain 7 (Capn7), transcript variant 1, mRNA.
ACCESSION   NM_009796
VERSION     NM_009796.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Yan Q, Huang C, Jiang Y, Shan H, Jiang R, Wang J, Liu J, Ding L,
            Yan G and Sun H.
  TITLE     Calpain7 impairs embryo implantation by downregulating
            beta3-integrin expression via degradation of HOXA10
  JOURNAL   Cell Death Dis 9 (3), 291 (2018)
   PUBMED   29459744
  REMARK    GeneRIF: Overexpression of CAPN7 in Ishikawa cells or in the uterus
            of mice inhibited embryo implantation in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins
            EC, Brown WT and Zhong N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L,
            Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J and
            Blackshaw S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR and Ellerby
            LM.
  TITLE     Inhibition of calpain cleavage of huntingtin reduces toxicity:
            accumulation of calpain/caspase fragments in the nucleus
  JOURNAL   J Biol Chem 279 (19), 20211-20220 (2004)
   PUBMED   14981075
  REMARK    GeneRIF: calpain-derived Htt fragmentation has a role in
            Huntington's disease and aberrant activation of calpains may play a
            role in HD pathogenesis
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Futai E, Kubo T, Sorimachi H, Suzuki K and Maeda T.
  TITLE     Molecular cloning of PalBH, a mammalian homologue of the
            Aspergillus atypical calpain PalB
  JOURNAL   Biochim Biophys Acta 1517 (2), 316-319 (2001)
   PUBMED   11342116
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Dear TN and Boehm T.
  TITLE     Diverse mRNA expression patterns of the mouse calpain genes Capn5,
            Capn6 and Capn11 during development
  JOURNAL   Mech Dev 89 (1-2), 201-209 (1999)
   PUBMED   10559499
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Franz T, Vingron M, Boehm T and Dear TN.
  TITLE     Capn7: a highly divergent vertebrate calpain with a novel
            C-terminal domain
  JOURNAL   Mamm Genome 10 (3), 318-321 (1999)
   PUBMED   10051333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855684.1, AB028640.1, BF462849.1 and BE988205.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by NM_009796.4.
            
            On Jan 30, 2018 this sequence version replaced NM_009796.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154277.1, SRR1660815.48451.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BB855684.1         1-86
            87-2934             AB028640.1         1-2848
            2935-3094           BF462849.1         132-291             c
            3095-3662           BE988205.1         1-568               c
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3662
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /note="calpain 7"
                     /db_xref="GeneID:12339"
                     /db_xref="MGI:MGI:1338030"
     exon            1..346
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2686
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /note="isoform 1 is encoded by transcript variant 1; palB
                     homolog"
                     /codon_start=1
                     /product="calpain-7 isoform 1"
                     /protein_id="NP_033926.1"
                     /db_xref="CCDS:CCDS26911.1"
                     /db_xref="GeneID:12339"
                     /db_xref="MGI:MGI:1338030"
                     /translation="MDASALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAE
                     MAGSSLERIQEKINEYLERVQALHSAVQSKSTDPLKSKHQLDLERAHFLVTQAFDEDE
                     KGNVEDAIELYTEAVELCLKTSSETADKTLQNKLKQLARQALDRAEALSEPLTKPFCK
                     LKSANMKTKTPPVRTHFPLGPNPFVEKPQAFISPQSCDAQGQKYTAEEIEVLRTTSKI
                     NGVEYVPFMSVDLRERFAYPMPFCDRLGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYT
                     VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITSIIYPQNKDGEPEYNPCGKYMV
                     KLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSN
                     SNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGVMTEAEGE
                     KWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFD
                     PRTAQKIDNGIFWISWDDLCQYYDVVYLSWNPALFKESTCIHSTWDAKQGPVKDAYSL
                     ANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADP
                     PPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKI
                     PSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIDKTGPLLIELRGPRQYSVG
                     FEVVAVSIMGDPGPHGFQRKSSGDYRCGFCYLELENIPAGIFNIIPSTFLPKQEGPFF
                     LDFNSTVPIKTTQLQ"
     exon            347..455
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            456..613
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            614..681
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            682..882
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            883..969
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1096
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1182
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1276
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1423
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1530
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1651
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1796
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1896
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2032
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2108
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2254
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2317
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2448
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2541
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..3648
                     /gene="Capn7"
                     /gene_synonym="PalBH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgggcgga gcaaggacgc gaggggtggg ggcggccgcg agggctccga gcccgggctg
       61 ctcggagctc gcagtcctcc gggcgggtct gaggtagtgg ggctccgtca tctcttccgc
      121 cgccctcgaa agtaaacttt gccactccac ccgcggggtc cccagttctc gccgcagtgc
      181 ctccgggcgt cggggttccg cgtcagggcc tgtctgcctc ccccggcgtg gggccttggg
      241 cgccatggac gcgtcggcgc tggagcggga cgccgtgcag ttcgcgcggc tggcagtgca
      301 gcgcgaccac gaaggccgct actctgaggc ggtgttttac tacaaggaag ctgcccaagc
      361 tttaatttat gctgagatgg caggatccag cctagaaagg atccaagaga agatcaatga
      421 gtatctggaa agagtgcaag cccttcactc tgcagttcag tcaaagagta ctgatccttt
      481 gaaatcaaaa caccagttgg atctagaacg tgcccatttt cttgttacac aagctttcga
      541 tgaagatgaa aaggggaatg tggaagatgc catagaatta tatacagaag ctgtggaact
      601 ctgtctaaaa acctcttctg aaactgctga caagactctg caaaataaat tgaaacagtt
      661 ggctcgacag gcactagata gagcagaagc attgagtgaa cctttgacaa agccattttg
      721 caaactcaag tcagcaaata tgaaaacaaa gactcctcca gtaagaacac actttcctct
      781 aggacctaat cctttcgttg aaaagcctca agcatttata agtccacagt catgtgatgc
      841 gcaaggacag aagtacacag cagaagagat agaagtgctc aggacaacat caaaaataaa
      901 tggtgtagaa tatgttcctt tcatgagtgt tgatctaagg gaacgctttg cttatccaat
      961 gcctttttgt gataggttgg gcaagcttcc attatcacct aaacaaaaaa ctacattttc
     1021 taaatgggta cgaccggaag atctcaccaa caatcctaca atgatataca ctgtgtccag
     1081 ttttagcata aagcagacaa tagtatcaga ttgttccttt gtggcatcgt tggctatcag
     1141 tgcagcgtat gagagacgat tcaataagaa gttaattacc agcataattt acccccagaa
     1201 taaggatgga gaaccagagt acaatccctg tggaaagtat atggtaaagc ttcacctcaa
     1261 tggtgttccg agaaaggtga taattgatga ccagttacct gttgatcaca aaggagaatt
     1321 gctgtgttct tattccaaca ataaaagtga attgtgggtg tcacttatag agaaagcata
     1381 catgaaagtt atgggaggat atgatttccc aggatccaac tcaaatattg atctgcatgc
     1441 actgactggg tggataccag aaaggattgc catgcattca gatagccaga cgttcagtaa
     1501 ggataactca ttcagaatgc tttatcaaag atttcacaaa ggagatgtcc tcatcaccgc
     1561 atcgacggga gtaatgactg aagctgaagg ggagaagtgg ggcctggttc ccactcatgc
     1621 ctatgcggtt ttggatatta gagagttcaa ggggctgaga tttattcagt taaaaaaccc
     1681 ttggagccat ttacgctgga aaggaaggta cagtgagaat gatgtgaaaa actggacccc
     1741 agaattgcag aagtatttaa actttgatcc acgaacagct cagaaaatag ataatggaat
     1801 attttggatt tcctgggatg atctttgcca gtattatgat gtagtttatt tgagttggaa
     1861 tccagctctt tttaaagaat caacttgcat tcacagtact tgggatgcta aacaaggacc
     1921 tgtgaaagat gcttatagcc tggccaacaa cccccagtac aaattggagg tgcagtgtcc
     1981 acaagggggt gctgcagttt gggttttgct tagtagacac ataacagaca aggatgactt
     2041 cgcaaataac cgtgagttta tcacaatggt tgtgtacaag actgatggca agaaggttta
     2101 ctacccagct gacccacctc catacattga tgggattcga attaacagcc ctcattactt
     2161 gactaagata aagctgacca cgcccgggac tcacaccttc accctagtgg tttctcagta
     2221 tgagaaacag aatacgattc attacacagt ccgggtgtat tcagcctgca gctttacttt
     2281 ttcgaagatc ccttcaccat acaccttatc caaacggata aatggaaagt ggagtggtca
     2341 aagtgctgga ggatgtggaa attttcagga gactcacaaa aataacccca tctaccaatt
     2401 ccatatagat aagactggac cgttattgat tgagctgaga ggaccaaggc aatacagtgt
     2461 tggatttgag gttgtagcag tttccataat gggagatcct ggtcctcatg gctttcagag
     2521 gaaatctagt ggtgactata ggtgtggatt ttgctactta gaactggaaa acatacctgc
     2581 tgggatcttt aatatcatcc ctagtacttt tttgcctaaa caagaaggac cttttttctt
     2641 ggactttaat agtactgtcc ccatcaagac aacacaactc caatgattga gaactctcag
     2701 ctattactgg attccatatt tcccagtctc agctcttcag acaaggagac aaatcacgat
     2761 ggtgaaccat cagaatggaa ttaaatcaaa agcatgttac ggagtctggt gctcgttgtg
     2821 gtgtttggta aggattttag atagtggaat taccttaatc acctgaaata ctgtttacat
     2881 ggtttgtgca cacagagctg gcgtgtactc ggtggcggct ctgtgtaaat cacaggctag
     2941 attcagccat cactgggaga tgctttcgtt aataggacac gaggaggaca atgaggacca
     3001 caggtccact gagtgcaaga gcagcctagt ttaggatctt gaaataccta tgtttcctgt
     3061 ttttacagag cacgtacgtt tagcccattt atgttgaccc caccatacat cttaaacaac
     3121 taattaccaa atgaattagg tcactgcaac taatttgaat ttttcattgt gtctttaatg
     3181 tttattgtcg tgtagctgtt aagctttaaa aaccgctgtt tagcttagca tggagatgct
     3241 caggcttaag aatgaaggtt gtcagtgtta ggtgcattgt ccattgtaga gaggaccgaa
     3301 gtatatttac tgttgctgtt cttagttctt agcaggttgg tgaatgtagc aatcagatgg
     3361 aaatgctgag gtttaaccgt agggttttaa ttgctctgta gtcagtgctt tcatcatggg
     3421 gacttgggga gtccttgaga atttagtata tggtgactga gttatacagc attcataaaa
     3481 agtgagtggt caggaattag tgtttacata aaatcatcac tgcagaatga tgctcaagat
     3541 tttcaagttc tggaaaatag gatgggatct gtcattgtct ctactttata attatcaaat
     3601 ctatttctac tgcctttgat tgaaataaaa tatttatact tatggaaaaa aaaaaaaaaa
     3661 aa
//
