LOCUS       NM_007603               3579 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus calpain 6 (Capn6), mRNA.
ACCESSION   NM_007603
VERSION     NM_007603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Xiang,C., Frietze,K.K., Bi,Y., Li,Y., Dal Pozzo,V., Pal,S.,
            Alexander,N., Baubet,V., D'Acunto,V., Mason,C.E., Davuluri,R.V. and
            Dahmane,N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Velecela,V., Torres-Cano,A., Garcia-Melero,A., Ramiro-Pareta,M.,
            Muller-Sanchez,C., Segarra-Mondejar,M., Chau,Y.Y.,
            Campos-Bonilla,B., Reina,M., Soriano,F.X., Hastie,N.D.,
            Martinez,F.O. and Martinez-Estrada,O.M.
  TITLE     Epicardial cell shape and maturation are regulated by Wt1 via
            transcriptional control of Bmp4
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31624071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Kim,B.H., Kim,D.Y., Oh,S., Ko,J.Y., Rah,G., Yoo,K.H. and Park,J.H.
  TITLE     Deficiency of calpain-6 inhibits primary ciliogenesis
  JOURNAL   BMB Rep 52 (10), 619-624 (2019)
   PUBMED   31619317
  REMARK    GeneRIF: Calpain-6 deficiency reduced the percentage of ciliated
            cells and impaired sonic hedgehog signaling. It has been speculated
            that this defect might be associated with decreased levels of
            alpha-tubulin acetylation at lysine 40.
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Dear,T.N. and Boehm,T.
  TITLE     Diverse mRNA expression patterns of the mouse calpain genes Capn5,
            Capn6 and Capn11 during development
  JOURNAL   Mech Dev 89 (1-2), 201-209 (1999)
   PUBMED   10559499
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Matena,K., Boehm,T. and Dear,N.
  TITLE     Genomic organization of mouse Capn5 and Capn6 genes confirms that
            they are a distinct calpain subfamily
  JOURNAL   Genomics 48 (1), 117-120 (1998)
   PUBMED   9503024
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Li,J., Nixon,R., Messer,A., Berman,S. and Bursztajn,S.
  TITLE     Altered gene expression for calpain/calpastatin system in motor
            neuron degeneration (Mnd) mutant mouse brain and spinal cord
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 174-186 (1998)
   PUBMED   9473662
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Sorimachi,H., Ishiura,S. and Suzuki,K.
  TITLE     Structure and physiological function of calpains
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 721-732 (1997)
   PUBMED   9396712
  REMARK    Review article
REFERENCE   10 (bases 1 to 3579)
  AUTHORS   Dear,N., Matena,K., Vingron,M. and Boehm,T.
  TITLE     A new subfamily of vertebrate calpains lacking a calmodulin-like
            domain: implications for calpain regulation and evolution
  JOURNAL   Genomics 45 (1), 175-184 (1997)
   PUBMED   9339374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN700442.1, BC052167.1 and AK145116.1.
            
            On Oct 6, 2007 this sequence version replaced NM_007603.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052167.1, AK145116.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-599               CN700442.1         1-599
            600-1689            BC052167.1         501-1590
            1690-2157           AK145116.1         1705-2172
            2158-3579           BC052167.1         2059-3480
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 64.83 cM"
     gene            1..3579
                     /gene="Capn6"
                     /note="calpain 6"
                     /db_xref="GeneID:12338"
                     /db_xref="MGI:MGI:1100850"
     exon            1..204
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            205..385
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2146
                     /gene="Capn6"
                     /codon_start=1
                     /product="calpain-6"
                     /protein_id="NP_031629.3"
                     /db_xref="CCDS:CCDS30455.1"
                     /db_xref="GeneID:12338"
                     /db_xref="MGI:MGI:1100850"
                     /translation="MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRL
                     LPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIP
                     NHKDQEWDPRKPEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWN
                     ALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGEL
                     YKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIRKLRLGERLVEVFSTEK
                     LYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNF
                     HKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVP
                     EDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTY
                     IDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWN
                     LARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQ
                     AIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVK
                     QGHISFKVISSDDLTEL"
     exon            386..517
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            518..726
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            727..919
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1113
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1191
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1378
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1501
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1704
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1826
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1963
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..3554
                     /gene="Capn6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capn6"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="Capn6"
                     /note="major polyA site"
ORIGIN      
        1 ggcacctccc cctgtgagca gagcttggta cagcccaaat agtttccagg ttaagaaagc
       61 cagaatcttt gttcagctgc actggccgaa cagacttagt ggggttacct ggctaagagc
      121 agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc
      181 agcagggttc ctgagctaac tcagacctag tttgatagca atgggtcctc ctctgaagct
      241 cttcaaaaac cagaagtacc aagaactgaa gcaggagtgc atgaaggatg gccgcctttt
      301 ctgtgaccca accttcctac cggagaatga ttctctgttt ttcaaccggc tgcttcctgg
      361 gaaggtggtg tggaagcgtc cacaggacat ttctgatgac ccccacctga ttgtgggcaa
      421 catcagcaac caccagctga tccagggcag attggggaac aaggcaatga tctctgcatt
      481 ttcctgtttg gctgttcagg agtcacactg gacaaaggca attcccaacc acaaggatca
      541 ggaatgggat cctcgaaagc cagagaaata cgctggaatc tttcacttcc gcttctggca
      601 ttttggagaa tggaccgagg tggtgattga tgacttgctt cccaccatca acggagatct
      661 ggtcttctca ttctccacct ccatgaatga gttttggaat gctctactgg aaaaagcgta
      721 tgcaaagctg ctgggctgtt atgaggcttt ggatggtctg accatcactg atatcatcat
      781 ggacttcact ggcacactgg ctgaaatcat tgacatgcag aaaggacgat acactgatct
      841 tgttgaggag aagtacaagc tgtttggaga actgtacaaa acgttcacca aaggaggtct
      901 aatttgctgc tccattgagt ctcccagcca ggaggaacaa gaagttgaaa cagactgggg
      961 actactgaag ggttatacct acaccatgac tgatattcgc aagctccgtc tcggagaaag
     1021 acttgtggaa gtcttcagta ctgagaagct gtatatggtt cgcctaagga acccattggg
     1081 aagacaggaa tggagtggcc cctggagtga aatttcagag gagtggcagc aactgactgt
     1141 aacagatcgc aagaacctag gacttgttat gtctgatgat ggagaatttt ggatgagtct
     1201 ggaagatttt tgccacaact ttcacaaact gaatgtctgc cgcaatgtga ataatcctgt
     1261 ttttggccgc aaggagctgg aatcagtggt gggatgttgg actgtggatg atgaccctct
     1321 gatgaaccga tcaggaggtt gctataacaa ccgtgatacc ttcttgcaga atcctcagta
     1381 cattttcact gtgcccgagg atggccataa agtcatcatg tcactgcaac agaaggacct
     1441 acgcacttac cgccgaatgg gaagacctga taattacatc attggttttg agctcttcaa
     1501 ggtggagatg aaccgaaggt tccgtcttca ccatctgtat attcaggagc gtgctgggac
     1561 ttccacttat atcgacaccc gtactgtgtt tctgagcaag tatctgaaga agggcagcta
     1621 cgtgcttgtt ccaaccatgt tccaacatgg ccgtaccagt gaatttctgc tgaggatctt
     1681 ctctgaagtg cccgtccagc tcagggaact gaccttggac atgcccaaga tgtcttgctg
     1741 gaacctggca cgtggctacc caaaggtggt tacccagatc actgtccaca gtgctgaggg
     1801 cctggagaag aagtatgcca atgaaactgt caatccatat ctgatcatca aatgtggaaa
     1861 ggaggaagtc cgttcccctg tccagaagaa tactgtgcat gccatttttg acacgcaggc
     1921 cattttctac agaaggacca ctgacattcc tattatcatc caggtgtgga acagcagaaa
     1981 attctgtgat cagttcctgg ggcaggttac tctcgatgct gaccccagcg actgccgtga
     2041 tctgaaatct ctgtacctgc gtaagaaggg tggtcctact gccaaagtca agcaaggtca
     2101 catcagcttc aaagttatct ctagcgatga tctcactgag ctctaagtag tcatcatcag
     2161 agaatcctga cagctttcca tcttcttttg tcaggcacaa ggtcttaact aagaccccac
     2221 gattactgaa attccacatt tattaatgtt ttctcttttc tgatatttcc catacctcct
     2281 gatccaagta gcatcagtag ctacataacc tatatacctc cagcagctgg acaggggagg
     2341 tgacaatccc atctggagat catacacacg tttactgaga aaagatcctt agggcttcca
     2401 ggggtgagat tcaaatggga caatagcaag aatgtggaca tcctacatgt gtgtttgctg
     2461 tttccacctg cctaacacat tttacctgta gggcttgttg atgaaggagg acagaggtga
     2521 tcaaggccaa gctggtctag cctgacatcc cagctcctaa ctgacactat ggatttatca
     2581 gccacatttc accagtagcc agagctgact tttaacagtc ccagccctta ccaccaccac
     2641 cacctctgga aagtgtggtc ctgccctaac tcaagtaact cccccacagt gttttacctt
     2701 catgttgagg aagcttccta ggtgcttaat caagagctgg agttcaatgc ggctgagaca
     2761 gtgagaaagg cttgagcttt agcaattggg aagccagctg tgtgccataa gagggagaag
     2821 ttgaagaagc tgcagtggga gacaaagcct cggtccccca cccatccaca cacacctaca
     2881 ctcacacacg cgcacgcaag cgcacacgaa ctaccattca gtcagtgggc aagaataagg
     2941 actagtgaag tatcatgcac accaaaagat ggatgaatct attcagtaat aggacagcca
     3001 gtttggggtc cctgactaca atgtgaaacc tcttgctgct gctagattta caaacaagcc
     3061 cattgccctg tgcttcctaa tatcattggt actgaaaact ctatatggga acctgagagt
     3121 ctgggtccca ccccgacccc tcaggctttt ccctctgttg ggaagctcca ctccccaggg
     3181 gtttgttact cagtatgtct acaaaatttc cttgtgaatc agtcattgta tgttcttccc
     3241 ttcatcctca tctatcagta ttctgcccct attcaaggcc cagcataaat tccacctcct
     3301 ccatgaagtt ctttcacatc ttatcccaag tcccacctcc aacaatattt cagtgcttct
     3361 gcaatgataa aaaactaaac atagttgtag tacttaggct agttcagcat gcattcattt
     3421 aaaaatacat tttgtagctc gctctttttg aactttctca ttttctatca cattttgcag
     3481 tctttgtaac ttttatagtg cctttgccac actgccttac aaacaaaatc acaataaagt
     3541 tcatattcaa taaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
