LOCUS       NM_001347334            5182 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus calpain 15 (Capn15), transcript variant 1, mRNA.
ACCESSION   NM_001347334 XM_006524604
VERSION     NM_001347334.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Beaman,M.M., Guidugli,L., Hammer,M., Barrows,C., Gregor,A., Lee,S.,
            Deak,K.L., McDonald,M.T., Jensen,C., Zaki,M.S., Masri,A.T.,
            Hobbs,C.A., Gleeson,J.G. and Cohen,J.L.
  TITLE     Novel association of Dandy-Walker malformation with CAPN15 variants
            expands the phenotype of oculogastrointestinal neurodevelopmental
            syndrome
  JOURNAL   Am J Med Genet A 191 (11), 2757-2767 (2023)
   PUBMED   37596828
  REMARK    GeneRIF: Novel association of Dandy-Walker malformation with CAPN15
            variants expands the phenotype of oculogastrointestinal
            neurodevelopmental syndrome.
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Zha,C., Gamache,K., Hardt,O.M. and Sossin,W.S.
  TITLE     Behavioral characterization of Capn15 conditional knockout mice
  JOURNAL   Behav Brain Res 454, 114635 (2023)
   PUBMED   37598906
  REMARK    GeneRIF: Behavioral characterization of Capn15 conditional knockout
            mice.
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Zha,C., Farah,C.A., Fonov,V., Rudko,D.A. and Sossin,W.S.
  TITLE     MRI of Capn15 Knockout Mice and Analysis of Capn 15 Distribution
            Reveal Possible Roles in Brain Development and Plasticity
  JOURNAL   Neuroscience 465, 128-141 (2021)
   PUBMED   33951504
REFERENCE   4  (bases 1 to 5182)
  AUTHORS   Zha,C., Farah,C.A., Holt,R.J., Ceroni,F., Al-Abdi,L., Thuriot,F.,
            Khan,A.O., Helaby,R., Levesque,S., Alkuraya,F.S., Kraus,A.,
            Ragge,N.K. and Sossin,W.S.
  TITLE     Biallelic variants in the small optic lobe calpain CAPN15 are
            associated with congenital eye anomalies, deafness and other
            neurodevelopmental deficits
  JOURNAL   Hum Mol Genet 29 (18), 3054-3063 (2020)
   PUBMED   32885237
  REMARK    GeneRIF: Biallelic variants in the small optic lobe calpain CAPN15
            are associated with congenital eye anomalies, deafness and other
            neurodevelopmental deficits.
REFERENCE   5  (bases 1 to 5182)
  AUTHORS   Kamei,M., Webb,G.C., Heydon,K., Hendry,I.A., Young,I.G. and
            Campbell,H.D.
  TITLE     Solh, the mouse homologue of the Drosophila melanogaster small
            optic lobes gene: organization, chromosomal mapping, and
            localization of gene product to the olfactory bulb
  JOURNAL   Genomics 64 (1), 82-89 (2000)
   PUBMED   10708520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On Nov 10, 2022 this sequence version replaced NM_001347334.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143711.1, SRR9219381.313798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC159277.3         47609-47897
            290-578             AC159277.3         59989-60277
            579-2079            AC159277.3         67841-69341
            2080-2288           AC159277.3         69913-70121
            2289-2472           AC159277.3         70223-70406
            2473-2696           AC159277.3         70474-70697
            2697-2822           AC159277.3         71289-71414
            2823-2975           AC159277.3         71496-71648
            2976-3137           AC159277.3         72557-72718
            3138-3636           AC159277.3         72805-73303
            3637-3815           AC159277.3         73383-73561
            3816-5182           AC159277.3         73635-75001
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.04 cM"
     gene            1..5182
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /note="calpain 15"
                     /db_xref="GeneID:50817"
                     /db_xref="MGI:MGI:1355075"
     exon            1..289
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            290..578
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..3993
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     optic lobes homolog"
                     /codon_start=1
                     /product="calpain-15 isoform 1"
                     /protein_id="NP_001334263.1"
                     /db_xref="CCDS:CCDS84286.1"
                     /db_xref="GeneID:50817"
                     /db_xref="MGI:MGI:1355075"
                     /translation="MGSSASSLAAETESDHGFPGGPPYPGPPAAAGWCRSGPGETVWG
                     SALVTRQHPRPRAQSHTHSPGSMATVGEWSCARCTFLNPAGQRQCSICEAPRHKPDLD
                     QILRLSVEEQKWPCARCTFRNFLGKEACEVCGFTPEPVPGAPLLPIINGVLPKPPTIL
                     VEPKGSGKEEAGPVRTAGLVATEPARGRPEGEEEREERGEEEEKEQEGEGERAEPGSG
                     WACQRCTLHNTPVASSCSACGGPRKLSLPRIPPEALVVPEVVAPTGFHVVPAPSQPVL
                     PGEGAEADSPSTSQGPTSTDQEPPRVPLFSPFSPTLQNNPVPRSRREVPPQLQPPVPE
                     AVQSSASTSSKGPQQGPGRAAAGASRLAELLSGKELLPGKRLSVLEEEVPESSPARCE
                     SCSDVIDLAGDIVRYTPASPSSPDFTTWSCARCTLRNPTTAPRCSVCGGSKLHGFQEH
                     SEPPTHCPDCGANKPGPCVGSCGRAPSAHKAVRLLPDRPGQWACPACTLINTPRAKHC
                     AACHTPQLLVTQCRGATPLRRRESMHVEKRRQTDEGEAKALWENIVAFCRENSVNFVD
                     DSFPPGPASVGFPVGDSVQQRVKQWLRPHEINCSVFRDHGTPWSVFHTLRPSDILQGL
                     LGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDDMLPCDE
                     AGFLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQVS
                     STNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYESLGLRPRHAYSVL
                     DVRDVQGSRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRAELMPHGSSEGVFWMEYSDF
                     IRYFDSVDICKVHSDWQEARVQGCFPSTAGGPVGVTALTVLERASLEFALFQEGSRRS
                     DSVDSHLLDLCILVFRATFGTGGRLSLGRLLAHSKRAVKKFVNCDVMLEPGEYAVVCC
                     AFNHWNPAPPGPPAQGKGPSQMRPTPSFPTSEPQSPPTGKLLAPLSTPPTASSPSAGV
                     PRGAPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCYYL
                     THGWAGLIVVVENRHPKSYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQ
                     LEGNAGFSITHRLAHRKAAQAFLSDWTASRGTHSPPLTPDVAGLHGPRPL"
     exon            579..2079
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2288
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2472
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2696
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2822
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2975
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3137
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3636
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3815
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..5182
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5160..5165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /note="hexamer: AATAAA"
     polyA_site      5182
                     /gene="Capn15"
                     /gene_synonym="Solh"
                     /note="major polyA site"
ORIGIN      
        1 gtagcctcgg gccccggctg ggcgccacgc tacggaagca gcgtaaggcg tagcgggtag
       61 gccgggcggg acggcgggcg ctagctacgg aggcgtttgt aaggttgccg ggccgagacg
      121 gatcttcgcg gccaaaacgc gctaagccgg cggagcatcg cggctggcgc gaaggggccc
      181 ttggtgccct ccggtcgaag ttgtgggtca accgactgag ggccggcact agggccgcgc
      241 ccgcctagac cgatcgcgag cgctgaggag gcgccgccgg ctcgctaagc cggctgccct
      301 ttctccggtg tgggcactct cctctctcca tgcttccatc cgtgtgccac cggccagagg
      361 tgaccaggcc cggctctcta cgtggccgct gtcagggggg ccatggggag ctccgcctcc
      421 tccctggctg ccgagacgga gtcagaccac ggcttccctg gggggccacc ctacccaggg
      481 cccccagcag cagctggctg gtgtaggagt ggccctgggg agactgtctg gggaagtgct
      541 ctggtcacca gacagcatcc acgacccagg gcccaaagcc acactcattc tcctgggtct
      601 atggccacag ttggggagtg gtcctgtgca cgctgcacct tcctgaaccc tgccggccaa
      661 cgccagtgct ccatctgtga ggccccccga cataagccag atcttgacca gatccttcgt
      721 ctcagcgtag aggagcagaa atggccctgt gcacgctgta cattccggaa ctttttaggc
      781 aaagaggctt gcgaagtgtg tggctttacc ccagagcctg ttcctggagc ccctctgctg
      841 cccattatca atggggtcct gcccaagcca cccaccatac tggtggagcc aaagggcagc
      901 ggtaaggagg aagcaggccc agtgcggaca gcagggctag tggccacaga gccagccaga
      961 gggcgccctg aaggagaaga agaaagagaa gaaagaggag aagaagaaga aaaggagcag
     1021 gagggcgagg gggagagggc agagcctggc agtggctggg catgccagcg ctgcacactg
     1081 cataacacac cagtggccag ctcttgttct gcctgtgggg gaccccggaa actgtcattg
     1141 cctcgcatcc ccccagaagc cctggtggtt cccgaggttg tagcccctac tggctttcat
     1201 gtcgttcctg ctccatccca gcctgtcctc cctggggaag gtgctgaggc tgattctcct
     1261 tctaccagcc agggtcccac ctccactgac caggagccac ccagggtacc actcttcagc
     1321 cccttctcac ccaccctaca gaacaaccct gtacccagaa gccgccggga ggtcccccct
     1381 cagcttcagc cacctgtgcc tgaggctgtt cagtcctcag cctccacaag ctccaaaggg
     1441 ccccagcagg gccctggaag agctgcagct ggggcctccc gcctcgctga gctactctca
     1501 ggcaaggagc tgctgccagg caagcgactg agtgtgttgg aggaggaggt cccagagagc
     1561 agccctgccc gctgtgagtc gtgcagtgat gtcattgacc tagctgggga cattgtgcgc
     1621 tacacacctg ccagtccctc cagccctgac ttcaccacct ggtcatgtgc caggtgtaca
     1681 cttaggaacc ccacaacagc ccccaggtgt tcagtgtgtg gtggctccaa gctgcatggt
     1741 ttccaggagc acagtgaacc ccctacccac tgccctgact gtggtgccaa caagcctggc
     1801 ccctgtgttg gctcctgtgg acgagctccc tcagcacaca aggctgtccg tctcttgccc
     1861 gatcgcccgg gtcagtgggc ctgcccggcc tgtactctga tcaacacacc tcgggccaag
     1921 cactgtgcag cctgccatac accacagctt ctggtgaccc agtgccgggg ggctaccccc
     1981 ctgaggcgca gggagagtat gcatgtggag aagcggaggc agacagatga gggcgaggcc
     2041 aaggcactct gggagaacat agtggctttc tgcagagaga atagtgtgaa ctttgtggat
     2101 gacagcttcc cccccgggcc tgcatctgtc ggcttcccag tgggcgacag cgtccagcag
     2161 cgagtgaaac agtggctgag gccccacgaa atcaactgct ctgtcttcag ggaccacggc
     2221 actccgtggt cagtcttcca caccctgagg ccctctgaca tcctacaggg gctgctgggg
     2281 aactgctggt tcctgagtgc gttggcagta ctggctgaac gtcccgacct cgtggagagg
     2341 gtgatggtca cacgtagcct atgtgcagag ggtgcctacc aggtgcggct gtgcaaagat
     2401 ggcacgtgga caacagtgct ggtggatgac atgctgccct gtgatgaggc tgggtttttg
     2461 ctcttctcac aggcacagcg gaagcagtta tgggtggccc tcattgagaa ggcactggcc
     2521 aagctgcacg gctcctactt tgccctccag gcagggcgtg ccattgaagg tctggccaca
     2581 ctaaccggag ccccctgtga gagcctggcg ctgcaggtca gctccactaa cccccgagag
     2641 gagcctgttg acactgatct catctgggcc aaaatgctga gttctaaaga ggctgggttc
     2701 ctcatgggtg cgtcctgcgg gggaggtaac atgaaggtag atgatgctgc ttacgagagc
     2761 ctgggtctgc gcccccgcca tgcttactct gtcttggatg ttcgtgatgt tcagggctcc
     2821 aggctcctgc gactccggaa cccatggggc cgtttctcct ggaatggcag ttggtcagat
     2881 gagtggccac actggccagg gcacctgcga gctgagctca tgccacacgg cagcagtgag
     2941 ggtgtcttct ggatggagta tagtgacttt atcaggtact tcgactctgt ggacatctgc
     3001 aaggtgcact cagactggca agaggcacgg gttcagggct gtttcccaag cactgccggt
     3061 gggcctgtgg gtgtgacagc actcacagtg ctggagcgtg cctcactgga gtttgccctc
     3121 ttccaggagg gcagcaggcg ctcggattca gtagacagcc acctcctgga tctgtgcatc
     3181 ctagtgttcc gggccacttt tggcactggt ggccgcctga gcctgggccg cctcttggcc
     3241 cacagcaaac gtgctgttaa gaagtttgtg aactgtgatg tcatgctgga gcctggggag
     3301 tatgctgtgg tatgctgtgc cttcaaccac tggaaccctg ctccaccagg gccccctgcc
     3361 cagggtaagg gccccagcca gatgaggccc acaccctcct tcccaacctc cgagccccaa
     3421 agcccaccca cgggaaagct gctggctccc ttatccacac cccccacagc ctccagcccc
     3481 tcagcagggg tcccccgagg tgcccccgag ccacccggcc acgtactcgc agtgtacagc
     3541 tccaggctgg tcatggtgga gccggtggag gcgcagccaa ccacactggc cgatgccatc
     3601 atcctgctca ctgagagccg gggcgagcgg catgagggtc gagagggcat gacctgctat
     3661 tacctgactc atggctgggc gggactcatc gtggtagtgg agaaccggca ccccaagtcc
     3721 tacctgcatg tgcaatgtga ctgcaccgac agcttcaatg tggtgtccac acgtggcagc
     3781 ctgcgcaccc aggacagtgt accacccctg cacaggcagg tcctggtgat cttgtctcag
     3841 ctggaaggca atgctggatt ctctatcacc catcgcctgg cacatcgcaa ggcagcccag
     3901 gccttcctca gtgactggac agcctctagg ggtacccaca gccccccact cacacctgat
     3961 gtggccggcc tacatggacc ccggccactg tgactgcagt tccctagggc aagggctgtg
     4021 tgcagatcta cccacctgcc cccctacatg cactttatga gggagacccc caatggagga
     4081 tgcttgaacc agaatctcag gaccctgccc agggagccgc cagccacagg gtgcagcctc
     4141 ccttgggcct ccctcccctc ctatcccacc ccaagtaccc tcagtacccc accaggcctc
     4201 ccagctgcca tgcagaatac ctcgaaccgg gtgggcttca ttccagtact tctgtcttga
     4261 gccctgggga cagcttcaga tggccaaggc ccaaaggggg cggccctgtg aatatggggt
     4321 cacttattat ggagaggcag cccagataaa tgttcgcaga accagtccgg gttttagagg
     4381 ccatgccctg ctcgccgtga gaacctgggc aaccctttgt ggggctcaga tctgctgctg
     4441 ctccccttgt ttgttcccaa gcccagctcc ctgccctaat gatcagggtc ctgatagccc
     4501 tggcatatga gcagtgcatt gcaggaagca gatgcctggt ggccatcggc cagggcttgg
     4561 ggacagctac acctcctgca acactatgca attcctggag cacctgccag gatcgaagcc
     4621 atgatggagc cacaggacag gagccagtcc cagccctgct gtctggagaa gtgctttgtc
     4681 cttagtttcc ctggccacag tcagctctgc ccatggcctc agtctgtcca caaagaggga
     4741 taccccctac tccggtccta tcacaggcac atgtaaggtg tgactgacta ctccctcccc
     4801 tagatgaggg agccaagctg cccacctgcc cagcattccc tcagctgctt gtcaaaatca
     4861 gagcccttac ctgccacatg gacgcctgag tcatttcctg ggccactgtt gtgcagcccc
     4921 ctaggtaggg gcagctccca agcccactgt ccctgcctcc atggggcttg ctagggtttt
     4981 tatacctaga gaaacattcc ccttccctct gggcctcctt ttactctgag ctgtgaatat
     5041 ttttaaccct gtaaatagga ccagctcttc gaacacagag actattttat cagctgtcag
     5101 tcccttcctt gttcgatgat gcaccccata ggccatttcc actcaggctc cacggaccaa
     5161 ataaaagtgt tttgttttgt aa
//
