LOCUS       NM_001013767            2575 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus calpain 11 (Capn11), mRNA.
ACCESSION   NM_001013767 XM_193876
VERSION     NM_001013767.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2575)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2575)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   4  (bases 1 to 2575)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 2575)
  AUTHORS   Ben-Aharon,I., Brown,P.R., Shalgi,R. and Eddy,E.M.
  TITLE     Calpain 11 is unique to mouse spermatogenic cells
  JOURNAL   Mol Reprod Dev 73 (6), 767-773 (2006)
   PUBMED   16541461
  REMARK    GeneRIF: Results demonstrate that calpain 11 is expressed
            specifically in the mouse testis.
REFERENCE   6  (bases 1 to 2575)
  AUTHORS   Hou,S.T., Jiang,S.X., Desbois,A., Huang,D., Kelly,J., Tessier,L.,
            Karchewski,L. and Kappler,J.
  TITLE     Calpain-cleaved collapsin response mediator protein-3 induces
            neuronal death after glutamate toxicity and cerebral ischemia
  JOURNAL   J Neurosci 26 (8), 2241-2249 (2006)
   PUBMED   16495451
  REMARK    GeneRIF: Collectively, these results reveal a novel role of CRMP-3
            in that calpain cleavage of CRMP-3 and the subsequent nuclear
            translocation of the truncated CRMP-3 evokes neuronal death in
            response to excitotoxicity and cerebral ischemia.
REFERENCE   7  (bases 1 to 2575)
  AUTHORS   Dear,T.N. and Boehm,T.
  TITLE     Diverse mRNA expression patterns of the mouse calpain genes Capn5,
            Capn6 and Capn11 during development
  JOURNAL   Mech Dev 89 (1-2), 201-209 (1999)
   PUBMED   10559499
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC165259.2.
            
            On Nov 17, 2006 this sequence version replaced NM_001013767.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY578330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC165259.2         195010-195074
            66-316              AC165259.2         200563-200813
            317-386             AC165259.2         201067-201136
            387-505             AC165259.2         210447-210565
            506-639             AC165259.2         211357-211490
            640-808             AC165259.2         211683-211851
            809-892             AC165259.2         214433-214516
            893-978             AC165259.2         214611-214696
            979-1053            AC165259.2         214835-214909
            1054-1217           AC165259.2         215087-215250
            1218-1393           AC165259.2         215449-215624
            1394-1405           AC165259.2         220040-220051
            1406-1617           AC165259.2         220336-220547
            1618-1657           AC165259.2         220911-220950
            1658-1723           AC165259.2         221214-221279
            1724-1781           AC165259.2         221387-221444
            1782-1846           AC165259.2         221556-221620
            1847-1915           AC165259.2         221870-221938
            1916-1994           AC165259.2         222232-222310
            1995-2108           AC165259.2         222418-222531
            2109-2167           AC165259.2         223535-223593
            2168-2575           AC165259.2         223708-224115
FEATURES             Location/Qualifiers
     source          1..2575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.59 cM"
     gene            1..2575
                     /gene="Capn11"
                     /note="calpain 11"
                     /db_xref="GeneID:268958"
                     /db_xref="MGI:MGI:1352490"
     exon            1..65
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2194
                     /gene="Capn11"
                     /EC_number="3.4.22.17"
                     /note="calcium-dependent thiol protease; CANP 11;
                     calcium-activated neutral proteinase 11"
                     /codon_start=1
                     /product="calpain-11"
                     /protein_id="NP_001013789.1"
                     /db_xref="CCDS:CCDS50121.1"
                     /db_xref="GeneID:268958"
                     /db_xref="MGI:MGI:1352490"
                     /translation="MLNYSDISWAEKGMVATINHSRLKDKGVGQHQNAYNYKNQNYED
                     LRAECLRKGELFEDPFFPAEPRSIGVKNLGPNSEHMQNIYWQRPKDIIHNPQFITNDF
                     SPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRNQSFKKNYAGIFHFQLWQFGHWL
                     NVVVDDRLPTRNNKLVFVHASHRQDFWSALLEKAYAKLIGSYGALSGGSTLEGLEDFT
                     GGVAQCIPLQKPPGNMLRLLKKALEKSSLMGCSIEVTDNSEVETMTHNMLVRGHAYAV
                     TGLEDVYYRDKLETLIRIQNPWGRVEWNGAWSDKATEWEEVSPDVRVQLLHKKDDGDF
                     WMSYEDFMSNFTLLEICNLTPDALNTWDYKSRWHSTFYEGSWRRGSTAGGCRNHPETF
                     WSNPQFKISLPEVDDPEDDSEKNEMVCTCLVALMQKNWRHAREGPQLLTIGFVIFSVP
                     KEFQNLRDIHLKKDFFLKYRDHGFSEIFINSREVNSHLRLPPGEYVIIPSTYEPHKDA
                     DFLLRVFTEKHSETWLLDDANRFEHLQEETVTDKDLDKDSLQLFKIMANEDGEVDMYA
                     LHKLLNRMTAKLRNFKTKGFSLEVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEI
                     FKECDEDRSGNLNSYEMRLAIEKAGIKMNNRVTEVVVARYSDNMIVDFDSFLNCFLRL
                     KAMFAFFLSMDTKKTGSICLDINQWLQITMWG"
     exon            66..316
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            317..386
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            387..505
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            506..639
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            640..808
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            809..892
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            893..978
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1053
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1217
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1393
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1405
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1617
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1657
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1723
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1781
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1846
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1915
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1994
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2108
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2167
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2575
                     /gene="Capn11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capn11"
                     /note="hexamer: AATAAA"
     polyA_site      2575
                     /gene="Capn11"
                     /note="major polyA site"
ORIGIN      
        1 tgctaggtgc tagctgttct aggtgttcat ctgatagata gccttcagga tgctgaacta
       61 ctcagacatc tcttgggctg aaaaaggaat ggtggctacc ataaaccact ccaggctcaa
      121 ggacaagggc gtgggccaac accaaaatgc ctacaactat aagaatcaga actatgagga
      181 ccttcgagca gagtgtctca ggaaggggga actgttcgaa gacccctttt tccctgctga
      241 acccaggtct atcggtgtca agaacctggg ccccaactct gaacacatgc agaatatcta
      301 ctggcagcgg ccaaaggata tcattcataa cccccagttc atcacgaatg acttctctcc
      361 cacggacatc tgccaaggga tcctggggga ctgctggctc ctggctgcca ttggctccct
      421 taccacctgc cccaaactgc tgtaccgtgt ggtgcccaga aatcagagct tcaagaagaa
      481 ctatgctggc atcttccact ttcagctttg gcagtttggg cactggttga acgtggtcgt
      541 ggacgaccgg ctgcccacta ggaacaacaa gctggtattc gtgcacgcct cccatcgcca
      601 ggatttctgg agcgccctgc tggagaaggc ctacgccaag ctgatcggat cctacggagc
      661 gctgtctgga ggcagcactt tggagggttt ggaagatttc acaggcggcg tagcacagtg
      721 cattccgctc cagaagcccc ctggcaacat gctaaggctc ctcaagaaag ccctggagaa
      781 gtcttccctc atgggctgtt ccattgaagt cacagacaat agtgaagtag aaaccatgac
      841 acataacatg ctggtgcgag gacatgctta tgcagtgact ggcctagagg atgtctacta
      901 cagagacaag ttggaaactc taattcggat ccaaaatcct tggggtcggg ttgaatggaa
      961 tggagcctgg agtgacaaag ccacagagtg ggaagaggtg agcccagatg ttcgggtaca
     1021 gctgctacac aagaaggatg atggcgattt ctggatgtcc tatgaagact tcatgagcaa
     1081 ctttacactg ctggagatct gcaacctcac cccggatgcc ctcaacacct gggattacaa
     1141 gagccgctgg cactccacct tctatgaggg cagctggcga aggggaagca ctgcaggggg
     1201 ctgcagaaac cacccggaga cgttctggag caacccccag ttcaagatct ctctcccgga
     1261 agtggatgac ccagaggatg actctgagaa aaacgaaatg gtttgcacct gtctggtggc
     1321 actgatgcag aagaactgga gacatgctcg agagggaccc cagctcctca ccataggctt
     1381 tgtcatcttc tcggtcccaa aggagtttca gaacctccgg gacatccacc ttaagaaaga
     1441 cttcttcttg aaataccggg accacggctt ttcagagatc ttcatcaact cgagggaggt
     1501 gaacagccat ctccggctgc ccccggggga atacgtcatt atcccctcca cctatgagcc
     1561 ccataaagat gctgacttcc tgcttcgggt cttcacggag aaacacagtg agacctggtt
     1621 gctggatgac gccaaccggt ttgaacatct ccaagaggag actgtcactg acaaggattt
     1681 ggacaaggat tctcttcagc tgtttaagat aatggcaaac gaggatggcg aagtggatat
     1741 gtatgcacta cacaaacttc tcaacaggat gacagctaaa ttaaggaact tcaagacgaa
     1801 gggctttagc ttggaagtct gtcgccggat gatcaacctc ctggataaag atggttctgg
     1861 caagctggag cttcatgaat tccaggtcct gtggaaaaag atcaagaaat ggacggaaat
     1921 cttcaaagag tgtgatgagg accgctcagg gaacttgaac tcctatgaga tgcgcctggc
     1981 aatagagaaa gcaggcatca agatgaacaa cagagtgacc gaggtagtcg ttgccaggta
     2041 ctcggataac atgattgtgg actttgacag cttcctcaac tgtttcctga ggctcaaggc
     2101 catgtttgcg ttcttcttat ccatggacac caagaaaact ggttctattt gcttggatat
     2161 taaccagtgg ctgcaaataa ccatgtgggg gtagggagat gcgaagcctg gctccctcgt
     2221 tcctccctcc gccggtggcg ctcctgctcc ggccaggatg gtggatgctc cttgtcgctc
     2281 tcgctctcca gtgccccagg cacagtgttt actctggtcc cctgatccgg gctgaccgga
     2341 acaccaacac ccccctcccc cacccccacc acgccccgag cactctcacg ccgtatttag
     2401 actaaaaatg aggtggattc tccgccagtt tttctctggc gaaggcaatc ttcagcttaa
     2461 gtgttcccgc gtgctgtcaa ctcacacccg cctcctagcc cgccctcttg tcaggaattc
     2521 catcgcctcc ccgcgccgcg tcgtacacat tattctaata aagaggacaa ggtta
//
