LOCUS       NM_011796               2877 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calpain 10 (Capn10), mRNA.
ACCESSION   NM_011796
VERSION     NM_011796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Arratia,L.M., Bermudes-Contreras,J.D., Juarez-Monroy,J.A.,
            Romero-Macias,E.A., Luna-Rojas,J.C., Lopez-Hidalgo,M., Vega,A.V.
            and Zamorano-Carrillo,A.
  TITLE     Experimental and computational evidence that Calpain-10 binds to
            the carboxy terminus of NaV1.2 and NaV1.6
  JOURNAL   Sci Rep 14 (1), 6761 (2024)
   PUBMED   38514708
  REMARK    GeneRIF: Experimental and computational evidence that Calpain-10
            binds to the carboxy terminus of NaV1.2 and NaV1.6.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Panico,P., Hiriart,M., Ostrosky-Wegman,P. and Salazar,A.M.
  TITLE     TUG is a calpain-10 substrate involved in the translocation of
            GLUT4 in adipocytes
  JOURNAL   J Mol Endocrinol 65 (3), 45-57 (2020)
   PUBMED   32698137
  REMARK    GeneRIF: TUG is a calpain-10 substrate involved in the
            translocation of GLUT4 in adipocytes.
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Hatta,T., Iemura,S.I., Ohishi,T., Nakayama,H., Seimiya,H.,
            Yasuda,T., Iizuka,K., Fukuda,M., Takeda,J., Natsume,T. and
            Horikawa,Y.
  TITLE     Calpain-10 regulates actin dynamics by proteolysis of
            microtubule-associated protein 1B
  JOURNAL   Sci Rep 8 (1), 16756 (2018)
   PUBMED   30425305
  REMARK    GeneRIF: Calpain-10 regulates actin dynamics by proteolysis of
            microtubule-associated protein 1B
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Cheverud,J.M., Fawcett,G.L., Jarvis,J.P., Norgard,E.A.,
            Pavlicev,M., Pletscher,L.S., Polonsky,K.S., Ye,H., Bell,G.I. and
            Semenkovich,C.F.
  TITLE     Calpain-10 is a component of the obesity-related quantitative trait
            locus Adip1
  JOURNAL   J Lipid Res 51 (5), 907-913 (2010)
   PUBMED   20388922
  REMARK    GeneRIF: Capn10 plays an important role in regulating obesity and
            diabetes in mice.
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Reed,N.A., Castellini,M.A., Ma,H., Shearer,T.R. and Duncan,M.K.
  TITLE     Protein expression patterns for ubiquitous and tissue specific
            calpains in the developing mouse lens
  JOURNAL   Exp Eye Res 76 (4), 433-443 (2003)
   PUBMED   12634108
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Horikawa,Y., Oda,N., Cox,N.J., Li,X., Orho-Melander,M., Hara,M.,
            Hinokio,Y., Lindner,T.H., Mashima,H., Schwarz,P.E., del
            Bosque-Plata,L., Horikawa,Y., Oda,Y., Yoshiuchi,I., Colilla,S.,
            Polonsky,K.S., Wei,S., Concannon,P., Iwasaki,N., Schulze,J.,
            Baier,L.J., Bogardus,C., Groop,L., Boerwinkle,E., Hanis,C.L. and
            Bell,G.I.
  TITLE     Genetic variation in the gene encoding calpain-10 is associated
            with type 2 diabetes mellitus
  JOURNAL   Nat Genet 26 (2), 163-175 (2000)
   PUBMED   11017071
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):502]
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   Dear,T.N., Meier,N.T., Hunn,M. and Boehm,T.
  TITLE     Gene structure, chromosomal localization, and expression pattern of
            Capn12, a new member of the calpain large subunit gene family
  JOURNAL   Genomics 68 (2), 152-160 (2000)
   PUBMED   10964513
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Braun,C., Engel,M., Theisinger,B., Welter,C. and Seifert,M.
  TITLE     CAPN 8: isolation of a new mouse calpain-isoenzyme
  JOURNAL   Biochem Biophys Res Commun 260 (3), 671-675 (1999)
   PUBMED   10403824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI986964.1, BC010969.1 and BB747799.1.
            
            On Feb 9, 2006 this sequence version replaced NM_011796.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005681.1, AF089089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               BI986964.1         234-600             c
            368-2870            BC010969.1         12-2514
            2871-2877           BB747799.1         445-451
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2877
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /note="calpain 10"
                     /db_xref="GeneID:23830"
                     /db_xref="MGI:MGI:1344392"
     exon            1..607
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..2467
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /EC_number="3.4.22.17"
                     /note="CANP 10; calcium-activated neutral proteinase 10;
                     calpain 8"
                     /codon_start=1
                     /product="calpain-10"
                     /protein_id="NP_035926.2"
                     /db_xref="CCDS:CCDS15181.1"
                     /db_xref="GeneID:23830"
                     /db_xref="MGI:MGI:1344392"
                     /translation="MRAVRAETPARELFRDAAFPASDSSLFYNLSTPLAQFREDITWR
                     RPQEICATPQLFPDNPWEGQVKQGLLGDCWFLCACAALQKSQHLLDQVFPPGQPGWSD
                     QKYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRCQREDVFWLPLLEKAYAKVHG
                     SYEHLWAGQVADALVDLTGSLAERWSLKDVTKASGQQDRPSGGEHRTCRQLLHLKDRC
                     LISCSVLSPRAGARELGEFHAFIISDLQELRSQTGQGILLLRIHNPWGRRCWQGLWRE
                     GGEGWNQVEPAKESELLAQLQEGEFWVEEEEFLREFDEVTIGYPVTEAGHLQSLHTER
                     VLCHTRTLPGAWVTGQSAGGCRNNSCFPCNPKFWLRLLEPSEVCVAVLQRPRRRLVGQ
                     TRALAGASPAPVNLPGKDYQAVGLHIWKVEKRKISLPRVLSAPPVAGTACHAYDREIH
                     LRCELSPGYYLAVPSTFLKDVPGQFLLRVFSTGKISLSAVRLATKGASPGTALPAGEW
                     ETVQLQGCWRAGQTAGGSRNFASYPCNPCLPFSVPEGAGPRYIRITLQQHCRLSDSQL
                     HPIGFHVFQVPADGENQDACSLLLQEPLLSCVPHRYAQEVSRLCLLSVGNYRIVPSTY
                     LPDTEGTFTVTIATRIDRQSIHSQEMLGQLLQEVSFMAVMKA"
     exon            608..739
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            740..936
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1154
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1296
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1463
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1726
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1929
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2191
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2391
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2437
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2877
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /note="hexamer: AATAAA"
     polyA_site      2870
                     /gene="Capn10"
                     /gene_synonym="Capn8; mKIAA1845"
                     /note="major polyA site"
ORIGIN      
        1 cgcctgtgat cagcgacgta tgctgggaac ggcgctgcat gctgggatag cattgacaaa
       61 gcgatctaaa ccaaagtgac ttttcagctt cctgtggtca ctgagacttc gatttcaagt
      121 ggctacagct gcgttgtccc gagcactaaa gcatacggac atcaggctag cactgcccag
      181 ttagaaacgc ggggaccacg ccctcgtgcg agagcagaac ctaccagtcc tgcacggttc
      241 tgcgctgcag ctcgtgcgtg attaggcagc tctgtcatat gacgcaagca cggctcctgg
      301 ttggctccag ccgggttacc tagacaacgg agcttgcggc gctaggctgc tctgcaccag
      361 taggtctccc gggctaagca aacacggttt gcagtgaagg ccgcgcactc gctcccgggc
      421 ggcgaccgag tccacgggcc gcagatggga gcccagggcg ccgaagatgc gggcggtccg
      481 ggccgagacg ccggcgcggg agctcttccg ggacgcggca ttccccgcct cggactcctc
      541 gctcttttac aacttgtcca cgcctctggc ccagtttcgg gaggacatca cttggagacg
      601 accccaggaa atctgtgcca cacctcagct gtttccagat aacccatggg agggacaggt
      661 gaagcaaggg ctgctgggag attgctggtt cctgtgtgcc tgtgccgccc ttcagaagag
      721 tcaacacctc ctggaccagg tcttccctcc aggacagcca ggctggtctg accagaaata
      781 ccaaggcttc ttcacctgtc ggatttggca gtttggacac tgggaggaag tgaccataga
      841 tgatcgtctg ccttgtcttg ccgggagact ctgcttttcc cggtgccaga gagaggatgt
      901 gttctggctt cccttactgg aaaaggccta tgctaaggtc catggatcgt atgagcacct
      961 gtgggcaggg caagtggcag atgccttagt ggatctcact ggaagcctgg cagaaaggtg
     1021 gagcttgaag gatgtaacga aagccagcgg ccagcaggac agacccagtg gtggggagca
     1081 cagaacttgt cggcagctac tccacctgaa ggaccggtgt ctaatcagct gctctgtgct
     1141 tagccccaga gcaggtgcca gggaactcgg agagttccat gccttcatca tctcagatct
     1201 gcaggagctc aggagtcaga ctggccaggg tatcctcctg ctgcggattc acaacccctg
     1261 gggccggcgt tgttggcagg gcctctggag agaaggaggt gaagggtgga accaggtaga
     1321 gccagctaag gagtctgagc tgctggccca actccaggaa ggagagttct gggtcgagga
     1381 agaggagttc ctcagggagt ttgatgaggt caccatcggc tacccagtca cagaggccgg
     1441 ccacctacag agtctccaca cagagagggt gctgtgccat acgcggacac tgcctggtgc
     1501 ctgggtgaca gggcagtcag caggaggctg ccggaacaac agttgctttc cctgcaaccc
     1561 caagttctgg ttacggctct tggaacccag cgaggtgtgt gtggctgttc ttcagagacc
     1621 ccggaggcgc ttagtgggcc agactcgggc actggcgggt gccagtcctg caccggtgaa
     1681 cctcccaggc aaagactacc aggctgtggg cctgcacatc tggaaggtag agaaacggaa
     1741 gatcagcctg cccagagtcc tgtctgcacc ccctgtggct ggcactgcat gccatgcgta
     1801 tgatcgtgag atccacttgc gttgtgagct ctcaccaggc tactacctgg ccgtccctag
     1861 cacctttttg aaggatgtgc cagggcagtt cctgctcaga gtcttctcca ctgggaaaat
     1921 ctccctcagt gccgtcaggc tggccaccaa gggtgcatcg cctggaacag ccctgcctgc
     1981 aggcgagtgg gagactgtgc agttgcaggg ctgctggaga gctggccaga cagctggggg
     2041 cagcaggaac tttgcctctt acccctgcaa tccctgcctc cctttctctg ttcctgaggg
     2101 tgctggcccc cgctacatcc gtatcaccct acagcaacac tgccggctca gtgacagcca
     2161 gctgcacccc attggtttcc atgtctttca ggttccagca gacggtgaga accaggacgc
     2221 gtgttccctg ctgctccagg agccactgct aagctgtgta ccacatcgct acgcccagga
     2281 agtgagccgc ctctgcctcc tttctgtggg gaactacagg attgttccct ccacctacct
     2341 gccagataca gagggtacct tcacggtaac catagcaacc agaatcgata ggcagtccat
     2401 ccacagccag gagatgctgg gccagctgct ccaggaggtc tcctttatgg cagtgatgaa
     2461 agcctgacac gagaccctgt gtgccagcca tggccagagt ggctgctgcc cctgtgccca
     2521 gcatccaggt gcatctccag ccagctacaa gccagcttct cgtcagctct ggaggttggc
     2581 tgtggacctt ggggctaaaa tagggtgctt tgtcctggat tgaagacatc tcgggtccag
     2641 tgggtgctgc agggcggggc tagaactccc aagtggtatc ttcattcctt agtgaaggcc
     2701 aggagattcc tggggcccgg gtttgttgtg gaaagctttg cagaatccac ataaccttct
     2761 tgacttcgga agccttacac taggcaggca gactgtgaca aatgctaaaa cctatttatt
     2821 acttgaaata tttttggaat gtgactttat aaataaacat gaataattta tggatta
//
