LOCUS       NM_007600               3119 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus calpain 1 (Capn1), transcript variant 1, mRNA.
ACCESSION   NM_007600
VERSION     NM_007600.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Xue,X., Xi,W., Li,W., Xiao,J., Wang,Z. and Zhang,Y.
  TITLE     Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing
            expression of calpain1 via miR-124-3p
  JOURNAL   ESC Heart Fail 10 (5), 3077-3090 (2023)
   PUBMED   37602925
  REMARK    GeneRIF: Hydrogen-rich saline alleviates cardiomyocyte apoptosis by
            reducing expression of calpain1 via miR-124-3p.
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Deng,H., Tian,X., Sun,H., Liu,H., Lu,M. and Wang,H.
  TITLE     Calpain-1 mediates vascular remodelling and fibrosis via HIF-1alpha
            in hypoxia-induced pulmonary hypertension
  JOURNAL   J Cell Mol Med 26 (10), 2819-2830 (2022)
   PUBMED   35365973
  REMARK    GeneRIF: Calpain-1 mediates vascular remodelling and fibrosis via
            HIF-1alpha in hypoxia-induced pulmonary hypertension.
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Sheng,X., Liu,C., Yan,G., Li,G., Liu,J., Yang,Y., Li,S., Li,Z.,
            Zhou,J., Zhen,X., Zhang,Y., Diao,Z., Hu,Y., Fu,C., Yao,B., Li,C.,
            Cao,Y., Lu,B., Yang,Z., Qin,Y., Sun,H. and Ding,L.
  TITLE     The mitochondrial protease LONP1 maintains oocyte development and
            survival by suppressing nuclear translocation of AIFM1 in mammals
  JOURNAL   EBioMedicine 75, 103790 (2022)
   PUBMED   34974310
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Saadane,A., Du,Y., Thoreson,W.B., Miyagi,M., Lessieur,E.M.,
            Kiser,J., Wen,X., Berkowitz,B.A. and Kern,T.S.
  TITLE     Photoreceptor Cell Calcium Dysregulation and Calpain Activation
            Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation
            in Prodromal Diabetic Retinopathy
  JOURNAL   Am J Pathol 191 (10), 1805-1821 (2021)
   PUBMED   34214506
  REMARK    GeneRIF: Photoreceptor Cell Calcium Dysregulation and Calpain
            Activation Promote Pathogenic Photoreceptor Oxidative Stress and
            Inflammation in Prodromal Diabetic Retinopathy.
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Yu,Q., Chen,S., Tang,H., Yang,H., Zhang,J., Shi,X., Li,J., Guo,W.
            and Zhang,S.
  TITLE     miR-140-5p alleviates mouse liver ischemia/reperfusion injury by
            targeting CAPN1
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34296301
  REMARK    GeneRIF: miR1405p alleviates mouse liver ischemia/reperfusion
            injury by targeting CAPN1.
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Sorimachi,H., Forsberg,N.E., Lee,H.J., Joeng,S.Y., Richard,I.,
            Beckmann,J.S., Ishiura,S. and Suzuki,K.
  TITLE     Highly conserved structure in the promoter region of the gene for
            muscle-specific calpain, p94
  JOURNAL   Biol Chem 377 (12), 859-864 (1996)
   PUBMED   8997499
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Spencer,M.J. and Tidball,J.G.
  TITLE     Calpain translocation during muscle fiber necrosis and regeneration
            in dystrophin-deficient mice
  JOURNAL   Exp Cell Res 226 (2), 264-272 (1996)
   PUBMED   8806430
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Li,J., Grynspan,F., Berman,S., Nixon,R. and Bursztajn,S.
  TITLE     Regional differences in gene expression for calcium activated
            neutral proteases (calpains) and their endogenous inhibitor
            calpastatin in mouse brain and spinal cord
  JOURNAL   J Neurobiol 30 (2), 177-191 (1996)
   PUBMED   8738748
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Ohno,S., Minoshima,S., Kudoh,J., Fukuyama,R., Shimizu,Y.,
            Ohmi-Imajoh,S., Shimizu,N. and Suzuki,K.
  TITLE     Four genes for the calpain family locate on four distinct human
            chromosomes
  JOURNAL   Cytogenet Cell Genet 53 (4), 225-229 (1990)
   PUBMED   2209092
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Moens,P.B. and Pearlman,R.E.
  TITLE     In situ DNA sequence mapping with surface-spread mouse pachytene
            chromosomes
  JOURNAL   Cytogenet Cell Genet 53 (4), 219-220 (1990)
   PUBMED   2209090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ078846.1, AK160940.1, AK149090.1 and AW457044.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_007600.4.
            
            On Nov 15, 2007 this sequence version replaced NM_007600.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050276.1, AK150084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CJ078846.1         2-62
            62-2608             AK160940.1         2-2548
            2609-3102           AK149090.1         1957-2450
            3103-3119           AW457044.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3119
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /note="calpain 1"
                     /db_xref="GeneID:12333"
                     /db_xref="MGI:MGI:88263"
     exon            1..142
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            143..410
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2285
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /EC_number="3.4.22.52"
                     /note="mu-calpain; CANP 1; muCANP; calpain mu-type;
                     micromolar-calpain; calpain-1 large subunit;
                     calcium-activated neutral proteinase 1"
                     /codon_start=1
                     /product="calpain-1 catalytic subunit"
                     /protein_id="NP_031626.1"
                     /db_xref="CCDS:CCDS37893.1"
                     /db_xref="GeneID:12333"
                     /db_xref="MGI:MGI:88263"
                     /translation="MTEELITPVYCTGVSAQVQKKRDKELGLGRHENAIKYLGQDYET
                     LRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSNPQFIVDGA
                     TRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQFGEWV
                     DVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFT
                     GGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSV
                     TGAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEF
                     WMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFW
                     VNPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPR
                     ELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDF
                     LLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQ
                     TILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFR
                     KFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLE
                     TMFRFFKLLDTDLDGVVTFDLFKWLQLTMFA"
     exon            411..480
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            481..599
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            600..733
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            734..902
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            903..986
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1072
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1147
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1308
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1484
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1496
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1705
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1745
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1811
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1869
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1934
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2003
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2082
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2199
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2258
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..3103
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /note="putative"
     polyA_site      3102
                     /gene="Capn1"
                     /gene_synonym="Capa-1; Capa1; mu-calpin"
                     /note="putative"
ORIGIN      
        1 gaggggcggt ggaggagggc ggggaggagg gcagggagga gggcagggag gagcgctctt
       61 cctggttggg ccctgccctg agctgccacc aaggaagcca gccccaggga ccgcagcaat
      121 ctcccaaact ccccttcccc aggatgacag aggagttaat cacccctgtg tactgcaccg
      181 gggtgtcagc ccaagtacag aagaagcggg acaaggagct gggcttgggc cgccatgaaa
      241 acgccatcaa gtacctgggc caggattatg aaacgcttcg ggcaagatgc ctgcagagtg
      301 gggtcctctt ccaagacgag gccttccctc cggtttctca tagcctgggc ttcaaggaac
      361 tgggtcctca ttcctctaaa acctatggca tcaaatggaa gcggcctacg gaactgatgt
      421 caaaccccca gttcatcgtg gatggagcca cccggacaga catctgccag ggagcactgg
      481 gggactgttg gctcctggct gccattgcct ccctcaccct caacgagact attctgcacc
      541 gagtggttcc ctacggccag agctttcagg atggctacgc tggcatcttt catttccagc
      601 tgtggcagtt cggggagtgg gtcgacgtgg tcatagatga cttgctgccc accaaggacg
      661 ggaagctggt gttcgtgcac tctgcccagg gcaacgaatt ctggagcgca ctgctggaga
      721 aagcctatgc taaagtgaat ggcagctatg aggctctttc gggaggctgc acctcagagg
      781 ccttcgagga ctttaccggt ggggtcactg agtggtacga cctgcagaag gcccccagcg
      841 acctctacca gatcattcta aaggccctgg aacgaggctc cttgctgggc tgctccatta
      901 atatctccga tatccgtgat ttagaggcta ttacttttaa gaacctggtg aggggccatg
      961 cgtactctgt gacgggcgcc aagcaggtaa cttaccaggg ccagcgggtg aacctaatcc
     1021 ggatgcggaa cccctggggt gaagtggagt ggaaaggacc ctggagtgac agctcctatg
     1081 agtggaacaa agtggacccc tatgaacgag agcagctgag ggtcaagatg gaggatgggg
     1141 agttctggat gtcgttccga gacttcatcc gtgaattcac caaactggaa atctgcaacc
     1201 ttacaccgga cgcccttaag agcaggaccc tccggaattg gaataccaca ttttacgagg
     1261 gcacctggcg tcggggaagc accgctggag gctgcaggaa ctacccagct accttctggg
     1321 taaaccccca gttcaagatc cggttggagg aggtggatga cgcagacgac tatgacaacc
     1381 gggagtcggg ctgcagcttc ttgctggccc tcatgcagaa acaccgccgc agggagcgtc
     1441 gctttggccg ggacatggag accatcggtt ttgcagtgta ccaggtccct cgggagctgg
     1501 cgggtcagcc tgtgcacttg aagcgtgatt tcttcctggc caacgcttct cgggcgcagt
     1561 cagagcactt catcaacctt cgggaagtca gcaaccgtat ccgcctgccg cccggggagt
     1621 acatagtggt gccctccacc ttcgagccca acaaagaagg cgacttcctg ctgcgcttct
     1681 tctcagagaa gaaggctggg acccaggaac tagatgacca gatccaggcc aacctccctg
     1741 atgagaaagt tctctctgaa gaggagattg atgacaactt caagaccttg ttcagcaagt
     1801 tggcagggga tgacatggag atcagcgtca aggagctaca gaccatcttg aacaggatca
     1861 ttagcaaaca caaagacctg cgcactaatg gcttcagcct ggagtcgtgc cgcagcatgg
     1921 tgaacctcat ggatcgagat ggcaacggga agctgggtct ggtggagttc aacatcctgt
     1981 ggaaccgcat ccgaaattac ctgaccatct tccggaagtt tgacctggac aagtctggca
     2041 gcatgagtgc ctatgagatg aggatggcca tcgaggctgc aggcttcaag cttaacaaga
     2101 agctgcatga actcataatc acccgctact cggagcccga cctggccgtg gactttgaca
     2161 actttgtgtg ctgtcttgtg cggctggaga ccatgttccg gtttttcaaa cttctggaca
     2221 cagacctgga tggtgttgtg acctttgatc tatttaagtg gctccagctg actatgtttg
     2281 cctgaagtgg ggaatcgctc cgctccagtt gcctttgttc ttccattctt cctctgccaa
     2341 gccacgcctc cccgccaagc cacgcctccc cgccgtgcca ctccagacta caccagcttc
     2401 tggtgccttc ctcagaacag gaaggaaggc acccttgtcc tcctgttccc cttgtcctcc
     2461 tgtcctttca cctccccact acctctgttc gactgctctg ggcagtcacg gggccctccc
     2521 tgcccctgta gtcagactgg gcaccctgac ccctgctcag ggctaagacc aggaagacag
     2581 ctccctgctc atccctgcct cggggcaggg gcaggggcag gggcaggggc aggggcaggg
     2641 gcaggggcag gggcaggcac ccctgcccct ccccctcgct gctactgtcc ggatgtgagt
     2701 cttgcctaat ctgtggaggc tctagcccct gtcatcccct agagctgcag acttcataac
     2761 cactagctag ctccctgtct gcacccgggt gttgaaggcc tcacctcact gtgggagccc
     2821 cacagccaga ctcaccttcc tgtgccttct gtgcagcagc caagatccct ctgcaaacca
     2881 aactacacct ctcctagcct gtgtgcccac caggaacttc ctggccccga gggtgctcag
     2941 gccctcccca tccccgaccc ctctccctct ctttttttgt atatatactg gtcattttca
     3001 agggaatgcc tgagggatga gtgtactggt tatggaggaa ctgggggtgg ggtagggagg
     3061 tcccgtgttt cagtgcagtg agaaaataaa atgaaaggct gtaaaaaaaa aaaaaaaaa
//
