LOCUS       NM_001042534            1400 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus capping actin protein, gelsolin like (Capg),
            transcript variant 2, mRNA.
ACCESSION   NM_001042534
VERSION     NM_001042534.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Ma Q, Zhao M, Long B and Li H.
  TITLE     Super-enhancer-associated gene CAPG promotes AML progression
  JOURNAL   Commun Biol 6 (1), 622 (2023)
   PUBMED   37296281
  REMARK    GeneRIF: Super-enhancer-associated gene CAPG promotes AML
            progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Wang X, Pierre V, Liu C, Senapati S, Park PS and Senyo SE.
  TITLE     Exogenous extracellular matrix proteins decrease cardiac fibroblast
            activation in stiffening microenvironment through CAPG
  JOURNAL   J Mol Cell Cardiol 159, 105-119 (2021)
   PUBMED   34118218
  REMARK    GeneRIF: Exogenous extracellular matrix proteins decrease cardiac
            fibroblast activation in stiffening microenvironment through CAPG.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor
            D, Tang DT, Grimmond SM and Little MH.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Hansen SD and Mullins RD.
  TITLE     VASP is a processive actin polymerase that requires monomeric actin
            for barbed end association
  JOURNAL   J Cell Biol 191 (3), 571-584 (2010)
   PUBMED   21041447
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Onoda K, Yu FX and Yin HL.
  TITLE     gCap39 is a nuclear and cytoplasmic protein
  JOURNAL   Cell Motil Cytoskeleton 26 (3), 227-238 (1993)
   PUBMED   8293478
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Prendergast GC and Ziff EB.
  TITLE     Mbh 1: a novel gelsolin/severin-related protein which binds actin
            in vitro and exhibits nuclear localization in vivo
  JOURNAL   EMBO J 10 (4), 757-766 (1991)
   PUBMED   1849072
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Yu FX, Johnston PA, Sudhof TC and Yin HL.
  TITLE     gCap39, a calcium ion- and polyphosphoinositide-regulated actin
            capping protein
  JOURNAL   Science 250 (4986), 1413-1415 (1990)
   PUBMED   2255912
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Johnston PA, Yu FX, Reynolds GA, Yin HL, Moomaw CR, Slaughter CA
            and Sudhof TC.
  TITLE     Purification and expression of gCap39. An intracellular and
            secreted Ca2(+)-dependent actin-binding protein enriched in
            mononuclear phagocytes
  JOURNAL   J Biol Chem 265 (29), 17946-17952 (1990)
   PUBMED   2211671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA289672.1, BY155308.1, AK152818.1 and AK165153.1.
            
            On Sep 22, 2012 this sequence version replaced NM_001042534.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            represents use of an alternate promoter compared to variant 1.
            Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146622.1, AK152818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AA289672.1         1-150
            151-176             BY155308.1         1-26
            177-1397            AK152818.1         2-1222
            1398-1400           AK165153.1         1212-1214
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..1400
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /note="capping actin protein, gelsolin like"
                     /db_xref="GeneID:12332"
                     /db_xref="MGI:MGI:1098259"
     exon            1..229
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..265
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1292
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /note="myc basic motif homolog 1; actin-capping protein
                     GCAP39; actin regulatory protein CAP-G; capping protein
                     (actin filament), gelsolin-like"
                     /codon_start=1
                     /product="macrophage-capping protein"
                     /protein_id="NP_001035999.1"
                     /db_xref="CCDS:CCDS39516.1"
                     /db_xref="GeneID:12332"
                     /db_xref="MGI:MGI:1098259"
                     /translation="MYTPIPQSGSPFPASVQDPGLHIWRVEKLKPVPIARESHGIFFS
                     GDSYLVLHNGPEEASHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNE
                     SDLFMSYFPRGLKYREGGVESAFHKTTSGATPAAIRKLYQVKGKKNIRATERALSWDS
                     FNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIITDGEEP
                     AEMIQVLGPKPALKEGNPEEDITADQTNAQAAALYKVSDATGQMNLTKVADSSPFASE
                     LLIPDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVADGFISRMRYSPNTQVEILPQ
                     GRESPIFKQFFKNWK"
     exon            266..438
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..593
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..761
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..911
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1004
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1137
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1226
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1400
                     /gene="Capg"
                     /gene_synonym="gCap39; mbh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctagtcag gctttaacct cccagtgacc atgtctgaga aatagcagcc ttccatccgc
       61 atggcccagc cttggagctg gctttcctga gcccttagac ttctgagtac tgagcctccc
      121 catgggtggg gcaggtgggt ggggcagccc agtggcgaag agggaagtta gaagctagct
      181 atcgaggggc aagctgagac gagtttgaga agaaaaggcc cgtggagagg tctgcaaaca
      241 gcatgtacac acccatccct cagagtggct ctccattccc ggcctcagtc caagacccag
      301 gcctacacat atggcgtgtg gagaagctga agccggtgcc catagcacga gagagccatg
      361 gcatcttttt ctctggggac tcctacctag tgcttcacaa tggcccagag gaggcttccc
      421 atctgcacct gtggataggc cagcagtcct cccgggatga gcagggggcc tgtgcagtgc
      481 tggctgtgca tctcaacacc ctgctggggg agcggccagt gcagcaccgt gaggttcaag
      541 gcaatgagtc tgacctcttc atgagctact tcccacgagg cctcaagtac cgggaaggtg
      601 gtgtagagtc ggcatttcac aagacaacct cgggcgccac cccagcagcc atcaggaagc
      661 tctaccaggt taaggggaag aagaacatcc gtgcgaccga gagggctctg agttgggaca
      721 gcttcaacac tggggactgc ttcatcctgg acctgggtca gaacatcttt gcctggtgtg
      781 gtggaaagtc caacatcctt gagcgcaaca aggcgaggga cctggccctg gccatcaggg
      841 acagcgagcg gcagggcaag gcccaggtgg aaatcatcac tgatggagag gagccagccg
      901 agatgattca ggttctgggc cccaagcctg ctctgaagga gggtaacccc gaggaagaca
      961 ttacagctga ccagaccaac gcccaggctg cagccctgta taaggtctct gatgccactg
     1021 gacagatgaa tctgaccaag gtggctgact ccagcccttt tgcctctgaa ctgctaattc
     1081 cagatgactg ctttgttctg gacaacgggc tgtgtggcaa aatctacatc tggaagggga
     1141 gaaaagctaa tgagaaagag cggcaggcag ccctccaagt ggctgatggc ttcatctctc
     1201 gaatgaggta ttccccaaac actcaggtgg agatactgcc ccagggccga gagagtccca
     1261 tcttcaagca attcttcaag aactggaagt gagggtgggt gtcccccatc tctgctctcc
     1321 tgcctcccac ccctgcctgc tgggtcagca ctgaggtgcc ctctggatgc tcaataaagg
     1381 acacattcca ttccctgctc
//
