LOCUS       NM_026056               3673 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus cyclase associated actin cytoskeleton regulatory
            protein 2 (Cap2), mRNA.
ACCESSION   NM_026056
VERSION     NM_026056.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3673)
  AUTHORS   Schuldt,C., Khudayberdiev,S., Chandra,B.D., Linne,U. and Rust,M.B.
  TITLE     Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2)
            to induce dendritic spine maturation
  JOURNAL   Cell Mol Life Sci 81 (1), 353 (2024)
   PUBMED   39154297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3673)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
REFERENCE   3  (bases 1 to 3673)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3673)
  AUTHORS   Alimov,N., Hoeprich,G.J., Padrick,S.B. and Goode,B.L.
  TITLE     Cyclase-associated protein interacts with actin filament barbed
            ends to promote depolymerization and formin displacement
  JOURNAL   J Biol Chem 299 (12), 105367 (2023)
   PUBMED   37863260
  REMARK    GeneRIF: Cyclase-associated protein interacts with actin filament
            barbed ends to promote depolymerization and formin displacement.
REFERENCE   5  (bases 1 to 3673)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3673)
  AUTHORS   Christoforou,N., Miller,R.A., Hill,C.M., Jie,C.C., McCallion,A.S.
            and Gearhart,J.D.
  TITLE     Mouse ES cell-derived cardiac precursor cells are multipotent and
            facilitate identification of novel cardiac genes
  JOURNAL   J Clin Invest 118 (3), 894-903 (2008)
   PUBMED   18246200
REFERENCE   7  (bases 1 to 3673)
  AUTHORS   Peche,V., Shekar,S., Leichter,M., Korte,H., Schroder,R.,
            Schleicher,M., Holak,T.A., Clemen,C.S., Ramanath-Y,B., Pfitzer,G.,
            Karakesisoglou,I. and Noegel,A.A.
  TITLE     CAP2, cyclase-associated protein 2, is a dual compartment protein
  JOURNAL   Cell Mol Life Sci 64 (19-20), 2702-2715 (2007)
   PUBMED   17805484
  REMARK    GeneRIF: CAP2 is significantly expressed only in brain, heart and
            skeletal muscle, and skin, a C-terminal fragment of CAP2 interacts
            with actin, indicating that CAP2 has the capacity to bind to actin
REFERENCE   8  (bases 1 to 3673)
  AUTHORS   Terami,H., Hidaka,K., Shirai,M., Narumiya,H., Kuroyanagi,T.,
            Arai,Y., Aburatani,H. and Morisaki,T.
  TITLE     Efficient capture of cardiogenesis-associated genes expressed in ES
            cells
  JOURNAL   Biochem Biophys Res Commun 355 (1), 47-53 (2007)
   PUBMED   17286962
REFERENCE   9  (bases 1 to 3673)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   10 (bases 1 to 3673)
  AUTHORS   Bertling,E., Hotulainen,P., Mattila,P.K., Matilainen,T.,
            Salminen,M. and Lappalainen,P.
  TITLE     Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin
            dynamics in mammalian nonmuscle cells
  JOURNAL   Mol Biol Cell 15 (5), 2324-2334 (2004)
   PUBMED   15004221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035556.1, AK013331.1, AK033071.1 and BM899250.1.
            
            On Jun 19, 2010 this sequence version replaced NM_026056.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035556.1, AK033071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AK035556.1         2-244
            244-2226            AK013331.1         1-1983
            2227-3655           AK033071.1         1983-3411
            3656-3673           BM899250.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 23.83 cM"
     gene            1..3673
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="cyclase associated actin cytoskeleton regulatory
                     protein 2"
                     /db_xref="GeneID:67252"
                     /db_xref="MGI:MGI:1914502"
     exon            1..309
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..431
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1741
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="CAP, adenylate cyclase-associated protein, 2"
                     /codon_start=1
                     /product="adenylyl cyclase-associated protein 2"
                     /protein_id="NP_080332.1"
                     /db_xref="CCDS:CCDS26484.1"
                     /db_xref="GeneID:67252"
                     /db_xref="MGI:MGI:1914502"
                     /translation="MTDMAGLMERLERAVIRLEQLSAGLDGPPRGCGEVNGVNGGVAP
                     SVEAFDKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQYQQPQENE
                     VAVLLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIAALGWIAVSPKPGPYVKEMN
                     DAATFYTNRVLKDYKHSDLRHVDWVRSYLNIWSELQAYIREHHTTGLTWSKTGPVAST
                     ASAFSILSSGPGLPPPPPPPPPPGPPPPFENEDKKEEPSPSRSALFAQLNQGEAITKG
                     LRHVTDDKKTYKNPSLRAQGQIRSPTKTHTPSPTSPKSNSPQKHTPVLELEGKKWRVE
                     YQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITVDNCKKFGLVFDHVVGIVE
                     VINSKDIQIQVMGRVPTISINKTEGCHLYLSEDALDCEIVSAKSSEMNVLVPQDDDYR
                     EFPIPEQFKTIWDGSKLVTEPAEIMA"
     exon            432..532
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..610
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            611..754
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            755..840
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..946
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1136
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1309
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1433
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1516
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1657
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..3658
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1929
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="major polyA site"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="hexamer: AGTAAA"
     regulatory      2991..2996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3002
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
     polyA_site      3017
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcatttcc tgcttgcacc ggcgatcgcc tctgccctcc tatctctctt ctcccacggc
       61 ccatctgtgt ctcctctctg ctcccttcct tgccaccccc gccctcggct gggtgctccc
      121 ggcccctccc gcgcccgtct gtatttggag ctgccggaag ctgcgggcga ctctccccga
      181 gagcagcgtg accgactcgg gctcccgtgc aggggggagg cggaggcagc accgggcctg
      241 cgggaggagg gcgcaagtgg ccggagccgg ctttgcatca ccgaagccag gacctgagct
      301 ctacagcaga atgacagaca tggcgggact gatggagagg ctggaacgtg cagtcatccg
      361 gctggagcag ctgtctgcag ggttagacgg acctcccaga ggctgcgggg aagtgaatgg
      421 tgtcaatgga ggtgtggcac cgtccgtgga agcttttgac aaactgataa acagtatggt
      481 ggccgagttc ttaaagaaca gccgagtcct tgctggtgac gtagagactc acgcagaaat
      541 ggtgcacggt gctttccaag cccagcgtgc ttttcttctc atggtctcgc agtaccaaca
      601 accccaagag aatgaagttg ctgtccttct gaagcccata tcggagaaga ttcaagaaat
      661 acagactttc cgagagagaa accggggaag caacatgttc aaccacctct cggcagtcag
      721 tgaaagcatc gccgccctgg gctggatagc cgtgtccccc aaacctggtc cttatgtcaa
      781 ggagatgaac gacgctgcca ccttttacac aaacagggtc ctgaaagact acaagcacag
      841 cgatctgcgc cacgtggatt gggtgaggtc ctacctcaac atctggagcg agctgcaagc
      901 ctacatcagg gaacaccaca ccacaggcct cacttggagc aaaacaggtc ctgtggcatc
      961 cacagcgtca gcgttttcca tcctctcctc tgggcctggt ctcccgccac cacctccacc
     1021 accacctcct cctgggccac ctccaccctt tgagaatgag gataaaaagg aggagccctc
     1081 cccttctcgc tcagctttat ttgcccagct caatcaagga gaagccatca ctaaagggct
     1141 ccggcatgtc acagatgaca agaagacata caagaatccc agcctgaggg ctcaaggaca
     1201 gattcgctct ccaaccaaaa ctcacacgcc gagccccaca tctccaaaat cgaattctcc
     1261 tcagaaacat actccagtgt tggagctgga agggaagaag tggagagtgg aataccaaga
     1321 ggacaggaat gaccttgtca tctccgagac cgagctgaaa caagtggctt acattttcaa
     1381 atgtgacaaa tccactcttc agataaaggg aaaagtgaac tccatcactg tcgataactg
     1441 caagaagttt ggcctggtgt ttgatcatgt ggtgggcatt gtggaagtga tcaactccaa
     1501 ggacattcag atccaggtaa tggggagagt accaacaatc tccattaata agacagaagg
     1561 atgccacctg tacctcagtg aagatgcact agactgtgag atcgtgagcg cgaagtcgtc
     1621 cgagatgaat gtcctggtcc ctcaggatga cgattataga gaattcccca ttcccgagca
     1681 gttcaagaca atatgggatg gctccaagct ggtcaccgaa cctgcagaga tcatggcctg
     1741 acatccaaga aatagccttc cctgagtctc ctctagcgaa cagaagcaag cagctaatag
     1801 gagctagatt ttaccatagc cccgacgccc gtgtccgtgt ccgaatcctg cagttctgtg
     1861 ccatggaaaa cagtatcttt tctggcaggc ttttatgggc gttttgaaat atttaacatt
     1921 tgatcatgat ttgtgtgtga ttttacttcc acgtgataac tagtaaacac ggcagttaaa
     1981 gggaaaagaa ttctgttccc atcacaccac caactccgta actgataagg aaaagccctg
     2041 cctatttctt cctttcagtt taattgctag ttgaaaaaaa aaaatgaagc cttagagaac
     2101 ctatgtatgt ttttaccttt tagacaactt taaaatagtc ttgtgcccta aagaataagg
     2161 ctctattttt taatttttac gtgctcccct ttatcagcgt ggacatcctg tcagcatgaa
     2221 tgaattcttc aatccatgct tttacacaca catatacaca aagagaaaac atctaaggaa
     2281 acacaatata ccctttatag ttactgaaaa acaaaagaaa tcctaactcc atctttctcg
     2341 tgagtcactt taaaagttct aatttgcctg catatcctaa gacaaagggt ggtggcaggg
     2401 aggggtgggg tgtggtaggg actcagtcct cagtttttgc tttgtaatac ctcatggtct
     2461 ggtttgaagg atagctcggc ctttgcgttg cagttttgaa gtcacccata gtatcagaca
     2521 accccataca ggtctctaat gcttattaga gatgagtccc ttttccactg gccaggctaa
     2581 ccagtgctaa ccagcctcaa agacaaaaat gcccaagagc ctgactattg cttctggaat
     2641 cagttgtttg gctctggttg ggttttctag tcttgatagt acacagactt ccaggcaagc
     2701 aacaacactc ttcgtgtctc ttctctgcac gtggccgaga actctgcagc tttttgggtc
     2761 ctgtgtaacg aagcatagcg ctaagctttt ggaaccagtg ggagcatcta gattgtgcct
     2821 acgaagaccc cgctggctat cattttttca gttttctaat agcttctata tccatacagt
     2881 cttcatatca ctgatgtttg tgtatcaaag ttttgctata aaagttctgt ccttatgaac
     2941 tatgtggtgg ctttagtaag tataattttt tgaacagtaa agttatacta agtaaaacca
     3001 aattgtttaa atactgagat gaattctcat tttggttttg catttgtttt gccctgtttt
     3061 atctttcgct tgctacttgt tgatttgttt gcggtcagcc agagatacaa agtgagacac
     3121 tattggaggt acttaatgcc gagcctgaca acttgagtgt gatctccagg aaccacgtgg
     3181 tggaaggaga gaagtgacct acacaagacg tcctctgacc tgtacataca catcatcaca
     3241 tcatgaatgc acatgccagt gcgcacacgc gcacacacac acacacacac acacacacac
     3301 acaagttttt tttaaaaact ttaaatttaa aaaaaataaa agtcaaaatg gagctggaga
     3361 catggcagca gttaggagct cggccgttct tgtagagaac ccacccatgt tcaagtccat
     3421 cacccacctg acagctcata acctcctgta actccagttc caaggaatct aacatcctcc
     3481 tgggtacctg catgcatgtg gtgcacctgc gcactcgatc acgcacatac acattcagtt
     3541 gtactttaat agtcaaaatg aaaattgcca tcacattata ttacatattt gcattatagt
     3601 ggccttatgt aaccagggtt gttttttttt ttttttttaa ttaaaaaata aaactagaaa
     3661 aaaaaaaaaa aaa
//
