LOCUS       NP_080332                476 aa            linear   ROD 28-APR-2025
DEFINITION  adenylyl cyclase-associated protein 2 [Mus musculus].
ACCESSION   NP_080332
VERSION     NP_080332.1
DBSOURCE    REFSEQ: accession NM_026056.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 476)
  AUTHORS   Schuldt,C., Khudayberdiev,S., Chandra,B.D., Linne,U. and Rust,M.B.
  TITLE     Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2)
            to induce dendritic spine maturation
  JOURNAL   Cell Mol Life Sci 81 (1), 353 (2024)
   PUBMED   39154297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 476)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
REFERENCE   3  (residues 1 to 476)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 476)
  AUTHORS   Alimov,N., Hoeprich,G.J., Padrick,S.B. and Goode,B.L.
  TITLE     Cyclase-associated protein interacts with actin filament barbed
            ends to promote depolymerization and formin displacement
  JOURNAL   J Biol Chem 299 (12), 105367 (2023)
   PUBMED   37863260
  REMARK    GeneRIF: Cyclase-associated protein interacts with actin filament
            barbed ends to promote depolymerization and formin displacement.
REFERENCE   5  (residues 1 to 476)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 476)
  AUTHORS   Christoforou,N., Miller,R.A., Hill,C.M., Jie,C.C., McCallion,A.S.
            and Gearhart,J.D.
  TITLE     Mouse ES cell-derived cardiac precursor cells are multipotent and
            facilitate identification of novel cardiac genes
  JOURNAL   J Clin Invest 118 (3), 894-903 (2008)
   PUBMED   18246200
REFERENCE   7  (residues 1 to 476)
  AUTHORS   Peche,V., Shekar,S., Leichter,M., Korte,H., Schroder,R.,
            Schleicher,M., Holak,T.A., Clemen,C.S., Ramanath-Y,B., Pfitzer,G.,
            Karakesisoglou,I. and Noegel,A.A.
  TITLE     CAP2, cyclase-associated protein 2, is a dual compartment protein
  JOURNAL   Cell Mol Life Sci 64 (19-20), 2702-2715 (2007)
   PUBMED   17805484
  REMARK    GeneRIF: CAP2 is significantly expressed only in brain, heart and
            skeletal muscle, and skin, a C-terminal fragment of CAP2 interacts
            with actin, indicating that CAP2 has the capacity to bind to actin
REFERENCE   8  (residues 1 to 476)
  AUTHORS   Terami,H., Hidaka,K., Shirai,M., Narumiya,H., Kuroyanagi,T.,
            Arai,Y., Aburatani,H. and Morisaki,T.
  TITLE     Efficient capture of cardiogenesis-associated genes expressed in ES
            cells
  JOURNAL   Biochem Biophys Res Commun 355 (1), 47-53 (2007)
   PUBMED   17286962
REFERENCE   9  (residues 1 to 476)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   10 (residues 1 to 476)
  AUTHORS   Bertling,E., Hotulainen,P., Mattila,P.K., Matilainen,T.,
            Salminen,M. and Lappalainen,P.
  TITLE     Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin
            dynamics in mammalian nonmuscle cells
  JOURNAL   Mol Biol Cell 15 (5), 2324-2334 (2004)
   PUBMED   15004221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035556.1, AK013331.1, AK033071.1 and BM899250.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035556.1, AK033071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 23.83 cM"
     Protein         1..476
                     /product="adenylyl cyclase-associated protein 2"
                     /note="CAP, adenylate cyclase-associated protein, 2"
                     /calculated_mol_wt=52731
     Region          5..64
                     /region_name="CAP_N"
                     /note="Adenylate cyclase associated (CAP) N terminal;
                     pfam01213"
                     /db_xref="CDD:460113"
     Region          223..322
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CYT6.1)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52481; propagated from
                     UniProtKB/Swiss-Prot (Q9CYT6.1)"
     Site            308
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P40123; propagated from
                     UniProtKB/Swiss-Prot (Q9CYT6.1)"
     Region          322..474
                     /region_name="CAP_C"
                     /note="Adenylate cyclase associated (CAP) C terminal;
                     pfam08603"
                     /db_xref="CDD:462532"
     CDS             1..476
                     /gene="Cap2"
                     /gene_synonym="2810452G09Rik"
                     /coded_by="NM_026056.4:311..1741"
                     /db_xref="CCDS:CCDS26484.1"
                     /db_xref="GeneID:67252"
                     /db_xref="MGI:MGI:1914502"
ORIGIN      
        1 mtdmaglmer leravirleq lsagldgppr gcgevngvng gvapsveafd klinsmvaef
       61 lknsrvlagd vethaemvhg afqaqrafll mvsqyqqpqe nevavllkpi sekiqeiqtf
      121 rernrgsnmf nhlsavsesi aalgwiavsp kpgpyvkemn daatfytnrv lkdykhsdlr
      181 hvdwvrsyln iwselqayir ehhttgltws ktgpvastas afsilssgpg lppppppppp
      241 pgppppfene dkkeepspsr salfaqlnqg eaitkglrhv tddkktyknp slraqgqirs
      301 ptkthtpspt spksnspqkh tpvlelegkk wrveyqedrn dlvisetelk qvayifkcdk
      361 stlqikgkvn sitvdnckkf glvfdhvvgi vevinskdiq iqvmgrvpti sinktegchl
      421 ylsedaldce ivsakssemn vlvpqdddyr efpipeqfkt iwdgsklvte paeima
//
