LOCUS       NM_001358035            2787 bp    mRNA    linear   ROD 13-APR-2024
DEFINITION  Mus musculus cyclase associated actin cytoskeleton regulatory
            protein 1 (Cap1), transcript variant 3, mRNA.
ACCESSION   NM_001358035 XM_006502695
VERSION     NM_001358035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Alimov,N., Hoeprich,G.J., Padrick,S.B. and Goode,B.L.
  TITLE     Cyclase-associated protein interacts with actin filament barbed
            ends to promote depolymerization and formin displacement
  JOURNAL   J Biol Chem 299 (12), 105367 (2023)
   PUBMED   37863260
  REMARK    GeneRIF: Cyclase-associated protein interacts with actin filament
            barbed ends to promote depolymerization and formin displacement.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Heinze,A. and Rust,M.B.
  TITLE     Loss of the actin regulator cyclase-associated protein 1 (CAP1)
            modestly affects dendritic spine remodeling during synaptic
            plasticity
  JOURNAL   Eur J Cell Biol 102 (4), 151357 (2023)
   PUBMED   37634312
  REMARK    GeneRIF: Loss of the actin regulator cyclase-associated protein 1
            (CAP1) modestly affects dendritic spine remodeling during synaptic
            plasticity.
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Heinze,A., Schuldt,C., Khudayberdiev,S., van Bommel,B., Hacker,D.,
            Schulz,T.G., Stringhi,R., Marcello,E., Mikhaylova,M. and Rust,M.B.
  TITLE     Functional interdependence of the actin regulators CAP1 and
            cofilin1 in control of dendritic spine morphology
  JOURNAL   Cell Mol Life Sci 79 (11), 558 (2022)
   PUBMED   36264429
  REMARK    Erratum:[Cell Mol Life Sci. 2024 Jan 18;81(1):46. PMID: 38236280]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Schneider,F., Metz,I., Khudayberdiev,S. and Rust,M.B.
  TITLE     Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2
            in Differentiating Neurons
  JOURNAL   Cells 10 (6), 1525 (2021)
   PUBMED   34204261
  REMARK    GeneRIF: Functional Redundancy of Cyclase-Associated Proteins CAP1
            and CAP2 in Differentiating Neurons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Makkonen,M., Bertling,E., Chebotareva,N.A., Baum,J. and
            Lappalainen,P.
  TITLE     Mammalian and malaria parasite cyclase-associated proteins catalyze
            nucleotide exchange on G-actin through a conserved mechanism
  JOURNAL   J Biol Chem 288 (2), 984-994 (2013)
   PUBMED   23184938
  REMARK    GeneRIF: study provides evidence that catalyzing nucleotide
            exchange on actin monomers via the beta-sheet domain is the most
            highly conserved function of CAPs from mammals to apicomplexan
            parasites.
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Armentano,M., Filosa,A., Andolfi,G. and Studer,M.
  TITLE     COUP-TFI is required for the formation of commissural projections
            in the forebrain by regulating axonal growth
  JOURNAL   Development 133 (21), 4151-4162 (2006)
   PUBMED   17021036
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Bertling,E., Hotulainen,P., Mattila,P.K., Matilainen,T.,
            Salminen,M. and Lappalainen,P.
  TITLE     Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin
            dynamics in mammalian nonmuscle cells
  JOURNAL   Mol Biol Cell 15 (5), 2324-2334 (2004)
   PUBMED   15004221
  REMARK    GeneRIF: CAP1 is widely expressed in mouse nonmuscle cells and
            promotes cofilin-induced actin dynamics.
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Hubberstey,A.V. and Mottillo,E.P.
  TITLE     Cyclase-associated proteins: CAPacity for linking signal
            transduction and actin polymerization
  JOURNAL   FASEB J 16 (6), 487-499 (2002)
   PUBMED   11919151
  REMARK    Review article
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Vojtek,A.B. and Cooper,J.A.
  TITLE     Identification and characterization of a cDNA encoding mouse CAP: a
            homolog of the yeast adenylyl cyclase associated protein
  JOURNAL   J Cell Sci 105 (Pt 3), 777-785 (1993)
   PUBMED   7691848
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN175073.1, AK053351.1 and
            AK137222.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by
            NM_001358035.2.
            
            On Nov 16, 2017 this sequence version replaced XM_006502695.1.
            
            Summary: The product of this gene plays a role in regulating actin
            dynamics by binding actin monomers and promoting the turnover of
            actin filaments. Reduced expression of this gene causes a reduction
            in actin filament turnover rates, causing multiple defects,
            including an increase in cell size, stress-fiber alterations, and
            defects in endocytosis and cell motility. A pseudogene of this gene
            is found on chromosome 14. Alternative splicing results in multiple
            transcript variants, but does not affect the protein. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154002.1, AK144094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               DN175073.1         1-441
            442-2607            AK053351.1         228-2393
            2608-2787           AK137222.1         2375-2554
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.27 cM"
     gene            1..2787
                     /gene="Cap1"
                     /note="cyclase associated actin cytoskeleton regulatory
                     protein 1"
                     /db_xref="GeneID:12331"
                     /db_xref="MGI:MGI:88262"
     exon            1..263
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..388
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..489
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..567
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..711
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..797
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..903
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1081
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1266
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1390
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1473
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1617
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..2787
                     /gene="Cap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccttgga ggcggagccc ttttccaaac gctcctaagc cagattctct ctccggtggc
       61 ggggaatgag ggcggagtca cgagcggagc ggccaaactt cttcctctcc cccgggctag
      121 cgttacagcc agtggttcat ttccggtggg ggtgccgcgc ccagtgaggg cccggaagtg
      181 ggtcgcgcga agaccgctgg gcggttcttg ccggaagtgg agagcggctg atcgcagtcc
      241 ggaggtgagg cggaactctt aagcaggtgg aacattatgg ctgacatgca aaatcttgta
      301 gaaagattgg agagggcagt gggccgcctg gaggcagtgt cacatacttc agacatgcac
      361 tgtggatatg gagacagccc ttcaaaagga gcagttccat atgtgcaagc atttgactcg
      421 ctgcttgcca atcccgtggc agagtacttg aagatgagta aggagatcgg gggagatgtg
      481 cagaaacacg cggagatggt ccacacaggc ctgaagttgg agcgagctct cctggctaca
      541 gcttctcagt gccagcagcc agctggtaat aaactttctg atttgttggc acctatctcg
      601 gagcagatcc aagaagttat aaccttccgg gagaagaacc gaggcagcaa gttttttaat
      661 catctatctg ctgtcagtga aagcatccag gccttgggct gggtggctct ggctgcgaaa
      721 cctggcccct ttgtgaaaga gatgaatgac gcggccatgt tttacacaaa tcgtgtcctc
      781 aaggagtaca gagatgtgga taagaagcat gtggactggg tcagagctta cttgagtata
      841 tggacggagc tgcaggctta catcaaggag tttcatacta ctggcctggc ctggagcaag
      901 acggggcctg tggcaaaaga actgagtgga ttgccatctg gaccctctgt gggatcaggc
      961 ccacctcctc ccccaccggg cccgcctcct cccccaatct ctaccagttc tggttctgac
     1021 gactctgcat cacgctcagc actgtttgca cagattaatc agggggaaag catcacacat
     1081 gccctgaaac atgtatctga tgacatgaag actcacaaga accctgccct gaaagctcag
     1141 agtggtccag ttcggagtgg ccccaaacca ttctctgcac ctaaacccca aactagcccc
     1201 tcccccaaac cagccacaaa gaaggaacca gctctgctgg aactggaagg caagaaatgg
     1261 agagtggaaa accaggagaa tgtttccaac ctggtgatcg atgacactga gctgaagcag
     1321 gtggcttaca tctacaagtg tgtcaacaca acattgcaaa tcaagggcaa aattaactcc
     1381 attacagtag ataactgtaa gaagcttggc ctggtgtttg atgacgtggt gggcattgtg
     1441 gagataatca atagtaggga tgtcaaagtt caggtgatgg gaaaagtgcc aaccatttcc
     1501 attaacaaaa cagatggctg ccatgcttac ctgagcaaga actccctgga ctgtgagata
     1561 gtcagtgcca aatcttctga gatgaatgtc ctcattccta ccgaaggcgg tgattttaac
     1621 gagttcccag tccccgagca gttcaagacc ctgtggaacg gacagaagtt ggtcaccaca
     1681 gtgacagaaa tcgctggata agcaaataca tgggtcctgt gccctctccc ttcacaccat
     1741 gggatacatc tgtatggaga cggttctttt ctagatttcc tctacctttc tgctcttaaa
     1801 ctgcttctct gctctgagaa gcccagctac ctgccttcac tgaaatatac ctcaggctga
     1861 gacgggcggg acagcaggtc agtggatctt caccggaagg tgcagcttct cggcatcagc
     1921 gcagctgcac cacaggctga gcttacagag cttcaggccc agactggggc accgaagctt
     1981 tcagctttgg gggtcattct accaacaatc agtccctgag ggttcacaac accctggaac
     2041 caaacatcag aatgcacact attctcctaa cagtgagcat ggggggcagg agccagggag
     2101 tctattaggt tctaaccaac ctagttttca ttgttgacaa gtgaggccag gcttccactc
     2161 gaccaaaagc taaggattgc cacccagcat tccaagcaga cttgtttcct aaaagcatcc
     2221 ttcatctgca ttccatcctg ggtcagcatc aaccacaaca tagcaggcat tcccttgcag
     2281 ctgcagtaca gtagcagtgt ccttttctga ggaaggaagt cttaaaccct ttccccccac
     2341 cccctgggat gactgccttg attcccatgg ggaacaactt taaagaaaac caccacagca
     2401 ttccaaggag tctggcgttc ctcctccctg ccagatgact gtcattgcct ccactcaccc
     2461 ttctgcttgt cactcggcag cttagggcct ctgcgcagga acctgactag gactatgacc
     2521 tccacggcgg ctgtttaggt ctcgacttac atcagaatct tgcacagcat tgcaaaatcc
     2581 cagtgctccc tctaggacac actgaccaaa atatgcaacc tttcctttcc tatttttttt
     2641 tttttttttt tttttttttg gtgggaaaag aggaagaaag attgtcctgt gacttctgcc
     2701 cattacctga ggcctgtgga aataaacctt tatgtactta aaattataca gaaaatagaa
     2761 taaagttaat accaaacttg tttagtt
//
