LOCUS       NM_007597               4292 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus calnexin (Canx), transcript variant 1, mRNA.
ACCESSION   NM_007597
VERSION     NM_007597.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4292)
  AUTHORS   Pujol,M., Paskevicius,T., Robinson,A., Dhillon,S., Eggleton,P.,
            Ferecsko,A.S., Gutowski,N., Holley,J., Smallwood,M., Newcombe,J.,
            Agellon,L.B. and Michalak,M.
  TITLE     Endothelial Cell-Derived Soluble CD200 Determines the Ability of
            Immune Cells to Cross the Blood-Brain Barrier
  JOURNAL   Int J Mol Sci 25 (17), 9262 (2024)
   PUBMED   39273210
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4292)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   4  (bases 1 to 4292)
  AUTHORS   Luningschror,P., Andreska,T., Veh,A., Wolf,D., Giridhar,N.J.,
            Moradi,M., Denzel,A. and Sendtner,M.
  TITLE     Calnexin controls TrkB cell surface transport and ER-phagy in mouse
            cerebral cortex development
  JOURNAL   Dev Cell 58 (18), 1733-1747 (2023)
   PUBMED   37506696
REFERENCE   5  (bases 1 to 4292)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4292)
  AUTHORS   Wiest,D.L., Burgess,W.H., McKean,D., Kearse,K.P. and Singer,A.
  TITLE     The molecular chaperone calnexin is expressed on the surface of
            immature thymocytes in association with clonotype-independent CD3
            complexes
  JOURNAL   EMBO J 14 (14), 3425-3433 (1995)
   PUBMED   7628443
REFERENCE   7  (bases 1 to 4292)
  AUTHORS   Carreno,B.M., Schreiber,K.L., McKean,D.J., Stroynowski,I. and
            Hansen,T.H.
  TITLE     Aglycosylated and phosphatidylinositol-anchored MHC class I
            molecules are associated with calnexin. Evidence implicating the
            class I-connecting peptide segment in calnexin association
  JOURNAL   J Immunol 154 (10), 5173-5180 (1995)
   PUBMED   7730623
REFERENCE   8  (bases 1 to 4292)
  AUTHORS   Kozak,C.A., Danciger,M., Bowes,C., Adamson,M.C., Palczewski,K.,
            Polans,A.S. and Farber,D.B.
  TITLE     Localization of three genes expressed in retina on mouse chromosome
            11
  JOURNAL   Mamm Genome 6 (2), 142-144 (1995)
   PUBMED   7767000
REFERENCE   9  (bases 1 to 4292)
  AUTHORS   Tjoelker,L.W., Seyfried,C.E., Eddy,R.L. Jr., Byers,M.G.,
            Shows,T.B., Calderon,J., Schreiber,R.B. and Gray,P.W.
  TITLE     Human, mouse, and rat calnexin cDNA cloning: identification of
            potential calcium binding motifs and gene localization to human
            chromosome 5
  JOURNAL   Biochemistry 33 (11), 3229-3236 (1994)
   PUBMED   8136357
REFERENCE   10 (bases 1 to 4292)
  AUTHORS   Schreiber,K.L., Bell,M.P., Huntoon,C.J., Rajagopalan,S.,
            Brenner,M.B. and McKean,D.J.
  TITLE     Class II histocompatibility molecules associate with calnexin
            during assembly in the endoplasmic reticulum
  JOURNAL   Int Immunol 6 (1), 101-111 (1994)
   PUBMED   8148318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY309447.1, AK084175.1, AK166649.1, AK004422.1, AK017254.1 and
            BX632165.1.
            
            On Nov 15, 2007 this sequence version replaced NM_007597.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.76263.1,
                                           SRR1660811.7630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BY309447.1         1-61
            62-2296             AK084175.1         2-2236
            2297-3283           AK166649.1         2272-3258
            3284-3777           AK004422.1         565-1058
            3778-4285           AK017254.1         565-1072
            4286-4292           BX632165.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..4292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.46 cM"
     gene            1..4292
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /note="calnexin"
                     /db_xref="GeneID:12330"
                     /db_xref="MGI:MGI:88261"
     exon            1..181
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            182..362
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1964
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /codon_start=1
                     /product="calnexin precursor"
                     /protein_id="NP_031623.1"
                     /db_xref="CCDS:CCDS24633.1"
                     /db_xref="GeneID:12330"
                     /db_xref="MGI:MGI:88261"
                     /translation="MEGKWLLCLLLVLGTAAVEAHDGHDDDAIDIEDDLDDVIEEVED
                     SKSKSDASTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYD
                     GKWEVDEMKETKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIE
                     CGGAYVKLLSKTAELSLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGVYEEK
                     HAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSRE
                     IEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDEPEYIPD
                     PDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNP
                     NYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDD
                     WANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKK
                     QSNAMEYKKTDAPQPDVKDEEGKEEEKNKRDEEEEEEKLEEKQKSDAEEDGVTGSQDE
                     EDSKPKAEEDEILNRSPRNRKPRRE"
     exon            363..436
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            437..495
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            496..637
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            720..912
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1102
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1216
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1373
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1589
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1709
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1830
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1910
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..4289
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3753..3758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /note="hexamer: AATAAA"
     polyA_site      3779
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /note="major polyA site"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
                     /note="hexamer: ATTAAA"
     polyA_site      4289
                     /gene="Canx"
                     /gene_synonym="1110069N15Rik; Cnx; D11Ertd153e"
ORIGIN      
        1 ggacgcgggg ttgggcttcg tgcggtgggg ctcgctcgcg cggcggccgt agccgaggcc
       61 tcttagttct gcggcacgtg acggtcgggc cgcctctgcc gctgtctcca ctgcagcacg
      121 gggccgggtg tgcgggtggg agaaggtgag ggagccgcca gtggtccccg ggaggctcga
      181 gatagatcat ggaagggaag tggttactgt gtttgctgct ggtccttgga actgcagctg
      241 ttgaggctca tgatggacat gatgatgacg cgattgatat tgaagatgat cttgatgatg
      301 ttattgaaga ggtagaagat tcaaaatcta aatcagatgc cagcactcct ccatctccaa
      361 aggtcaccta caaagctcca gttccaacag gggaggttta ttttgctgac tcctttgaca
      421 gagggtctct gtcagggtgg attttatcta aagccaaaaa agatgacact gatgatgaaa
      481 ttgccaaata tgatggaaag tgggaagtag atgagatgaa ggaaacaaag cttccagggg
      541 ataaaggact tgtactgatg tctcgggcca agcatcatgc catctctgct aaactgaata
      601 agcccttcct gtttgatacc aagcctctca ttgttcagta tgaggttaat tttcagaatg
      661 gaatagaatg tggtggtgcc tatgtgaagc tgctttccaa gacggcagag ctcagcctgg
      721 atcaattcca cgacaagact ccctatacta ttatgtttgg tccagataag tgtggagagg
      781 actacaaact gcatttcatc tttcgacaca aaaatcccaa gacaggtgta tatgaagaaa
      841 aacatgctaa gaggccagat gcagatctga agacctattt cactgacaag aaaacgcatc
      901 tttatacatt aatcttgaat ccagacaata gttttgaaat attagttgac cagtctgttg
      961 tgaacagtgg aaatctgcta aatgacatga ctcctcctgt aaacccttca cgtgaaattg
     1021 aagacccaga agaccggaag cctgaagatt gggatgaaag gcccaaaata gcagatccag
     1081 atgctgtcaa gccagatgac tgggatgaag acgccccttc taagatccca gatgaagagg
     1141 ccaccaagcc tgaaggctgg ctagacgacg aacctgagta tattccagac cctgatgcag
     1201 agaagccaga ggattgggat gaggatatgg acggagaatg ggaggctcct cagattgcca
     1261 accccaagtg tgagtcagcc cctgggtgtg gtgtctggca gcgacctatg attgacaacc
     1321 ccaattataa gggcaaatgg aagcctccaa tgattgacaa ccctaactac cagggaatct
     1381 ggaaaccaag gaaaatacca aatccagatt tctttgaaga cctagaacct tttaagatga
     1441 ctcctttcag tgctattggt ttggagctct ggtccatgac atccgacatc ttttttgaca
     1501 actttatcat tagtggtgac cgaagagtag ttgatgattg ggccaatgat gggtggggcc
     1561 tgaagaaagc tgctgatggg gctgctgagc caggtgtagt gctgcagatg ctggaggcag
     1621 ctgaagagcg tccatggctt tgggtggtct acattttgac tgtagctttg ccagtgttcc
     1681 ttgtgatcct cttctgctgt tctggaaaga aacagtccaa tgctatggag tacaagaaga
     1741 cggatgctcc ccagccagat gtgaaggatg aagaagggaa ggaagaagag aagaacaaga
     1801 gggatgaaga ggaagaagag gagaagcttg aagagaaaca gaagagtgat gctgaagaag
     1861 atggtgttac tggcagtcaa gatgaggaag atagcaagcc taaagcagag gaggatgaaa
     1921 ttttgaacag atcgccaaga aacagaaagc cacgaagaga gtgaaacaat ctttaagaac
     1981 ttgatctgtg atttcctctc cctccccttc ccctgcaaat gtggtcctag gagagggcct
     2041 ggtgtacctt aggtgggagc tcaaaacctc aagatgtcac catcaacagg ttccagtgaa
     2101 tactagcctg taattttaaa catctagcag taaataattg cagttgtaat gtaaaggacc
     2161 ctgtttctgt agaaaggaaa acatttaaca taatggttgt gaaatgtaac atgaagcaac
     2221 taactagtgt tttgttgttt ttaaaatttt ccaggtttgt cttttttttt ttccttttcc
     2281 tttttttttt ttttttagat acaatgatag aatttttgcc agtttaaaat cttggcttaa
     2341 tttaatatat tcatttgttc atgcagaaat aacaccaaca ttaggaatgc tagggagaat
     2401 gaattgccgt ttttataata acttttttaa gtttggtatt aaagcattca tgtgtctgtc
     2461 ctaaaattgt aatcacgttc aagtgcagtt atttgtggtt ataaatcttg ttttgtgtgc
     2521 ttccattagt taattcctct taaagacaca agagcgattg gatggaagcc caaatttata
     2581 tcaaagttcc ctttacattg tattgaatag acccaaaaag aactaaaagg agactttgac
     2641 ttggtcattt cacatcagat cataaagtgc agtgttctgt tgccctagag actgctccat
     2701 tcacaagcac ctttgaagag ggaaggagct ggcttcatgt agcagttcat actgtacttc
     2761 ccacatagga ggtctgacag ctcgggtcct ctggagcaca aggcttttta aggaatgctg
     2821 gtggtgcctg ggtagataat tacatcactt gttccactgt gttgacactg ttttcctcat
     2881 ggatctcctc cattcctagc tttctctgct atgcattttc ttcacagcgc agcttgcggt
     2941 ccgttgctga aaattataag ctctgcatag tgttggcttt actgtgatga catgtttctt
     3001 cttttttagc tggcccacac ctttctaggg tccaactaca ggatagatta cagactttcc
     3061 attagtgtct atttctttta ctctgtgtag actttagaaa gtctaatcaa tccagagatg
     3121 ggccaattca gaattgacta taattgaaca cctgctaaaa gtatttatgg gaggattgac
     3181 acacagcatg agttatttga cttttgtagg atatttaaaa tcttcatttg cagttcatgt
     3241 aacagttgtg tcttaaaatt cacataataa agcagtcctg ttcaaaaaaa aaattttttt
     3301 tttgtggctt gtagaatttt ttaaaagtgt atttagggct ttttgttttt tgtttgtttt
     3361 tttgttttgt ttttcatgtg gaatgcagat gggtgctaga ggagcctctc ccacatcact
     3421 atagtgtaat attattacac cacactgaaa tgtattcaga aacagatgtt tcaatttcat
     3481 tctttctcca gaggtggtcc agttgtacca atgatactat tccttgcact gaatatatat
     3541 aaacactctt cagtgtttat attggggaaa tactgggaaa gaaatatatt tgttaaggat
     3601 gaaggctgta tctgttgtct ttataaacac tggttcattt cttttgaggg tggaatgcat
     3661 ttttcttcct gttcagtgct ttatcaccat ctgttgtttg tggtcacagt gaccatagct
     3721 atgtagcgga cgtttccaaa tgtatagagt gaaataaaca gttactagca agaaatgaat
     3781 acatgtctgc aggtttctcc ttgaagcaaa catggggatg attgcttttc tagaaatcgg
     3841 tttatctgtt tcatcattct acattgacat tgttttgtgc ctactttata ttcacccagg
     3901 ctgtacaatg acaggtttat ttatgtcact ggtggtggtc attgcctttt tgggtccctc
     3961 ttcctccctc aaggttccat tgaagctcca gcctccttaa atacctgact cgttagtaaa
     4021 tgatcagcag tcttcagctc ttaaaaaaag cgtagagggc aggtattgta gctgagtagg
     4081 tagaactgct aagcgtgtgc aaggttccgt gggtctgatt cctggcactg aattaagata
     4141 gataaaggcc cttatattct gattttctat gctggactcc ttgttgtaaa atgtccatgc
     4201 cagtagtact cttctattgt ccacttttca gattgtcaca ctgctaaatg acattatatt
     4261 aaagcccgtg ttaaatatct gtatcataaa aa
//
